5 recherche sur le mot-clé 'Mental Disorders/epidemiology'

Covid-19, social restrictions, and mental distress among young people: a UK longitudinal, population-based study / Gemma KNOWLES in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1392-1404 Titre : Covid-19, social restrictions, and mental distress among young people: a UK longitudinal, population-based study Type de document : texte imprimé Auteurs : Gemma KNOWLES, Auteur ; Charlotte GAYER-ANDERSON, Auteur ; Alice TURNER, Auteur ; Lynsey DORN, Auteur ; Joseph M.K. LAM, Auteur ; Samantha DAVIS, Auteur ; Rachel BLAKEY, Auteur ; Katie LOWIS, Auteur ; SCHOOLS WORKING GROUP, Auteur ; YOUNG PERSONS ADVISORY GROUP, Auteur ; Vanessa PINFOLD, Auteur ; Natalie CREARY, Auteur ; Jacqui DYER, Auteur ; Stephani L. HATCH, Auteur ; George B. PLOUBIDIS, Auteur ; Kamaldeep BHUI, Auteur ; Seeromanie HARDING, Auteur ; Craig MORGAN, Auteur Article en page(s) : p.1392-1404 Langues : Anglais (eng) Mots-clés : Adolescent  Male  Female  Humans  Child  covid-19  Communicable Disease Control  Pandemics  Mental Disorders/epidemiology  Mental Health  Covid-19  adolescence  cohort  mental distress Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is a critical period for social and emotional development. We sought to examine the impacts of Covid-19 and related social restrictions and school closures on adolescent mental health, particularly among disadvantaged, marginalised, and vulnerable groups. METHODS: We analysed four waves of data - 3 pre-Covid-19 (2016-2019) and 1 mid-Covid-19 (May-Aug 2020; n, 1074; 12-18 years old,>80% minority ethnic groups, 25% free school meals) from REACH (Resilience, Ethnicity, and AdolesCent Mental Health), an adolescent cohort based in inner-London, United Kingdom. Mental health was assessed using validated measures at each time point. We estimated temporal trends in mental distress and examined variations in changes in distress, pre- to mid-Covid-19, by social group, and by pre- and mid-pandemic risks. RESULTS: We found no evidence of an overall increase in mental distress midpandemic (15.9%, 95% CI: 13.0, 19.4) compared with prepandemic (around 18%). However, there were variations in changes in mental distress by subgroups. There were modest variations by social group and by pre-Covid risks (e.g., a small increase in distress among girls (b [unstandardised beta coefficient] 0.42 [-0.19, 1.03]); a small decrease among boys (b - 0.59 [-1.37, 0.19]); p for interaction .007). The most notable variations were by midpandemic risks: that is, broadly, increases in distress among those reporting negative circumstances and impacts (e.g., in finances, housing, social support and relationships, and daily routines) and decreases in distress among those reporting positive impacts. CONCLUSIONS: We found strong evidence that mental distress increased among young people who were most negatively impacted by Covid-19 and by related social restrictions during the first lockdown in the United Kingdom. En ligne : http://dx.doi.org/10.1111/jcpp.13586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Covid-19, social restrictions, and mental distress among young people: a UK longitudinal, population-based study [texte imprimé] / Gemma KNOWLES, Auteur ; Charlotte GAYER-ANDERSON, Auteur ; Alice TURNER, Auteur ; Lynsey DORN, Auteur ; Joseph M.K. LAM, Auteur ; Samantha DAVIS, Auteur ; Rachel BLAKEY, Auteur ; Katie LOWIS, Auteur ; SCHOOLS WORKING GROUP, Auteur ; YOUNG PERSONS ADVISORY GROUP, Auteur ; Vanessa PINFOLD, Auteur ; Natalie CREARY, Auteur ; Jacqui DYER, Auteur ; Stephani L. HATCH, Auteur ; George B. PLOUBIDIS, Auteur ; Kamaldeep BHUI, Auteur ; Seeromanie HARDING, Auteur ; Craig MORGAN, Auteur . - p.1392-1404. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1392-1404 Mots-clés : Adolescent  Male  Female  Humans  Child  covid-19  Communicable Disease Control  Pandemics  Mental Disorders/epidemiology  Mental Health  Covid-19  adolescence  cohort  mental distress Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is a critical period for social and emotional development. We sought to examine the impacts of Covid-19 and related social restrictions and school closures on adolescent mental health, particularly among disadvantaged, marginalised, and vulnerable groups. METHODS: We analysed four waves of data - 3 pre-Covid-19 (2016-2019) and 1 mid-Covid-19 (May-Aug 2020; n, 1074; 12-18 years old,>80% minority ethnic groups, 25% free school meals) from REACH (Resilience, Ethnicity, and AdolesCent Mental Health), an adolescent cohort based in inner-London, United Kingdom. Mental health was assessed using validated measures at each time point. We estimated temporal trends in mental distress and examined variations in changes in