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Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong / R. Y. F. HO in Journal of Autism and Developmental Disorders, 51-11 (November 2021)
[article]
Titre : Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong Type de document : Texte imprimé et/ou numérique Auteurs : R. Y. F. HO, Auteur ; D. ZHANG, Auteur ; S. K. C. CHAN, Auteur ; T. T. GAO, Auteur ; E. K. P. LEE, Auteur ; H. H. M. LO, Auteur ; P. AU YEUNG, Auteur ; Kelly Y. C. LAI, Auteur ; Susan M. BOGELS, Auteur ; E. I. DE BRUIN, Auteur ; S. Y. S. WONG, Auteur Article en page(s) : p.4147-4159 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/therapy China Hong Kong Humans Mindfulness Parenting Parents Autism spectrum disorder Effectiveness Feasibility MYmind Index. décimale : PER Périodiques Résumé : This study investigated the feasibility and preliminary effectiveness of a concurrent mindfulness program (MYmind) on Chinese adolescents with autism spectrum disorder and their parents in Hong Kong, China using a randomized controlled trial with a waitlist control group. Results showed the study had 80% compliance rate, 0% dropout rate, and 89% response rate. Between-group comparisons showed mindfulness had trend effects on parent's rumination (g?=?1.16), mindful parenting (d?=?0.6), parenting style (d?=?0.59), and parenting stress (d?=?0.5). The study demonstrated the feasibility of the MYmind program in the Chinese context. A larger trial with longer follow-up period is suggested to better examine the effect of mindfulness on adolescents with ASD and their parents. En ligne : http://dx.doi.org/10.1007/s10803-020-04729-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4147-4159[article] Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong [Texte imprimé et/ou numérique] / R. Y. F. HO, Auteur ; D. ZHANG, Auteur ; S. K. C. CHAN, Auteur ; T. T. GAO, Auteur ; E. K. P. LEE, Auteur ; H. H. M. LO, Auteur ; P. AU YEUNG, Auteur ; Kelly Y. C. LAI, Auteur ; Susan M. BOGELS, Auteur ; E. I. DE BRUIN, Auteur ; S. Y. S. WONG, Auteur . - p.4147-4159.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4147-4159
Mots-clés : Adolescent Autism Spectrum Disorder/therapy China Hong Kong Humans Mindfulness Parenting Parents Autism spectrum disorder Effectiveness Feasibility MYmind Index. décimale : PER Périodiques Résumé : This study investigated the feasibility and preliminary effectiveness of a concurrent mindfulness program (MYmind) on Chinese adolescents with autism spectrum disorder and their parents in Hong Kong, China using a randomized controlled trial with a waitlist control group. Results showed the study had 80% compliance rate, 0% dropout rate, and 89% response rate. Between-group comparisons showed mindfulness had trend effects on parent's rumination (g?=?1.16), mindful parenting (d?=?0.6), parenting style (d?=?0.59), and parenting stress (d?=?0.5). The study demonstrated the feasibility of the MYmind program in the Chinese context. A larger trial with longer follow-up period is suggested to better examine the effect of mindfulness on adolescents with ASD and their parents. En ligne : http://dx.doi.org/10.1007/s10803-020-04729-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 ‘Do It Yourself’ in the parent–professional partnership for the assessment and diagnosis of children with autism spectrum conditions in Hong Kong: A qualitative study / Hilda S.W. HO in Autism, 18-7 (October 2014)
[article]
Titre : ‘Do It Yourself’ in the parent–professional partnership for the assessment and diagnosis of children with autism spectrum conditions in Hong Kong: A qualitative study Type de document : Texte imprimé et/ou numérique Auteurs : Hilda S.W. HO, Auteur ; Huso YI, Auteur ; Sian GRIFFITHS, Auteur ; Dorothy F.Y. CHAN, Auteur ; Stuart MURRAY, Auteur Article en page(s) : p.832-844 Langues : Anglais (eng) Mots-clés : autism spectrum conditions clinical pathway Hong Kong parent–professional partnership qualitative study Index. décimale : PER Périodiques Résumé : Timely and appropriate care for children with autism spectrum conditions is affected by the interaction between healthcare professionals and parents. Despite the importance of the parent–professional partnership, there is a dearth of cultural-specific data on parent–professional partnership in the Chinese context. We conducted 10 in-depth life-history interviews with parents of children with autism spectrum conditions in Hong Kong who were diagnosed during preschool years. Using an interpretative phenomenological analytic method, five themes were constructed to represent the context of parent–professional partnership in Hong Kong along the pathway of seeking a diagnosis: (a) access to the assessment and diagnosis of autism spectrum conditions, (b) multiple procedures of assessment, (c) consultation prior to diagnosis and assessment, (d) communication of diagnosis and assessment result and (e) post-assessment isolation. Parental narratives highlight the important domains of parent–professional partnership and reflect the complexity of diagnosis and the lack of a cohesive system. For many parents, the assessment procedure was marred by a series of obstacles, which were further exacerbated by a poorly developed parent–professional partnership. Suggestions for parent–professional partnership development include establishing an evidence-based best practice guideline for Hong Kong, creating pre-assessment information workshops for parents to attend and equipping professionals with knowledge about autism spectrum conditions and enhanced communication skills. En ligne : http://dx.doi.org/10.1177/1362361313508230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Autism > 18-7 (October 2014) . - p.832-844[article] ‘Do It Yourself’ in the parent–professional partnership for the assessment and diagnosis of children with autism spectrum conditions in Hong Kong: A qualitative study [Texte imprimé et/ou numérique] / Hilda S.W. HO, Auteur ; Huso YI, Auteur ; Sian GRIFFITHS, Auteur ; Dorothy F.Y. CHAN, Auteur ; Stuart MURRAY, Auteur . - p.832-844.
