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Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density / S. R. BERKOWICZ in Molecular Autism, 7 (2016)
[article]
Titre : Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density Type de document : Texte imprimé et/ou numérique Auteurs : S. R. BERKOWICZ, Auteur ; T. J. FEATHERBY, Auteur ; Z. QU, Auteur ; A. GIOUSOH, Auteur ; N. A. BORG, Auteur ; J. I. HENG, Auteur ; J. C. WHISSTOCK, Auteur ; P. I. BIRD, Auteur Article en page(s) : 22p. Langues : Anglais (eng) Mots-clés : Animals Attention Deficit Disorder with Hyperactivity/metabolism/pathology Autism Spectrum Disorder/metabolism/pathology Behavior, Animal Brain/metabolism/pathology Disease Models, Animal Female Genotype Glycoproteins/genetics/metabolism Interneurons/metabolism Male Memory, Short-Term Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Nerve Tissue Proteins/deficiency/genetics/metabolism Parvalbumins/genetics/metabolism Phenotype Real-Time Polymerase Chain Reaction Vocalization, Animal Autism spectrum disorder Brinp1 Cortex Hyperactivity Interneuron Knock-out Neurodevelopment Parvalbumin Index. décimale : PER Périodiques Résumé : BACKGROUND: BMP/RA-inducible neural-specific protein 1 (Brinp1) is highly conserved in vertebrates, and continuously expressed in the neocortex, hippocampus, olfactory bulb and cerebellum from mid-embryonic development through to adulthood. METHODS: Brinp1 knock-out (Brinp1(-/-)) mice were generated by Cre-recombinase-mediated removal of the third exon of Brinp1. Knock-out mice were characterised by behavioural phenotyping, immunohistochemistry and expression analysis of the developing and adult brain. RESULTS: Absence of Brinp1 during development results in a behavioural phenotype resembling autism spectrum disorder (ASD), in which knock-out mice show reduced sociability and changes in vocalisation capacity. In addition, Brinp1(-/-) mice exhibit hyper-locomotor activity, have impaired short-term memory, and exhibit poor reproductive success. Brinp1(-/-) mice show increased density of parvalbumin-expressing interneurons in the adult mouse brain. Brinp1(-/-) mice do not show signs of altered neural precursor proliferation or increased apoptosis during late embryonic brain development. The expression of the related neuronal migration genes Astn1 and Astn2 is increased in the brains of Brinp1(-/-) mice, suggesting that they may ameliorate the effects of Brinp1 loss. CONCLUSIONS: Brinp1 plays an important role in normal brain development and function by influencing neuronal distribution within the cortex. The increased cortical PV-positive interneuron density and altered behaviour of Brinp1(-/-) mice resemble features of a subset of human neurological disorders; namely autism spectrum disorder (ASD) and the hyperactivity aspect of attention deficit hyperactivity disorder (ADHD). En ligne : http://dx.doi.org/10.1186/s13229-016-0079-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 22p.[article] Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density [Texte imprimé et/ou numérique] / S. R. BERKOWICZ, Auteur ; T. J. FEATHERBY, Auteur ; Z. QU, Auteur ; A. GIOUSOH, Auteur ; N. A. BORG, Auteur ; J. I. HENG, Auteur ; J. C. WHISSTOCK, Auteur ; P. I. BIRD, Auteur . - 22p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 22p.
Mots-clés : Animals Attention Deficit Disorder with Hyperactivity/metabolism/pathology Autism Spectrum Disorder/metabolism/pathology Behavior, Animal Brain/metabolism/pathology Disease Models, Animal Female Genotype Glycoproteins/genetics/metabolism Interneurons/metabolism Male Memory, Short-Term Mice Mice, Inbred C57BL Mice, Knockout Motor Activity Nerve Tissue Proteins/deficiency/genetics/metabolism Parvalbumins/genetics/metabolism Phenotype Real-Time Polymerase Chain Reaction Vocalization, Animal Autism spectrum disorder Brinp1 Cortex Hyperactivity Interneuron Knock-out Neurodevelopment Parvalbumin Index. décimale : PER Périodiques Résumé : BACKGROUND: BMP/RA-inducible neural-specific protein 1 (Brinp1) is highly conserved in vertebrates, and continuously expressed in the neocortex, hippocampus, olfactory bulb and cerebellum from mid-embryonic development through to adulthood. METHODS: Brinp1 knock-out (Brinp1(-/-)) mice were generated by Cre-recombinase-mediated removal of the third exon of Brinp1. Knock-out mice were characterised by behavioural phenotyping, immunohistochemistry and expression analysis of the developing and adult brain. RESULTS: Absence of Brinp1 during development results in a behavioural phenotype resembling autism spectrum disorder (ASD), in which knock-out mice show reduced sociability and changes in vocalisation capacity. In addition, Brinp1(-/-) mice exhibit hyper-locomotor activity, have impaired short-term memory, and exhibit poor reproductive success. Brinp1(-/-) mice show increased density of parvalbumin-expressing interneurons in the adult mouse brain. Brinp1(-/-) mice do not show signs of altered neural precursor proliferation or increased apoptosis during late embryonic brain development. The expression of the related neuronal migration genes Astn1 and Astn2 is increased in the brains of Brinp1(-/-) mice, suggesting that they may ameliorate the effects of Brinp1 loss. CONCLUSIONS: Brinp1 plays an important role in normal brain development and function by influencing neuronal distribution within the cortex. The increased cortical PV-positive interneuron density and altered behaviour of Brinp1(-/-) mice resemble features of a subset of human neurological disorders; namely autism spectrum disorder (ASD) and the hyperactivity aspect of attention deficit hyperactivity disorder (ADHD). En ligne : http://dx.doi.org/10.1186/s13229-016-0079-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Brief Report: Examining the Links Between Language Processes and Working Memory Impairments in Toddlers and Preschoolers with ASD / Sarah R. EDMUNDS in Journal of Autism and Developmental Disorders, 52-4 (April 2022)