distress, pre- to mid-Covid-19, by social group, and by pre- and mid-pandemic risks. RESULTS: We found no evidence of an overall increase in mental distress midpandemic (15.9%, 95% CI: 13.0, 19.4) compared with prepandemic (around 18%). However, there were variations in changes in mental distress by subgroups. There were modest variations by social group and by pre-Covid risks (e.g., a small increase in distress among girls (b [unstandardised beta coefficient] 0.42 [-0.19, 1.03]); a small decrease among boys (b - 0.59 [-1.37, 0.19]); p for interaction .007). The most notable variations were by midpandemic risks: that is, broadly, increases in distress among those reporting negative circumstances and impacts (e.g., in finances, housing, social support and relationships, and daily routines) and decreases in distress among those reporting positive impacts. CONCLUSIONS: We found strong evidence that mental distress increased among young people who were most negatively impacted by Covid-19 and by related social restrictions during the first lockdown in the United Kingdom. En ligne : http://dx.doi.org/10.1111/jcpp.13586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Maternal mental health mediates the effects of pandemic-related stressors on adolescent psychopathology during COVID-19 / Liliana J. LENGUA in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1544-1552 Titre : Maternal mental health mediates the effects of pandemic-related stressors on adolescent psychopathology during COVID-19 Type de document : texte imprimé Auteurs : Liliana J. LENGUA, Auteur ; Stephanie F. THOMPSON, Auteur ; Stephanie Gyuri KIM, Auteur ; Maya L. ROSEN, Auteur ; Alexandra M. RODMAN, Auteur ; Steven W. KASPAREK, Auteur ; Makeda MAYES, Auteur ; Maureen ZALEWSKI, Auteur ; Andrew N. MELTZOFF, Auteur ; Katie A. MCLAUGHLIN, Auteur Article en page(s) : p.1544-1552 Langues : Anglais (eng) Mots-clés : Female  Humans  Adolescent  Child  Pandemics  Mental Health  COVID-19/epidemiology  Mothers/psychology  Mental Disorders/epidemiology  COVID-19 pandemic  externalizing  internalizing  maternal mental health Index. décimale : PER Périodiques Résumé : BACKGROUND: This study examined whether COVID-19-related maternal mental health changes contributed to changes in adolescent psychopathology. METHODS: A community sample of 226 adolescents (12 years old before COVID-19) and their mothers were asked to complete COVID-19 surveys early in the pandemic (April-May 2020, adolescents 14 years) and approximately 6 months later (November 2020-January 2021). Surveys assessed pandemic-related stressors (health, financial, social, school, environment) and mental health. RESULTS: Lower pre-pandemic family income-to-needs ratio was associated with higher pre-pandemic maternal mental health symptoms (anxiety, depression) and adolescent internalizing and externalizing problems, and with experiencing more pandemic-related stressors. Pandemic-related stressors predicted increases in maternal mental health symptoms, but not adolescent symptoms when other variables were covaried. Higher maternal mental health symptoms predicted concurrent increases in adolescent internalizing and externalizing. Maternal mental health mediated the effects of pre-pandemic income and pandemic-related stressors on adolescent internalizing and externalizing problems. CONCLUSIONS: Results indicate that adolescent mental health is closely tied to maternal mental health during community-level stressors such as COVID-19, and that pre-existing family economic context and adolescent symptoms increase risk for elevations in symptoms of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Maternal mental health mediates the effects of pandemic-related stressors on adolescent psychopathology during COVID-19 [texte imprimé] / Liliana J. LENGUA, Auteur ; Stephanie F. THOMPSON, Auteur ; Stephanie Gyuri KIM, Auteur ; Maya L. ROSEN, Auteur ; Alexandra M. RODMAN, Auteur ; Steven W. KASPAREK, Auteur ; Makeda MAYES, Auteur ; Maureen ZALEWSKI, Auteur ; Andrew N. MELTZOFF, Auteur ; Katie A. MCLAUGHLIN, Auteur . - p.1544-1552. