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Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism / Chie SHIMMURA in Molecular Autism, (March 2013)
[article]
Titre : Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism Type de document : Texte imprimé et/ou numérique Auteurs : Chie SHIMMURA, Auteur ; Katsuaki SUZUKI, Auteur ; Yasuhide IWATA, Auteur ; Kenji J. TSUCHIYA, Auteur ; Koji OHNO, Auteur ; Hideo MATSUZAKI, Auteur ; Keiko IWATA, Auteur ; Yosuke KAMENO, Auteur ; Taro TAKAHASHI, Auteur ; Tomoyasu WAKUDA, Auteur ; Kazuhiko NAKAMURA, Auteur ; Kenji HASHIMOTO, Auteur ; Norio MORI, Auteur Année de publication : 2013 Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism Glutamate Glutaminase Glutamate-glutamine cycle Anterior cingulate cortex Index. décimale : PER Périodiques Résumé : BACKGROUND:Accumulating evidence suggests that dysfunction in the glutamatergic system may underlie the pathophysiology of autism. The anterior cingulate cortex (ACC) has been implicated in autism as well as in glutamatergic neurotransmission. We hypothesized that alterations in the glutamate-glutamine cycle in the ACC might play a role in the pathophysiology of autism.METHODS:We performed Western blot analyses for the protein expression levels of enzymes in the glutamate-glutamine cycle, including glutamine synthetase, kidney-type glutaminase, liver-type glutaminase, and glutamate dehydrogenases 1 and 2, in the ACC of postmortem brain of individuals with autism (n=7) and control subjects (n=13).RESULTS:We found that the protein levels of kidney-type glutaminase, but not those of the other enzymes measured, in the ACC were significantly lower in subjects with autism than in controls.CONCLUSION:The results suggest that reduced expression of kidney-type glutaminase may account for putative alterations in glutamatergic neurotransmission in the ACC in autism. En ligne : http://dx.doi.org/10.1186/2040-2392-4-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Molecular Autism > (March 2013) . - 7 p.[article] Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism [Texte imprimé et/ou numérique] / Chie SHIMMURA, Auteur ; Katsuaki SUZUKI, Auteur ; Yasuhide IWATA, Auteur ; Kenji J. TSUCHIYA, Auteur ; Koji OHNO, Auteur ; Hideo MATSUZAKI, Auteur ; Keiko IWATA, Auteur ; Yosuke KAMENO, Auteur ; Taro TAKAHASHI, Auteur ; Tomoyasu WAKUDA, Auteur ; Kazuhiko NAKAMURA, Auteur ; Kenji HASHIMOTO, Auteur ; Norio MORI, Auteur . - 2013 . - 7 p.
Langues : Anglais (eng)
in Molecular Autism > (March 2013) . - 7 p.
Mots-clés : Autism Glutamate Glutaminase Glutamate-glutamine cycle Anterior cingulate cortex Index. décimale : PER Périodiques Résumé : BACKGROUND:Accumulating evidence suggests that dysfunction in the glutamatergic system may underlie the pathophysiology of autism. The anterior cingulate cortex (ACC) has been implicated in autism as well as in glutamatergic neurotransmission. We hypothesized that alterations in the glutamate-glutamine cycle in the ACC might play a role in the pathophysiology of autism.METHODS:We performed Western blot analyses for the protein expression levels of enzymes in the glutamate-glutamine cycle, including glutamine synthetase, kidney-type glutaminase, liver-type glutaminase, and glutamate dehydrogenases 1 and 2, in the ACC of postmortem brain of individuals with autism (n=7) and control subjects (n=13).RESULTS:We found that the protein levels of kidney-type glutaminase, but not those of the other enzymes measured, in the ACC were significantly lower in subjects with autism than in controls.CONCLUSION:The results suggest that reduced expression of kidney-type glutaminase may account for putative alterations in glutamatergic neurotransmission in the ACC in autism. En ligne : http://dx.doi.org/10.1186/2040-2392-4-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder / Tamar KOLODNY in Autism Research, 13-7 (July 2020)
[article]
