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Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development / Lisa A. CROEN in Autism Research, 12-10 (October 2019)
[article]
Titre : Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : Lisa A. CROEN, Auteur ; Y. QIAN, Auteur ; Paul ASHWOOD, Auteur ; O. ZERBO, Auteur ; Diana SCHENDEL, Auteur ; J. PINTO-MARTIN, Auteur ; M. DANIELE FALLIN, Auteur ; S. LEVY, Auteur ; Laura A. SCHIEVE, Auteur ; M. YEARGIN-ALLSOPP, Auteur ; Katherine R. SABOURIN, Auteur ; Jennifer L. AMES, Auteur Article en page(s) : p.1551-1561 Langues : Anglais (eng) Mots-clés : autism developmental disorder immune function infection neurodevelopment prenatal Index. décimale : PER Périodiques Résumé : Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case-control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3-5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14-4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551-1561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multisite study in the United States-the Study to Explore Early Development-we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD. En ligne : http://dx.doi.org/10.1002/aur.2175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408
in Autism Research > 12-10 (October 2019) . - p.1551-1561[article] Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development [Texte imprimé et/ou numérique] / Lisa A. CROEN, Auteur ; Y. QIAN, Auteur ; Paul ASHWOOD, Auteur ; O. ZERBO, Auteur ; Diana SCHENDEL, Auteur ; J. PINTO-MARTIN, Auteur ; M. DANIELE FALLIN, Auteur ; S. LEVY, Auteur ; Laura A. SCHIEVE, Auteur ; M. YEARGIN-ALLSOPP, Auteur ; Katherine R. SABOURIN, Auteur ; Jennifer L. AMES, Auteur . - p.1551-1561.
Langues : Anglais (eng)
in Autism Research > 12-10 (October 2019) . - p.1551-1561
Mots-clés : autism developmental disorder immune function infection neurodevelopment prenatal Index. décimale : PER Périodiques Résumé : Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case-control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3-5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14-4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551-1561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multisite study in the United States-the Study to Explore Early Development-we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD. En ligne : http://dx.doi.org/10.1002/aur.2175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders / Hjördis Osk ATLADOTTIR in Journal of Autism and Developmental Disorders, 40-12 (December 2010)
[article]
Titre : Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Hjördis Osk ATLADOTTIR, Auteur ; Poul THORSEN, Auteur ; Lars OSTERGAARD, Auteur ; Diana SCHENDEL, Auteur ; Sanne LEMCKE, Auteur ; Morsi W. ABDALLAH, Auteur ; Erik T. PARNER, Auteur Année de publication : 2010 Article en page(s) : p.1423-1430 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Autism Infection Influenza Prenatal infection Maternal infection Index. décimale : PER Périodiques Résumé : Exposure to prenatal infection has been suggested to cause deficiencies in fetal neurodevelopment. In this study we included all children born in Denmark from 1980, through 2005. Diagnoses of autism spectrum disorders (ASDs) and maternal infection were obtained through nationwide registers. Data was analyzed using Cox proportional hazards regression. No association was found between any maternal infection and diagnosis of ASDs in the child when looking at the total period of pregnancy: adjusted hazard ratio = 1.14 (CI: 0.96–1.34). However, admission to hospital due to maternal viral infection in the first trimester and maternal bacterial infection in the second trimester were found to be associated with diagnosis of ASDs in the offspring, adjusted hazard ratio = 2.98 (CI: 1.29–7.15) and adjusted hazard ratio = 1.42 (CI: 1.08–1.87), respectively. Our results support prior hypotheses concerning early prenatal viral infection increasing the risk of ASDs. En ligne : http://dx.doi.org/10.1007/s10803-010-1006-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1423-1430[article] Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Hjördis Osk ATLADOTTIR, Auteur ; Poul THORSEN, Auteur ; Lars OSTERGAARD, Auteur ; Diana SCHENDEL, Auteur ; Sanne LEMCKE, Auteur ; Morsi W. ABDALLAH, Auteur ; Erik T. PARNER, Auteur . - 2010 . - p.1423-1430.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1423-1430
