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Neurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood / Rachael BEDFORD in Molecular Autism, 8 (2017)
[article]
Titre : Neurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood Type de document : Texte imprimé et/ou numérique Auteurs : Rachael BEDFORD, Auteur ; T. GLIGA, Auteur ; E. SHEPHARD, Auteur ; M. ELSABBAGH, Auteur ; A. PICKLES, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur Article en page(s) : 49p. Langues : Anglais (eng) Mots-clés : Autism Diagnosis High risk Infants Neurocognitive Prediction Siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: Prospective studies of infants at high familial risk for autism spectrum disorder (ASD) have identified a number of putative early markers that are associated with ASD outcome at 3 years of age. However, some diagnostic changes occur between toddlerhood and mid-childhood, which raises the question of whether infant markers remain associated with diagnosis into mid-childhood. METHODS: First, we tested whether infant neurocognitive markers (7-month neural response to eye gaze shifts and 14-month visual disengagement latencies) as well as an observational marker of emerging ASD behaviours (the Autism Observation Scale for Infants; AOSI) predicted ASD outcome in high-risk (HR) 7-year-olds with and without an ASD diagnosis (HR-ASD and HR-No ASD) and low risk (LR) controls. Second, we tested whether the neurocognitive markers offer predictive power over and above the AOSI. RESULTS: Both neurocognitive markers distinguished children with an ASD diagnosis at 7 years of age from those in the HR-No ASD and LR groups. Exploratory analysis suggested that neurocognitive markers may further differentiate stable versus lost/late diagnosis across the 3 to 7 year period, which will need to be tested in larger samples. At both 7 and 14 months, combining the neurocognitive marker with the AOSI offered a significantly improved model fit over the AOSI alone. CONCLUSIONS: Infant neurocognitive markers relate to ASD in mid-childhood, improving predictive power over and above an early observational marker. The findings have implications for understanding the neurodevelopmental mechanisms that lead from risk to disorder and for identification of potential targets of pre-emptive intervention. En ligne : http://dx.doi.org/10.1186/s13229-017-0167-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 8 (2017) . - 49p.[article] Neurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood [Texte imprimé et/ou numérique] / Rachael BEDFORD, Auteur ; T. GLIGA, Auteur ; E. SHEPHARD, Auteur ; M. ELSABBAGH, Auteur ; A. PICKLES, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur . - 49p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 49p.
Mots-clés : Autism Diagnosis High risk Infants Neurocognitive Prediction Siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: Prospective studies of infants at high familial risk for autism spectrum disorder (ASD) have identified a number of putative early markers that are associated with ASD outcome at 3 years of age. However, some diagnostic changes occur between toddlerhood and mid-childhood, which raises the question of whether infant markers remain associated with diagnosis into mid-childhood. METHODS: First, we tested whether infant neurocognitive markers (7-month neural response to eye gaze shifts and 14-month visual disengagement latencies) as well as an observational marker of emerging ASD behaviours (the Autism Observation Scale for Infants; AOSI) predicted ASD outcome in high-risk (HR) 7-year-olds with and without an ASD diagnosis (HR-ASD and HR-No ASD) and low risk (LR) controls. Second, we tested whether the neurocognitive markers offer predictive power over and above the AOSI. RESULTS: Both neurocognitive markers distinguished children with an ASD diagnosis at 7 years of age from those in the HR-No ASD and LR groups. Exploratory analysis suggested that neurocognitive markers may further differentiate stable versus lost/late diagnosis across the 3 to 7 year period, which will need to be tested in larger samples. At both 7 and 14 months, combining the neurocognitive marker with the AOSI offered a significantly improved model fit over the AOSI alone. CONCLUSIONS: Infant neurocognitive markers relate to ASD in mid-childhood, improving predictive power over and above an early observational marker. The findings have implications for understanding the neurodevelopmental mechanisms that lead from risk to disorder and for identification of potential targets of pre-emptive intervention. En ligne : http://dx.doi.org/10.1186/s13229-017-0167-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder / A. ESTES in Journal of Autism and Developmental Disorders, 48-4 (April 2018)