[article]
Titre : Brief Report: Examining the Links Between Language Processes and Working Memory Impairments in Toddlers and Preschoolers with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Sarah R. EDMUNDS, Auteur ; Carly COLMAN, Auteur ; Paige VIDAL, Auteur ; Susan FAJA, Auteur Article en page(s) : p.1872-1880 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications Child, Preschool Cognition Humans Language Memory, Short-Term Autism spectrum disorder Executive function Verbal self-talk Working memory Index. décimale : PER Périodiques Résumé : Deficits in working memory have not been fully explored in toddlers and preschoolers with autism spectrum disorder (ASD). We investigated the relationship between language (verbal ability, verbal self-talk) and visuospatial working memory in 2- and 4-year-olds with ASD (n=65) and typical development (TD) (n=54). Children with ASD displayed impairments in working memory and verbal ability, but not verbal self-talk, compared to TD peers. Verbal ability and working memory were positively correlated; this association was stronger for children with ASD. For 2-year-olds, self-talk and working memory were negatively correlated. Results suggest that verbal ability and working memory are linked, especially for young children with ASD. Self-talk may be a compensatory strategy for toddlers with less developed working memory. En ligne : http://dx.doi.org/10.1007/s10803-021-05049-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1872-1880[article] Brief Report: Examining the Links Between Language Processes and Working Memory Impairments in Toddlers and Preschoolers with ASD [Texte imprimé et/ou numérique] / Sarah R. EDMUNDS, Auteur ; Carly COLMAN, Auteur ; Paige VIDAL, Auteur ; Susan FAJA, Auteur . - p.1872-1880.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1872-1880
Mots-clés : Autism Spectrum Disorder/complications Child, Preschool Cognition Humans Language Memory, Short-Term Autism spectrum disorder Executive function Verbal self-talk Working memory Index. décimale : PER Périodiques Résumé : Deficits in working memory have not been fully explored in toddlers and preschoolers with autism spectrum disorder (ASD). We investigated the relationship between language (verbal ability, verbal self-talk) and visuospatial working memory in 2- and 4-year-olds with ASD (n=65) and typical development (TD) (n=54). Children with ASD displayed impairments in working memory and verbal ability, but not verbal self-talk, compared to TD peers. Verbal ability and working memory were positively correlated; this association was stronger for children with ASD. For 2-year-olds, self-talk and working memory were negatively correlated. Results suggest that verbal ability and working memory are linked, especially for young children with ASD. Self-talk may be a compensatory strategy for toddlers with less developed working memory. En ligne : http://dx.doi.org/10.1007/s10803-021-05049-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Subject-performed task effect on working memory performance in children with autism spectrum disorder / Lijuan WANG in Autism Research, 15-9 (September 2022)
[article]
Titre : Subject-performed task effect on working memory performance in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lijuan WANG, Auteur ; Tingting XIE, Auteur ; Huan MA, Auteur ; Miao XU, Auteur ; Xiaochun XIE, Auteur Article en page(s) : p.1698-1709 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications Child Cognition Humans Intellectual Disability/complications Intelligence Memory, Short-Term SPT effect autism spectrum disorder movement component working memory for instruction Index. décimale : PER Périodiques Résumé : A previous study found that children with autism spectrum disorder (ASD) have better recall when they perform instructions (subject-performed task [SPT]) than when they passively hear instructions (verbal task [VT]) in a working memory task for instructions, an effect that is called the SPT effect. This study explored whether the SPT effect exhibited by ASD children is caused by the movement component or by processing materials twice. More importantly, this study explored whether intelligence influences the SPT effect exhibited by ASD children. ASD children with three levels of intelligence (NÂ =Â 56) and a control group, children with intellectual disability (ID) who had low intelligence but did not have ASD (NÂ =Â 21), were asked to perform working memory tasks for instructions under VT, SPT and repeated (hearing the instruction twice) conditions. No significant difference in performance was observed between the VT and repeated conditions, regardless of the child's level of intelligence. ASD children with lower-middle intelligence exhibited a smaller SPT effect than ASD children with upper-middle intelligence. Critically, while ASD children with low intelligence did not exhibit the SPT effect, an ID group with equivalent low intelligence did show this effect. Therefore, these results show that the SPT effect for ASD children is caused by the movement component and is uniquely associated with a certain level of intelligence, namely, lower middle and higher levels of intelligence. LAY SUMMARY: In ASD children, the benefit of physically performing instructions for working memory performance is uniquely associated with a certain level of intelligence. Only ASD children with lower-middle intelligence (and higher) benefit from physically performing instructions, and higher intelligence increases this benefit; ASD children with low intelligence do not show this benefit. This benefit in ASD children is attributed to the additional motoric code generated by physical performance. En ligne : http://dx.doi.org/10.1002/aur.2710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483
