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Developmental differences in neural connectivity for semantic processing in youths with autism / L. Y. FAN in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)
[article]
Titre : Developmental differences in neural connectivity for semantic processing in youths with autism Type de document : Texte imprimé et/ou numérique Auteurs : L. Y. FAN, Auteur ; James R. BOOTH, Auteur ; M. LIU, Auteur ; Tai-Li CHOU, Auteur ; S. S. GAU, Auteur Article en page(s) : p.1090-1099 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder Brain/diagnostic imaging Brain Mapping Child Humans Magnetic Resonance Imaging Neural Pathways Semantics Semantic differential difference fMRI functional connectivity psychophysiological interaction Index. décimale : PER Périodiques Résumé : BACKGROUND: Youths with autism spectrum disorder (ASD) rely more on lower-level visual processing as revealed by greater occipital activation, yet less effectively engage higher-level processing of modality-independent semantic knowledge as indicated by reduced frontal activation, compared to typically developing (TD) youths. However, little is known about age-dependent differences in neural connectivity during semantic processing in youths with ASD as compared to TD youths. METHODS: Four groups were recruited: 31 ASD children (mean age = 10.5 years old), 33 TD children (mean age = 10.4), 30 ASD adolescents (mean age = 14.9), and 34 TD adolescents (mean age = 15.1). We explored their differences in neural connectivity by using functional magnetic resonance imaging (fMRI) with psychophysiological interaction (PPI) during semantic judgments. RESULTS: In comparison with TD children, children with ASD showed greater activation in the left cuneus and weaker connectivity between the left cuneus and left middle temporal gyrus (MTG). In comparison with TD adolescents, adolescents with ASD showed less activation in the left inferior frontal gyrus (IFG) and weaker functional connectivity between the left IFG and left MTG. CONCLUSIONS: Children with ASD may rely more on visual processes in the occipital cortex that are disconnected from modality-independent semantics in the temporal cortex. However, adolescents with ASD may less effectively engage frontal mechanisms involved in the top-down control of modality-independent semantic knowledge in the temporal cortex. Our findings provide evidence of developmental differences in the neural substrates of the alterations in semantic processing in youths with ASD compared to TD youths. En ligne : http://dx.doi.org/10.1111/jcpp.13373 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1090-1099[article] Developmental differences in neural connectivity for semantic processing in youths with autism [Texte imprimé et/ou numérique] / L. Y. FAN, Auteur ; James R. BOOTH, Auteur ; M. LIU, Auteur ; Tai-Li CHOU, Auteur ; S. S. GAU, Auteur . - p.1090-1099.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1090-1099
Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder Brain/diagnostic imaging Brain Mapping Child Humans Magnetic Resonance Imaging Neural Pathways Semantics Semantic differential difference fMRI functional connectivity psychophysiological interaction Index. décimale : PER Périodiques Résumé : BACKGROUND: Youths with autism spectrum disorder (ASD) rely more on lower-level visual processing as revealed by greater occipital activation, yet less effectively engage higher-level processing of modality-independent semantic knowledge as indicated by reduced frontal activation, compared to typically developing (TD) youths. However, little is known about age-dependent differences in neural connectivity during semantic processing in youths with ASD as compared to TD youths. METHODS: Four groups were recruited: 31 ASD children (mean age = 10.5 years old), 33 TD children (mean age = 10.4), 30 ASD adolescents (mean age = 14.9), and 34 TD adolescents (mean age = 15.1). We explored their differences in neural connectivity by using functional magnetic resonance imaging (fMRI) with psychophysiological interaction (PPI) during semantic judgments. RESULTS: In comparison with TD children, children with ASD showed greater activation in the left cuneus and weaker connectivity between the left cuneus and left middle temporal gyrus (MTG). In comparison with TD adolescents, adolescents with ASD showed less activation in the left inferior frontal gyrus (IFG) and weaker functional connectivity between the left IFG and left MTG. CONCLUSIONS: Children with ASD may rely more on visual processes in the occipital cortex that are disconnected from modality-independent semantics in the temporal cortex. However, adolescents with ASD may less effectively engage frontal mechanisms involved in the top-down control of modality-independent semantic knowledge in the temporal cortex. Our findings provide evidence of developmental differences in the neural substrates of the alterations in semantic processing in youths with ASD compared to TD youths. En ligne : http://dx.doi.org/10.1111/jcpp.13373 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder / Vânia TAVARES in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
[article]
Titre : Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Vânia TAVARES, Auteur ; Luís Afonso FERNANDES, Auteur ; Marília ANTUNES, Auteur ; Hugo FERREIRA, Auteur ; Diana PRATA, Auteur Article en page(s) : p.3088-3101 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Brain Mapping/methods Female Humans Magnetic Resonance Imaging/methods Male Neural Pathways Sex Characteristics Autism spectrum disorder Functional connectivity Functional magnetic resonance imaging Independent component analysis Resting-state networks Index. décimale : PER Périodiques Résumé : Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD-in suggestive compatibility with ASD cognitive and neuroscientific theories. En ligne : http://dx.doi.org/10.1007/s10803-021-05191-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3088-3101[article] Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Vânia TAVARES, Auteur ; Luís Afonso FERNANDES, Auteur ; Marília ANTUNES, Auteur ; Hugo FERREIRA, Auteur ; Diana PRATA, Auteur . - p.3088-3101.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3088-3101
Mots-clés : Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Brain Mapping/methods Female Humans Magnetic Resonance Imaging/methods Male Neural Pathways Sex Characteristics Autism spectrum disorder Functional connectivity Functional magnetic resonance imaging Independent component analysis Resting-state networks Index. décimale : PER Périodiques Résumé : Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD-in suggestive compatibility with ASD cognitive and neuroscientific theories. En ligne : http://dx.doi.org/10.1007/s10803-021-05191-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477