[article]
Titre : Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. ESTES, Auteur ; J. MUNSON, Auteur ; T. S. JOHN, Auteur ; Stephen R. DAGER, Auteur ; A. RODDA, Auteur ; Kelly N. BOTTERON, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; M. J. GURALNICK, Auteur Article en page(s) : p.1122-1132 Langues : Anglais (eng) Mots-clés : Autism High risk Parent Peer relations Preschool Sibling Index. décimale : PER Périodiques Résumé : Preschool-aged siblings of children with ASD are at high-risk (HR) for ASD and related challenges, but little is known about their emerging peer competence and friendships. Parents are the main providers of peer-relationship opportunities during preschool. Understanding parental challenges supporting early peer relationships is needed for optimal peer competence and friendships in children with ASD. We describe differences in peer relationships among three groups of preschool-aged children (15 HR-ASD, 53 HR-NonASD, 40 low-risk, LR), and examine parent support activities at home and arranging community-based peer activities. Children with ASD demonstrated precursors to poor peer competence and friendship outcomes. Parents in the HR group showed resilience in many areas, but providing peer opportunities for preschool-age children with ASD demanded significant adaptations. En ligne : http://dx.doi.org/10.1007/s10803-017-3202-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351
in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1122-1132[article] Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. ESTES, Auteur ; J. MUNSON, Auteur ; T. S. JOHN, Auteur ; Stephen R. DAGER, Auteur ; A. RODDA, Auteur ; Kelly N. BOTTERON, Auteur ; Heather C. HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; J. PIVEN, Auteur ; M. J. GURALNICK, Auteur . - p.1122-1132.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1122-1132
Mots-clés : Autism High risk Parent Peer relations Preschool Sibling Index. décimale : PER Périodiques Résumé : Preschool-aged siblings of children with ASD are at high-risk (HR) for ASD and related challenges, but little is known about their emerging peer competence and friendships. Parents are the main providers of peer-relationship opportunities during preschool. Understanding parental challenges supporting early peer relationships is needed for optimal peer competence and friendships in children with ASD. We describe differences in peer relationships among three groups of preschool-aged children (15 HR-ASD, 53 HR-NonASD, 40 low-risk, LR), and examine parent support activities at home and arranging community-based peer activities. Children with ASD demonstrated precursors to poor peer competence and friendship outcomes. Parents in the HR group showed resilience in many areas, but providing peer opportunities for preschool-age children with ASD demanded significant adaptations. En ligne : http://dx.doi.org/10.1007/s10803-017-3202-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351 Sex differences in the association between infant markers and later autistic traits / Rachael BEDFORD in Molecular Autism, 7 (2016)
[article]
Titre : Sex differences in the association between infant markers and later autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Rachael BEDFORD, Auteur ; E. J. JONES, Auteur ; M. H. JOHNSON, Auteur ; A. PICKLES, Auteur ; Tony CHARMAN, Auteur ; T. GLIGA, Auteur Article en page(s) : 21p. Langues : Anglais (eng) Mots-clés : Attention/physiology Autism Spectrum Disorder/diagnosis/pathology Female Fixation, Ocular/physiology Humans Infant Male Phenotype Risk Factors Severity of Illness Index Sex Factors Siblings Surveys and Questionnaires Video Recording Autism Differential liability High risk Infants Sex difference Index. décimale : PER Périodiques Résumé : BACKGROUND: Although it is well established that the prevalence of autism spectrum disorder (ASD) is higher in males than females, there is relatively little understanding of the underlying mechanisms and their developmental time course. Sex-specific protective or risk factors have often been invoked to explain these differences, but such factors are yet to be identified. METHODS: We take a developmental approach, using a prospective sample of 104 infants at high and low familial risk for ASD, to characterise sex differences in infant markers known to predict emerging autism symptoms. We examine three markers previously shown to be associated with