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Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? / Sumi HOSHIKO in Autism Research, 4-6 (December 2011)
[article]
Titre : Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? Type de document : Texte imprimé et/ou numérique Auteurs : Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur Année de publication : 2012 Article en page(s) : p.456-463 Langues : Anglais (eng) Mots-clés : epidemiology autism thyroid environment hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151
in Autism Research > 4-6 (December 2011) . - p.456-463[article] Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? [Texte imprimé et/ou numérique] / Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur . - 2012 . - p.456-463.
Langues : Anglais (eng)
in Autism Research > 4-6 (December 2011) . - p.456-463
Mots-clés : epidemiology autism thyroid environment hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam / S. H. F. LEE in Journal of Autism and Developmental Disorders, 51-12 (December 2021)
[article]
Titre : 2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam Type de document : Texte imprimé et/ou numérique Auteurs : S. H. F. LEE, Auteur ; S. A. AZIZ, Auteur ; M. HAMID, Auteur ; Y. C. LIM, Auteur ; D. KOH, Auteur ; L. L. CHAW, Auteur Article en page(s) : p.4577-4586 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology Brunei Case-Control Studies Child Child, Preschool Female Fingers Hand Humans Male Sex Characteristics 2D:4D ratio 2D:4D ratio symmetry Androgens Autism spectrum disorders (ASD) Brunei Darussalam Digit ratio Extreme male brain (EMB) Hormones Testosterone this manuscript. Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite the global increase in the prevalence of autism spectrum disorders (ASD), relevant research studies are lacking in Brunei Darussalam. Various studies have shown a significant association between a lowered 2D:4D ratio (ratio of second digit/index finger to the fourth digit/ring finger) and ASD, making it one of the potential phenotypic biomarkers for early detection of autism, which is important for early intervention and management. OBJECTIVE: The objective of this study is to explore the association between 2D:4D ratio and ASD in Brunei Darussalam, as a potential tool to complement early ASD diagnosis. METHODS: We conducted a case-control study comprising 28 ASD and 62 typically developing (TD) children in the case and control group, respectively (age range: 3-11 years old; median age: 6 years old). Median 2D:4D ratios were measured, compared and analysed between the two groups. Logistic regression models were used to explore potential associations between the median 2D:4D ratio and ASD in respective gender, for both left and right hands, independently. RESULTS: Our study shows that the median 2D:4D ratio of left hand in ASD males is significantly lower than those in TD males, after adjusting for ethnicity and age [Odds Ratio (OR)?=?0.57 (95% Confidence Interval (CI): 0.31-0.96); p?=?0.044]. For females, there is no association of ASD with the median left hand 2D:4D ratio [OR?=?3.09 (95% CI: 0.98-19.86); p?=?0.144] or the median right hand 2D:4D ratio [OR?=?1.23 (95% CI: 0.42-3.88); p?=?0.702]. Our study also shows a significant positive correlation and/or a reduced asymmetry between the average 2D:4D ratio of left hands and right hands in ASD males (Pearson's correlation (r)?=?0.48; 95% CI: 0.076-0.75, p?=?0.023). CONCLUSIONS: There is significant association between a lowered median 2D:4D ratio of the left hand (in males only) and ASD diagnosis. Once validated in a larger sample size, a lowered median 2D:4D ratio on the left hand may be a potential tool to complement ASD diagnosis for males in our study population. There is no association between the median 2D:4D ratio (left or right hands) and ASD in females, which could be due to the small female sample size and/or the possibility of different aetiology for ASD in females. Reduced asymmetry between the average 2D:4D ratio of left and right hands observed in ASD males only (not in ASD females) also suggests the importance of considering gender-specific biomarkers for ASD diagnosis. En ligne : http://dx.doi.org/10.1007/s10803-021-04899-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4577-4586[article] 2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam [Texte imprimé et/ou numérique] / S. H. F. LEE, Auteur ; S. A. AZIZ, Auteur ; M. HAMID, Auteur ; Y. C. LIM, Auteur ; D. KOH, Auteur ; L. L. CHAW, Auteur . - p.4577-4586.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4577-4586
Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology Brunei Case-Control Studies Child Child, Preschool Female Fingers Hand Humans Male Sex Characteristics 2D:4D ratio 2D:4D ratio symmetry Androgens Autism spectrum disorders (ASD) Brunei Darussalam Digit ratio Extreme male brain (EMB) Hormones Testosterone this manuscript. Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite the global increase in the prevalence of autism spectrum disorders (ASD), relevant research studies are lacking in Brunei Darussalam. Various studies have shown a significant association between a lowered 2D:4D ratio (ratio of second digit/index finger to the fourth digit/ring finger) and ASD, making it one of the potential phenotypic biomarkers for early detection of autism, which is important for early intervention and management. OBJECTIVE: The objective of this study is to explore the association between 2D:4D ratio and ASD in Brunei Darussalam, as a potential tool to complement early ASD diagnosis. METHODS: We conducted a case-control study comprising 28 ASD and 62 typically developing (TD) children in the case and control group, respectively (age range: 3-11 years old; median age: 6 years old). Median 2D:4D ratios were measured, compared and analysed between the two groups. Logistic regression models were used to explore potential associations between the median 2D:4D ratio and ASD in respective gender, for both left and right hands, independently. RESULTS: Our study shows that the median 2D:4D ratio of left hand in ASD males is significantly lower than those in TD males, after adjusting for ethnicity and age [Odds Ratio (OR)?