10 recherche sur le mot-clé 'Hormones'

Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? / Sumi HOSHIKO in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.456-463 Titre : Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? Type de document : texte imprimé Auteurs : Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur Année de publication : 2012 Article en page(s) : p.456-463 Langues : Anglais (eng) Mots-clés : epidemiology  autism  thyroid  environment  hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? [texte imprimé] / Sumi HOSHIKO, Auteur ; Judith K. GRETHER, Auteur ; Gayle C. WINDHAM, Auteur ; Daniel W. SMITH, Auteur ; Karen FESSEL, Auteur . - 2012 . - p.456-463. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.456-463 Mots-clés : epidemiology  autism  thyroid  environment  hormones Index. décimale : PER Périodiques Résumé : Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30–5.75; 1994: OR = 1.71 (95% CI 0.57–5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. En ligne : http://dx.doi.org/10.1002/aur.219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

The intersection and developmental trajectory of morning cortisol and testosterone in autistic and neurotypical youth / Trey MCGONIGLE ; Rachael A. MUSCATELLO ; Simon VANDEKAR ; Rachel CALVOSA in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 27 Titre : The intersection and developmental trajectory of morning cortisol and testosterone in autistic and neurotypical youth Type de document : texte imprimé Auteurs : Trey MCGONIGLE, Auteur ; Rachael A. MUSCATELLO, Auteur ; Simon VANDEKAR, Auteur ; Rachel CALVOSA, Auteur Article en page(s) : 27 Langues : Anglais (eng) Mots-clés : Humans  Testosterone/metabolism  Female  Male  Hydrocortisone/metabolism  Adolescent  Child  Saliva/metabolism/chemistry  Longitudinal Studies  Autism Spectrum Disorder/metabolism  Autistic Disorder/metabolism  Autism  Cortisol  HPA axis  Hpg  Hormones  Puberty  Testosterone  carried out in accordance with the Code of Ethics of the World Medical  Association (Declaration of Helsinki). The Vanderbilt Institutional Review Board  approved the study. Prior to inclusion in the study, informed written consent and  assent were obtained from all parents and study participants, respectively.  Consent for publication: Not applicable. Competing interests: The authors declare  no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Behavioral endocrinology examines associations between hormone expression, such as testosterone and cortisol, and behavior; both of which have been implicated in autism spectrum disorder (ASD). The overarching aim of the study was to examine the intersection of sex-based (Male, Female), hormonal (testosterone, cortisol), diagnostic (ASD, typically developing, (TD)) and developmental (age, puberty) patterns over four years of a longitudinal study in a well-characterized sample of youth (spanning 10 to 17 years). METHODS: In year 1 (Y1), participants included 140 autistic youth (36 females, 104 males) and 105 TD youth (46 females, 59 males.). For Y4, participants included 83 ASD and 77 TD youth. Immediate waking morning salivary samples were collected for hormone assay. Mixed effects and ordinary linear regression models were used, as well as mediation effects of hormones on behavior. RESULTS: For cortisol, there was a significant diagnosis by sex by age interaction (X(2) = 15.62, df = 3, p = 0.0014, S = 0.2446) showing that autistic females evidence higher morning cortisol that increased over developmental progression compared to TD females. Moreover, ASD males had stunted testosterone growth compared to TD males (Est = 0.1530, p = 0.0130). Regarding biobehavioral associations in year 1, diagnosis (X(2) = 80.72, df = 1, p < 0.0001, S = 0.5704) and cortisol (X(2) = 14.42, df = 3, p = 0.0024, S = 0.2159) were associated with social problems; however, there were no effects for testosterone on diagnosis or a mediation effect on social problems. There was a significant effect of diagnosis on CBCL Aggression score (X(2) = 34.39, df = 1, p < 0.0001, S = 0.3692) independent of hormonal measurements. LIMITATIONS: Despite the large sample, it was not fully representative based on race, ethnicity or intellectual profile. Attrition of the sample is also acknowledged especially between portions of Y2 and Y3 due to the COVID-19 pandemic. Finally, only the immediate morning salivary samples were used due to lower and undetectable concentration levels of testosterone