Titre : Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tamar KOLODNY, Auteur ; Michael-Paul SCHALLMO, Auteur ; Jennifer GERDTS, Auteur ; Richard A. E. EDDEN, Auteur ; Raphael BERNIER, Auteur ; Scott O. MURRAY, Auteur Article en page(s) : p.1111-1129 Langues : Anglais (eng) Mots-clés : auditory cortex autism spectrum disorders glutamate magnetic resonance spectroscopy sensorimotor cortex visual cortex ?-aminobutyric acid Index. décimale : PER Périodiques Résumé : The balance of excitation and inhibition in neural circuits is hypothesized to be increased in autism spectrum disorder, possibly mediated by altered signaling of the inhibitory neurotransmitter ?-aminobutyric acid (GABA), yet empirical evidence in humans is inconsistent. We used edited magnetic resonance spectroscopy (MRS) to quantify signals associated with both GABA and the excitatory neurotransmitter glutamate in multiple regions of the sensory and sensorimotor cortex, including primary visual, auditory, and motor areas in adult individuals with autism and in neurotypical controls. Despite the strong a priori hypothesis of reduced GABA in autism spectrum disorder, we found no group differences in neurometabolite concentrations in any of the examined regions and no correlations of MRS measure with psychophysical visual sensitivity or autism symptomatology. We demonstrate high data quality that is comparable across groups, with a relatively large sample of well-characterized participants, and use Bayesian statistics to corroborate the lack of any group differences. We conclude that levels of GABA and Glx (glutamate, glutamine, and glutathione) in the sensory and sensorimotor cortex, as measured with MRS at 3T, are comparable in adults with autism and neurotypical individuals. Autism Res 2020, 13: 1111-1129. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: ?-Aminobutyric acid (GABA) and glutamate are the main inhibitory and excitatory neurotransmitters in the human brain, respectively, and their balanced interaction is necessary for neural function. Previous research suggests that the GABA and glutamate systems might be altered in autism. In this study, we used magnetic resonance spectroscopy to measure concentrations of these neurotransmitters in the sensory areas in the brains of young adults with autism. In contradiction to the common hypothesis of reduced GABA in autism, we demonstrate that concentrations of both GABA and glutamate, in all the brain regions examined, are comparable in individuals with autism and in neurotypical adults. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429
in Autism Research > 13-7 (July 2020) . - p.1111-1129[article] Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Tamar KOLODNY, Auteur ; Michael-Paul SCHALLMO, Auteur ; Jennifer GERDTS, Auteur ; Richard A. E. EDDEN, Auteur ; Raphael BERNIER, Auteur ; Scott O. MURRAY, Auteur . - p.1111-1129.
Langues : Anglais (eng)
in Autism Research > 13-7 (July 2020) . - p.1111-1129
Mots-clés : auditory cortex autism spectrum disorders glutamate magnetic resonance spectroscopy sensorimotor cortex visual cortex ?-aminobutyric acid Index. décimale : PER Périodiques Résumé : The balance of excitation and inhibition in neural circuits is hypothesized to be increased in autism spectrum disorder, possibly mediated by altered signaling of the inhibitory neurotransmitter ?-aminobutyric acid (GABA), yet empirical evidence in humans is inconsistent. We used edited magnetic resonance spectroscopy (MRS) to quantify signals associated with both GABA and the excitatory neurotransmitter glutamate in multiple regions of the sensory and sensorimotor cortex, including primary visual, auditory, and motor areas in adult individuals with autism and in neurotypical controls. Despite the strong a priori hypothesis of reduced GABA in autism spectrum disorder, we found no group differences in neurometabolite concentrations in any of the examined regions and no correlations of MRS measure with psychophysical visual sensitivity or autism symptomatology. We demonstrate high data quality that is comparable across groups, with a relatively large sample of well-characterized participants, and use Bayesian statistics to corroborate the lack of any group differences. We conclude that levels of GABA and Glx (glutamate, glutamine, and glutathione) in the sensory and sensorimotor cortex, as measured with MRS at 3T, are comparable in adults with autism and neurotypical individuals. Autism Res 2020, 13: 1111-1129. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: ?