Mots-clés : Autism spectrum disorder Autism Infection Influenza Prenatal infection Maternal infection Index. décimale : PER Périodiques Résumé : Exposure to prenatal infection has been suggested to cause deficiencies in fetal neurodevelopment. In this study we included all children born in Denmark from 1980, through 2005. Diagnoses of autism spectrum disorders (ASDs) and maternal infection were obtained through nationwide registers. Data was analyzed using Cox proportional hazards regression. No association was found between any maternal infection and diagnosis of ASDs in the child when looking at the total period of pregnancy: adjusted hazard ratio = 1.14 (CI: 0.96–1.34). However, admission to hospital due to maternal viral infection in the first trimester and maternal bacterial infection in the second trimester were found to be associated with diagnosis of ASDs in the offspring, adjusted hazard ratio = 2.98 (CI: 1.29–7.15) and adjusted hazard ratio = 1.42 (CI: 1.08–1.87), respectively. Our results support prior hypotheses concerning early prenatal viral infection increasing the risk of ASDs. En ligne : http://dx.doi.org/10.1007/s10803-010-1006-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 Childhood developmental vulnerabilities associated with early life exposure to infectious and noninfectious diseases and maternal mental illness / M. J. GREEN in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)
[article]
Titre : Childhood developmental vulnerabilities associated with early life exposure to infectious and noninfectious diseases and maternal mental illness Type de document : Texte imprimé et/ou numérique Auteurs : M. J. GREEN, Auteur ; M. KARIUKI, Auteur ; K. DEAN, Auteur ; K. R. LAURENS, Auteur ; S. TZOUMAKIS, Auteur ; F. HARRIS, Auteur ; Vaughan J. CARR, Auteur Article en page(s) : p.801-810 Langues : Anglais (eng) Mots-clés : Cns Risk factors developmental epidemiology developmental psychopathology infection maternal factors Index. décimale : PER Périodiques Résumé : BACKGROUND: Fetal exposure to infectious and noninfectious diseases may influence early childhood developmental functioning, on the path to later mental illness. Here, we investigated the effects of in utero exposure to maternal infection and noninfectious diseases during pregnancy on offspring developmental vulnerabilities at age 5 years, in the context of estimated effects for early childhood exposures to infectious and noninfectious diseases and maternal mental illness. METHODS: We used population data for 66,045 children from an intergenerational record linkage study (the New South Wales Child Development Study), for whom a cross-sectional assessment of five developmental competencies (physical, social, emotional, cognitive, and communication) was obtained at school entry, using the Australian Early Development Census (AEDC). Child and maternal exposures to infectious or noninfectious diseases were determined from the NSW Ministry of Health Admitted Patients Data Collection (APDC) and maternal mental illness exposure was derived from both APDC and Mental Health Ambulatory Data collections. Multinomial logistic regression analyses were used to examine unadjusted and adjusted associations between these physical and mental health exposures and child developmental vulnerabilities at age 5 years. RESULTS: Among the physical disease exposures, maternal infectious diseases during pregnancy and early childhood infection conferred the largest associations with developmental vulnerabilities at age 5 years; maternal noninfectious illness during pregnancy also retained small but significant associations with developmental vulnerabilities even when adjusted for other physical and mental illness exposures and covariates known to be associated with early childhood development (e.g., child's sex, socioeconomic disadvantage, young maternal age, prenatal smoking). Among all exposures examined, maternal mental illness first diagnosed prior to childbirth conferred the greatest odds of developmental vulnerability at age 5 years. CONCLUSIONS: Prenatal exposure to infectious or noninfectious diseases appear to influence early childhood physical, social, emotional and cognitive developmental vulnerabilities that may represent intermediate phenotypes for subsequent mental disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12856 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.801-810[article] Childhood developmental vulnerabilities associated with early life exposure to infectious and noninfectious diseases and maternal mental illness [Texte imprimé et/ou numérique] / M. J. GREEN, Auteur ; M. KARIUKI, Auteur ; K. DEAN, Auteur ; K. R. LAURENS, Auteur ; S. TZOUMAKIS, Auteur ; F. HARRIS, Auteur ; Vaughan J. CARR, Auteur . - p.801-810.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.801-810