=?0.57 (95% Confidence Interval (CI): 0.31-0.96); p?=?0.044]. For females, there is no association of ASD with the median left hand 2D:4D ratio [OR?=?3.09 (95% CI: 0.98-19.86); p?=?0.144] or the median right hand 2D:4D ratio [OR?=?1.23 (95% CI: 0.42-3.88); p?=?0.702]. Our study also shows a significant positive correlation and/or a reduced asymmetry between the average 2D:4D ratio of left hands and right hands in ASD males (Pearson's correlation (r)?=?0.48; 95% CI: 0.076-0.75, p?=?0.023). CONCLUSIONS: There is significant association between a lowered median 2D:4D ratio of the left hand (in males only) and ASD diagnosis. Once validated in a larger sample size, a lowered median 2D:4D ratio on the left hand may be a potential tool to complement ASD diagnosis for males in our study population. There is no association between the median 2D:4D ratio (left or right hands) and ASD in females, which could be due to the small female sample size and/or the possibility of different aetiology for ASD in females. Reduced asymmetry between the average 2D:4D ratio of left and right hands observed in ASD males only (not in ASD females) also suggests the importance of considering gender-specific biomarkers for ASD diagnosis. En ligne : http://dx.doi.org/10.1007/s10803-021-04899-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study / L. MYERS in Journal of Autism and Developmental Disorders, 48-9 (September 2018)
[article]
Titre : 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study Type de document : Texte imprimé et/ou numérique Auteurs : L. MYERS, Auteur ; A. VAN'T WESTEINDE, Auteur ; R. KUJA-HALKOLA, Auteur ; K. TAMMIMIES, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3244-3252 Langues : Anglais (eng) Mots-clés : 2D:4D ratio Adhd Autism Hormones Neurodevelopmental disorders Sex Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252[article] 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study [Texte imprimé et/ou numérique] / L. MYERS, Auteur ; A. VAN'T WESTEINDE, Auteur ; R. KUJA-HALKOLA, Auteur ; K. TAMMIMIES, Auteur ; Sven BÖLTE, Auteur . - p.3244-3252.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252
Mots-clés : 2D:4D ratio Adhd Autism Hormones Neurodevelopmental disorders Sex Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course / Ilia N. KARATOREOS in Journal of Child Psychology and Psychiatry, 54-4 (April 2013)
[article]
Titre : Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course Type de document : Texte imprimé et/ou numérique Auteurs : Ilia N. KARATOREOS, Auteur ; Bruce S. MCEWEN, Auteur Article en page(s) : p.337-347 Mots-clés : Allostasis hormones neurobiology aging brain development Index. décimale : PER Périodiques Résumé : Background Adaptation is key to survival. An organism must adapt to environmental challenges in order to be able to thrive in the environment in which they find themselves. Resilience can be thought of as a measure of the ability of an organism to adapt, and to withstand challenges to its stability. In higher animals, the brain is a key player in this process of adaptation and resilience, and through a process known as “allostasis” can obtain “stability through change”; protecting homeostasis in the face of stressors in the environment. Mediators of allostasis, such as glucocorticoids, can cause changes in the structure and function of neural circuits, clearly impacting behavior. How developmental stage interacts with stress and leads to long-lasting changes is a key question addressed in this review. Scope and Methods We discuss the concept of allostasis, its role in resilience, the neural and physiological systems mediating these responses, the modulatory role of development, and the consequences for adult functioning. We present this in the context of mediators the brain and body engage to protect against threats to homeostasis. The review has been informed by comprehensive searches on PubMed and Scopus through November 2012. Findings Stressors in the environment can have long lasting effects on development, depending upon the stage of life at which they are experienced. As such, adverse childhood experiences can alter resilience of individuals, making it more difficult for them to respond normally to adverse situations in adulthood, but the brain maintains the capacity to re-enter a more plastic state where such effects can be mitigated. Conclusions The brain regulates responses that allow for adaptation to challenges in the environment. The capacity of the brain and body to withstand challenges to stability can be considered as “resilience”. While adverse childhood experiences can have long-term negative consequences, under the right circumstances, the brain can re-enter plastic states, and negative outcomes may be mitigated, even later in life. En ligne : http://dx.doi.org/10.1111/jcpp.12054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194
in Journal of Child Psychology and Psychiatry > 54-4 (April 2013) . - p.337-347[article] Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course [Texte imprimé et/ou numérique] / Ilia N. KARATOREOS, Auteur ; Bruce S. MCEWEN, Auteur . - p.337-347.
