7 recherche sur le mot-clé 'Image Processing, Computer-Assisted'

Computer-vision analysis of craniofacial dysmorphology in 22q11.2 deletion syndrome and psychosis spectrum disorders / David R. ROALF in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Computer-vision analysis of craniofacial dysmorphology in 22q11.2 deletion syndrome and psychosis spectrum disorders Type de document : texte imprimé Auteurs : David R. ROALF, Auteur ; Donna M. MCDONALD-MCGINN, Auteur ; Joelle JEE, Auteur ; Mckenna KRALL, Auteur ; T Blaine CROWLEY, Auteur ; Paul J. MOBERG, Auteur ; Christian KOHLER, Auteur ; Monica E. CALKINS, Auteur ; Andrew J.D. CROW, Auteur ; Nicole FLEISCHER, Auteur ; R. Sean GALLAGHER, Auteur ; Virgilio GONZENBACH, Auteur ; Kelly CLARK, Auteur ; Ruben C. GUR, Auteur ; Emily MCCLELLAN, Auteur ; Daniel E. MCGINN, Auteur ; Arianna MORDY, Auteur ; Kosha RUPAREL, Auteur ; Bruce I. TURETSKY, Auteur ; Russell T. SHINOHARA, Auteur ; Lauren WHITE, Auteur ; Elaine ZACKAI, Auteur ; Raquel E. GUR, Auteur Langues : Anglais (eng) Mots-clés : Humans  DiGeorge Syndrome/genetics/physiopathology  Psychotic Disorders/genetics  Female  Male  Adolescent  Child  Craniofacial Abnormalities/genetics  Young Adult  Adult  Machine Learning  Image Processing, Computer-Assisted  22q11.2 deletion syndrome  Clinical high-risk psychosis  Computer-vision  Face  Minor physical anomalies  Psychosis  Schizophrenia  to provide F2G Gestalt data for facial photographs. She was not involved in  project design, implementation, or data analysis. She reviewed and edited the  final manuscript. No other authors have any competing interest to report. Index. décimale : PER Périodiques Résumé : BACKGROUND: Minor physical anomalies (MPAs) are congenital morphological abnormalities linked to disruptions of fetal development. MPAs are common in 22q11.2 deletion syndrome (22q11DS) and psychosis spectrum disorders (PS) and likely represent a disruption of early embryologic development that may help identify overlapping mechanisms linked to psychosis in these disorders. METHODS: Here, 2D digital photographs were collected from 22q11DS (n = 150), PS (n = 55), and typically developing (TD; n = 93) individuals. Photographs were analyzed using two computer-vision techniques: (1) DeepGestalt algorithm (Face2Gene (F2G)) technology to identify the presence of genetically mediated facial disorders, and (2) Emotrics-a semi-automated machine learning technique that localizes and measures facial features. RESULTS: F2G reliably identified patients with 22q11DS; faces of PS patients were matched to several genetic conditions including FragileX and 22q11DS. PCA-derived factor loadings of all F2G scores indicated unique and overlapping facial patterns that were related to both 22q11DS and PS. Regional facial measurements of the eyes and nose were smaller in 22q11DS as compared to TD, while PS showed intermediate measurements. CONCLUSIONS: The extent to which craniofacial dysmorphology 22q11DS and PS overlapping and evident before the impairment or distress of sub-psychotic symptoms may allow us to identify at-risk youths more reliably and at an earlier stage of development. En ligne : https://dx.doi.org/10.1186/s11689-024-09547-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Computer-vision analysis of craniofacial dysmorphology in 22q11.2 deletion syndrome and psychosis spectrum disorders [texte imprimé] / David R. ROALF, Auteur ; Donna M. MCDONALD-MCGINN, Auteur ; Joelle JEE, Auteur ; Mckenna KRALL, Auteur ; T Blaine CROWLEY, Auteur ; Paul J. MOBERG, Auteur ; Christian KOHLER, Auteur ; Monica E. CALKINS, Auteur ; Andrew J.D. CROW, Auteur ; Nicole FLEISCHER, Auteur ; R. Sean GALLAGHER, Auteur ; Virgilio GONZENBACH, Auteur ; Kelly CLARK, Auteur ; Ruben C. GUR, Auteur ; Emily MCCLELLAN, Auteur ; Daniel E. MCGINN, Auteur ; Arianna MORDY, Auteur ; Kosha RUPAREL, Auteur ; Bruce I. TURETSKY, Auteur ; Russell T. SHINOHARA, Auteur ; Lauren WHITE, Auteur ; Elaine ZACKAI, Auteur ; Raquel E. GUR, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  DiGeorge Syndrome/genetics/physiopathology  Psychotic Disorders/genetics  Female  Male  Adolescent  Child  Craniofacial