in younger and female children. CONCLUSIONS: Collectively, these findings underscore the need to elucidate the biobehavioral patterns that emerge during the complex adolescent transition for autistic youth to determine how they impact clinical and long-term outcomes. The unique hormonal trajectories may be related to differences in advanced pubertal progression and affective states found in autistic females. En ligne : https://dx.doi.org/10.1186/s13229-025-00658-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] The intersection and developmental trajectory of morning cortisol and testosterone in autistic and neurotypical youth [texte imprimé] / Trey MCGONIGLE, Auteur ; Rachael A. MUSCATELLO, Auteur ; Simon VANDEKAR, Auteur ; Rachel CALVOSA, Auteur . - 27. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 27 Mots-clés : Humans  Testosterone/metabolism  Female  Male  Hydrocortisone/metabolism  Adolescent  Child  Saliva/metabolism/chemistry  Longitudinal Studies  Autism Spectrum Disorder/metabolism  Autistic Disorder/metabolism  Autism  Cortisol  HPA axis  Hpg  Hormones  Puberty  Testosterone  carried out in accordance with the Code of Ethics of the World Medical  Association (Declaration of Helsinki). The Vanderbilt Institutional Review Board  approved the study. Prior to inclusion in the study, informed written consent and  assent were obtained from all parents and study participants, respectively.  Consent for publication: Not applicable. Competing interests: The authors declare  no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Behavioral endocrinology examines associations between hormone expression, such as testosterone and cortisol, and behavior; both of which have been implicated in autism spectrum disorder (ASD). The overarching aim of the study was to examine the intersection of sex-based (Male, Female), hormonal (testosterone, cortisol), diagnostic (ASD, typically developing, (TD)) and developmental (age, puberty) patterns over four years of a longitudinal study in a well-characterized sample of youth (spanning 10 to 17 years). METHODS: In year 1 (Y1), participants included 140 autistic youth (36 females, 104 males) and 105 TD youth (46 females, 59 males.). For Y4, participants included 83 ASD and 77 TD youth. Immediate waking morning salivary samples were collected for hormone assay. Mixed effects and ordinary linear regression models were used, as well as mediation effects of hormones on behavior. RESULTS: For cortisol, there was a significant diagnosis by sex by age interaction (X(2) = 15.62, df = 3, p = 0.0014, S = 0.2446) showing that autistic females evidence higher morning cortisol that increased over developmental progression compared to TD females. Moreover, ASD males had stunted testosterone growth compared to TD males (Est = 0.1530, p = 0.0130). Regarding biobehavioral associations in year 1, diagnosis (X(2) = 80.72, df = 1, p < 0.0001, S = 0.5704) and cortisol (X(2) = 14.42, df = 3, p = 0.0024, S = 0.2159) were associated with social problems; however, there were no effects for testosterone on diagnosis or a mediation effect on social problems. There was a significant effect of diagnosis on CBCL Aggression score (X(2) = 34.39, df = 1, p < 0.0001, S = 0.3692) independent of hormonal measurements. LIMITATIONS: Despite the large sample, it was not fully representative based on race, ethnicity or intellectual profile. Attrition of the sample is also acknowledged especially between portions of Y2 and Y3 due to the COVID-19 pandemic. Finally, only the immediate morning salivary samples were used due to lower and undetectable concentration levels of testosterone in younger and female children. CONCLUSIONS: Collectively, these findings underscore the need to elucidate the biobehavioral patterns that emerge during the complex adolescent transition for autistic youth to determine how they impact clinical and long-term outcomes. The unique hormonal trajectories may be related to differences in advanced pubertal progression and affective states found in autistic females. En ligne : https://dx.doi.org/10.1186/s13229-025-00658-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam / Shirley H.F. LEE in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4577-4586 Titre : 2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam Type de document : texte imprimé Auteurs : Shirley H.F. LEE, Auteur ; Syahiirah Abd AZIZ, Auteur ; Mawarni HAMID, Auteur ; Ya Chee LIM, Auteur ; David KOH, Auteur ; Li Ling CHAW, Auteur Article en page(s) : p.4577-4586 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Brunei  Case-Control Studies  Child  Child, Preschool  Female  Fingers  Hand  Humans  Male  Sex Characteristics  2D:4D ratio  2D:4D ratio symmetry  Androgens  Autism spectrum disorders (ASD)  Brunei Darussalam  Digit ratio  Extreme male brain (EMB)  Hormones  Testosterone  this manuscript. Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite the global increase in the prevalence of autism spectrum disorders (ASD), relevant research studies are lacking in Brunei Darussalam. Various studies have shown a significant association between a lowered 2D:4D ratio (ratio of second digit/index finger to the fourth digit/ring finger) and ASD, making it one of the potential phenotypic biomarkers for early detection of autism, which is important for early intervention and management. OBJECTIVE: The objective of this study is to explore the association between 2D:4D ratio and ASD in Brunei Darussalam, as a potential tool to complement early ASD diagnosis. METHODS: We conducted a case-control study comprising 28 ASD and 62 typically developing (TD) children in the case and control group, respectively (age range: 3-11 years old; median age: 6 years old). Median 2D:4D ratios were measured, compared and analysed between the two groups. Logistic regression models were used to explore potential associations between the median 2D:4D ratio and ASD in respective gender, for both left and right hands, independently. RESULTS: Our study shows that the median 2D:4D ratio of left hand in ASD males is significantly lower than those in TD males, after adjusting for ethnicity and age [Odds Ratio (OR) = 0.57 (95% Confidence Interval (CI): 0.31-0.96); p = 0.044]. For females, there is no association of ASD with the median left hand 2D:4D ratio [OR = 3.09 (95% CI: 0.98-19.86); p = 0.144] or the median right hand 2D:4D ratio [OR = 1.23 (95% CI: 0.42-3.88); p = 0.702]. Our study also shows a significant positive correlation and/or a reduced asymmetry between the average 2D:4D ratio of left hands and right hands in ASD males (Pearson's correlation (r) = 0.48; 95% CI: 0.076-0.75, p = 0.023). CONCLUSIONS: There is significant association between a lowered median 2D:4D ratio of the left hand (in males only) and ASD diagnosis. Once validated in a larger sample size, a lowered median 2D:4D ratio on the left hand may be a potential tool to complement ASD diagnosis for males in our study population. There is no association between the median 2D:4D ratio (left or right hands) and ASD in females, which could be due to the small female sample size and/or the possibility of different aetiology for ASD in females. Reduced asymmetry between the average 2D:4D ratio of left and right hands observed in ASD males only (not in ASD females) also suggests the importance of considering gender-specific biomarkers for ASD diagnosis. En ligne : http://dx.doi.org/10.1007/s10803-021-04899-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] 2D:4D Ratio and Autism Spectrum Disorder in Brunei Darussalam [texte imprimé] / Shirley H.F. LEE, Auteur ; Syahiirah Abd AZIZ, Auteur ; Mawarni HAMID, Auteur ; Ya Chee LIM, Auteur ; David KOH, Auteur ; Li Ling CHAW, Auteur . - p.4577-4586. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4577-4586 Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Brunei  Case-Control Studies  Child  Child, Preschool  Female  Fingers  Hand  Humans  Male  Sex Characteristics  2D:4D ratio  2D:4D ratio symmetry  Androgens  Autism spectrum disorders (ASD)  Brunei Darussalam  Digit ratio  Extreme male brain (EMB)  Hormones  Testosterone  this manuscript. Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite the global increase in the prevalence of autism spectrum disorders (ASD), relevant research studies are lacking in Brunei Darussalam. Various studies have shown a significant association between a lowered 2D:4D ratio (ratio of second digit/index finger to the fourth digit/ring finger) and ASD, making it one of the potential phenotypic biomarkers for early detection of autism, which is important for early intervention and management. OBJECTIVE: The objective of this study is to explore the association between 2D:4D ratio and ASD in Brunei Darussalam, as a potential tool to complement early ASD diagnosis. METHODS: We conducted a case-control study comprising 28 ASD and 62 typically developing (TD) children in the case and control group, respectively (age range: 3-11 years