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Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development / Alison B. SINGER in Journal of Autism and Developmental Disorders, 46-11 (November 2016)
[article]
Titre : Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : Alison B. SINGER, Auteur ; Gayle C. WINDHAM, Auteur ; Lisa A. CROEN, Auteur ; Julie L. DANIELS, Auteur ; Brian K. LEE, Auteur ; Yinge QIAN, Auteur ; Diana SCHENDEL, Auteur ; M. Daniele FALLIN, Auteur ; Igor BURSTYN, Auteur Article en page(s) : p.3458-3468 Langues : Anglais (eng) Mots-clés : Autism Maternal occupation Exposure Maternal Asthma Allergy Index. décimale : PER Périodiques Résumé : Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96–2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2882-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293
in Journal of Autism and Developmental Disorders > 46-11 (November 2016) . - p.3458-3468[article] Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development [Texte imprimé et/ou numérique] / Alison B. SINGER, Auteur ; Gayle C. WINDHAM, Auteur ; Lisa A. CROEN, Auteur ; Julie L. DANIELS, Auteur ; Brian K. LEE, Auteur ; Yinge QIAN, Auteur ; Diana SCHENDEL, Auteur ; M. Daniele FALLIN, Auteur ; Igor BURSTYN, Auteur . - p.3458-3468.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-11 (November 2016) . - p.3458-3468
Mots-clés : Autism Maternal occupation Exposure Maternal Asthma Allergy Index. décimale : PER Périodiques Résumé : Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96–2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2882-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population / Kandice J. VARCIN in Autism Research, 12-1 (January 2019)
[article]
Titre : Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Kandice J. VARCIN, Auteur ; J. P. NEWNHAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.80-88 Langues : Anglais (eng) Mots-clés : autism spectrum disorder body mass index maternal obesity prenatal Index. décimale : PER Périodiques Résumé : There is an emerging body of evidence demonstrating that maternal obesity at the time of conception increases the risk for Autism Spectrum Disorders (ASD) among offspring. We explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. A large sample of women, recruited during the second trimester of pregnancy, had their height measured and reported their pre-pregnancy weight. These measurements were then converted to a Body Mass Index (BMI) using the formula: (weight in kilograms)/(height in metres(2) ). At 19-20 years of age, 1238 offspring of these women completed a measure of autistic-like traits, the Autism-Spectrum Quotient (AQ). Regression analyses identified a positive association between increasing maternal pre-pregnancy BMI and increasing AQ Total Score amongst offspring; this association was maintained even after controlling for a range of variables including maternal/obstetric factors (age at conception, education, smoking, alcohol consumption, hypertensive diseases, diabetes, threatened abortion), paternal BMI at pregnancy, and child factors (parity, sex) (P < .01, R(2) =.03). Chi-square analyses found that women with pre-pregnancy obesity (BMI >/= 30) were more likely to have offspring with high scores (>/=26) on the AQ (P = .01). Follow-up binary logistic regression analyses also accounting for the same obstetric and sociodemographic variables found that the offspring of women with pre-pregnancy obesity were at a statistically significantly increased risk of having high scores (>/=26) on the AQ (OR: 2.80; 95% CI: 1.06, 7.43). This study provides further evidence that maternal pre-pregnancy obesity is associated with autism-like behaviors in offspring. Autism Research 2019, 12: 80-88. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The current study explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. We found that pre-pregnancy body mass index in women is associated with the amount of autistic-like traits in their children in early adulthood. Specifically, women who were obese at the time of conception were more likely to have a child who had high levels of autistic-like traits in early adulthood. En ligne : http://dx.doi.org/10.1002/aur.1973 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376
in Autism Research > 12-1 (January 2019) . - p.80-88[article] Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population [Texte imprimé et/ou numérique] / Kandice J. VARCIN, Auteur ; J. P. NEWNHAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.80-88.
Langues : Anglais (eng)
in Autism Research > 12-1 (January 2019) . - p.80-88
Mots-clés : autism spectrum disorder body mass index maternal obesity prenatal Index. décimale : PER Périodiques Résumé : There is an emerging body of evidence demonstrating that maternal obesity at the time of conception increases the risk for Autism Spectrum Disorders (ASD) among offspring. We explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. A large sample of women, recruited during the second trimester of pregnancy, had their height measured and reported their pre-pregnancy weight. These measurements were then converted to a Body Mass Index (BMI) using the formula: (weight in kilograms)/(height in metres(2) ). At 19-20 years of age, 1238 offspring of these women completed a measure of autistic-like traits, the Autism-Spectrum Quotient (AQ). Regression analyses identified a positive association between increasing maternal pre-pregnancy BMI and increasing AQ Total Score amongst offspring; this association was maintained even after controlling for a range of variables including maternal/obstetric factors (age at conception, education, smoking, alcohol consumption, hypertensive diseases, diabetes, threatened abortion), paternal BMI at pregnancy, and child factors (parity, sex) (P < .01, R(2) =.03). Chi-square analyses found that women with pre-pregnancy obesity (BMI >/= 30) were more likely to have offspring with high scores (>/=26) on the AQ (P = .01). Follow-up binary logistic regression analyses also accounting for the same obstetric and sociodemographic variables found that the offspring of women with pre-pregnancy obesity were at a statistically significantly increased risk of having high scores (>/=26) on the AQ (OR: 2.80; 95% CI: 1.06, 7.43). This study provides further evidence that maternal pre-pregnancy obesity is associated with autism-like behaviors in offspring. Autism Research 2019, 12: 80-88. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The current study explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. We found that pre-pregnancy body mass index in women is associated with the amount of autistic-like traits in their children in early adulthood. Specifically, women who were obese at the time of conception were more likely to have a child who had high levels of autistic-like traits in early adulthood. En ligne : http://dx.doi.org/10.1002/aur.1973 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis / M. WANG in Molecular Autism, 8 (2017)
