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Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families / J. PAGE in Molecular Autism, 7 (2016)
[article]
Titre : Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families Type de document : Texte imprimé et/ou numérique Auteurs : J. PAGE, Auteur ; John N. CONSTANTINO, Auteur ; K. ZAMBRANA, Auteur ; E. MARTIN, Auteur ; I. TUNC, Auteur ; Y. ZHANG, Auteur ; Anna ABBACCHI, Auteur ; D. MESSINGER, Auteur Article en page(s) : 39p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/genetics Child Child, Preschool Female Genetic Predisposition to Disease Hispanic Americans/genetics Humans Male Parents Phenotype Siblings Ancestry Assortative mating Hispanic Measurement Social Responsiveness Scale Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent studies have indicated that quantitative autistic traits (QATs) of parents reflect inherited liabilities that may index background genetic risk for clinical autism spectrum disorder (ASD) in their offspring. Moreover, preferential mating for QATs has been observed as a potential factor in concentrating autistic liabilities in some families across generations. Heretofore, intergenerational studies of QATs have focused almost exclusively on Caucasian populations-the present study explored these phenomena in a well-characterized Hispanic population. METHODS: The present study examined QAT scores in siblings and parents of 83 Hispanic probands meeting research diagnostic criteria for ASD, and 64 non-ASD controls, using the Social Responsiveness Scale-2 (SRS-2). Ancestry of the probands was characterized by genotype, using information from 541,929 single nucleotide polymorphic markers. RESULTS: In families of Hispanic children with an ASD diagnosis, the pattern of quantitative trait correlations observed between ASD-affected children and their first-degree relatives (ICCs on the order of 0.20), between unaffected first-degree relatives in ASD-affected families (sibling/mother ICC = 0.36; sibling/father ICC = 0.53), and between spouses (mother/father ICC = 0.48) were in keeping with the influence of transmitted background genetic risk and strong preferential mating for variation in quantitative autistic trait burden. Results from analysis of ancestry-informative genetic markers among probands in this sample were consistent with that from other Hispanic populations. CONCLUSIONS: Quantitative autistic traits represent measurable indices of inherited liability to ASD in Hispanic families. The accumulation of autistic traits occurs within generations, between spouses, and across generations, among Hispanic families affected by ASD. The occurrence of preferential mating for QATs-the magnitude of which may vary across cultures-constitutes a mechanism by which background genetic liability for ASD can accumulate in a given family in successive generations. En ligne : http://dx.doi.org/10.1186/s13229-016-0100-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 39p.[article] Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families [Texte imprimé et/ou numérique] / J. PAGE, Auteur ; John N. CONSTANTINO, Auteur ; K. ZAMBRANA, Auteur ; E. MARTIN, Auteur ; I. TUNC, Auteur ; Y. ZHANG, Auteur ; Anna ABBACCHI, Auteur ; D. MESSINGER, Auteur . - 39p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 39p.