Abnormalities/genetics  Young Adult  Adult  Machine Learning  Image Processing, Computer-Assisted  22q11.2 deletion syndrome  Clinical high-risk psychosis  Computer-vision  Face  Minor physical anomalies  Psychosis  Schizophrenia  to provide F2G Gestalt data for facial photographs. She was not involved in  project design, implementation, or data analysis. She reviewed and edited the  final manuscript. No other authors have any competing interest to report. Index. décimale : PER Périodiques Résumé : BACKGROUND: Minor physical anomalies (MPAs) are congenital morphological abnormalities linked to disruptions of fetal development. MPAs are common in 22q11.2 deletion syndrome (22q11DS) and psychosis spectrum disorders (PS) and likely represent a disruption of early embryologic development that may help identify overlapping mechanisms linked to psychosis in these disorders. METHODS: Here, 2D digital photographs were collected from 22q11DS (n = 150), PS (n = 55), and typically developing (TD; n = 93) individuals. Photographs were analyzed using two computer-vision techniques: (1) DeepGestalt algorithm (Face2Gene (F2G)) technology to identify the presence of genetically mediated facial disorders, and (2) Emotrics-a semi-automated machine learning technique that localizes and measures facial features. RESULTS: F2G reliably identified patients with 22q11DS; faces of PS patients were matched to several genetic conditions including FragileX and 22q11DS. PCA-derived factor loadings of all F2G scores indicated unique and overlapping facial patterns that were related to both 22q11DS and PS. Regional facial measurements of the eyes and nose were smaller in 22q11DS as compared to TD, while PS showed intermediate measurements. CONCLUSIONS: The extent to which craniofacial dysmorphology 22q11DS and PS overlapping and evident before the impairment or distress of sub-psychotic symptoms may allow us to identify at-risk youths more reliably and at an earlier stage of development. En ligne : https://dx.doi.org/10.1186/s11689-024-09547-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces / Rocco MENNELLA in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 7p. Titre : Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces Type de document : texte imprimé Auteurs : Rocco MENNELLA, Auteur ; Rachel C. LEUNG, Auteur ; Margot J. TAYLOR, Auteur ; Benjamin T. DUNKLEY, Auteur Article en page(s) : 7p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/*psychology  Brain/*physiology  Brain Mapping/*methods  Facial Expression  Female  Humans  Image Processing, Computer-Assisted  Magnetoencephalography/*methods  Male  Social Perception  Young Adult  *Autism  *Emotional faces  *Functional connectivity  *Magnetoencephalography  *Social brain  *Young adults Index. décimale : PER Périodiques Résumé : BACKGROUND: Socio-emotional difficulties in autism spectrum disorder (ASD) are thought to reflect impaired functional connectivity within the "social brain". Nonetheless, a whole-brain characterization of the fast responses in functional connectivity during implicit processing of emotional faces in adults with ASD is lacking. METHODS: The present study used magnetoencephalography to investigate early responses in functional connectivity, as measured by interregional phase synchronization, during implicit processing of angry, neutral and happy faces. The sample (n = 44) consisted of 22 young adults with ASD and 22 age- and sex-matched typically developed (TD) controls. RESULTS: Reduced phase-synchrony in the beta band around 300 ms emerged during processing of angry faces in the ASD compared to TD group, involving key areas of the social brain. In the same time window, de-synchronization in the beta band in the amygdala was reduced in the ASD group across conditions. CONCLUSIONS: This is the first demonstration of atypical global and local synchrony patterns in the social brain in adults with ASD during implicit processing of emotional faces. The present results replicate and substantially extend previous findings on adolescents, highlighting that atypical brain synchrony during processing of socio-emotional stimuli is a hallmark of clinical sequelae in autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0123-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces [texte imprimé] / Rocco MENNELLA, Auteur ; Rachel C. LEUNG, Auteur ; Margot J. TAYLOR, Auteur ; Benjamin T. DUNKLEY, Auteur . - 7p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 7p. Mots-clés : Adult  Autism Spectrum Disorder/*psychology  Brain/*physiology  Brain Mapping/*methods  Facial Expression  Female  Humans  Image Processing, Computer-Assisted  Magnetoencephalography/*methods  Male  Social Perception  Young Adult  *Autism  *Emotional faces  *Functional connectivity  *Magnetoencephalography  *Social brain  *Young adults Index. décimale : PER Périodiques Résumé : BACKGROUND: Socio-emotional difficulties in autism spectrum disorder (ASD) are thought to reflect impaired functional connectivity within the "social brain". Nonetheless, a whole-brain characterization of the fast responses in functional connectivity during implicit processing of emotional faces in adults with ASD is lacking. METHODS: The present study used magnetoencephalography to investigate early responses in functional connectivity, as measured by interregional phase synchronization, during implicit processing of angry, neutral and happy faces. The sample (n = 44) consisted of 22 young adults with ASD and 22 age- and sex-matched typically developed (TD) controls. RESULTS: Reduced phase-synchrony in the beta band around 300 ms emerged during processing of angry faces in the ASD compared to TD group, involving key areas of the social brain. In the same time window, de-synchronization in the beta band in the amygdala was reduced in the ASD group across conditions. CONCLUSIONS: This is the first demonstration of atypical global and local synchrony patterns in the social brain in adults with ASD during implicit processing of emotional faces. The present results replicate and substantially extend previous findings on adolescents, highlighting that atypical brain synchrony during processing of socio-emotional stimuli is a hallmark of clinical sequelae in autism. En ligne : http://dx.doi.org/10.1186/s13229-017-0123-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study / Annika RAUSCH in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 13p. Titre : Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study Type de document : texte imprimé Auteurs : Annika RAUSCH, Auteur ; Wenxin ZHANG, Auteur ; Koen V. HAAK, Auteur ; Maarten MENNES, Auteur ; Erno J. HERMANS, Auteur ; Erik VAN OORT, Auteur ; Guido VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; Wouter B. GROEN, Auteur Article en page(s) : 13p. Langues : Anglais (eng) Mots-clés : Adolescent  Afferent Pathways/pathology/physiopathology  Amygdala/pathology/physiopathology  Autism Spectrum Disorder/pathology/physiopathology  Basolateral Nuclear Complex/pathology/physiopathology  Central Amygdaloid Nucleus/pathology/physiopathology  Connectome  Efferent Pathways/pathology/physiopathology  Emotions  Female  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Models, Neurological  Models, Psychological  Neocortex/pathology/physiopathology  Nerve Net/pathology/physiopathology  Signal-To-Noise Ratio  Social Perception  Surveys and Questionnaires  Temporal Lobe/pathology/physiopathology  Young Adult  Amygdala  Autism spectrum disorder  Centromedial  Connectivity  Input-output  Laterobasal  Nuclei  Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study [texte imprimé] / Annika RAUSCH, Auteur ; Wenxin ZHANG, Auteur ; Koen V. HAAK, Auteur ; Maarten MENNES, Auteur ; Erno J. HERMANS, Auteur ; Erik VAN OORT, Auteur ; Guido VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; Wouter B. GROEN, Auteur . - 13p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 13p. Mots-clés : Adolescent  Afferent Pathways/pathology/physiopathology  Amygdala/pathology/physiopathology  Autism Spectrum Disorder/pathology/physiopathology  Basolateral Nuclear Complex/pathology/physiopathology  Central Amygdaloid Nucleus/pathology/physiopathology  Connectome  Efferent Pathways/pathology/physiopathology  Emotions  Female  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Models, Neurological  