[article]
Titre : The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : M. WANG, Auteur ; K. LI, Auteur ; D. ZHAO, Auteur ; L. LI, Auteur Article en page(s) : 51p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Children Folic acid supplements Maternal Meta-analysis Index. décimale : PER Périodiques Résumé : Previous reviews have been conducted to evaluate the association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders (ASD) in children, with no definitive conclusion. We therefore conducted a more comprehensive meta-analysis to reassess the relationship between folic acid and the risk of ASD. The electronic databases PubMed, Web of Knowledge, and Wanfang Data were carefully searched to find eligible studies as recent as March 2017. A random effects model was used to combine the relative risk (RR) with 95% confidence intervals (CI). Sensitivity analysis and publication bias were conducted. A total of 12 articles with 16 studies comprising 4514 ASD cases were included in this report. It was found that supplementation with folic acid during pregnancy could reduce the risk of ASD [RR = 0.771, 95% CI = 0.641-0.928, I(2) = 59.7%, Pheterogeneity = 0.001] as compared to those women without folic acid supplementation. The associations were significant among Asian, European, and American populations. In summary, this comprehensive meta-analysis suggested that maternal use of folic acid supplements during pregnancy could significantly reduce the risk of ASD in children regardless of ethnicity, as compared to those women who did not supplement with folic acid. En ligne : http://dx.doi.org/10.1186/s13229-017-0170-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331
in Molecular Autism > 8 (2017) . - 51p.[article] The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis [Texte imprimé et/ou numérique] / M. WANG, Auteur ; K. LI, Auteur ; D. ZHAO, Auteur ; L. LI, Auteur . - 51p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 51p.
Mots-clés : Autism spectrum disorders Children Folic acid supplements Maternal Meta-analysis Index. décimale : PER Périodiques Résumé : Previous reviews have been conducted to evaluate the association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders (ASD) in children, with no definitive conclusion. We therefore conducted a more comprehensive meta-analysis to reassess the relationship between folic acid and the risk of ASD. The electronic databases PubMed, Web of Knowledge, and Wanfang Data were carefully searched to find eligible studies as recent as March 2017. A random effects model was used to combine the relative risk (RR) with 95% confidence intervals (CI). Sensitivity analysis and publication bias were conducted. A total of 12 articles with 16 studies comprising 4514 ASD cases were included in this report. It was found that supplementation with folic acid during pregnancy could reduce the risk of ASD [RR = 0.771, 95% CI = 0.641-0.928, I(2) = 59.7%, Pheterogeneity = 0.001] as compared to those women without folic acid supplementation. The associations were significant among Asian, European, and American populations. In summary, this comprehensive meta-analysis suggested that maternal use of folic acid supplements during pregnancy could significantly reduce the risk of ASD in children regardless of ethnicity, as compared to those women who did not supplement with folic acid. En ligne : http://dx.doi.org/10.1186/s13229-017-0170-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 Brief Report: Burden of Care in Mothers of Children with Autism Spectrum Disorder or Intellectual Disability / Jenny FAIRTHORNE in Journal of Autism and Developmental Disorders, 46-3 (March 2016)
[article]
Titre : Brief Report: Burden of Care in Mothers of Children with Autism Spectrum Disorder or Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Jenny FAIRTHORNE, Auteur ; Nick KLERK, Auteur ; Helen LEONARD, Auteur Article en page(s) : p.1103-1109 Langues : Anglais (eng) Mots-clés : Intellectual Autism Psychiatric Maternal Mothers Down Hospitalisation Index. décimale : PER Périodiques Résumé : Compared to other mothers, mothers of children with autism spectrum disorder (ASD) or intellectual disability (ID) have higher rates of treatment episodes for psychiatric disorders. We aimed to estimate the maternal burden of care by comparing the length of hospitalisations for psychiatric disorders and the treatment rates for psychiatric disorders after the birth in mothers of children with ASD/ID and no psychiatric history to that of other mothers with no psychiatric history. Mothers of children with ID of known cause (not Down syndrome) and mothers of children ASD without ID emerged as particularly vulnerable. Mothers of children with Down syndrome were resilient. The development of specialised organisations to provide support to mothers of children with ID of known cause (not Down syndrome) and mothers of children with ASD without ID could assist them to maintain their mental health. En ligne : http://dx.doi.org/10.1007/s10803-015-2629-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1103-1109[article] Brief Report: Burden of Care in Mothers of Children with Autism Spectrum Disorder or Intellectual Disability [Texte imprimé et/ou numérique] / Jenny FAIRTHORNE, Auteur ; Nick KLERK, Auteur ; Helen LEONARD, Auteur . - p.1103-1109.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1103-1109
Mots-clés : Intellectual Autism Psychiatric Maternal Mothers Down Hospitalisation Index. décimale : PER Périodiques Résumé : Compared to other mothers, mothers of children with autism spectrum disorder (ASD) or intellectual disability (ID) have higher rates of treatment episodes for psychiatric disorders. We aimed to estimate the maternal burden of care by comparing the length of hospitalisations for psychiatric disorders and the treatment rates for psychiatric disorders after the birth in mothers of children with ASD/ID and no psychiatric history to that of other mothers with no psychiatric history. Mothers of children with ID of known cause (not Down syndrome) and mothers of children ASD without ID emerged as particularly vulnerable. Mothers of children with Down syndrome were resilient. The development of specialised organisations to provide support to mothers of children with ID of known cause (not Down syndrome) and mothers of children with ASD without ID could assist them to maintain their mental health. En ligne : http://dx.doi.org/10.1007/s10803-015-2629-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282