Mots-clés : Adolescent Adult Autism Spectrum Disorder/genetics Child Child, Preschool Female Genetic Predisposition to Disease Hispanic Americans/genetics Humans Male Parents Phenotype Siblings Ancestry Assortative mating Hispanic Measurement Social Responsiveness Scale Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent studies have indicated that quantitative autistic traits (QATs) of parents reflect inherited liabilities that may index background genetic risk for clinical autism spectrum disorder (ASD) in their offspring. Moreover, preferential mating for QATs has been observed as a potential factor in concentrating autistic liabilities in some families across generations. Heretofore, intergenerational studies of QATs have focused almost exclusively on Caucasian populations-the present study explored these phenomena in a well-characterized Hispanic population. METHODS: The present study examined QAT scores in siblings and parents of 83 Hispanic probands meeting research diagnostic criteria for ASD, and 64 non-ASD controls, using the Social Responsiveness Scale-2 (SRS-2). Ancestry of the probands was characterized by genotype, using information from 541,929 single nucleotide polymorphic markers. RESULTS: In families of Hispanic children with an ASD diagnosis, the pattern of quantitative trait correlations observed between ASD-affected children and their first-degree relatives (ICCs on the order of 0.20), between unaffected first-degree relatives in ASD-affected families (sibling/mother ICC = 0.36; sibling/father ICC = 0.53), and between spouses (mother/father ICC = 0.48) were in keeping with the influence of transmitted background genetic risk and strong preferential mating for variation in quantitative autistic trait burden. Results from analysis of ancestry-informative genetic markers among probands in this sample were consistent with that from other Hispanic populations. CONCLUSIONS: Quantitative autistic traits represent measurable indices of inherited liability to ASD in Hispanic families. The accumulation of autistic traits occurs within generations, between spouses, and across generations, among Hispanic families affected by ASD. The occurrence of preferential mating for QATs-the magnitude of which may vary across cultures-constitutes a mechanism by which background genetic liability for ASD can accumulate in a given family in successive generations. En ligne : http://dx.doi.org/10.1186/s13229-016-0100-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 A comparison of the ASD experience of low-SES hispanic and non-hispanic white parents / A. FERGUSON in Autism Research, 12-12 (December)
[article]
Titre : A comparison of the ASD experience of low-SES hispanic and non-hispanic white parents Type de document : Texte imprimé et/ou numérique Auteurs : A. FERGUSON, Auteur ; D. C. VIGIL, Auteur Année de publication : 2019 Article en page(s) : p.1880-1890 Langues : Anglais (eng) Mots-clés : Hispanic Ses autism spectrum disorder Index. décimale : PER Périodiques Résumé : This study compared the experiences of Hispanic families, who were primarily of Mexican heritage, and non-Hispanic White families from the United States both from low socioeconomic status (SES) backgrounds having a child with a diagnosis of Autism Spectrum Disorder (ASD). The Centers for Disease Control and Prevention (CDC) reports that Hispanic children are diagnosed with ASD 2 years later than non-Hispanic White children [Baio et al., MMWR Surveillance Summaries 2018:67(SS-6): 1-23]. However, there has been limited investigation in exploring how SES might impact both diagnosis and experience. A survey of basic demographic information and a qualitative survey were used for this study. Basic demographic information obtained included SES, parent educational level, age of diagnosis of the children, religious affiliation, and marital status. Hour-long interviews were conducted to gather information about the personal experiences of these families relating to diagnoses and treatment. Comparative results of basic demographic information showed no difference in age of diagnosis between the two groups when SES was controlled. Although SES was controlled, the non-Hispanic White families had a higher education level and were slightly wealthier. Qualitatively, similarities included family support, doctor response to parent concerns, and acceptance of diagnosis by family members and friends. Differences included religious views, acceptance of diagnosis, knowledge of developmental milestones, and finding resources. Most significantly, the findings indicate no difference in the age of diagnosis of ASD between the Hispanic and non-Hispanic White children, which could be attributed to increased awareness and having access to a proactive parent organization. Autism Res 2019, 12: 1880-1890. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study showed that Hispanic and Non-Hispanic White children from poor backgrounds got a diagnosis of Autism Spectrum Disorder (ASD) at the same age. Results show differences in religious views, acceptance of diagnosis, knowledge of milestones, and finding resources. This might be because people are more aware of ASD today and Hispanic families were involved with an active parent organization. En ligne : http://dx.doi.org/10.1002/aur.2223 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413
in Autism Research > 12-12 (December) . - p.1880-1890[article] A comparison of the ASD experience of low-SES hispanic and non-hispanic white parents [Texte imprimé et/ou numérique] / A. FERGUSON, Auteur ; D. C. VIGIL, Auteur . - 2019 . - p.1880-1890.
