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White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism / O. FRUNDT in Journal of Autism and Developmental Disorders, 48-2 (February 2018)
[article]
Titre : White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism Type de document : Texte imprimé et/ou numérique Auteurs : O. FRUNDT, Auteur ; R. SCHULZ, Auteur ; D. SCHOTTLE, Auteur ; B. CHENG, Auteur ; G. THOMALLA, Auteur ; H. BRAASS, Auteur ; C. GANOS, Auteur ; N. DAVID, Auteur ; I. PEIKER, Auteur ; A. K. ENGEL, Auteur ; T. BAUMER, Auteur ; A. MUNCHAU, Auteur Article en page(s) : p.417-429 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Diffusion tensor imaging Fiber tracking Imitation Mirror neuron system Index. décimale : PER Périodiques Résumé : Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity. En ligne : https://doi.org/10.1007/s10803-017-3332-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.417-429[article] White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism [Texte imprimé et/ou numérique] / O. FRUNDT, Auteur ; R. SCHULZ, Auteur ; D. SCHOTTLE, Auteur ; B. CHENG, Auteur ; G. THOMALLA, Auteur ; H. BRAASS, Auteur ; C. GANOS, Auteur ; N. DAVID, Auteur ; I. PEIKER, Auteur ; A. K. ENGEL, Auteur ; T. BAUMER, Auteur ; A. MUNCHAU, Auteur . - p.417-429.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-2 (February 2018) . - p.417-429
Mots-clés : Autism spectrum disorders Diffusion tensor imaging Fiber tracking Imitation Mirror neuron system Index. décimale : PER Périodiques Résumé : Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity. En ligne : https://doi.org/10.1007/s10803-017-3332-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=337 Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder / Hsiang-Yun CHIEN in Autism Research, 8-6 (December 2015)
[article]
Titre : Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hsiang-Yun CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yung-Chin HSU, Auteur ; Yu-Jen CHEN, Auteur ; Yu-Chun LO, Auteur ; Yao-Chia SHIH, Auteur ; Wen-Yih Isaac TSENG, Auteur Article en page(s) : p.694-708 Langues : Anglais (eng) Mots-clés : autism spectrum disorder mirror neuron system diffusion spectrum imaging cortical thickness white matter integrity tractography social communication Index. décimale : PER Périodiques Résumé : Previous studies using neural activity recording and neuroimaging techniques have reported functional deficits in the mirror neuron system (MNS) for individuals with autism spectrum disorder (ASD). However, a few studies focusing on gray and white matter structures of the MNS have yielded inconsistent results. The current study recruited adolescents and young adults with ASD (aged 15–26 years) and age-matched typically developing (TD) controls (aged 14–25 years). The cortical thickness (CT) and microstructural integrity of the tracts connecting the regions forming the classical MNS were investigated. High-resolution T1-weighted imaging and diffusion spectrum imaging were performed to quantify the CT and tract integrity, respectively. The structural covariance of the CT of the MNS regions revealed a weaker coordination of the MNS network in ASD. A strong correlation was found between the integrity of the right frontoparietal tracts and the social communication subscores measured by the Chinese version of the Social Communication Questionnaire. The results showed that there were no significant mean differences in the CTs and tract integrity between the ASD and TD groups, but revealed a moderate or even reverse age effect on the frontal MNS structures in ASD. In conclusion, aberrant structural coordination may be an underlying factor affecting the function of the MNS in ASD patients. The association between the right frontoparietal tracts and social communication performance implies a neural correlate of communication processing in the autistic brain. This study provides evidence of abnormal MNS structures and their influence on social communication in individuals with ASD. Autism Res 2015, 8: 694–708. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1484 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278
in Autism Research > 8-6 (December 2015) . - p.694-708[article] Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Hsiang-Yun CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yung-Chin HSU, Auteur ; Yu-Jen CHEN, Auteur ; Yu-Chun LO, Auteur ; Yao-Chia SHIH, Auteur ; Wen-Yih Isaac TSENG, Auteur . - p.694-708.