Models, Psychological  Neocortex/pathology/physiopathology  Nerve Net/pathology/physiopathology  Signal-To-Noise Ratio  Social Perception  Surveys and Questionnaires  Temporal Lobe/pathology/physiopathology  Young Adult  Amygdala  Autism spectrum disorder  Centromedial  Connectivity  Input-output  Laterobasal  Nuclei  Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity / Chase C. DOUGHERTY in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 28p. Titre : Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity Type de document : texte imprimé Auteurs : Chase C. DOUGHERTY, Auteur ; David W. EVANS, Auteur ; Gajendra J. KATUWAL, Auteur ; Andrew M. MICHAEL, Auteur Article en page(s) : 28p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Algorithms  Autism Spectrum Disorder/diagnostic imaging/pathology  Child  Cross-Sectional Studies  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Severity of Illness Index  Temporal Lobe/anatomy & histology  Young Adult  Asymmetry  Autism spectrum disorder  Development  Fusiform gyrus  Structural imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: While asymmetry in the fusiform gyrus (FFG) has been reported in functional and structural studies in typically developing controls (TDC), few studies have examined FFG asymmetry in autism spectrum disorder (ASD) subjects and those studies are limited by small sample sizes, and confounded by cognitive ability or handedness. No previous work has examined FFG surface area or cortical thickness asymmetry in ASD; nor do we understand the trajectory of FFG asymmetry over time. Finally, it is not known how FFG structural asymmetry relates to ASD symptom severity. METHODS: In this study, we examined FFG volume, surface area, and cortical thickness asymmetry, as well as their cross-sectional trajectories in a large sample of right-handed males aged 7 to 25 years with 128 ASD and 127 TDC subjects using general linear models. In addition, we examined the relationship between FFG asymmetry and ASD severity using the Autism Diagnostic Observation Schedule (ADOS) and Gotham autism severity scores. RESULTS: Findings revealed that while group differences were evident with mean leftward asymmetry in ASD and mean near symmetry in TDC volume and surface area, asymmetry for both groups existed on a spectrum encompassing leftward and rightward asymmetry. In ASD subjects, volume asymmetry was negatively associated with ADOS and autism severity score symptom measures, with a subset of rightward asymmetric patients being most severely affected. We also observed differential trajectory of surface area asymmetry: ASD subjects exhibited a change from leftward asymmetry toward symmetry from age 7 to 25, whereas TDCs exhibited the reverse trend with a change from near symmetry toward leftward symmetry over the observed age range. CONCLUSIONS: Abnormalities in FFG structural asymmetry are related to symptom severity in ASD and show differential developmental trajectory compared to TDC. This study is the first to note these findings. These results may have important implications for understanding the role of FFG asymmetry in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0089-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity [texte imprimé] / Chase C. DOUGHERTY, Auteur ; David W. EVANS, Auteur ; Gajendra J. KATUWAL, Auteur ; Andrew M. MICHAEL, Auteur . - 28p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 28p. Mots-clés : Adolescent  Adult  Algorithms  Autism Spectrum Disorder/diagnostic imaging/pathology  Child  Cross-Sectional Studies  Humans  Image Processing, Computer-Assisted  Magnetic Resonance Imaging  Male  Severity of Illness Index  Temporal Lobe/anatomy & histology  Young Adult  Asymmetry  Autism spectrum disorder  Development  Fusiform gyrus  Structural imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: While asymmetry in the fusiform gyrus (FFG) has been reported in functional and structural studies in typically developing controls (TDC), few studies have examined FFG asymmetry in autism spectrum disorder (ASD) subjects and those studies are limited by small sample sizes, and confounded by cognitive ability or