Langues : Anglais (eng)
in Autism > 18-7 (October 2014) . - p.832-844
Mots-clés : autism spectrum conditions clinical pathway Hong Kong parent–professional partnership qualitative study Index. décimale : PER Périodiques Résumé : Timely and appropriate care for children with autism spectrum conditions is affected by the interaction between healthcare professionals and parents. Despite the importance of the parent–professional partnership, there is a dearth of cultural-specific data on parent–professional partnership in the Chinese context. We conducted 10 in-depth life-history interviews with parents of children with autism spectrum conditions in Hong Kong who were diagnosed during preschool years. Using an interpretative phenomenological analytic method, five themes were constructed to represent the context of parent–professional partnership in Hong Kong along the pathway of seeking a diagnosis: (a) access to the assessment and diagnosis of autism spectrum conditions, (b) multiple procedures of assessment, (c) consultation prior to diagnosis and assessment, (d) communication of diagnosis and assessment result and (e) post-assessment isolation. Parental narratives highlight the important domains of parent–professional partnership and reflect the complexity of diagnosis and the lack of a cohesive system. For many parents, the assessment procedure was marred by a series of obstacles, which were further exacerbated by a poorly developed parent–professional partnership. Suggestions for parent–professional partnership development include establishing an evidence-based best practice guideline for Hong Kong, creating pre-assessment information workshops for parents to attend and equipping professionals with knowledge about autism spectrum conditions and enhanced communication skills. En ligne : http://dx.doi.org/10.1177/1362361313508230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly / C. W. WONG in Autism Research, 11-8 (August 2018)
[article]
Titre : Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly Type de document : Texte imprimé et/ou numérique Auteurs : C. W. WONG, Auteur ; P. M. Y. OR, Auteur ; Y. WANG, Auteur ; L. LI, Auteur ; J. LI, Auteur ; M. YAN, Auteur ; Y. CAO, Auteur ; H. M. LUK, Auteur ; T. M. F. TONG, Auteur ; N. R. LESLIE, Auteur ; I. F. LO, Auteur ; K. W. CHOY, Auteur ; A. M. L. CHAN, Auteur Article en page(s) : p.1098-1109 Langues : Anglais (eng) Mots-clés : Hong Kong Pten PTEN hamartoma tumor syndrome autism spectrum disorders macrocephaly Index. décimale : PER Périodiques Résumé : PTEN is a tumor suppressor gene inactivated in over 30% of human cancers. It encodes a lipid phosphatase that serves as a gatekeeper of the phosphoinositide 3-kinase signaling pathway. Germline mutation frequently occurs in this gene in patients diagnosed with PTEN Hamartoma Tumor Syndrome (PHTS). PHTS individuals are characterized by macrocephaly, benign growth of multiple tissues and increased tumor risk. In addition, autistic phenotypes are found in 10-20% of individuals carrying the germline PTEN mutation with macrocephaly. In this report, 13 suspected PHTS patients were screened for mutation in the PTEN gene. A missense variant (c. 302T > C) substituting the isoleucine at codon 101 to a threonine, a single nucleotide insertion (c. 327-328insC) causing a frame shift mutation and termination at codon 109, and a nonsense variant (c. 1003C > T) truncated the protein at codon 335 were identified. The I101T mutation significantly reduced PTEN protein expression levels by 2.5- to 4.0-fold. Mechanistically, I101T reduced the protein half-life of PTEN possibly due to enhanced polyubiquitination at Lysine 13. However, the I101T mutant retained almost 30% of the lipid phosphatase activity of the wild-type protein. Finally, the I101T mutant has reduced phosphorylation at a PTEN auto-dephosphorylation site at Threonine 366 and a lowered ratio of nuclear to cytosolic protein level. These partial losses of multiple PTEN biochemical functions may contribute to the tissue overgrowth and autistic features of this PHTS patient. Autism Res 2018, 11: 1098-1109. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: The genetics of autism spectrum disorders is highly complex with individual risk influenced by both genetic and environmental factors. Mutation in the human PTEN gene confers a high risk of developing autistic behavior. This report revealed that PTEN mutations occurred in 23% of a selected group of Hong Kong patients harboring autistic features with gross overgrowth symptoms. Detailed characterization of a PTEN mutation revealed reduced protein stability as one of the underlying mechanisms responsible for reduced PTEN activity. En ligne : http://dx.doi.org/10.1002/aur.1950 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Autism Research > 11-8 (August 2018) . - p.1098-1109[article] Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly [Texte imprimé et/ou numérique] / C. W. WONG, Auteur ; P. M. Y. OR, Auteur ; Y. WANG, Auteur ; L. LI, Auteur ; J. LI, Auteur ; M. YAN, Auteur ; Y. CAO, Auteur ; H. M. LUK, Auteur ; T. M. F. TONG, Auteur ; N. R. LESLIE, Auteur ; I. F. LO, Auteur ; K. W. CHOY, Auteur ; A. M. L. CHAN, Auteur . - p.1098-1109.