in Journal of Child Psychology and Psychiatry > 54-4 (April 2013) . - p.337-347
Mots-clés : Allostasis hormones neurobiology aging brain development Index. décimale : PER Périodiques Résumé : Background Adaptation is key to survival. An organism must adapt to environmental challenges in order to be able to thrive in the environment in which they find themselves. Resilience can be thought of as a measure of the ability of an organism to adapt, and to withstand challenges to its stability. In higher animals, the brain is a key player in this process of adaptation and resilience, and through a process known as “allostasis” can obtain “stability through change”; protecting homeostasis in the face of stressors in the environment. Mediators of allostasis, such as glucocorticoids, can cause changes in the structure and function of neural circuits, clearly impacting behavior. How developmental stage interacts with stress and leads to long-lasting changes is a key question addressed in this review. Scope and Methods We discuss the concept of allostasis, its role in resilience, the neural and physiological systems mediating these responses, the modulatory role of development, and the consequences for adult functioning. We present this in the context of mediators the brain and body engage to protect against threats to homeostasis. The review has been informed by comprehensive searches on PubMed and Scopus through November 2012. Findings Stressors in the environment can have long lasting effects on development, depending upon the stage of life at which they are experienced. As such, adverse childhood experiences can alter resilience of individuals, making it more difficult for them to respond normally to adverse situations in adulthood, but the brain maintains the capacity to re-enter a more plastic state where such effects can be mitigated. Conclusions The brain regulates responses that allow for adaptation to challenges in the environment. The capacity of the brain and body to withstand challenges to stability can be considered as “resilience”. While adverse childhood experiences can have long-term negative consequences, under the right circumstances, the brain can re-enter plastic states, and negative outcomes may be mitigated, even later in life. En ligne : http://dx.doi.org/10.1111/jcpp.12054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 Beyond the hype and hope: Critical considerations for intranasal oxytocin research in autism spectrum disorder / Gail A. ALVARES in Autism Research, 10-1 (January 2017)
[article]
Titre : Beyond the hype and hope: Critical considerations for intranasal oxytocin research in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gail A. ALVARES, Auteur ; Daniel S. QUINTANA, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.25-41 Langues : Anglais (eng) Mots-clés : oxytocin neuropeptide hormones nasal spray Index. décimale : PER Périodiques Résumé : Extensive research efforts in the last decade have been expended into understanding whether intranasal oxytocin may be an effective therapeutic in treating social communication impairments in individuals with autism spectrum disorder (ASD). After much hyped early findings, subsequent clinical trials of longer-term administration have yielded more conservative and mixed evidence. However, it is still unclear at this stage whether these more disappointing findings reflect a true null effect or are mitigated by methodological differences masking true effects. In this review, we comprehensively evaluate the rationale for oxytocin as a therapeutic, evaluating evidence from randomized controlled trials, case reports, and open-label studies of oxytocin administration in individuals with ASD. The evidence to date, including reviews of preregistered trials, suggests a number of critical considerations for the design and interpretation of research in this area. These include considering the choice of ASD outcome measures, dosing and nasal spray device issues, and participant selection. Despite these limitations in the field to date, there remains significant potential for oxytocin to ameliorate aspects of the persistent and debilitating social impairments in individuals with ASD. Given the considerable media hype around new treatments for ASD, as well as the needs of eager families, there is an urgent need for researchers to prioritise considering such factors when conducting well-designed and controlled studies to further advance this field. En ligne : http://dx.doi.org/10.1002/aur.1692 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=302
in Autism Research > 10-1 (January 2017) . - p.25-41[article] Beyond the hype and hope: Critical considerations for intranasal oxytocin research in autism spectrum disorder [Texte imprimé et/ou numérique] / Gail A. ALVARES, Auteur ; Daniel S. QUINTANA, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.25-41.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.25-41
Mots-clés : oxytocin neuropeptide hormones nasal spray Index. décimale : PER Périodiques Résumé : Extensive research efforts in the last decade have been expended into understanding whether intranasal oxytocin may be an effective therapeutic in treating social communication impairments in individuals with autism spectrum disorder (ASD). After much hyped early findings, subsequent clinical trials of longer-term administration have yielded more conservative and mixed evidence. However, it is still unclear at this stage whether these more disappointing findings reflect a true null effect or are mitigated by methodological differences masking true effects. In this review, we comprehensively evaluate the rationale for oxytocin as a therapeutic, evaluating evidence from randomized controlled trials, case reports, and open-label studies of oxytocin administration in individuals with ASD. The evidence to date, including reviews of preregistered trials, suggests a number of critical considerations for the design and interpretation of research in this area. These include considering the choice of ASD outcome measures, dosing and nasal spray device issues, and participant selection. Despite these limitations in the field to date, there remains significant potential for oxytocin to ameliorate aspects of the persistent and debilitating social impairments in individuals with ASD. Given the considerable media hype around new treatments for ASD, as well as the needs of eager families, there is an urgent need for researchers to prioritise considering such factors when conducting well-designed and controlled studies to further advance this field. En ligne : http://dx.doi.org/10.1002/aur.1692 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=302 Commentary: Is there a there there in hair? A reflection on child maltreatment and hair cortisol concentrations in White et al. (2017) / Philip A. FISHER in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)
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