Langues : Anglais (eng)
in Autism Research > 12-12 (December) . - p.1880-1890
Mots-clés : Hispanic Ses autism spectrum disorder Index. décimale : PER Périodiques Résumé : This study compared the experiences of Hispanic families, who were primarily of Mexican heritage, and non-Hispanic White families from the United States both from low socioeconomic status (SES) backgrounds having a child with a diagnosis of Autism Spectrum Disorder (ASD). The Centers for Disease Control and Prevention (CDC) reports that Hispanic children are diagnosed with ASD 2 years later than non-Hispanic White children [Baio et al., MMWR Surveillance Summaries 2018:67(SS-6): 1-23]. However, there has been limited investigation in exploring how SES might impact both diagnosis and experience. A survey of basic demographic information and a qualitative survey were used for this study. Basic demographic information obtained included SES, parent educational level, age of diagnosis of the children, religious affiliation, and marital status. Hour-long interviews were conducted to gather information about the personal experiences of these families relating to diagnoses and treatment. Comparative results of basic demographic information showed no difference in age of diagnosis between the two groups when SES was controlled. Although SES was controlled, the non-Hispanic White families had a higher education level and were slightly wealthier. Qualitatively, similarities included family support, doctor response to parent concerns, and acceptance of diagnosis by family members and friends. Differences included religious views, acceptance of diagnosis, knowledge of developmental milestones, and finding resources. Most significantly, the findings indicate no difference in the age of diagnosis of ASD between the Hispanic and non-Hispanic White children, which could be attributed to increased awareness and having access to a proactive parent organization. Autism Res 2019, 12: 1880-1890. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study showed that Hispanic and Non-Hispanic White children from poor backgrounds got a diagnosis of Autism Spectrum Disorder (ASD) at the same age. Results show differences in religious views, acceptance of diagnosis, knowledge of milestones, and finding resources. This might be because people are more aware of ASD today and Hispanic families were involved with an active parent organization. En ligne : http://dx.doi.org/10.1002/aur.2223 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 The Relationship Between Optimism, Coping, and Depressive Symptoms in Hispanic Mothers and Fathers of Children with Autism Spectrum Disorder / Kelcie WILLIS in Journal of Autism and Developmental Disorders, 46-7 (July 2016)
[article]
Titre : The Relationship Between Optimism, Coping, and Depressive Symptoms in Hispanic Mothers and Fathers of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kelcie WILLIS, Auteur ; Lisa TIMMONS, Auteur ; Megan PRUITT, Auteur ; Hoa Lam SCHNEIDER, Auteur ; Michael ALESSANDRI, Auteur ; Naomi V. EKAS, Auteur Article en page(s) : p.2427-2440 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Hispanic Optimism Coping Psychological well-being Mothers Fathers Index. décimale : PER Périodiques Résumé : This study examined gender differences in the relationship between dispositional optimism, coping, and depressive symptoms of Hispanic mothers (n = 46) and fathers (n = 43) of children with autism spectrum disorder. Coping was hypothesized to mediate the relationship between optimism and depressive symptoms. The results revealed that mothers reported greater depressive symptoms and greater use of positive and support coping than fathers; however, both mothers and fathers reported similar levels of optimism and use of avoidant coping. In addition, positive and avoidant coping strategies mediated the association between optimism and depressive symptoms for both mothers and fathers. Clinical implications for this study include interventions for improving optimistic outlooks as well as interventions that improve parents’ coping skills and therefore reduce negative outcomes. En ligne : http://dx.doi.org/10.1007/s10803-016-2776-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290
in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2427-2440[article] The Relationship Between Optimism, Coping, and Depressive Symptoms in Hispanic Mothers and Fathers of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kelcie WILLIS, Auteur ; Lisa TIMMONS, Auteur ; Megan PRUITT, Auteur ; Hoa Lam SCHNEIDER, Auteur ; Michael ALESSANDRI, Auteur ; Naomi V. EKAS, Auteur . - p.2427-2440.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2427-2440
