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2 recherche sur le mot-clé 'Mendelian randomization'
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Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study / Paul MADLEY-DOWD in Molecular Autism, 13 (2022)
[article]
Titre : Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Paul MADLEY-DOWD, Auteur ; Christina DARDANI, Auteur ; Robyn E. WOOTTON, Auteur ; Kyle DACK, Auteur ; Tom PALMER, Auteur ; Rupert THURSTON, Auteur ; Alexandra HAVDAHL, Auteur ; Jean GOLDING, Auteur ; Deborah LAWLOR, Auteur ; Dheeraj RAI, Auteur Article en page(s) : 44 p. Langues : Anglais (eng) Mots-clés : Child Pregnancy Female Humans Autistic Disorder/epidemiology/etiology Longitudinal Studies Cohort Studies Prospective Studies Vitamin D Alspac Autism Mendelian randomization Index. décimale : PER Périodiques Résumé : BACKGROUND: There has been a growing interest in the association between maternal levels of vitamin D during pregnancy and offspring autism. However, whether any associations reflect causal effects is still inconclusive. METHODS: We used data from a UK-based pregnancy cohort study (Avon Longitudinal Study of Parents and Children) comprising 7689 births between 1991 and 1992 with maternal blood vitamin D levels recorded during pregnancy and at least one recorded outcome measure, including autism diagnosis and autism-associated traits. The association between each outcome with seasonal and gestational age-adjusted maternal serum 25-hydroxyvitamin D during pregnancy was estimated using confounder-adjusted regression models. Multiple imputation was used to account for missing data, and restricted cubic splines were used to investigate nonlinear associations. Mendelian randomization was used to strengthen causal inference. RESULTS: No strong evidence of an association between maternal serum 25-hydroxyvitamin D during pregnancy and any offspring autism-associated outcome was found using multivariable regression analysis (autism diagnosis: adjusted OR=0.98, 95% CI=0.90-1.06), including with multiple imputation (autism diagnosis: adjusted OR=0.99, 95% CI=0.93-1.06), and no evidence of a causal effect was suggested by Mendelian randomization (autism diagnosis: causal OR=1.08, 95% CI=0.46-2.55). Some evidence of increased odds of autism-associated traits at lower levels of maternal serum 25-hydroxyvitamin D was found using spline analysis. LIMITATIONS: Our study was potentially limited by low power, particularly for diagnosed autism cases as an outcome. The cohort may not have captured the extreme lows of the distribution of serum 25-hydroxyvitamin D, and our analyses may have been biased by residual confounding and missing data. CONCLUSIONS: The present study found no strong evidence of a causal link between maternal vitamin D levels in pregnancy and offspring diagnosis or traits of autism. En ligne : http://dx.doi.org/10.1186/s13229-022-00523-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Molecular Autism > 13 (2022) . - 44 p.[article] Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study [Texte imprimé et/ou numérique] / Paul MADLEY-DOWD, Auteur ; Christina DARDANI, Auteur ; Robyn E. WOOTTON, Auteur ; Kyle DACK, Auteur ; Tom PALMER, Auteur ; Rupert THURSTON, Auteur ; Alexandra HAVDAHL, Auteur ; Jean GOLDING, Auteur ; Deborah LAWLOR, Auteur ; Dheeraj RAI, Auteur . - 44 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 44 p.
