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Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits / D. L. FLORIS in Molecular Autism, 7 (2016)
[article]
Titre : Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits Type de document : Texte imprimé et/ou numérique Auteurs : D. L. FLORIS, Auteur ; A. D. BARBER, Auteur ; M. B. NEBEL, Auteur ; M. MARTINELLI, Auteur ; Meng-Chuan LAI, Auteur ; D. CROCETTI, Auteur ; Simon BARON-COHEN, Auteur ; J. SUCKLING, Auteur ; J. J. PEKAR, Auteur ; S. H. MOSTOFSKY, Auteur Article en page(s) : 35p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/physiopathology Brain/diagnostic imaging/physiopathology Case-Control Studies Child Female Functional Laterality/physiology Humans Image Processing, Computer-Assisted Language Magnetic Resonance Imaging Male Neuropsychological Tests Autism Hemispheric specialization Intrinsic functional connectivity Lateralization Motor deficits Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. En ligne : http://dx.doi.org/10.1186/s13229-016-0096-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 35p.[article] Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits [Texte imprimé et/ou numérique] / D. L. FLORIS, Auteur ; A. D. BARBER, Auteur ; M. B. NEBEL, Auteur ; M. MARTINELLI, Auteur ; Meng-Chuan LAI, Auteur ; D. CROCETTI, Auteur ; Simon BARON-COHEN, Auteur ; J. SUCKLING, Auteur ; J. J. PEKAR, Auteur ; S. H. MOSTOFSKY, Auteur . - 35p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 35p.
Mots-clés : Autism Spectrum Disorder/physiopathology Brain/diagnostic imaging/physiopathology Case-Control Studies Child Female Functional Laterality/physiology Humans Image Processing, Computer-Assisted Language Magnetic Resonance Imaging Male Neuropsychological Tests Autism Hemispheric specialization Intrinsic functional connectivity Lateralization Motor deficits Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. En ligne : http://dx.doi.org/10.1186/s13229-016-0096-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD) / M. MODY in Journal of Autism and Developmental Disorders, 47-1 (January 2017)
[article]
Titre : Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : M. MODY, Auteur ; A. M. SHUI, Auteur ; L. A. NOWINSKI, Auteur ; S. B. GOLAS, Auteur ; C. FERRONE, Auteur ; J. A. O’ROURKE, Auteur ; C. J. MCDOUGLE, Auteur Article en page(s) : p.155-162 Langues : Anglais (eng) Mots-clés : Autism Motor deficits Language Social interactions Index. décimale : PER Périodiques Résumé : Many children with autism spectrum disorder (ASD) have notable difficulties in motor, speech and language domains. The connection between motor skills (oral-motor, manual-motor) and speech and language deficits reported in other developmental disorders raises important questions about a potential relationship between motor skills and speech-language deficits in ASD. To this end, we examined data from children with ASD (n?=?1781), 2–17 years of age, enrolled in the Autism Speaks—Autism Treatment Network (AS-ATN) registry who completed a multidisciplinary evaluation that included diagnostic, physical, cognitive and behavioral assessments as part of a routine standard of care protocol. After adjusting for age, non-verbal IQ, Attention Deficit Hyperactivity Disorder (ADHD) medication use, and muscle tone, separate multiple linear regression analyses revealed significant positive associations of fine motor skills (FM) with both expressive language (EL) and receptive language (RL) skills in an impaired FM subgroup; in contrast, the impaired gross motor (GM) subgroup showed no association with EL but a significant negative association with RL. Similar analyses between motor skills and interpersonal relationships across the sample found both GM skills and FM skills to be associated with social interactions. These results suggest potential differences in the contributions of fine versus gross motor skills to autistic profiles and may provide another lens with which to view communication differences across the autism spectrum for use in treatment interventions. En ligne : http://dx.doi.org/10.1007/s10803-016-2934-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Journal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.155-162[article] Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD) [Texte imprimé et/ou numérique] / M. MODY, Auteur ; A. M. SHUI, Auteur ; L. A. NOWINSKI, Auteur ; S. B. GOLAS, Auteur ; C. FERRONE, Auteur ; J. A. O’ROURKE, Auteur ; C. J. MCDOUGLE, Auteur . - p.155-162.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-1 (January 2017) . - p.155-162