old; median age: 6 years old). Median 2D:4D ratios were measured, compared and analysed between the two groups. Logistic regression models were used to explore potential associations between the median 2D:4D ratio and ASD in respective gender, for both left and right hands, independently. RESULTS: Our study shows that the median 2D:4D ratio of left hand in ASD males is significantly lower than those in TD males, after adjusting for ethnicity and age [Odds Ratio (OR) = 0.57 (95% Confidence Interval (CI): 0.31-0.96); p = 0.044]. For females, there is no association of ASD with the median left hand 2D:4D ratio [OR = 3.09 (95% CI: 0.98-19.86); p = 0.144] or the median right hand 2D:4D ratio [OR = 1.23 (95% CI: 0.42-3.88); p = 0.702]. Our study also shows a significant positive correlation and/or a reduced asymmetry between the average 2D:4D ratio of left hands and right hands in ASD males (Pearson's correlation (r) = 0.48; 95% CI: 0.076-0.75, p = 0.023). CONCLUSIONS: There is significant association between a lowered median 2D:4D ratio of the left hand (in males only) and ASD diagnosis. Once validated in a larger sample size, a lowered median 2D:4D ratio on the left hand may be a potential tool to complement ASD diagnosis for males in our study population. There is no association between the median 2D:4D ratio (left or right hands) and ASD in females, which could be due to the small female sample size and/or the possibility of different aetiology for ASD in females. Reduced asymmetry between the average 2D:4D ratio of left and right hands observed in ASD males only (not in ASD females) also suggests the importance of considering gender-specific biomarkers for ASD diagnosis. En ligne : http://dx.doi.org/10.1007/s10803-021-04899-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study / Lynnea MYERS in Journal of Autism and Developmental Disorders, 48-9 (September 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252 Titre : 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study Type de document : texte imprimé Auteurs : Lynnea MYERS, Auteur ; Annelies VAN'T WESTEINDE, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Kristiina TAMMIMIES, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3244-3252 Langues : Anglais (eng) Mots-clés : 2D:4D ratio  Adhd  Autism  Hormones  Neurodevelopmental disorders  Sex  Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study [texte imprimé] / Lynnea MYERS, Auteur ; Annelies VAN'T WESTEINDE, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Kristiina TAMMIMIES, Auteur ; Sven BÖLTE, Auteur . - p.3244-3252. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252 Mots-clés : 2D:4D ratio  Adhd  Autism  Hormones  Neurodevelopmental disorders  Sex  Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course / Ilia N. KARATOREOS in Journal of Child Psychology and Psychiatry, 54-4 (April 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-4 (April 2013) . - p.337-347 Titre : Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course Type de document : texte imprimé Auteurs : Ilia N. KARATOREOS, Auteur ; Bruce S. MCEWEN, Auteur Article en page(s) : p.337-347 Mots-clés : Allostasis  hormones  neurobiology  aging  brain development Index. décimale : PER Périodiques Résumé : Background Adaptation is key to survival. An organism must adapt to environmental challenges in order to be able to thrive in the environment in which they find themselves. Resilience can be thought of as a measure of the ability of an organism to adapt, and to withstand challenges to its stability. In higher animals, the brain is a key player in this process of adaptation and resilience, and through a process known as “allostasis” can obtain “stability through change”; protecting homeostasis in the face of stressors in the environment. Mediators of allostasis, such as glucocorticoids, can cause changes in the structure and function of neural circuits, clearly impacting behavior. How developmental stage interacts with stress and leads to long-lasting changes is a key question addressed in this review. Scope and Methods We discuss the concept of allostasis, its role in resilience, the neural and physiological systems mediating these responses, the modulatory role of development, and the consequences for adult functioning. We present this in the context of mediators the brain and body engage to protect against threats to homeostasis. The review has been informed by comprehensive searches on PubMed and Scopus through November 