Mots-clés : Autism spectrum disorder Hispanic Optimism Coping Psychological well-being Mothers Fathers Index. décimale : PER Périodiques Résumé : This study examined gender differences in the relationship between dispositional optimism, coping, and depressive symptoms of Hispanic mothers (n = 46) and fathers (n = 43) of children with autism spectrum disorder. Coping was hypothesized to mediate the relationship between optimism and depressive symptoms. The results revealed that mothers reported greater depressive symptoms and greater use of positive and support coping than fathers; however, both mothers and fathers reported similar levels of optimism and use of avoidant coping. In addition, positive and avoidant coping strategies mediated the association between optimism and depressive symptoms for both mothers and fathers. Clinical implications for this study include interventions for improving optimistic outlooks as well as interventions that improve parents’ coping skills and therefore reduce negative outcomes. En ligne : http://dx.doi.org/10.1007/s10803-016-2776-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 The role of family cohesion in the psychological adjustment of non-Hispanic White and Hispanic mothers of children with autism spectrum disorder / Naomi V. EKAS in Research in Autism Spectrum Disorders, 21 (January 2016)
[article]
Titre : The role of family cohesion in the psychological adjustment of non-Hispanic White and Hispanic mothers of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Naomi V. EKAS, Auteur ; Christine GHILAIN, Auteur ; Megan PRUITT, Auteur ; Seniz CELIMLI, Auteur ; Anibal GUTIERREZ, Auteur ; Michael ALESSANDRI, Auteur Article en page(s) : p.10-24 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Parenting Family cohesion Hispanic Depression Mothers Index. décimale : PER Périodiques Résumé : The current study utilizes a process-oriented approach to understand both personal and family factors influencing the development of depressive symptoms among non-Hispanic White and Hispanic mothers of children with ASD. Family cohesion was hypothesized to mediate the associations between the personal factors (optimism, benefit finding, social support) and depressive symptoms. Mothers of 117 children with ASD (Hispanic n = 73; non-Hispanic White n = 44) completed measures of depressive symptoms, family cohesion, social support, optimism, and benefit finding. Results from this study indicate that optimism, benefit finding, and social support are important predictors of positive maternal adjustment. Furthermore, these factors contribute to better family functioning, namely family cohesion. The mediation models containing optimism, benefit finding, partner and family support were significant for both Hispanic and non-Hispanic White mothers, suggesting a similar mediation process for both racial/ethnic groups. However, family cohesion was a significant mediator of the relationship between friend support and depressive symptoms for Hispanic mothers only. The results of this study complement and extend previous research examining family functioning among mothers of children with ASD and have implications for the development of interventions aimed at increasing maternal well-being. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274
in Research in Autism Spectrum Disorders > 21 (January 2016) . - p.10-24[article] The role of family cohesion in the psychological adjustment of non-Hispanic White and Hispanic mothers of children with autism spectrum disorder [Texte imprimé et/ou numérique] / Naomi V. EKAS, Auteur ; Christine GHILAIN, Auteur ; Megan PRUITT, Auteur ; Seniz CELIMLI, Auteur ; Anibal GUTIERREZ, Auteur ; Michael ALESSANDRI, Auteur . - p.10-24.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 21 (January 2016) . - p.10-24