Mots-clés : Autism Motor deficits Language Social interactions Index. décimale : PER Périodiques Résumé : Many children with autism spectrum disorder (ASD) have notable difficulties in motor, speech and language domains. The connection between motor skills (oral-motor, manual-motor) and speech and language deficits reported in other developmental disorders raises important questions about a potential relationship between motor skills and speech-language deficits in ASD. To this end, we examined data from children with ASD (n?=?1781), 2–17 years of age, enrolled in the Autism Speaks—Autism Treatment Network (AS-ATN) registry who completed a multidisciplinary evaluation that included diagnostic, physical, cognitive and behavioral assessments as part of a routine standard of care protocol. After adjusting for age, non-verbal IQ, Attention Deficit Hyperactivity Disorder (ADHD) medication use, and muscle tone, separate multiple linear regression analyses revealed significant positive associations of fine motor skills (FM) with both expressive language (EL) and receptive language (RL) skills in an impaired FM subgroup; in contrast, the impaired gross motor (GM) subgroup showed no association with EL but a significant negative association with RL. Similar analyses between motor skills and interpersonal relationships across the sample found both GM skills and FM skills to be associated with social interactions. These results suggest potential differences in the contributions of fine versus gross motor skills to autistic profiles and may provide another lens with which to view communication differences across the autism spectrum for use in treatment interventions. En ligne : http://dx.doi.org/10.1007/s10803-016-2934-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 Failure in Pantomime Action Execution Correlates with the Severity of Social Behavior Deficits in Children with Autism: A Praxis Study / Valentina GIZZONIO in Journal of Autism and Developmental Disorders, 45-10 (October 2015)
[article]
Titre : Failure in Pantomime Action Execution Correlates with the Severity of Social Behavior Deficits in Children with Autism: A Praxis Study Type de document : Texte imprimé et/ou numérique Auteurs : Valentina GIZZONIO, Auteur ; Pietro AVANZINI, Auteur ; Cristina CAMPI, Auteur ; Sonia ORIVOLI, Auteur ; Benedetta PICCOLO, Auteur ; Gaetano CANTALUPO, Auteur ; Carlo Alberto TASSINARI, Auteur ; Giacomo RIZZOLATTI, Auteur ; Maddalena FABBRI-DESTRO, Auteur Article en page(s) : p.3085-3097 Langues : Anglais (eng) Mots-clés : Children with autism Motor deficits Imitation Florida Apraxia Battery Pantomime action Meaningless gestures Index. décimale : PER Périodiques Résumé : Here we describe the performance of children with autism, their siblings, and typically developing children using the Florida Apraxia Battery. Children with autism showed the lowest performance in all sections of the test. They were mostly impaired in pantomime actions execution on imitation and on verbal command, and in imitation of meaningless gestures. Interestingly, a correlation was found between performance in pantomime actions and the severity of social behavior deficits. We conclude that the presence of a rigid internal model prevents the execution of an exact copy of the observed pantomime actions and that the deficit in imitation of meaningless gestures is most likely due to a deficit in the mechanisms responsible for visuomotor transformations. En ligne : http://dx.doi.org/10.1007/s10803-015-2461-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3085-3097[article] Failure in Pantomime Action Execution Correlates with the Severity of Social Behavior Deficits in Children with Autism: A Praxis Study [Texte imprimé et/ou numérique] / Valentina GIZZONIO, Auteur ; Pietro AVANZINI, Auteur ; Cristina CAMPI, Auteur ; Sonia ORIVOLI, Auteur ; Benedetta PICCOLO, Auteur ; Gaetano CANTALUPO, Auteur ; Carlo Alberto TASSINARI, Auteur ; Giacomo RIZZOLATTI, Auteur ; Maddalena FABBRI-DESTRO, Auteur . - p.3085-3097.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3085-3097