Mots-clés : Child Pregnancy Female Humans Autistic Disorder/epidemiology/etiology Longitudinal Studies Cohort Studies Prospective Studies Vitamin D Alspac Autism Mendelian randomization Index. décimale : PER Périodiques Résumé : BACKGROUND: There has been a growing interest in the association between maternal levels of vitamin D during pregnancy and offspring autism. However, whether any associations reflect causal effects is still inconclusive. METHODS: We used data from a UK-based pregnancy cohort study (Avon Longitudinal Study of Parents and Children) comprising 7689 births between 1991 and 1992 with maternal blood vitamin D levels recorded during pregnancy and at least one recorded outcome measure, including autism diagnosis and autism-associated traits. The association between each outcome with seasonal and gestational age-adjusted maternal serum 25-hydroxyvitamin D during pregnancy was estimated using confounder-adjusted regression models. Multiple imputation was used to account for missing data, and restricted cubic splines were used to investigate nonlinear associations. Mendelian randomization was used to strengthen causal inference. RESULTS: No strong evidence of an association between maternal serum 25-hydroxyvitamin D during pregnancy and any offspring autism-associated outcome was found using multivariable regression analysis (autism diagnosis: adjusted OR=0.98, 95% CI=0.90-1.06), including with multiple imputation (autism diagnosis: adjusted OR=0.99, 95% CI=0.93-1.06), and no evidence of a causal effect was suggested by Mendelian randomization (autism diagnosis: causal OR=1.08, 95% CI=0.46-2.55). Some evidence of increased odds of autism-associated traits at lower levels of maternal serum 25-hydroxyvitamin D was found using spline analysis. LIMITATIONS: Our study was potentially limited by low power, particularly for diagnosed autism cases as an outcome. The cohort may not have captured the extreme lows of the distribution of serum 25-hydroxyvitamin D, and our analyses may have been biased by residual confounding and missing data. CONCLUSIONS: The present study found no strong evidence of a causal link between maternal vitamin D levels in pregnancy and offspring diagnosis or traits of autism. En ligne : http://dx.doi.org/10.1186/s13229-022-00523-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Longitudinal effects and environmental moderation of ALDH2 and ADH1B gene variants on substance use from age 14 to 40 / Gretchen R. B. SAUNDERS in Development and Psychopathology, 34-5 (December 2022)
[article]
Titre : Longitudinal effects and environmental moderation of ALDH2 and ADH1B gene variants on substance use from age 14 to 40 Type de document : Texte imprimé et/ou numérique Auteurs : Gretchen R. B. SAUNDERS, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur ; Scott VRIEZE, Auteur Article en page(s) : p.1856-1864 Langues : Anglais (eng) Mots-clés : alcohol development longitudinal Mendelian randomization trajectory Index. décimale : PER Périodiques Résumé : Alcohol use and dependence are strongly affected by variation in aldehyde dehydrogenase (ALDH2) and, to a lesser extent, alcohol dehydrogenase (ADH1B) genes. We use this genetic variation with an adoption design to test the causal role of alcohol use on other drug use, as well as the moderating role of adoptive parent, sibling, and peer alcohol use. Longitudinal models were run on 412 genotyped adopted individuals of East Asian ancestry with multiple assessments between ages 14 and 40. We found robust associations between alcohol frequency, quantity, and maximum drinks and ALDH2, but not ADH1B, status. The magnitude of the ALDH2 protective effect increased with age, particularly for maximum drinks, though estimates were smaller than previously reported in ancestrally similar individuals in East/North-East Asian countries. These results suggest that sociocultural factors in Minnesota may reduce the protective effects of ALDH2. We found that peer alcohol use, but not parent or sibling use, predicted adopted offspring’s use, and that these environmental influences did not vary by ALDH2 status. Finally, we did not find strong evidence of associations between ALDH2 status and tobacco, marijuana, or illegal drug use, contrary to expectation if alcohol serves as a gateway to use of other drugs. En ligne : http://dx.doi.org/10.1017/S0954579422000712 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492
in Development and Psychopathology > 34-5 (December 2022) . - p.1856-1864[article] Longitudinal effects and environmental moderation of ALDH2 and ADH1B gene variants on substance use from age 14 to 40 [Texte imprimé et/ou numérique] / Gretchen R. B. SAUNDERS, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur ; Scott VRIEZE, Auteur . - p.1856-1864.
Langues : Anglais (eng)
in Development and Psychopathology > 34-5 (December 2022) . - p.1856-1864
Mots-clés : alcohol development longitudinal Mendelian randomization trajectory Index. décimale : PER Périodiques Résumé : Alcohol use and dependence are strongly affected by variation in aldehyde dehydrogenase (ALDH2) and, to a lesser extent, alcohol dehydrogenase (ADH1B) genes. We use this genetic variation with an adoption design to test the causal role of alcohol use on other drug use, as well as the moderating role of adoptive parent, sibling, and peer alcohol use. Longitudinal models were run on 412 genotyped adopted individuals of East Asian ancestry with multiple assessments between ages 14 and 40. We found robust associations between alcohol frequency, quantity, and maximum drinks and ALDH2, but not ADH1B, status. The magnitude of the ALDH2 protective effect increased with age, particularly for maximum drinks, though estimates were smaller than previously reported in ancestrally similar individuals in East/North-East Asian countries. These results suggest that sociocultural factors in Minnesota may reduce the protective effects of ALDH2. We found that peer alcohol use, but not parent or sibling use, predicted adopted offspring’s use, and that these environmental influences did not vary by ALDH2 status. Finally, we did not find strong evidence of associations between ALDH2 status and tobacco, marijuana, or illegal drug use, contrary to expectation if alcohol serves as a gateway to use of other drugs. En ligne : http://dx.doi.org/10.1017/S0954579422000712 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492