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A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children / H. MAZAHERY in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
[article]
Titre : A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children Type de document : Texte imprimé et/ou numérique Auteurs : H. MAZAHERY, Auteur ; C. A. CONLON, Auteur ; K. L. BECK, Auteur ; O. MUGRIDGE, Auteur ; M. C. KRUGER, Auteur ; W. STONEHOUSE, Auteur ; C. A. CAMARGO, Auteur ; B. J. MEYER, Auteur ; B. TSANG, Auteur ; B. JONES, Auteur ; P. R. VON HURST, Auteur Article en page(s) : p.1778-1794 Langues : Anglais (eng) Mots-clés : Autism Children Core symptoms Intervention Omega-3 Supplement Vitamin D Index. décimale : PER Périodiques Résumé : We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5-8.0 years) received daily 2000 IU vitamin D3, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (P < 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made. En ligne : http://dx.doi.org/10.1007/s10803-018-3860-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1778-1794[article] A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children [Texte imprimé et/ou numérique] / H. MAZAHERY, Auteur ; C. A. CONLON, Auteur ; K. L. BECK, Auteur ; O. MUGRIDGE, Auteur ; M. C. KRUGER, Auteur ; W. STONEHOUSE, Auteur ; C. A. CAMARGO, Auteur ; B. J. MEYER, Auteur ; B. TSANG, Auteur ; B. JONES, Auteur ; P. R. VON HURST, Auteur . - p.1778-1794.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1778-1794
Mots-clés : Autism Children Core symptoms Intervention Omega-3 Supplement Vitamin D Index. décimale : PER Périodiques Résumé : We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5-8.0 years) received daily 2000 IU vitamin D3, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (P < 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made. En ligne : http://dx.doi.org/10.1007/s10803-018-3860-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 Reduction in behavior problems with omega-3 supplementation in children aged 8–16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial / Adrian RAINE in Journal of Child Psychology and Psychiatry, 56-5 (May 2015)
[article]
Titre : Reduction in behavior problems with omega-3 supplementation in children aged 8–16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial Type de document : Texte imprimé et/ou numérique Auteurs : Adrian RAINE, Auteur ; Jill PORTNOY, Auteur ; Jianghong LIU, Auteur ; Tashneem MAHOOMED, Auteur ; Joseph R. HIBBELN, Auteur Article en page(s) : p.509-520 Langues : Anglais (eng) Mots-clés : Omega-3 externalizing internalizing aggression randomized trial Index. décimale : PER Périodiques Résumé : Background While limited evidence suggests that omega-3 supplementation may reduce antisocial behavior in children, studies have not reported on posttreatment follow-up and most treatment periods have been of short duration. This study tests the hypothesis that omega-3 supplementation over 6 months will reduce behavior problems in children both at the end of treatment and at 6 months post treatment. Methods In this randomized, double-blind, placebo-controlled, stratified, parallel-group trial, a community sample of 8–16 year old children were randomized into a treatment group (N = 100) and a placebo-control group (N = 100). The supplementation consisted of a fruit drink containing 1 g/day of omega-3 or a placebo consisting of the same fruit drink without omega-3. Participants, caregivers, and research assistants were blinded to group assignment. The primary outcome measures of externalizing and internalizing behavior problems were reported by both caregivers and their children in a laboratory setting at 0 months (baseline), 6 months (end of treatment) and 12 months (6 months post treatment), together with the secondary outcome measures of parental antisocial behavior. Data were analyzed on an intention-to-treat basis including all participants. Trial registration: ClinicalTrials.gov: http://clinicaltrials.gov/ct2/show/NCT02016079?term=mauritius&rank=2 Results Significant group × time interactions were observed with the treatment group showing long-term improvements in child behavior problems. The average posttreatment effect size was d = ?.59. Effects were documented for parent reports, but with the exception of proactive and reactive aggression, child-report data were nonsignificant. Parents whose children took omega-3 showed significant posttreatment reductions in their own antisocial and aggressive behavior. This improvement in caregiver behavior partly mediated the improvements observed in child behavior. Conclusions Findings provide initial evidence that omega-3 supplementation can produce sustained reductions in externalizing and internalizing behavior problems. Results are the first to report improvements in caregiver behavior, and to establish this improvement as a part-mechanism for the efficacy of omega-3. En ligne : http://dx.doi.org/10.1111/jcpp.12314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.509-520[article] Reduction in behavior problems with omega-3 supplementation in children aged 8–16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial [Texte imprimé et/ou numérique] / Adrian RAINE, Auteur ; Jill PORTNOY, Auteur ; Jianghong LIU, Auteur ; Tashneem MAHOOMED, Auteur ; Joseph R. HIBBELN, Auteur . - p.509-520.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.509-520