later autistic social-communication symptoms: the Autism Observation Scale for Infants (AOSI) total score, attention disengagement speed and gaze following behaviour. Our aim was to test whether sex differences were already present in these markers at 1 year of age, which would suggest sex-specific mechanisms of risk or protection. RESULTS: While no sex differences were found in any of the three markers investigated, we found sex differences in their relationship to 3-year autism traits; all three markers significantly predicted later autism traits only in the boys. CONCLUSIONS: Previously identified 'early autism markers' were associated with later autism symptoms only in boys. This suggests that there may be additional moderating risk or protective factors which remain to be identified. Our findings have important implications for prospective studies in terms of directly testing for the moderating effect of sex on emerging autistic traits. En ligne : http://dx.doi.org/10.1186/s13229-016-0081-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 21p.[article] Sex differences in the association between infant markers and later autistic traits [Texte imprimé et/ou numérique] / Rachael BEDFORD, Auteur ; E. J. JONES, Auteur ; M. H. JOHNSON, Auteur ; A. PICKLES, Auteur ; Tony CHARMAN, Auteur ; T. GLIGA, Auteur . - 21p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 21p.
Mots-clés : Attention/physiology Autism Spectrum Disorder/diagnosis/pathology Female Fixation, Ocular/physiology Humans Infant Male Phenotype Risk Factors Severity of Illness Index Sex Factors Siblings Surveys and Questionnaires Video Recording Autism Differential liability High risk Infants Sex difference Index. décimale : PER Périodiques Résumé : BACKGROUND: Although it is well established that the prevalence of autism spectrum disorder (ASD) is higher in males than females, there is relatively little understanding of the underlying mechanisms and their developmental time course. Sex-specific protective or risk factors have often been invoked to explain these differences, but such factors are yet to be identified. METHODS: We take a developmental approach, using a prospective sample of 104 infants at high and low familial risk for ASD, to characterise sex differences in infant markers known to predict emerging autism symptoms. We examine three markers previously shown to be associated with later autistic social-communication symptoms: the Autism Observation Scale for Infants (AOSI) total score, attention disengagement speed and gaze following behaviour. Our aim was to test whether sex differences were already present in these markers at 1 year of age, which would suggest sex-specific mechanisms of risk or protection. RESULTS: While no sex differences were found in any of the three markers investigated, we found sex differences in their relationship to 3-year autism traits; all three markers significantly predicted later autism traits only in the boys. CONCLUSIONS: Previously identified 'early autism markers' were associated with later autism symptoms only in boys. This suggests that there may be additional moderating risk or protective factors which remain to be identified. Our findings have important implications for prospective studies in terms of directly testing for the moderating effect of sex on emerging autistic traits. En ligne : http://dx.doi.org/10.1186/s13229-016-0081-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder / M. MILLER in Journal of Child Psychology and Psychiatry, 60-5 (May 2019)
[article]
Titre : The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. MILLER, Auteur ; A. M. IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; L. J. BELL, Auteur ; A. J. SCHWICHTENBERG, Auteur ; T. HUTMAN, Auteur ; S. OZONOFF, Auteur Article en page(s) : p.516-523 Langues : Anglais (eng) Mots-clés : Dysregulation autism spectrum disorder high risk preschool siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: The 'dysregulation profile' (DP) is a measure of emotional and behavioral dysregulation that may cut across diagnostic boundaries. Siblings of children with autism spectrum disorder (ASD) who do not develop ASD themselves are at risk for atypical outcomes including behavioral challenges and therefore may be a useful population in which to investigate the structure of the DP in preschoolers. METHODS: We sought to examine the factor structure and predictors of the DP in a sample enriched for a wide range of phenotypic variation-36-month-olds with and without family histories of ASD-and to determine whether children with genetic liability for ASD