in Autism Research > 15-9 (September 2022) . - p.1698-1709[article] Subject-performed task effect on working memory performance in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Lijuan WANG, Auteur ; Tingting XIE, Auteur ; Huan MA, Auteur ; Miao XU, Auteur ; Xiaochun XIE, Auteur . - p.1698-1709.
Langues : Anglais (eng)
in Autism Research > 15-9 (September 2022) . - p.1698-1709
Mots-clés : Autism Spectrum Disorder/complications Child Cognition Humans Intellectual Disability/complications Intelligence Memory, Short-Term SPT effect autism spectrum disorder movement component working memory for instruction Index. décimale : PER Périodiques Résumé : A previous study found that children with autism spectrum disorder (ASD) have better recall when they perform instructions (subject-performed task [SPT]) than when they passively hear instructions (verbal task [VT]) in a working memory task for instructions, an effect that is called the SPT effect. This study explored whether the SPT effect exhibited by ASD children is caused by the movement component or by processing materials twice. More importantly, this study explored whether intelligence influences the SPT effect exhibited by ASD children. ASD children with three levels of intelligence (NÂ =Â 56) and a control group, children with intellectual disability (ID) who had low intelligence but did not have ASD (NÂ =Â 21), were asked to perform working memory tasks for instructions under VT, SPT and repeated (hearing the instruction twice) conditions. No significant difference in performance was observed between the VT and repeated conditions, regardless of the child's level of intelligence. ASD children with lower-middle intelligence exhibited a smaller SPT effect than ASD children with upper-middle intelligence. Critically, while ASD children with low intelligence did not exhibit the SPT effect, an ID group with equivalent low intelligence did show this effect. Therefore, these results show that the SPT effect for ASD children is caused by the movement component and is uniquely associated with a certain level of intelligence, namely, lower middle and higher levels of intelligence. LAY SUMMARY: In ASD children, the benefit of physically performing instructions for working memory performance is uniquely associated with a certain level of intelligence. Only ASD children with lower-middle intelligence (and higher) benefit from physically performing instructions, and higher intelligence increases this benefit; ASD children with low intelligence do not show this benefit. This benefit in ASD children is attributed to the additional motoric code generated by physical performance. En ligne : http://dx.doi.org/10.1002/aur.2710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 Visual working memory performance is intact across development in autism spectrum disorder / Andrew LYNN in Autism Research, 15-5 (May 2022)
[article]
Titre : Visual working memory performance is intact across development in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Andrew LYNN, Auteur ; Beatriz LUNA, Auteur ; Kirsten O'HEARN, Auteur Article en page(s) : p.881-891 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/complications Child Cognition Humans Memory, Short-Term attention autism child development visual processing working memory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with atypical visual processing and deficits in working memory (WM). Visual WM performance typically improves between childhood and adulthood, but such improvement may be atypical in ASD. To better understand how visual WM develops, we used a well-established change detection task across multiple visual features. We examined visual WM for color, shape, and pattern in children, adolescents, and adults with and without ASD. VWM capacity and performance for all visual features improved across age similarly for both the TD and ASD groups. While performance was better on set size 4 trials than set size 8 trials for color, shape, and no change trials, such an effect was not evident for pattern change trials. Overall, the present findings suggest that VWM for different visual features may be intact across development in ASD. The ability to hold multiple objects in mind (WM) improves across typical development, but it remains unclear whether such improvement occurs in ASD. We found that developmental improvements in WM for different types of object details (e.g., color, shape, and pattern) is generally similar for both ASD and typical development. LAY SUMMARY: The ability to hold multiple objects in mind (working memory [WM]) improves across typical development, but it remains unclear whether such improvement occurs in autism spectrum disorder (ASD). We found that developmental improvements in WM for different types of object details (e.g., color, shape, pattern) is generally similar for both ASD and typical development. En ligne : http://dx.doi.org/10.1002/aur.2683 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473
in Autism Research > 15-5 (May 2022) . - p.881-891[article] Visual working memory performance is intact across development in autism spectrum disorder [Texte imprimé et/ou numérique] / Andrew LYNN, Auteur ; Beatriz LUNA, Auteur ; Kirsten O'HEARN, Auteur . - p.881-891.