Mots-clés : Cns Risk factors developmental epidemiology developmental psychopathology infection maternal factors Index. décimale : PER Périodiques Résumé : BACKGROUND: Fetal exposure to infectious and noninfectious diseases may influence early childhood developmental functioning, on the path to later mental illness. Here, we investigated the effects of in utero exposure to maternal infection and noninfectious diseases during pregnancy on offspring developmental vulnerabilities at age 5 years, in the context of estimated effects for early childhood exposures to infectious and noninfectious diseases and maternal mental illness. METHODS: We used population data for 66,045 children from an intergenerational record linkage study (the New South Wales Child Development Study), for whom a cross-sectional assessment of five developmental competencies (physical, social, emotional, cognitive, and communication) was obtained at school entry, using the Australian Early Development Census (AEDC). Child and maternal exposures to infectious or noninfectious diseases were determined from the NSW Ministry of Health Admitted Patients Data Collection (APDC) and maternal mental illness exposure was derived from both APDC and Mental Health Ambulatory Data collections. Multinomial logistic regression analyses were used to examine unadjusted and adjusted associations between these physical and mental health exposures and child developmental vulnerabilities at age 5 years. RESULTS: Among the physical disease exposures, maternal infectious diseases during pregnancy and early childhood infection conferred the largest associations with developmental vulnerabilities at age 5 years; maternal noninfectious illness during pregnancy also retained small but significant associations with developmental vulnerabilities even when adjusted for other physical and mental illness exposures and covariates known to be associated with early childhood development (e.g., child's sex, socioeconomic disadvantage, young maternal age, prenatal smoking). Among all exposures examined, maternal mental illness first diagnosed prior to childbirth conferred the greatest odds of developmental vulnerability at age 5 years. CONCLUSIONS: Prenatal exposure to infectious or noninfectious diseases appear to influence early childhood physical, social, emotional and cognitive developmental vulnerabilities that may represent intermediate phenotypes for subsequent mental disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12856 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 Early Life Antibiotic Exposure and the Subsequent Risk of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis / Hai-Ying YU in Journal of Autism and Developmental Disorders, 52-5 (May 2022)
[article]
Titre : Early Life Antibiotic Exposure and the Subsequent Risk of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Hai-Ying YU, Auteur ; Yuan-Yue ZHOU, Auteur ; Li-Ya PAN, Auteur ; Xue ZHANG, Auteur ; Hai-Yin JIANG, Auteur Article en page(s) : p.2236-2246 Langues : Anglais (eng) Mots-clés : Anti-Bacterial Agents/adverse effects Attention Deficit Disorder with Hyperactivity/epidemiology Autism Spectrum Disorder/complications/etiology Humans Siblings Infection Neurodevelopment Risk Systematic Index. décimale : PER Périodiques Résumé : This study was conducted to assess this association between early life antibiotic exposure and the risk of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in later life. The results showed that early life antibiotic exposure was associated with an increased risk of ASD (OR=1.13, 95% confidence interval (CI): 1.07-1.21) or ADHD (OR=1.18, 95% CI: 1.1-1.27). However, this association for ASD (OR=1.04, 95% CI: 0.97-1.11) or ADHD (OR=0.98, 95% CI: 0.94-1.02) disappeared when data from sibling-matched studies were pooled. The statistically significant association between early life antibiotic exposure and ASD or ADHD in later life can be partially explained by unmeasured genetic and familial confounding factors. En ligne : http://dx.doi.org/10.1007/s10803-021-05121-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Journal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2236-2246[article] Early Life Antibiotic Exposure and the Subsequent Risk of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / Hai-Ying YU, Auteur ; Yuan-Yue ZHOU, Auteur ; Li-Ya PAN, Auteur ; Xue ZHANG, Auteur ; Hai-Yin JIANG, Auteur . - p.2236-2246.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2236-2246
Mots-clés : Anti-Bacterial Agents/adverse effects Attention Deficit Disorder with Hyperactivity/epidemiology Autism Spectrum Disorder/complications/etiology Humans Siblings Infection Neurodevelopment Risk Systematic Index. décimale : PER Périodiques Résumé : This study was conducted to assess this association between early life antibiotic exposure and the risk of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in later life. The results showed that early life antibiotic exposure was associated with an increased risk of ASD (OR=1.13, 95% confidence interval (CI): 1.07-1.21) or ADHD (OR=1.18, 95% CI: 1.1-1.27). However, this association for ASD (OR=1.04, 95% CI: 0.97-1.11) or ADHD (OR=0.98, 95% CI: 0.94-1.02) disappeared when data from sibling-matched studies were pooled. The statistically significant association between early life antibiotic exposure and ASD or ADHD in later life can be partially explained by unmeasured genetic and familial confounding factors. En ligne : http://dx.doi.org/10.1007/s10803-021-05121-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476