are at risk for a phenotype characterized by elevated dysregulation. Data were collected from 415 children with (n = 253) and without (n = 162) an older sibling with ASD, all without ASD themselves, at 18, 24, and 36 months of age. RESULTS: Our findings replicate prior reports, conducted in predominantly clinically referred and older samples, supporting the superiority of a bifactor model of the DP in the preschool period compared to the second-order and one-factor models. Examiner ratings were longitudinally and concurrently associated with the DP at 36 months of age. Family history of ASD was associated with higher dysregulation in the Anxious/Depressed dimension. CONCLUSIONS: These findings support the relevance of examining the structure of psychopathology in preschoolers and suggest that examiner observations as early as 18 months of age, particularly of overactivity, may help identify risk for later DP-related concerns. Non-ASD preschoolers with family histories of ASD may be at risk for a phenotype characterized by elevated dysregulation particularly in the Anxious/Depressed dimension by age 3. En ligne : http://dx.doi.org/10.1111/jcpp.13003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392
in Journal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.516-523[article] The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder [Texte imprimé et/ou numérique] / M. MILLER, Auteur ; A. M. IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; L. J. BELL, Auteur ; A. J. SCHWICHTENBERG, Auteur ; T. HUTMAN, Auteur ; S. OZONOFF, Auteur . - p.516-523.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.516-523
Mots-clés : Dysregulation autism spectrum disorder high risk preschool siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: The 'dysregulation profile' (DP) is a measure of emotional and behavioral dysregulation that may cut across diagnostic boundaries. Siblings of children with autism spectrum disorder (ASD) who do not develop ASD themselves are at risk for atypical outcomes including behavioral challenges and therefore may be a useful population in which to investigate the structure of the DP in preschoolers. METHODS: We sought to examine the factor structure and predictors of the DP in a sample enriched for a wide range of phenotypic variation-36-month-olds with and without family histories of ASD-and to determine whether children with genetic liability for ASD are at risk for a phenotype characterized by elevated dysregulation. Data were collected from 415 children with (n = 253) and without (n = 162) an older sibling with ASD, all without ASD themselves, at 18, 24, and 36 months of age. RESULTS: Our findings replicate prior reports, conducted in predominantly clinically referred and older samples, supporting the superiority of a bifactor model of the DP in the preschool period compared to the second-order and one-factor models. Examiner ratings were longitudinally and concurrently associated with the DP at 36 months of age. Family history of ASD was associated with higher dysregulation in the Anxious/Depressed dimension. CONCLUSIONS: These findings support the relevance of examining the structure of psychopathology in preschoolers and suggest that examiner observations as early as 18 months of age, particularly of overactivity, may help identify risk for later DP-related concerns. Non-ASD preschoolers with family histories of ASD may be at risk for a phenotype characterized by elevated dysregulation particularly in the Anxious/Depressed dimension by age 3. En ligne : http://dx.doi.org/10.1111/jcpp.13003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392 Language and motor skills in siblings of children with autism spectrum disorder: A meta-analytic review / Dunia GARRIDO in Autism Research, 10-11 (November 2017)
[article]
Titre : Language and motor skills in siblings of children with autism spectrum disorder: A meta-analytic review Type de document : Texte imprimé et/ou numérique Auteurs : Dunia GARRIDO, Auteur ; Dafina PETROVA, Auteur ; Linda R. WATSON, Auteur ; Rocio GARCIA-RETAMERO, Auteur ; Gloria CARBALLO, Auteur Article en page(s) : p.1737-1750 Langues : Anglais (eng) Mots-clés : autism siblings high risk language motor meta-analysis Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) show significant linguistic and motor impairments compared to children with typical development (TD). Findings from studies of siblings of children with ASD show similarities to conclusions from studies of children with ASD. The current meta-analysis reviewed studies reporting linguistic and/or motor skills in siblings of children with ASD compared to siblings of children with TD. Thirty-four studies published between 1994 and 2016 met all inclusion criteria. We compared three different age groups (12 months or younger, 13 to 24 months, and 25 to 36 months). At 12 months, compared to siblings of children with TD, siblings of children with ASD had worse receptive language (d?