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Altered functional resting-state hypothalamic connectivity and abnormal pituitary morphology in children with Prader-Willi syndrome / A. LUKOSHE in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)
[article]
Titre : Altered functional resting-state hypothalamic connectivity and abnormal pituitary morphology in children with Prader-Willi syndrome Type de document : Texte imprimé et/ou numérique Auteurs : A. LUKOSHE, Auteur ; S. E. VAN DIJK, Auteur ; G. E. VAN DEN BOSCH, Auteur ; A. VAN DER LUGT, Auteur ; T. WHITE, Auteur ; A. C. HOKKEN-KOELEGA, Auteur Article en page(s) : p.12 Langues : Anglais (eng) Mots-clés : 15q11-q13 Functional resting-state connectivity Hypothalamus Neurodevelopmental disorders Pituitary gland Prader-Willi syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder, characterized by endocrine problems and hyperphagia, indicating hypothalamic-pituitary dysfunction. However, few studies have explored the underlying neurobiology of the hypothalamus and its functional connectivity with other brain regions. Thus, the aim of this study was to examine the anatomical differences of the hypothalamus, mammillary bodies, and pituitary gland as well as resting state functional connectivity of the hypothalamus in children with PWS. METHODS: Twenty-seven children with PWS (13 DEL, 14 mUPD) and 28 typically developing children were included. Manual segmentations by a blinded investigator were performed to determine the volumes of the hypothalamus, mammillary bodies, and pituitary gland. In addition, brain-wide functional connectivity analysis was performed using the obtained masks of the hypothalamus. RESULTS: Children with PWS showed altered resting state functional connectivity between hypothalamus and right and left lateral occipital complex, compared to healthy controls. In addition, children with PWS had on average a 50% smaller pituitary volume, an irregular shape of the pituitary, and a longer pituitary stalk. Pituitary volume did not increase in volume during puberty in PWS. No volumetric differences in the hypothalamus and mammillary bodies were found. In all subjects, the posterior pituitary bright spot was observed. CONCLUSIONS: We report altered functional hypothalamic connectivity with lateral occipital complexes in both hemispheres, which are implicated in response to food and reward system, and absence of connectivity might therefore at least partially contribute to the preoccupation with food in PWS. En ligne : http://dx.doi.org/10.1186/s11689-017-9188-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.12[article] Altered functional resting-state hypothalamic connectivity and abnormal pituitary morphology in children with Prader-Willi syndrome [Texte imprimé et/ou numérique] / A. LUKOSHE, Auteur ; S. E. VAN DIJK, Auteur ; G. E. VAN DEN BOSCH, Auteur ; A. VAN DER LUGT, Auteur ; T. WHITE, Auteur ; A. C. HOKKEN-KOELEGA, Auteur . - p.12.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.12
Mots-clés : 15q11-q13 Functional resting-state connectivity Hypothalamus Neurodevelopmental disorders Pituitary gland Prader-Willi syndrome Index. décimale : PER Périodiques Résumé : BACKGROUND: Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder, characterized by endocrine problems and hyperphagia, indicating hypothalamic-pituitary dysfunction. However, few studies have explored the underlying neurobiology of the hypothalamus and its functional connectivity with other brain regions. Thus, the aim of this study was to examine the anatomical differences of the hypothalamus, mammillary bodies, and pituitary gland as well as resting state functional connectivity of the hypothalamus in children with PWS. METHODS: Twenty-seven children with PWS (13 DEL, 14 mUPD) and 28 typically developing children were included. Manual segmentations by a blinded investigator were performed to determine the volumes of the hypothalamus, mammillary bodies, and pituitary gland. In addition, brain-wide functional connectivity analysis was performed using the obtained masks of the hypothalamus. RESULTS: Children with PWS showed altered resting state functional connectivity between hypothalamus and right and left lateral occipital complex, compared to healthy controls. In addition, children with PWS had on average a 50% smaller pituitary volume, an irregular shape of the pituitary, and a longer pituitary stalk. Pituitary volume did not increase in volume during puberty in PWS. No volumetric differences in the hypothalamus and mammillary bodies were found. In all subjects, the posterior pituitary bright spot was observed. CONCLUSIONS: We report altered functional hypothalamic connectivity with lateral occipital complexes in both hemispheres, which are implicated in response to food and reward system, and absence of connectivity might therefore at least partially contribute to the preoccupation with food in PWS. En ligne : http://dx.doi.org/10.1186/s11689-017-9188-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 Atypical modulation of hypothalamic activity by social context in ASD / Thierry CHAMINADE in Research in Autism Spectrum Disorders, 10 (February 2015)