2012. Findings Stressors in the environment can have long lasting effects on development, depending upon the stage of life at which they are experienced. As such, adverse childhood experiences can alter resilience of individuals, making it more difficult for them to respond normally to adverse situations in adulthood, but the brain maintains the capacity to re-enter a more plastic state where such effects can be mitigated. Conclusions The brain regulates responses that allow for adaptation to challenges in the environment. The capacity of the brain and body to withstand challenges to stability can be considered as “resilience”. While adverse childhood experiences can have long-term negative consequences, under the right circumstances, the brain can re-enter plastic states, and negative outcomes may be mitigated, even later in life. En ligne : http://dx.doi.org/10.1111/jcpp.12054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course [texte imprimé] / Ilia N. KARATOREOS, Auteur ; Bruce S. MCEWEN, Auteur . - p.337-347. in Journal of Child Psychology and Psychiatry > 54-4 (April 2013) . - p.337-347 Mots-clés : Allostasis  hormones  neurobiology  aging  brain development Index. décimale : PER Périodiques Résumé : Background Adaptation is key to survival. An organism must adapt to environmental challenges in order to be able to thrive in the environment in which they find themselves. Resilience can be thought of as a measure of the ability of an organism to adapt, and to withstand challenges to its stability. In higher animals, the brain is a key player in this process of adaptation and resilience, and through a process known as “allostasis” can obtain “stability through change”; protecting homeostasis in the face of stressors in the environment. Mediators of allostasis, such as glucocorticoids, can cause changes in the structure and function of neural circuits, clearly impacting behavior. How developmental stage interacts with stress and leads to long-lasting changes is a key question addressed in this review. Scope and Methods We discuss the concept of allostasis, its role in resilience, the neural and physiological systems mediating these responses, the modulatory role of development, and the consequences for adult functioning. We present this in the context of mediators the brain and body engage to protect against threats to homeostasis. The review has been informed by comprehensive searches on PubMed and Scopus through November 2012. Findings Stressors in the environment can have long lasting effects on development, depending upon the stage of life at which they are experienced. As such, adverse childhood experiences can alter resilience of individuals, making it more difficult for them to respond normally to adverse situations in adulthood, but the brain maintains the capacity to re-enter a more plastic state where such effects can be mitigated. Conclusions The brain regulates responses that allow for adaptation to challenges in the environment. The capacity of the brain and body to withstand challenges to stability can be considered as “resilience”. While adverse childhood experiences can have long-term negative consequences, under the right circumstances, the brain can re-enter plastic states, and negative outcomes may be mitigated, even later in life. En ligne : http://dx.doi.org/10.1111/jcpp.12054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Beyond the hype and hope: Critical considerations for intranasal oxytocin research in autism spectrum disorder / Gail A. ALVARES in Autism Research, 10-1 (January 2017)  

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Commentary: Is there a there there in hair? A reflection on child maltreatment and hair cortisol concentrations in White et al. (2017) / Philip A. FISHER in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

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Les fondements génétiques et psychophysiologiques de l'agression / Ginette DIONNE

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Hypospadias and increased risk for neurodevelopmental disorders / Agnieszka BUTWICKA in Journal of Child Psychology and Psychiatry, 56-2 (February 2015)  

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Overlap of autism and conditions associated with atypical sex hormone levels or response: A systematic review and meta-analysis / Tamara MAY in Research in Autism Spectrum Disorders, 80 (February 2021)  

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