Langues : Anglais (eng)
in Autism Research > 11-8 (August 2018) . - p.1098-1109
Mots-clés : Hong Kong Pten PTEN hamartoma tumor syndrome autism spectrum disorders macrocephaly Index. décimale : PER Périodiques Résumé : PTEN is a tumor suppressor gene inactivated in over 30% of human cancers. It encodes a lipid phosphatase that serves as a gatekeeper of the phosphoinositide 3-kinase signaling pathway. Germline mutation frequently occurs in this gene in patients diagnosed with PTEN Hamartoma Tumor Syndrome (PHTS). PHTS individuals are characterized by macrocephaly, benign growth of multiple tissues and increased tumor risk. In addition, autistic phenotypes are found in 10-20% of individuals carrying the germline PTEN mutation with macrocephaly. In this report, 13 suspected PHTS patients were screened for mutation in the PTEN gene. A missense variant (c. 302T > C) substituting the isoleucine at codon 101 to a threonine, a single nucleotide insertion (c. 327-328insC) causing a frame shift mutation and termination at codon 109, and a nonsense variant (c. 1003C > T) truncated the protein at codon 335 were identified. The I101T mutation significantly reduced PTEN protein expression levels by 2.5- to 4.0-fold. Mechanistically, I101T reduced the protein half-life of PTEN possibly due to enhanced polyubiquitination at Lysine 13. However, the I101T mutant retained almost 30% of the lipid phosphatase activity of the wild-type protein. Finally, the I101T mutant has reduced phosphorylation at a PTEN auto-dephosphorylation site at Threonine 366 and a lowered ratio of nuclear to cytosolic protein level. These partial losses of multiple PTEN biochemical functions may contribute to the tissue overgrowth and autistic features of this PHTS patient. Autism Res 2018, 11: 1098-1109. (c) 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: The genetics of autism spectrum disorders is highly complex with individual risk influenced by both genetic and environmental factors. Mutation in the human PTEN gene confers a high risk of developing autistic behavior. This report revealed that PTEN mutations occurred in 23% of a selected group of Hong Kong patients harboring autistic features with gross overgrowth symptoms. Detailed characterization of a PTEN mutation revealed reduced protein stability as one of the underlying mechanisms responsible for reduced PTEN activity. En ligne : http://dx.doi.org/10.1002/aur.1950 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 Understanding Hong Kong Chinese Families’ Experiences of an Autism/ASD Diagnosis / Kathleen TAIT in Journal of Autism and Developmental Disorders, 46-4 (April 2016)
[article]
Titre : Understanding Hong Kong Chinese Families’ Experiences of an Autism/ASD Diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Kathleen TAIT, Auteur ; Francis FUNG, Auteur ; Aihua HU, Auteur ; Naomi SWELLER, Auteur ; Wei WANG, Auteur Année de publication : 2016 Article en page(s) : p.1164-1183 Langues : Anglais (eng) Mots-clés : Parental information Diagnosis Autism spectrum disorder Hong Kong SAR Index. décimale : PER Périodiques Résumé : Little is known about the experience of Chinese parents of children diagnosed with autism spectrum disorders (ASD) living in the Hong Kong Special Administrative Region. Seventy-five parents of children (aged 6 months–18 years) with ASD diagnoses completed the Family Quality of Life Scale. Forty-five parents from the original surveyed cohort, also participated in semi-structured interviews. Parents’ perceptions of their child’s disability were influenced both by their cultural background and by the limited and expensive, pre- and post-diagnostic services available. Longer waiting times to diagnosis were associated with lower emotional well-being and perceived disability-related support. Clinicians are encouraged to become part of the support network for parents of children with ASD, to help parents to adjust to caring for their child. En ligne : http://dx.doi.org/10.1007/s10803-015-2650-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284
in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1164-1183[article] Understanding Hong Kong Chinese Families’ Experiences of an Autism/ASD Diagnosis [Texte imprimé et/ou numérique] / Kathleen TAIT, Auteur ; Francis FUNG, Auteur ; Aihua HU, Auteur ; Naomi SWELLER, Auteur ; Wei WANG, Auteur . - 2016 . - p.1164-1183.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1164-1183