=??.43, 95% CI [?.53, ?.33]) and expressive language skills (d?=??.40, 95% CI [?.57, ?.23]), and these effects were sustained at 24 and 36 months. Similar, albeit smaller differences in fine motor skills were detected at 12 months (d?=??.22, 95% CI [?.39, ?.04]), and these differences were larger at 36 months (d?=??.36, 95% CI [?.54, ?.17]). There were differences in gross motor skills at 12 months (d?=??.22, 95% CI [?.40, ?.04]), but only a few studies were available at later ages. Compared to siblings of children with TD, infants who have siblings with ASD have worse linguistic and motor skills. These differences are detectable as early as when infants are 12 months old and seem to be sustained until they are 3 years old. Differences in language skills are larger than those in motor skills, especially during the first year. Autism Res 2017, 10: 1737–1750. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We reviewed studies reporting linguistic and/or motor skills in siblings of children with autism spectrum disorder (ASD) compared to those in siblings of children with typical development. The results showed that as a group, those infants who have siblings with ASD have less advanced linguistic and motor skills. These differences are detectable when infants are 12 months old and seem to be sustained until they are 3 years old. Differences in language skills are larger than those in motor skills. En ligne : http://dx.doi.org/10.1002/aur.1829 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-11 (November 2017) . - p.1737-1750[article] Language and motor skills in siblings of children with autism spectrum disorder: A meta-analytic review [Texte imprimé et/ou numérique] / Dunia GARRIDO, Auteur ; Dafina PETROVA, Auteur ; Linda R. WATSON, Auteur ; Rocio GARCIA-RETAMERO, Auteur ; Gloria CARBALLO, Auteur . - p.1737-1750.
Langues : Anglais (eng)
in Autism Research > 10-11 (November 2017) . - p.1737-1750
Mots-clés : autism siblings high risk language motor meta-analysis Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) show significant linguistic and motor impairments compared to children with typical development (TD). Findings from studies of siblings of children with ASD show similarities to conclusions from studies of children with ASD. The current meta-analysis reviewed studies reporting linguistic and/or motor skills in siblings of children with ASD compared to siblings of children with TD. Thirty-four studies published between 1994 and 2016 met all inclusion criteria. We compared three different age groups (12 months or younger, 13 to 24 months, and 25 to 36 months). At 12 months, compared to siblings of children with TD, siblings of children with ASD had worse receptive language (d?=??.43, 95% CI [?.53, ?.33]) and expressive language skills (d?=??.40, 95% CI [?.57, ?.23]), and these effects were sustained at 24 and 36 months. Similar, albeit smaller differences in fine motor skills were detected at 12 months (d?=??.22, 95% CI [?.39, ?.04]), and these differences were larger at 36 months (d?=??.36, 95% CI [?.54, ?.17]). There were differences in gross motor skills at 12 months (d?=??.22, 95% CI [?.40, ?.04]), but only a few studies were available at later ages. Compared to siblings of children with TD, infants who have siblings with ASD have worse linguistic and motor skills. These differences are detectable as early as when infants are 12 months old and seem to be sustained until they are 3 years old. Differences in language skills are larger than those in motor skills, especially during the first year. Autism Res 2017, 10: 1737–1750. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We reviewed studies reporting linguistic and/or motor skills in siblings of children with autism spectrum disorder (ASD) compared to those in siblings of children with typical development. The results showed that as a group, those infants who have siblings with ASD have less advanced linguistic and motor skills. These differences are detectable when infants are 12 months old and seem to be sustained until they are 3 years old. Differences in language skills are larger than those in motor skills. En ligne : http://dx.doi.org/10.1002/aur.1829 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322