Mots-clés : Children with autism Motor deficits Imitation Florida Apraxia Battery Pantomime action Meaningless gestures Index. décimale : PER Périodiques Résumé : Here we describe the performance of children with autism, their siblings, and typically developing children using the Florida Apraxia Battery. Children with autism showed the lowest performance in all sections of the test. They were mostly impaired in pantomime actions execution on imitation and on verbal command, and in imitation of meaningless gestures. Interestingly, a correlation was found between performance in pantomime actions and the severity of social behavior deficits. We conclude that the presence of a rigid internal model prevents the execution of an exact copy of the observed pantomime actions and that the deficit in imitation of meaningless gestures is most likely due to a deficit in the mechanisms responsible for visuomotor transformations. En ligne : http://dx.doi.org/10.1007/s10803-015-2461-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 Rhythmic bimanual coordination is impaired in young children with autism spectrum disorder / Robert W. ISENHOWER in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)
[article]
Titre : Rhythmic bimanual coordination is impaired in young children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Robert W. ISENHOWER, Auteur ; Kerry L. MARSHA, Auteur ; Michael J. RICHARDSON, Auteur ; Molly HELT, Auteur ; R.C. SCHMIDT, Auteur ; Deborah A. FEIN, Auteur Année de publication : 2012 Article en page(s) : p.25-31 Langues : Anglais (eng) Mots-clés : ASD Motor deficits Bimanual coordination Index. décimale : PER Périodiques Résumé : Impairments in motor coordination are a common behavioral manifestation of autism spectrum disorder (ASD). We, therefore, used a drumming methodology to examine rhythmic bimanual coordination in children diagnosed with ASD (M = 47.3 months) and age-matched typically developing (TD) children (M = 42.6 months). Both groups were instructed to drum on a pad in two required phases: in-phase (drumsticks striking the pad simultaneously) and anti-phase (drumsticks striking in alteration). Analysis revealed that TD children were more able than children with ASD to stay in the required phase relationships for both in-phase and anti-phase coordination. Movement variability was higher for children with ASD than TD children. Imitation ability of the ASD group was somewhat related to their performance on the task. We discuss the implications that deficits in bimanual (intra-personal) coordination may have for social and interpersonal coordination in children with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.08.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146
in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.25-31[article] Rhythmic bimanual coordination is impaired in young children with autism spectrum disorder [Texte imprimé et/ou numérique] / Robert W. ISENHOWER, Auteur ; Kerry L. MARSHA, Auteur ; Michael J. RICHARDSON, Auteur ; Molly HELT, Auteur ; R.C. SCHMIDT, Auteur ; Deborah A. FEIN, Auteur . - 2012 . - p.25-31.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.25-31
Mots-clés : ASD Motor deficits Bimanual coordination Index. décimale : PER Périodiques Résumé : Impairments in motor coordination are a common behavioral manifestation of autism spectrum disorder (ASD). We, therefore, used a drumming methodology to examine rhythmic bimanual coordination in children diagnosed with ASD (M = 47.3 months) and age-matched typically developing (TD) children (M = 42.6 months). Both groups were instructed to drum on a pad in two required phases: in-phase (drumsticks striking the pad simultaneously) and anti-phase (drumsticks striking in alteration). Analysis revealed that TD children were more able than children with ASD to stay in the required phase relationships for both in-phase and anti-phase coordination. Movement variability was higher for children with ASD than TD children. Imitation ability of the ASD group was somewhat related to their performance on the task. We discuss the implications that deficits in bimanual (intra-personal) coordination may have for social and interpersonal coordination in children with ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.08.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 Abnormal Gait Patterns in Autism Spectrum Disorder and Their Correlations with Social Impairments / Linlin GONG in Autism Research, 13-7 (July 2020)
[article]