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1544-1552 Mots-clés : Female  Humans  Adolescent  Child  Pandemics  Mental Health  COVID-19/epidemiology  Mothers/psychology  Mental Disorders/epidemiology  COVID-19 pandemic  externalizing  internalizing  maternal mental health Index. décimale : PER Périodiques Résumé : BACKGROUND: This study examined whether COVID-19-related maternal mental health changes contributed to changes in adolescent psychopathology. METHODS: A community sample of 226 adolescents (12 years old before COVID-19) and their mothers were asked to complete COVID-19 surveys early in the pandemic (April-May 2020, adolescents 14 years) and approximately 6 months later (November 2020-January 2021). Surveys assessed pandemic-related stressors (health, financial, social, school, environment) and mental health. RESULTS: Lower pre-pandemic family income-to-needs ratio was associated with higher pre-pandemic maternal mental health symptoms (anxiety, depression) and adolescent internalizing and externalizing problems, and with experiencing more pandemic-related stressors. Pandemic-related stressors predicted increases in maternal mental health symptoms, but not adolescent symptoms when other variables were covaried. Higher maternal mental health symptoms predicted concurrent increases in adolescent internalizing and externalizing. Maternal mental health mediated the effects of pre-pandemic income and pandemic-related stressors on adolescent internalizing and externalizing problems. CONCLUSIONS: Results indicate that adolescent mental health is closely tied to maternal mental health during community-level stressors such as COVID-19, and that pre-existing family economic context and adolescent symptoms increase risk for elevations in symptoms of psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Health comorbidities and cognitive abilities across the lifespan in Down syndrome / Carla M. STARTIN in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Health comorbidities and cognitive abilities across the lifespan in Down syndrome Type de document : texte imprimé Auteurs : Carla M. STARTIN, Auteur ; Hana D'SOUZA, Auteur ; George BALL, Auteur ; Sarah HAMBURG, Auteur ; Rosalyn HITHERSAY, Auteur ; Kate M.O. HUGHES, Auteur ; Esha MASSAND, Auteur ; Annette KARMILOFF-SMITH, Auteur ; Michael S.C. THOMAS, Auteur ; LONDOWNS CONSORTIUM, Auteur ; Andre STRYDOM, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Aged  Aged, 80 and over  Child  Child, Preschool  Cognition  Comorbidity  Down Syndrome/epidemiology  Female  Humans  Infant  Language Development Disorders/epidemiology  Longevity  Male  Mental Disorders/epidemiology  Middle Aged  Sex Characteristics  United Kingdom/epidemiology  Young Adult  Cognitive outcomes  Down syndrome  Health comorbidities  Intellectual disability  Psychiatric comorbidities  Receptive language ability Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown. We aimed to describe patterns of physical health and psychiatric comorbidity prevalence, and receptive language ability, in DS across the lifespan, and determine relationships with cognitive outcomes. METHODS: Detailed medical histories were collected and cognitive abilities measured using standardised tests for 602 individuals with DS from England and Wales (age range 3 months to 73 years). Differences in prevalence rates between age groups and between males and females were determined using chi-squared or Fisher's exact tests. In adults, rates for psychiatric comorbidities were compared to expected population rates using standardised morbidity ratios (SMRs). Adapted ANCOVA functions were constructed to explore age and sex associations with receptive language ability across the lifespan, and regression analyses were performed to determine whether the presence of health comorbidities or physical phenotypes predicted cognitive abilities. RESULTS: Multiple comorbidities showed prevalence differences across the lifespan, though there were few sex differences. In adults, SMRs were increased in males and decreased in females with DS for schizophrenia, bipolar disorder, and anxiety. Further, SMRs were increased in both males and females with DS for dementia, autism, ADHD, and depression, with differences more pronounced in females for dementia and autism, and in males for depression. Across the lifespan, receptive language abilities increasingly deviated from age-typical levels, and males scored poorer than females. Only autism and epilepsy were associated with poorer cognitive ability in those aged 16-35 years, with no relationships for physical health comorbidities, including congenital heart defects. CONCLUSIONS: Our results indicate the prevalence of multiple comorbidities varies across the lifespan in DS, and in adults, rates for psychiatric comorbidities show different patterns for males and females relative to expected population rates. Further, most health comorbidities are not associated with poorer cognitive outcomes in DS, apart from autism and epilepsy. It is essential for clinicians to consider such differences to provide appropriate care and treatment for those with DS and to provide prognostic information relating to cognitive outcomes in those with comorbidities. En ligne : https://dx.doi.org/10.1186/s11689-019-9306-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Health comorbidities and cognitive abilities across the lifespan in Down