Langues : Anglais (eng)
in Autism Research > 15-5 (May 2022) . - p.881-891
Mots-clés : Adolescent Adult Autism Spectrum Disorder/complications Child Cognition Humans Memory, Short-Term attention autism child development visual processing working memory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is associated with atypical visual processing and deficits in working memory (WM). Visual WM performance typically improves between childhood and adulthood, but such improvement may be atypical in ASD. To better understand how visual WM develops, we used a well-established change detection task across multiple visual features. We examined visual WM for color, shape, and pattern in children, adolescents, and adults with and without ASD. VWM capacity and performance for all visual features improved across age similarly for both the TD and ASD groups. While performance was better on set size 4 trials than set size 8 trials for color, shape, and no change trials, such an effect was not evident for pattern change trials. Overall, the present findings suggest that VWM for different visual features may be intact across development in ASD. The ability to hold multiple objects in mind (WM) improves across typical development, but it remains unclear whether such improvement occurs in ASD. We found that developmental improvements in WM for different types of object details (e.g., color, shape, and pattern) is generally similar for both ASD and typical development. LAY SUMMARY: The ability to hold multiple objects in mind (working memory [WM]) improves across typical development, but it remains unclear whether such improvement occurs in autism spectrum disorder (ASD). We found that developmental improvements in WM for different types of object details (e.g., color, shape, pattern) is generally similar for both ASD and typical development. En ligne : http://dx.doi.org/10.1002/aur.2683 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 Comparing the Executive Function Ability of Autistic and Non-autistic Adolescents with a Manualised Battery of Neuropsychological Tasks / Lorcan KENNY in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
[article]
Titre : Comparing the Executive Function Ability of Autistic and Non-autistic Adolescents with a Manualised Battery of Neuropsychological Tasks Type de document : Texte imprimé et/ou numérique Auteurs : Lorcan KENNY, Auteur ; Anna REMINGTON, Auteur ; Elizabeth PELLICANO, Auteur Article en page(s) : p.3169-3181 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder Autistic Disorder Child Cognition Executive Function Humans Memory, Short-Term Neuropsychological Tests Young Adult Cognitive ability NIH-EXAMINER battery Index. décimale : PER Périodiques Résumé : Performance on a single executive function (EF) task (e.g., a card sorting task) is often taken to represent ability on the underlying subcomponent of EF (e.g., set shifting) without accounting for the non-specific and non-executive skills employed to complete the task. This study used a manualised battery of EF tasks to derive individual task scores and latent EF scores. Seventy-nine adolescents aged between 11 and 19 years, including 37 autistic and 42 non-autistic participants, matched on cognitive ability, completed the battery. Autistic adolescents had moderate global EF difficulties and had significantly more difficulties on some individual tasks. However, the samples did not differ on any of the specific individual subcomponents of EF (fluency, cognitive control and working memory). En ligne : http://dx.doi.org/10.1007/s10803-021-05034-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3169-3181[article] Comparing the Executive Function Ability of Autistic and Non-autistic Adolescents with a Manualised Battery of Neuropsychological Tasks [Texte imprimé et/ou numérique] / Lorcan KENNY, Auteur ; Anna REMINGTON, Auteur ; Elizabeth PELLICANO, Auteur . - p.3169-3181.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3169-3181
Mots-clés : Adolescent Adult Autism Spectrum Disorder Autistic Disorder Child Cognition Executive Function Humans Memory, Short-Term Neuropsychological Tests Young Adult Cognitive ability NIH-EXAMINER battery Index. décimale : PER Périodiques Résumé : Performance on a single executive function (EF) task (e.g., a card sorting task) is often taken to represent ability on the underlying subcomponent of EF (e.g., set shifting) without accounting for the non-specific and non-executive skills employed to complete the task. This study used a manualised battery of EF tasks to derive individual task scores and latent EF scores. Seventy-nine adolescents aged between 11 and 19 years, including 37 autistic and 42 non-autistic participants, matched on cognitive ability, completed the battery. Autistic adolescents had moderate global EF difficulties and had significantly more difficulties on some individual tasks. However, the samples did not differ on any of the specific individual subcomponents of EF (fluency, cognitive control and working memory). En ligne : http://dx.doi.org/10.1007/s10803-021-05034-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477