Mots-clés : Parental information Diagnosis Autism spectrum disorder Hong Kong SAR Index. décimale : PER Périodiques Résumé : Little is known about the experience of Chinese parents of children diagnosed with autism spectrum disorders (ASD) living in the Hong Kong Special Administrative Region. Seventy-five parents of children (aged 6 months–18 years) with ASD diagnoses completed the Family Quality of Life Scale. Forty-five parents from the original surveyed cohort, also participated in semi-structured interviews. Parents’ perceptions of their child’s disability were influenced both by their cultural background and by the limited and expensive, pre- and post-diagnostic services available. Longer waiting times to diagnosis were associated with lower emotional well-being and perceived disability-related support. Clinicians are encouraged to become part of the support network for parents of children with ASD, to help parents to adjust to caring for their child. En ligne : http://dx.doi.org/10.1007/s10803-015-2650-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284 The Effectiveness of a School-Based Social Cognitive Intervention on the Social Participation of Chinese Children with Autism / P. P. P. CHEUNG in Journal of Autism and Developmental Disorders, 51-6 (June 2021)
[article]
Titre : The Effectiveness of a School-Based Social Cognitive Intervention on the Social Participation of Chinese Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : P. P. P. CHEUNG, Auteur ; T. BROWN, Auteur ; M. L. YU, Auteur ; A. M. H. SIU, Auteur Article en page(s) : p.1894-1908 Langues : Anglais (eng) Mots-clés : Adolescent Autistic Disorder/psychology/therapy Child Cognitive Behavioral Therapy/methods Hong Kong Humans Male Parents Program Evaluation School Mental Health Services Schools Social Cognition Social Participation/psychology Social Skills Theory of Mind Autism Social participation Social skills training Social-cognitive intervention Index. décimale : PER Périodiques Résumé : This study evaluates the efficacy of a school-based social cognitive intervention for children with autism. Seventy-four children and adolescents were taught visually scaffolded, theory of mind-based social skills program. Using a mixed-methods approach, children's social competence was assessed at pre-test and post-test. Compared to a waitlist control group, children in the intervention group demonstrated significantly greater gains on theory-of-mind and social skill measures. Focus groups and interviews were conducted to explore parents' views and generalization of children's social skills across settings. Children's social participation exhibited improvement in home, community, and school settings. The study findings offer promising evidence for a cost-effective program and support of the school-based social skills intervention for children with ASD in Hong Kong context. En ligne : http://dx.doi.org/10.1007/s10803-020-04683-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.1894-1908[article] The Effectiveness of a School-Based Social Cognitive Intervention on the Social Participation of Chinese Children with Autism [Texte imprimé et/ou numérique] / P. P. P. CHEUNG, Auteur ; T. BROWN, Auteur ; M. L. YU, Auteur ; A. M. H. SIU, Auteur . - p.1894-1908.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.1894-1908
Mots-clés : Adolescent Autistic Disorder/psychology/therapy Child Cognitive Behavioral Therapy/methods Hong Kong Humans Male Parents Program Evaluation School Mental Health Services Schools Social Cognition Social Participation/psychology Social Skills Theory of Mind Autism Social participation Social skills training Social-cognitive intervention Index. décimale : PER Périodiques Résumé : This study evaluates the efficacy of a school-based social cognitive intervention for children with autism. Seventy-four children and adolescents were taught visually scaffolded, theory of mind-based social skills program. Using a mixed-methods approach, children's social competence was assessed at pre-test and post-test. Compared to a waitlist control group, children in the intervention group demonstrated significantly greater gains on theory-of-mind and social skill measures. Focus groups and interviews were conducted to explore parents' views and generalization of children's social skills across settings. Children's social participation exhibited improvement in home, community, and school settings. The study findings offer promising evidence for a cost-effective program and support of the school-based social skills intervention for children with ASD in Hong Kong context. En ligne : http://dx.doi.org/10.1007/s10803-020-04683-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 The Role of Child Problem Behaviors in Autism Spectrum Symptoms and Parenting Stress: A Primary School-Based Study / Q. K. Y. SIU in Journal of Autism and Developmental Disorders, 49-3 (March 2019)
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