syndrome [texte imprimé] / Carla M. STARTIN, Auteur ; Hana D'SOUZA, Auteur ; George BALL, Auteur ; Sarah HAMBURG, Auteur ; Rosalyn HITHERSAY, Auteur ; Kate M.O. HUGHES, Auteur ; Esha MASSAND, Auteur ; Annette KARMILOFF-SMITH, Auteur ; Michael S.C. THOMAS, Auteur ; LONDOWNS CONSORTIUM, Auteur ; Andre STRYDOM, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Adolescent  Adult  Aged  Aged, 80 and over  Child  Child, Preschool  Cognition  Comorbidity  Down Syndrome/epidemiology  Female  Humans  Infant  Language Development Disorders/epidemiology  Longevity  Male  Mental Disorders/epidemiology  Middle Aged  Sex Characteristics  United Kingdom/epidemiology  Young Adult  Cognitive outcomes  Down syndrome  Health comorbidities  Intellectual disability  Psychiatric comorbidities  Receptive language ability Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS) is associated with variable intellectual disability and multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive outcomes is unknown. We aimed to describe patterns of physical health and psychiatric comorbidity prevalence, and receptive language ability, in DS across the lifespan, and determine relationships with cognitive outcomes. METHODS: Detailed medical histories were collected and cognitive abilities measured using standardised tests for 602 individuals with DS from England and Wales (age range 3 months to 73 years). Differences in prevalence rates between age groups and between males and females were determined using chi-squared or Fisher's exact tests. In adults, rates for psychiatric comorbidities were compared to expected population rates using standardised morbidity ratios (SMRs). Adapted ANCOVA functions were constructed to explore age and sex associations with receptive language ability across the lifespan, and regression analyses were performed to determine whether the presence of health comorbidities or physical phenotypes predicted cognitive abilities. RESULTS: Multiple comorbidities showed prevalence differences across the lifespan, though there were few sex differences. In adults, SMRs were increased in males and decreased in females with DS for schizophrenia, bipolar disorder, and anxiety. Further, SMRs were increased in both males and females with DS for dementia, autism, ADHD, and depression, with differences more pronounced in females for dementia and autism, and in males for depression. Across the lifespan, receptive language abilities increasingly deviated from age-typical levels, and males scored poorer than females. Only autism and epilepsy were associated with poorer cognitive ability in those aged 16-35 years, with no relationships for physical health comorbidities, including congenital heart defects. CONCLUSIONS: Our results indicate the prevalence of multiple comorbidities varies across the lifespan in DS, and in adults, rates for psychiatric comorbidities show different patterns for males and females relative to expected population rates. Further, most health comorbidities are not associated with poorer cognitive outcomes in DS, apart from autism and epilepsy. It is essential for clinicians to consider such differences to provide appropriate care and treatment for those with DS and to provide prognostic information relating to cognitive outcomes in those with comorbidities. En ligne : https://dx.doi.org/10.1186/s11689-019-9306-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Does maternal psychopathology bias reports of offspring symptoms? A study using moderated non-linear factor analysis / Thomas M. OLINO in Journal of Child Psychology and Psychiatry, 62-10 (October 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1195-1201 Titre : Does maternal psychopathology bias reports of offspring symptoms? A study using moderated non-linear factor analysis Type de document : texte imprimé Auteurs : Thomas M. OLINO, Auteur ; Giorgia MICHELINI, Auteur ; Rebekah J. MENNIES, Auteur ; Roman KOTOV, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.1195-1201 Langues : Anglais (eng) Mots-clés : Adolescent  Bias  Factor Analysis, Statistical  Family  Female  Humans  Mental Disorders/epidemiology  Mothers  Psychopathology  Maternal bias  maternal psychopathology  youth psychopathology Index. décimale : PER Périodiques Résumé : BACKGROUND: Mood-state biases in maternal reports of emotional and behavioral problems in their children have been a major concern for the field. However, few studies have addressed this issue from a measurement invariance perspective. METHODS: Using data from baseline assessment of the Adolescent Brain Cognitive Development (ABCD) study (n = 8,507 mother-child dyads; youth aged 9-11 years), we examined how dimensions of maternal psychopathology, including internalizing problems, were