-Aminobutyric acid (GABA) and glutamate are the main inhibitory and excitatory neurotransmitters in the human brain, respectively, and their balanced interaction is necessary for neural function. Previous research suggests that the GABA and glutamate systems might be altered in autism. In this study, we used magnetic resonance spectroscopy to measure concentrations of these neurotransmitters in the sensory areas in the brains of young adults with autism. In contradiction to the common hypothesis of reduced GABA in autism, we demonstrate that concentrations of both GABA and glutamate, in all the brain regions examined, are comparable in individuals with autism and in neurotypical adults. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders / Rabindra TIROUVANZIAM in Journal of Autism and Developmental Disorders, 42-5 (May 2012)
[article]
Titre : Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Rabindra TIROUVANZIAM, Auteur ; Tetyana V. OBUKHANYCH, Auteur ; Julie LAVAL, Auteur ; Pavel A. ARONOV, Auteur ; Robin LIBOVE, Auteur ; Arpita GOSWAMI BANERJEE, Auteur ; Karen J. PARKER, Auteur ; Ruth O’HARA, Auteur ; Leonard A. HERZENBERG, Auteur ; Leonore A. HERZENBERG, Auteur ; Antonio Y. HARDAN, Auteur Année de publication : 2012 Article en page(s) : p.827-836 Langues : Anglais (eng) Mots-clés : Blood Predictive value Polar neutral amino acids Leucine Glutamate Index. décimale : PER Périodiques Résumé : The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1314-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154
in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.827-836[article] Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Rabindra TIROUVANZIAM, Auteur ; Tetyana V. OBUKHANYCH, Auteur ; Julie LAVAL, Auteur ; Pavel A. ARONOV, Auteur ; Robin LIBOVE, Auteur ; Arpita GOSWAMI BANERJEE, Auteur ; Karen J. PARKER, Auteur ; Ruth O’HARA, Auteur ; Leonard A. HERZENBERG, Auteur ; Leonore A. HERZENBERG, Auteur ; Antonio Y. HARDAN, Auteur . - 2012 . - p.827-836.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.827-836
Mots-clés : Blood Predictive value Polar neutral amino acids Leucine Glutamate Index. décimale : PER Périodiques Résumé : The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1314-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 Excitotoxicity in Autism : The Role of Glutamate in Pathogenesis and Treatment / Martin EVERS
Titre : Excitotoxicity in Autism : The Role of Glutamate in Pathogenesis and Treatment Type de document : Texte imprimé et/ou numérique Auteurs : Martin EVERS, Auteur ; Eric HOLLANDER, Auteur Année de publication : 2008 Importance : p.133-145 Langues : Anglais (eng) Mots-clés : Glutamate Neurotoxicité Excitotoxicité Neurodeveloppement Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=703 Excitotoxicity in Autism : The Role of Glutamate in Pathogenesis and Treatment [Texte imprimé et/ou numérique] / Martin EVERS, Auteur ; Eric HOLLANDER, Auteur . - 2008 . - p.133-145.
Langues : Anglais (eng)
Mots-clés : Glutamate Neurotoxicité Excitotoxicité Neurodeveloppement Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=703 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Increased Glutamate Concentration in the Auditory Cortex of Persons With Autism and First-Degree Relatives: A 1H-MRS Study / Mark S. BROWN in Autism Research, 6-1 (February 2013)
[article]
Titre : Increased Glutamate Concentration in the Auditory Cortex of Persons With Autism and First-Degree Relatives: A 1H-MRS Study Type de document : Texte imprimé et/ou numérique Auteurs : Mark S. BROWN, Auteur ; Debra SINGEL, Auteur ; Susan HEPBURN, Auteur ; Donald C. ROJAS, Auteur Année de publication : 2013 Article en page(s) : p.1-10 Langues : Anglais (eng) Mots-clés : glutamate n-acetyl-aspartate creatine spectroscopy auditory cortex Index. décimale : PER Périodiques Résumé : Increased glutamate levels have been reported in the hippocampal and frontal regions of persons with autism using proton magnetic resonance spectroscopy (1H-MRS). Although autism spectrum disorders (ASDs) are highly heritable, MRS studies have not included relatives of persons with ASD. We therefore conducted a study to determine if glutamate levels are elevated in people with autism and parents of children with autism. Single-voxel, point-resolved spectroscopy data were acquired at 3T for left and right hemisphere auditory cortical voxels in 13 adults with autism, 15 parents of children with autism, and 15 adult control subjects. The primary measure was glutamate?