Titre : Abnormal Gait Patterns in Autism Spectrum Disorder and Their Correlations with Social Impairments Type de document : Texte imprimé et/ou numérique Auteurs : Linlin GONG, Auteur ; Yajie LIU, Auteur ; Li YI, Auteur ; Jing FANG, Auteur ; Yisheng YANG, Auteur ; Kunlin WEI, Auteur Article en page(s) : p.1215-1226 Langues : Anglais (eng) Mots-clés : autism gait motor coordination motor deficits social impairments Index. décimale : PER Périodiques Résumé : Ground walking in humans is typically stable, symmetrical, characterized by smooth heel-to-toe ground contact. Previous studies on children with autism spectrum disorder (ASD) identified various gait abnormalities. However, they produced inconsistent findings, particularly for the occurrence of toe walking and gait symmetry between feet, owing to their reliance on retrospective reports, visual analysis of videos, or kinematic analysis of the gait. The present study examined gait functions in children with ASD using plantar pressure that quantified foot-ground interaction with high spatial and temporal resolutions. Fifty-eight 4-6-year-old children with ASD (12 low-functioning and 46 high-functioning autism) and 28 age-matched typically developed children walked straight 6 m at their preferred speed for 10 repetitions. We found that both ASD groups walked with more flat-footed contact pattern, more left-right asymmetry, and larger step-to-step variability than their controls. Furthermore, these abnormal gait characteristics were related to social impairments measured by the Autism Spectrum Quotient and Social Responsive Scale, supporting a close association between impaired motor coordination and core symptoms of autism. Autism Res 2020, 13: 1215-1226. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined gait functions among children with autism by measuring their foot plantar pressure during simple straight walking. Children with ASD walked with a characteristic foot-ground contact pattern with inappropriate contact forces and large step-to-step variability when compared with their age-matched controls. These walking abnormalities were dependent on their social impairments but independent from their intelligence, indicating a close relationship between atypical motor coordination and core symptoms of autism. En ligne : http://dx.doi.org/10.1002/aur.2302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429
in Autism Research > 13-7 (July 2020) . - p.1215-1226[article] Abnormal Gait Patterns in Autism Spectrum Disorder and Their Correlations with Social Impairments [Texte imprimé et/ou numérique] / Linlin GONG, Auteur ; Yajie LIU, Auteur ; Li YI, Auteur ; Jing FANG, Auteur ; Yisheng YANG, Auteur ; Kunlin WEI, Auteur . - p.1215-1226.
Langues : Anglais (eng)
in Autism Research > 13-7 (July 2020) . - p.1215-1226
Mots-clés : autism gait motor coordination motor deficits social impairments Index. décimale : PER Périodiques Résumé : Ground walking in humans is typically stable, symmetrical, characterized by smooth heel-to-toe ground contact. Previous studies on children with autism spectrum disorder (ASD) identified various gait abnormalities. However, they produced inconsistent findings, particularly for the occurrence of toe walking and gait symmetry between feet, owing to their reliance on retrospective reports, visual analysis of videos, or kinematic analysis of the gait. The present study examined gait functions in children with ASD using plantar pressure that quantified foot-ground interaction with high spatial and temporal resolutions. Fifty-eight 4-6-year-old children with ASD (12 low-functioning and 46 high-functioning autism) and 28 age-matched typically developed children walked straight 6 m at their preferred speed for 10 repetitions. We found that both ASD groups walked with more flat-footed contact pattern, more left-right asymmetry, and larger step-to-step variability than their controls. Furthermore, these abnormal gait characteristics were related to social impairments measured by the Autism Spectrum Quotient and Social Responsive Scale, supporting a close association between impaired motor coordination and core symptoms of autism. Autism Res 2020, 13: 1215-1226. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined gait functions among children with autism by measuring their foot plantar pressure during simple straight walking. Children with ASD walked with a characteristic foot-ground contact pattern with inappropriate contact forces and large step-to-step variability when compared with their age-matched controls. These walking abnormalities were dependent on their social impairments but independent from their intelligence, indicating a close relationship between atypical motor coordination and core symptoms of autism. En ligne : http://dx.doi.org/10.1002/aur.2302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429