associated with indices of bias in reports of their children's dimensions of internalizing, externalizing, neurodevelopmental, detachment, somatoform psychopathology using moderated non-linear factor analysis. Moderated non-linear factor analyses examined multiple potential biases in maternal reports of youth psychopathology. RESULTS: Across analyses, we found very small magnitudes of associations between dimensions of maternal psychopathology and biases in reports of child emotional and behavioral problems. CONCLUSIONS: Based on these results, we find little psychometric evidence for maternal psychopathology biasing reports of child behavior problems. En ligne : http://dx.doi.org/10.1111/jcpp.13394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Does maternal psychopathology bias reports of offspring symptoms? A study using moderated non-linear factor analysis [texte imprimé] / Thomas M. OLINO, Auteur ; Giorgia MICHELINI, Auteur ; Rebekah J. MENNIES, Auteur ; Roman KOTOV, Auteur ; Daniel N. KLEIN, Auteur . - p.1195-1201. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1195-1201 Mots-clés : Adolescent  Bias  Factor Analysis, Statistical  Family  Female  Humans  Mental Disorders/epidemiology  Mothers  Psychopathology  Maternal bias  maternal psychopathology  youth psychopathology Index. décimale : PER Périodiques Résumé : BACKGROUND: Mood-state biases in maternal reports of emotional and behavioral problems in their children have been a major concern for the field. However, few studies have addressed this issue from a measurement invariance perspective. METHODS: Using data from baseline assessment of the Adolescent Brain Cognitive Development (ABCD) study (n = 8,507 mother-child dyads; youth aged 9-11 years), we examined how dimensions of maternal psychopathology, including internalizing problems, were associated with indices of bias in reports of their children's dimensions of internalizing, externalizing, neurodevelopmental, detachment, somatoform psychopathology using moderated non-linear factor analysis. Moderated non-linear factor analyses examined multiple potential biases in maternal reports of youth psychopathology. RESULTS: Across analyses, we found very small magnitudes of associations between dimensions of maternal psychopathology and biases in reports of child emotional and behavioral problems. CONCLUSIONS: Based on these results, we find little psychometric evidence for maternal psychopathology biasing reports of child behavior problems. En ligne : http://dx.doi.org/10.1111/jcpp.13394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Psychiatric illness and regression in individuals with Phelan-McDermid syndrome / Teresa M. KOHLENBERG in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Psychiatric illness and regression in individuals with Phelan-McDermid syndrome Type de document : texte imprimé Auteurs : Teresa M. KOHLENBERG, Auteur ; M. Pilar TRELLES, Auteur ; Brittany MCLARNEY, Auteur ; Catalina BETANCUR, Auteur ; Audrey THURM, Auteur ; Alexander KOLEVZON, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Bipolar Disorder/epidemiology  Catatonia/epidemiology  Chromosome Deletion  Chromosome Disorders/psychology  Chromosomes, Human, Pair 22  Female  Humans  Male  Mental Disorders/epidemiology  Middle Aged  Phenotype  Regression, Psychology  Young Adult  Bipolar disorder  Catatonia  Depression  Mania  Phelan-McDermid syndrome  Psychosis  Regression  SHANK3  Takeda, 5 AM Ventures, sema4, and LabCorp. The other authors declare that they  have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Phelan-McDermid syndrome (PMS) is a genetic condition characterized by intellectual disability, speech and language deficits, hypotonia, autism spectrum disorder, and epilepsy. PMS is caused by 22q13.33 deletions or mutations affecting SHANK3, which codes for a critical scaffolding protein in excitatory synapses. SHANK3 variants are also known to be associated with an increased risk for regression, as well as for psychiatric disorders, including bipolar disorder and catatonia. This study aimed to further describe these phenomena in PMS and to explore any relationship between psychiatric illness and regression after early childhood. METHODS: Thirty-eight people with PMS were recruited to this study through the Phelan-McDermid Syndrome Foundation based on caregiver report of distinct development of psychiatric symptoms. Caregivers completed a clinician-administered semi-structured interview focused on eliciting psychiatric symptomatology. Data from the PMS International Registry were used to confirm genetic diagnoses of participants and to provide a larger sample for comparison. RESULTS: The mean age of the 38 participants was 24.7 years (range = 13 to 50; SD = 