Mots-clés : Autism spectrum disorder Parenting Family cohesion Hispanic Depression Mothers Index. décimale : PER Périodiques Résumé : The current study utilizes a process-oriented approach to understand both personal and family factors influencing the development of depressive symptoms among non-Hispanic White and Hispanic mothers of children with ASD. Family cohesion was hypothesized to mediate the associations between the personal factors (optimism, benefit finding, social support) and depressive symptoms. Mothers of 117 children with ASD (Hispanic n = 73; non-Hispanic White n = 44) completed measures of depressive symptoms, family cohesion, social support, optimism, and benefit finding. Results from this study indicate that optimism, benefit finding, and social support are important predictors of positive maternal adjustment. Furthermore, these factors contribute to better family functioning, namely family cohesion. The mediation models containing optimism, benefit finding, partner and family support were significant for both Hispanic and non-Hispanic White mothers, suggesting a similar mediation process for both racial/ethnic groups. However, family cohesion was a significant mediator of the relationship between friend support and depressive symptoms for Hispanic mothers only. The results of this study complement and extend previous research examining family functioning among mothers of children with ASD and have implications for the development of interventions aimed at increasing maternal well-being. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274 Race/Ethnicity-Resolved Time Trends in United States ASD Prevalence Estimates from IDEA and ADDM / C. NEVISON in Journal of Autism and Developmental Disorders, 49-12 (December 2019)
[article]
Titre : Race/Ethnicity-Resolved Time Trends in United States ASD Prevalence Estimates from IDEA and ADDM Type de document : Texte imprimé et/ou numérique Auteurs : C. NEVISON, Auteur ; Walter ZAHORODNY, Auteur Article en page(s) : p.4721-4730 Langues : Anglais (eng) Mots-clés : Addm Autism Spectrum Disorder Black Hispanic Idea Prevalence Race/ethnicity Time trends White Index. décimale : PER Périodiques Résumé : Race-specific time trends in Autism Spectrum Disorder prevalence are tracked among 3-5 year-olds and 8 year-olds identified by the U.S. Individuals with Disabilities Education Act (IDEA) and the Autism and Developmental Disabilities Monitoring (ADDM) Network, respectively. White ASD prevalence historically has been higher than other racial groups but plateaued for IDEA birth cohorts from ~ 2004 to 2007 before resuming its increase. Black and Hispanic IDEA prevalence increased continuously and caught up to whites by birth year ~ 2008 and ~ 2013, respectively, with black prevalence subsequently exceeding white prevalence in the majority of states. Plateaus in white prevalence occurred in some ADDM states for birth years 2002-2006, but IDEA trends suggest prevalence will increase across all racial groups in ADDM's birth year 2008 report. En ligne : http://dx.doi.org/10.1007/s10803-019-04188-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411
in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4721-4730[article] Race/Ethnicity-Resolved Time Trends in United States ASD Prevalence Estimates from IDEA and ADDM [Texte imprimé et/ou numérique] / C. NEVISON, Auteur ; Walter ZAHORODNY, Auteur . - p.4721-4730.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4721-4730
Mots-clés : Addm Autism Spectrum Disorder Black Hispanic Idea Prevalence Race/ethnicity Time trends White Index. décimale : PER Périodiques Résumé : Race-specific time trends in Autism Spectrum Disorder prevalence are tracked among 3-5 year-olds and 8 year-olds identified by the U.S. Individuals with Disabilities Education Act (IDEA) and the Autism and Developmental Disabilities Monitoring (ADDM) Network, respectively. White ASD prevalence historically has been higher than other racial groups but plateaued for IDEA birth cohorts from ~ 2004 to 2007 before resuming its increase. Black and Hispanic IDEA prevalence increased continuously and caught up to whites by birth year ~ 2008 and ~ 2013, respectively, with black prevalence subsequently exceeding white prevalence in the majority of states. Plateaus in white prevalence occurred in some ADDM states for birth years 2002-2006, but IDEA trends suggest prevalence will increase across all racial groups in ADDM's birth year 2008 report. En ligne : http://dx.doi.org/10.1007/s10803-019-04188-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 California Autism Prevalence by County and Race/Ethnicity: Declining Trends Among Wealthy Whites / Cynthia NEVISON in Journal of Autism and Developmental Disorders, 50-11 (November 2020)
PermalinkRandomized pilot study of a special education advocacy program for Latinx/minority parents of children with autism spectrum disorder / P. LUELMO in Autism, 25-6 (August 2021)
PermalinkRandomized pilot study of a special education advocacy program for Latinx/minority parents of children with autism spectrum disorder / Paul LUELMO in Autism, 26-6 (August 2022)
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