+?glutamine (Glx). Additional measures included n-acetyl-aspartate (NAA), choline (Cho), myoinositol (mI), and creatine (Cr). The autism group had significantly higher Glx, NAA, and Cr concentrations than the control subjects. Parents did not differ from control subjects on any measures. No significant differences in Cho or mI levels were seen among groups. No reliable correlations between autism symptom measures, and MRS variables were seen after Bonferroni correction for multiple comparisons. The elevation in Glx in autism is consistent with prior MRS data in the hippocampus and frontal lobe and may suggest increased cortical excitability. Increased NAA and Cr may indicate brain metabolism disturbances in autism. In the current study, we found no reliable evidence of a familial effect for any spectroscopy measure. This may indicate that these metabolites have no heritable component in autism, the presence of a compensatory factor in parents, or sample-specific limitations such as the participation of singleton families. En ligne : http://dx.doi.org/10.1002/aur.1260 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192
in Autism Research > 6-1 (February 2013) . - p.1-10[article] Increased Glutamate Concentration in the Auditory Cortex of Persons With Autism and First-Degree Relatives: A 1H-MRS Study [Texte imprimé et/ou numérique] / Mark S. BROWN, Auteur ; Debra SINGEL, Auteur ; Susan HEPBURN, Auteur ; Donald C. ROJAS, Auteur . - 2013 . - p.1-10.
Langues : Anglais (eng)
in Autism Research > 6-1 (February 2013) . - p.1-10
Mots-clés : glutamate n-acetyl-aspartate creatine spectroscopy auditory cortex Index. décimale : PER Périodiques Résumé : Increased glutamate levels have been reported in the hippocampal and frontal regions of persons with autism using proton magnetic resonance spectroscopy (1H-MRS). Although autism spectrum disorders (ASDs) are highly heritable, MRS studies have not included relatives of persons with ASD. We therefore conducted a study to determine if glutamate levels are elevated in people with autism and parents of children with autism. Single-voxel, point-resolved spectroscopy data were acquired at 3T for left and right hemisphere auditory cortical voxels in 13 adults with autism, 15 parents of children with autism, and 15 adult control subjects. The primary measure was glutamate?+?glutamine (Glx). Additional measures included n-acetyl-aspartate (NAA), choline (Cho), myoinositol (mI), and creatine (Cr). The autism group had significantly higher Glx, NAA, and Cr concentrations than the control subjects. Parents did not differ from control subjects on any measures. No significant differences in Cho or mI levels were seen among groups. No reliable correlations between autism symptom measures, and MRS variables were seen after Bonferroni correction for multiple comparisons. The elevation in Glx in autism is consistent with prior MRS data in the hippocampus and frontal lobe and may suggest increased cortical excitability. Increased NAA and Cr may indicate brain metabolism disturbances in autism. In the current study, we found no reliable evidence of a familial effect for any spectroscopy measure. This may indicate that these metabolites have no heritable component in autism, the presence of a compensatory factor in parents, or sample-specific limitations such as the participation of singleton families. En ligne : http://dx.doi.org/10.1002/aur.1260 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 Glutamatergic agents in Autism Spectrum Disorders: Current trends / Roberto CANITANO in Research in Autism Spectrum Disorders, 8-3 (March 2014)
PermalinkBrief Report: Pilot Single-Blind Placebo Lead-In Study of Acamprosate in Youth with Autistic Disorder / Craig ERICKSON in Journal of Autism and Developmental Disorders, 44-4 (April 2014)
PermalinkCerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder / J. P. HEGARTY in Journal of Autism and Developmental Disorders, 48-10 (October 2018)
PermalinkIncreased prefrontal GABA concentrations in adults with autism spectrum disorders / Simon MAIER in Autism Research, 15-7 (July 2022)
PermalinkNon-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument / Masafumi HARADA in Journal of Autism and Developmental Disorders, 41-4 (April 2011)
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