10.06). Females (31 of 38 cases; 82%) and sequence variants (15 of 38 cases; 39%) were over-represented in this sample, compared to base rates in the PMS International Registry. Onset of psychiatric symptoms occurred at a mean age of 15.4 years (range = 7 to 32), with presentations marked by prominent disturbances of mood. Enduring substantial loss of functional skills after onset of psychiatric changes was seen in 25 cases (66%). Symptomst indicative of catatonia occurred in 20 cases (53%). Triggers included infections, changes in hormonal status, and stressful life events. CONCLUSIONS: This study confirms that individuals with PMS are at risk of developing severe neuropsychiatric illness in adolescence or early adulthood, including bipolar disorder, catatonia, and lasting regression of skills. These findings should increase the awareness of these phenotypes and lead to earlier diagnosis and the implementation of appropriate interventions. Our findings also highlight the importance of genetic testing in the work-up of individuals with intellectual disability and acute psychiatric illness or regression. Future research is needed to clarify the prevalence and nature of psychiatric disorders and regression among larger unbiased samples of individuals with PMS. En ligne : https://dx.doi.org/10.1186/s11689-020-9309-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Psychiatric illness and regression in individuals with Phelan-McDermid syndrome [texte imprimé] / Teresa M. KOHLENBERG, Auteur ; M. Pilar TRELLES, Auteur ; Brittany MCLARNEY, Auteur ; Catalina BETANCUR, Auteur ; Audrey THURM, Auteur ; Alexander KOLEVZON, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Adolescent  Adult  Bipolar Disorder/epidemiology  Catatonia/epidemiology  Chromosome Deletion  Chromosome Disorders/psychology  Chromosomes, Human, Pair 22  Female  Humans  Male  Mental Disorders/epidemiology  Middle Aged  Phenotype  Regression, Psychology  Young Adult  Bipolar disorder  Catatonia  Depression  Mania  Phelan-McDermid syndrome  Psychosis  Regression  SHANK3  Takeda, 5 AM Ventures, sema4, and LabCorp. The other authors declare that they  have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Phelan-McDermid syndrome (PMS) is a genetic condition characterized by intellectual disability, speech and language deficits, hypotonia, autism spectrum disorder, and epilepsy. PMS is caused by 22q13.33 deletions or mutations affecting SHANK3, which codes for a critical scaffolding protein in excitatory synapses. SHANK3 variants are also known to be associated with an increased risk for regression, as well as for psychiatric disorders, including bipolar disorder and catatonia. This study aimed to further describe these phenomena in PMS and to explore any relationship between psychiatric illness and regression after early childhood. METHODS: Thirty-eight people with PMS were recruited to this study through the Phelan-McDermid Syndrome Foundation based on caregiver report of distinct development of psychiatric symptoms. Caregivers completed a clinician-administered semi-structured interview focused on eliciting psychiatric symptomatology. Data from the PMS International Registry were used to confirm genetic diagnoses of participants and to provide a larger sample for comparison. RESULTS: The mean age of the 38 participants was 24.7 years (range = 13 to 50; SD = 10.06). Females (31 of 38 cases; 82%) and sequence variants (15 of 38 cases; 39%) were over-represented in this sample, compared to base rates in the PMS International Registry. Onset of psychiatric symptoms occurred at a mean age of 15.4 years (range = 7 to 32), with presentations marked by prominent disturbances of mood. Enduring substantial loss of functional skills after onset of psychiatric changes was seen in 25 cases (66%). Symptomst indicative of catatonia occurred in 20 cases (53%). Triggers included infections, changes in hormonal status, and stressful life events. CONCLUSIONS: This study confirms that individuals with PMS are at risk of developing severe neuropsychiatric illness in adolescence or early adulthood, including bipolar disorder, catatonia, and lasting regression of skills. These findings should increase the awareness of these phenotypes and lead to earlier diagnosis and the implementation of appropriate interventions. Our findings also highlight the importance of genetic testing in the work-up of individuals with intellectual disability and acute psychiatric illness or regression. Future research is needed to clarify the prevalence and nature of psychiatric disorders and regression among larger unbiased samples of individuals with PMS. En ligne : https://dx.doi.org/10.1186/s11689-020-9309-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573