Langues : Anglais (eng)
in Autism Research > 8-6 (December 2015) . - p.694-708
Mots-clés : autism spectrum disorder mirror neuron system diffusion spectrum imaging cortical thickness white matter integrity tractography social communication Index. décimale : PER Périodiques Résumé : Previous studies using neural activity recording and neuroimaging techniques have reported functional deficits in the mirror neuron system (MNS) for individuals with autism spectrum disorder (ASD). However, a few studies focusing on gray and white matter structures of the MNS have yielded inconsistent results. The current study recruited adolescents and young adults with ASD (aged 15–26 years) and age-matched typically developing (TD) controls (aged 14–25 years). The cortical thickness (CT) and microstructural integrity of the tracts connecting the regions forming the classical MNS were investigated. High-resolution T1-weighted imaging and diffusion spectrum imaging were performed to quantify the CT and tract integrity, respectively. The structural covariance of the CT of the MNS regions revealed a weaker coordination of the MNS network in ASD. A strong correlation was found between the integrity of the right frontoparietal tracts and the social communication subscores measured by the Chinese version of the Social Communication Questionnaire. The results showed that there were no significant mean differences in the CTs and tract integrity between the ASD and TD groups, but revealed a moderate or even reverse age effect on the frontal MNS structures in ASD. In conclusion, aberrant structural coordination may be an underlying factor affecting the function of the MNS in ASD patients. The association between the right frontoparietal tracts and social communication performance implies a neural correlate of communication processing in the autistic brain. This study provides evidence of abnormal MNS structures and their influence on social communication in individuals with ASD. Autism Res 2015, 8: 694–708. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1484 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 Both the mirror and the affordance systems might be impaired in adults with high autistic traits. Evidence from EEG mu and beta rhythms / M. DE VEGA in Autism Research, 12-7 (July 2019)
[article]
Titre : Both the mirror and the affordance systems might be impaired in adults with high autistic traits. Evidence from EEG mu and beta rhythms Type de document : Texte imprimé et/ou numérique Auteurs : M. DE VEGA, Auteur ; I. PADRON, Auteur ; I. Z. MORENO, Auteur ; E. GARCIA-MARCO, Auteur ; A. DOMINGUEZ, Auteur ; H. MARRERO, Auteur ; S. HERNANDEZ, Auteur Année de publication : 2019 Article en page(s) : p.1032-1042 Langues : Anglais (eng) Mots-clés : affordances electroencephalography (EEG) mirror neuron system mu rhythms Index. décimale : PER Périodiques Résumé : The association of autism spectrum disorder (ASD) with an altered mirror neuron system is still controversial. At the same time, the processing of object affordances by persons with ASD is a neglected issue. In this electroencephalographic study, adults differing in their autism quotient (AQ) scores were selected. We found anomalous modulation of mu and beta rhythms in high-AQ, compared to low-AQ persons, while they watched a set of goal-directed manual actions. This confirms that observing actions involving implicit intentions most clearly reveals the impairment of the mirror neurons system (MNS). The high-AQ group also showed anomalous mu and beta modulation when they looked at pictures of manipulable objects, indicating a deficit in processing motor affordances. We conclude that high-AQ adults have neural impairment of both the MNS and the affordance systems, which could underlie their relational problems with both people and objects. Autism Res 2019, 12: 1032-1042. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Adults with autistic traits (high-autism quotient [AQ] scores) and matched controls (low-AQ) observed intentional hand actions, and pictures of manipulable and non-manipulable objects. The high-AQ group compared to the control group, showed anomalous modulation of the electroencephalographic motoric rhythms (mu and beta) while observing familiar goal-directed actions, confirming an impairment of their mirror neuron system. Also, their brain rhythms were anomalous when they watched manipulable objects, which suggest a dysfunction in their relation with objects (affordance system). En ligne : http://dx.doi.org/10.1002/aur.2121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402
in Autism Research > 12-7 (July 2019) . - p.1032-1042[article] Both the mirror and the affordance systems might be impaired in adults with high autistic traits. Evidence from EEG mu and beta rhythms [Texte imprimé et/ou numérique] / M. DE VEGA, Auteur ; I. PADRON, Auteur ; I. Z. MORENO, Auteur ; E. GARCIA-MARCO, Auteur ; A. DOMINGUEZ, Auteur ; H. MARRERO, Auteur ; S. HERNANDEZ, Auteur . - 2019 . - p.1032-1042.