[article]
Titre : Atypical modulation of hypothalamic activity by social context in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Thierry CHAMINADE, Auteur ; David DA FONSECA, Auteur ; Delphine ROSSET, Auteur ; Gordon CHENG, Auteur ; Christine DERUELLE, Auteur Article en page(s) : p.41-50 Langues : Anglais (eng) Mots-clés : Autism Social interaction Mentalization Social motivation Hypothalamus Index. décimale : PER Périodiques Résumé : High-functioning individuals with Autism Spectrum Disorder (ASD) and age- and verbal IQ-matched controls (CTL) were fMRI scanned when playing “stone paper scissors”. They believed they were playing against three different opponents: a Human, a Robot endowed with an artificial intelligence attempting to win the game, and a Computer running a random number generator. No differences between ASD and CTL reached significance in canonical mentalizing regions, in the medial prefrontal cortex and right temporoparietal junction. In contrast, activity in a cluster located in the left hypothalamus, attributed to the paraventricular hypothalamic nucleus (PHN), increased in the CTL, but not ASD, group when participants played against the human compared to the artificial agent. The left temporoparietal junction (lTPJ), that has been previously associated with anthropomorphization, influenced this PHN cluster activity differently between groups, with a significantly negative functional connectivity when CTL played against the robot and when ASD participants played against the human. Brain activity results are consistent with the hypothesis that hypothalamus-secreted neurohormones, including oxytocin, could support motivation for social interactions and be impaired in autism. Brain connectivity results suggest that cortical encoding of social context information, putatively related to anthropomorphism, has a reversed effect on hypothalamus activity in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Research in Autism Spectrum Disorders > 10 (February 2015) . - p.41-50[article] Atypical modulation of hypothalamic activity by social context in ASD [Texte imprimé et/ou numérique] / Thierry CHAMINADE, Auteur ; David DA FONSECA, Auteur ; Delphine ROSSET, Auteur ; Gordon CHENG, Auteur ; Christine DERUELLE, Auteur . - p.41-50.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 10 (February 2015) . - p.41-50
Mots-clés : Autism Social interaction Mentalization Social motivation Hypothalamus Index. décimale : PER Périodiques Résumé : High-functioning individuals with Autism Spectrum Disorder (ASD) and age- and verbal IQ-matched controls (CTL) were fMRI scanned when playing “stone paper scissors”. They believed they were playing against three different opponents: a Human, a Robot endowed with an artificial intelligence attempting to win the game, and a Computer running a random number generator. No differences between ASD and CTL reached significance in canonical mentalizing regions, in the medial prefrontal cortex and right temporoparietal junction. In contrast, activity in a cluster located in the left hypothalamus, attributed to the paraventricular hypothalamic nucleus (PHN), increased in the CTL, but not ASD, group when participants played against the human compared to the artificial agent. The left temporoparietal junction (lTPJ), that has been previously associated with anthropomorphization, influenced this PHN cluster activity differently between groups, with a significantly negative functional connectivity when CTL played against the robot and when ASD participants played against the human. Brain activity results are consistent with the hypothesis that hypothalamus-secreted neurohormones, including oxytocin, could support motivation for social interactions and be impaired in autism. Brain connectivity results suggest that cortical encoding of social context information, putatively related to anthropomorphism, has a reversed effect on hypothalamus activity in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260