handedness. No previous work has examined FFG surface area or cortical thickness asymmetry in ASD; nor do we understand the trajectory of FFG asymmetry over time. Finally, it is not known how FFG structural asymmetry relates to ASD symptom severity. METHODS: In this study, we examined FFG volume, surface area, and cortical thickness asymmetry, as well as their cross-sectional trajectories in a large sample of right-handed males aged 7 to 25 years with 128 ASD and 127 TDC subjects using general linear models. In addition, we examined the relationship between FFG asymmetry and ASD severity using the Autism Diagnostic Observation Schedule (ADOS) and Gotham autism severity scores. RESULTS: Findings revealed that while group differences were evident with mean leftward asymmetry in ASD and mean near symmetry in TDC volume and surface area, asymmetry for both groups existed on a spectrum encompassing leftward and rightward asymmetry. In ASD subjects, volume asymmetry was negatively associated with ADOS and autism severity score symptom measures, with a subset of rightward asymmetric patients being most severely affected. We also observed differential trajectory of surface area asymmetry: ASD subjects exhibited a change from leftward asymmetry toward symmetry from age 7 to 25, whereas TDCs exhibited the reverse trend with a change from near symmetry toward leftward symmetry over the observed age range. CONCLUSIONS: Abnormalities in FFG structural asymmetry are related to symptom severity in ASD and show differential developmental trajectory compared to TDC. This study is the first to note these findings. These results may have important implications for understanding the role of FFG asymmetry in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0089-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits / Dorothea L. FLORIS in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 35p. Titre : Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits Type de document : texte imprimé Auteurs : Dorothea L. FLORIS, Auteur ; Anita D. BARBER, Auteur ; Mary Beth NEBEL, Auteur ; Mary MARTINELLI, Auteur ; Meng-Chuan LAI, Auteur ; Deana CROCETTI, Auteur ; Simon BARON-COHEN, Auteur ; John SUCKLING, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur Article en page(s) : 35p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/physiopathology  Brain/diagnostic imaging/physiopathology  Case-Control Studies  Child  Female  Functional Laterality/physiology  Humans  Image Processing, Computer-Assisted  Language  Magnetic Resonance Imaging  Male  Neuropsychological Tests  Autism  Hemispheric specialization  Intrinsic functional connectivity  Lateralization  Motor deficits Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. En ligne : http://dx.doi.org/10.1186/s13229-016-0096-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits [texte imprimé] / Dorothea L. FLORIS, Auteur ; Anita D. BARBER, Auteur ; Mary Beth NEBEL, Auteur ; Mary MARTINELLI, Auteur ; Meng-Chuan LAI, Auteur ; Deana CROCETTI, Auteur ; Simon BARON-COHEN, Auteur ; John SUCKLING, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur . - 35p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 35p. Mots-clés : Autism Spectrum Disorder/physiopathology  Brain/diagnostic imaging/physiopathology  Case-Control Studies  Child  Female  Functional Laterality/physiology  Humans  Image Processing, Computer-Assisted  Language  Magnetic Resonance Imaging  Male  Neuropsychological Tests  Autism  Hemispheric specialization  Intrinsic functional connectivity  Lateralization  Motor deficits Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. En ligne : http://dx.doi.org/10.1186/s13229-016-0096-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Cortical morphological markers in children with autism: a structural magnetic resonance imaging study of thickness, area, volume, and gyrification / Daniel Y.J. YANG in Molecular Autism, 7 (2016)  

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A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children / Derek Sayre ANDREWS in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

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