Langues : Anglais (eng)
in Autism Research > 12-7 (July 2019) . - p.1032-1042
Mots-clés : affordances electroencephalography (EEG) mirror neuron system mu rhythms Index. décimale : PER Périodiques Résumé : The association of autism spectrum disorder (ASD) with an altered mirror neuron system is still controversial. At the same time, the processing of object affordances by persons with ASD is a neglected issue. In this electroencephalographic study, adults differing in their autism quotient (AQ) scores were selected. We found anomalous modulation of mu and beta rhythms in high-AQ, compared to low-AQ persons, while they watched a set of goal-directed manual actions. This confirms that observing actions involving implicit intentions most clearly reveals the impairment of the mirror neurons system (MNS). The high-AQ group also showed anomalous mu and beta modulation when they looked at pictures of manipulable objects, indicating a deficit in processing motor affordances. We conclude that high-AQ adults have neural impairment of both the MNS and the affordance systems, which could underlie their relational problems with both people and objects. Autism Res 2019, 12: 1032-1042. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Adults with autistic traits (high-autism quotient [AQ] scores) and matched controls (low-AQ) observed intentional hand actions, and pictures of manipulable and non-manipulable objects. The high-AQ group compared to the control group, showed anomalous modulation of the electroencephalographic motoric rhythms (mu and beta) while observing familiar goal-directed actions, confirming an impairment of their mirror neuron system. Also, their brain rhythms were anomalous when they watched manipulable objects, which suggest a dysfunction in their relation with objects (affordance system). En ligne : http://dx.doi.org/10.1002/aur.2121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder / Martin SCHULTE-RUTHER in Autism Research, 10-2 (February 2017)
[article]
Titre : Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Martin SCHULTE-RUTHER, Auteur ; Ellen OTTE, Auteur ; Kübra ADIGÜZEL, Auteur ; Christine FIRK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Iring KOCH, Auteur ; Kerstin KONRAD, Auteur Article en page(s) : p.298-310 Langues : Anglais (eng) Mots-clés : mirror neuron system electromyography imitation autism perception action compatibility facial emotions Index. décimale : PER Périodiques Résumé : It has been suggested that an early deficit in the human mirror neuron system (MNS) is an important feature of autism. Recent findings related to simple hand and finger movements do not support a general dysfunction of the MNS in autism. Studies investigating facial actions (e.g., emotional expressions) have been more consistent, however, mostly relied on passive observation tasks. We used a new variant of a compatibility task for the assessment of automatic facial mimicry responses that allowed for simultaneous control of attention to facial stimuli. We used facial electromyography in 18 children and adolescents with Autism spectrum disorder (ASD) and 18 typically developing controls (TDCs). We observed a robust compatibility effect in ASD, that is, the execution of a facial expression was facilitated if a congruent facial expression was observed. Time course analysis of RT distributions and comparison to a classic compatibility task (symbolic Simon task) revealed that the facial compatibility effect appeared early and increased with time, suggesting fast and sustained activation of motor codes during observation of facial expressions. We observed a negative correlation of the compatibility effect with age across participants and in ASD, and a positive correlation between self-rated empathy and congruency for smiling faces in TDC but not in ASD. This pattern of results suggests that basic motor mimicry is intact in ASD, but is not associated with complex social cognitive abilities such as emotion understanding and empathy. En ligne : http://dx.doi.org/10.1002/aur.1654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-2 (February 2017) . - p.298-310[article] Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Martin SCHULTE-RUTHER, Auteur ; Ellen OTTE, Auteur ; Kübra ADIGÜZEL, Auteur ; Christine FIRK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Iring KOCH, Auteur ; Kerstin KONRAD, Auteur . - p.298-310.
Langues : Anglais (eng)
in Autism Research > 10-2 (February 2017) . - p.298-310
Mots-clés : mirror neuron system electromyography imitation autism perception action compatibility facial emotions Index. décimale : PER Périodiques Résumé : It has been suggested that an early deficit in the human mirror neuron system (MNS) is an important feature of autism. Recent findings related to simple hand and finger movements do not support a general dysfunction of the MNS in autism. Studies investigating facial actions (e.g., emotional expressions) have been more consistent, however, mostly relied on passive observation tasks. We used a new variant of a compatibility task for the assessment of automatic facial mimicry responses that allowed for simultaneous control of attention to facial stimuli. We used facial electromyography in 18 children and adolescents with Autism spectrum disorder (ASD) and 18 typically developing controls (TDCs). We observed a robust compatibility effect in ASD, that is, the execution of a facial expression was facilitated if a congruent facial expression was observed. Time course analysis of RT distributions and comparison to a classic compatibility task (symbolic Simon task) revealed that the facial compatibility effect appeared early and increased with time, suggesting fast and sustained activation of motor codes during observation of facial expressions. We observed a negative correlation of the compatibility effect with age across participants and in ASD, and a positive correlation between self-rated empathy and congruency for smiling faces in TDC but not in ASD. This pattern of results suggests that basic motor mimicry is intact in ASD, but is not associated with complex social cognitive abilities such as emotion understanding and empathy. En ligne : http://dx.doi.org/10.1002/aur.1654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Motor network activation during human action observation and imagery: Mu rhythm EEG evidence on typical and atypical neurodevelopment / Olivia Morgan LAPENTA in Research in Autism Spectrum Disorders, 8-7 (July 2014)
[article]
Titre : Motor network activation during human action observation and imagery: Mu rhythm EEG evidence on typical and atypical neurodevelopment Type de document : Texte imprimé et/ou numérique Auteurs : Olivia Morgan LAPENTA, Auteur ; Paulo Sérgio BOGGIO, Auteur Article en page(s) : p.759-766 Langues : Anglais (eng) Mots-clés : Motor imagery Action observation Mu rhythm Mirror neuron system Autism EEG Index. décimale : PER Périodiques Résumé : Abstract The mental simulation theory suggests activation of the motor network during imagery and observation of human movements, similarly to the activation during action execution and is proposed to be mediated by the mirror neuron system. This activation can be measured by several technologies such as electroencephalography, magnetoencephalography, functional magnetic resonance imaging and positron emission tomography. It is proposed that motor network activation and therefore increased cortical excitability of primary motor cortex occur due to premotor mirror neuron system inputs. This mechanism has been demonstrated as important for planning actions and seems relevant for anticipating others actions and for empathy establishing as well as for language development. In this review we focused on studies relative to electroencephalography data of motor neural network activation during movement observation and imagery in typical and atypical development. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.759-766[article] Motor network activation during human action observation and imagery: Mu rhythm EEG evidence on typical and atypical neurodevelopment [Texte imprimé et/ou numérique] / Olivia Morgan LAPENTA, Auteur ; Paulo Sérgio BOGGIO, Auteur . - p.759-766.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.759-766
Mots-clés : Motor imagery Action observation Mu rhythm Mirror neuron system Autism EEG Index. décimale : PER Périodiques Résumé : Abstract The mental simulation theory suggests activation of the motor network during imagery and observation of human movements, similarly to the activation during action execution and is proposed to be mediated by the mirror neuron system. This activation can be measured by several technologies such as electroencephalography, magnetoencephalography, functional magnetic resonance imaging and positron emission tomography. It is proposed that motor network activation and therefore increased cortical excitability of primary motor cortex occur due to premotor mirror neuron system inputs. This mechanism has been demonstrated as important for planning actions and seems relevant for anticipating others actions and for empathy establishing as well as for language development. In this review we focused on studies relative to electroencephalography data of motor neural network activation during movement observation and imagery in typical and atypical development. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 PermalinkValence Scaling of Dynamic Facial Expressions is Altered in High-Functioning Subjects with Autism Spectrum Disorders: an fMRI Study / Jukka S. RAHKO in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
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