Mots-clés : Omega-3 externalizing internalizing aggression randomized trial Index. décimale : PER Périodiques Résumé : Background While limited evidence suggests that omega-3 supplementation may reduce antisocial behavior in children, studies have not reported on posttreatment follow-up and most treatment periods have been of short duration. This study tests the hypothesis that omega-3 supplementation over 6 months will reduce behavior problems in children both at the end of treatment and at 6 months post treatment. Methods In this randomized, double-blind, placebo-controlled, stratified, parallel-group trial, a community sample of 8–16 year old children were randomized into a treatment group (N = 100) and a placebo-control group (N = 100). The supplementation consisted of a fruit drink containing 1 g/day of omega-3 or a placebo consisting of the same fruit drink without omega-3. Participants, caregivers, and research assistants were blinded to group assignment. The primary outcome measures of externalizing and internalizing behavior problems were reported by both caregivers and their children in a laboratory setting at 0 months (baseline), 6 months (end of treatment) and 12 months (6 months post treatment), together with the secondary outcome measures of parental antisocial behavior. Data were analyzed on an intention-to-treat basis including all participants. Trial registration: ClinicalTrials.gov: http://clinicaltrials.gov/ct2/show/NCT02016079?term=mauritius&rank=2 Results Significant group × time interactions were observed with the treatment group showing long-term improvements in child behavior problems. The average posttreatment effect size was d = ?.59. Effects were documented for parent reports, but with the exception of proactive and reactive aggression, child-report data were nonsignificant. Parents whose children took omega-3 showed significant posttreatment reductions in their own antisocial and aggressive behavior. This improvement in caregiver behavior partly mediated the improvements observed in child behavior. Conclusions Findings provide initial evidence that omega-3 supplementation can produce sustained reductions in externalizing and internalizing behavior problems. Results are the first to report improvements in caregiver behavior, and to establish this improvement as a part-mechanism for the efficacy of omega-3. En ligne : http://dx.doi.org/10.1111/jcpp.12314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Maternal polyunsaturated fatty acids and risk for autism spectrum disorder in the MARBLES high-risk study / Yunru HUANG in Autism, 24-5 (July 2020)
[article]
Titre : Maternal polyunsaturated fatty acids and risk for autism spectrum disorder in the MARBLES high-risk study Type de document : Texte imprimé et/ou numérique Auteurs : Yunru HUANG, Auteur ; Ana-Maria IOSIF, Auteur ; Robin L. HANSEN, Auteur ; Rebecca J. SCHMIDT, Auteur Article en page(s) : p.1191-1200 Langues : Anglais (eng) Mots-clés : autism dietary fat omega-3 omega-6 polyunsaturated fatty acids pregnancy Index. décimale : PER Périodiques Résumé : Prior studies suggest that maternal polyunsaturated fatty acids intake during pregnancy may have protective effects on autism spectrum disorder in their children. However, they did not examine detailed timing of maternal polyunsaturated fatty acid intake during pregnancy, nor did they evaluate plasma concentrations. This study investigates whether maternal polyunsaturated fatty acids in defined time windows of pregnancy, assessed by both questionnaires and biomarkers, are associated with risk of autism spectrum disorder and other non-typical development in the children. Food frequency questionnaires were used to estimate maternal polyunsaturated fatty acid intake during the first and second half of pregnancy. Gas chromatography measured maternal plasma polyunsaturated fatty acid concentrations in the third trimester. In all, 258 mother-child pairs from a prospective cohort were included. All mothers already had a child with autism spectrum disorder and were planning a pregnancy or pregnant with another child. Children were clinically assessed longitudinally and diagnosed at 36 months. For polyunsaturated fatty acid intake from questionnaires, we only found mothers consuming more omega-3 in the second half of pregnancy were 40% less likely to have children with autism spectrum disorder. For polyunsaturated fatty acid concentrations in the third-trimester plasma, we did not observe any statistical significance in relation to the risk of autism spectrum disorder. However, our study confirmed associations from previous studies between higher maternal docosahexaenoic acid and eicosapentaenoic acid plasma concentrations in the late pregnancy and reduced risk for non-typical development. This study markedly advanced understandings of whether and when maternal polyunsaturated fatty acid intake influences risk for autism spectrum disorder and sets the stage for prevention at the behavioral and educational level. En ligne : http://dx.doi.org/10.1177/1362361319877792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Autism > 24-5 (July 2020) . - p.1191-1200[article] Maternal polyunsaturated fatty acids and risk for autism spectrum disorder in the MARBLES high-risk study [Texte imprimé et/ou numérique] / Yunru HUANG, Auteur ; Ana-Maria IOSIF, Auteur ; Robin L. HANSEN, Auteur ; Rebecca J. SCHMIDT, Auteur . - p.1191-1200.
Langues : Anglais (eng)
in Autism > 24-5 (July 2020) . - p.1191-1200
Mots-clés : autism dietary fat omega-3 omega-6 polyunsaturated fatty acids pregnancy Index. décimale : PER Périodiques Résumé : Prior studies suggest that maternal polyunsaturated fatty acids intake during pregnancy may have protective effects on autism spectrum disorder in their children. However, they did not examine detailed timing of maternal polyunsaturated fatty acid intake during pregnancy, nor did they evaluate plasma concentrations. This study investigates whether maternal polyunsaturated fatty acids in defined time windows of pregnancy, assessed by both questionnaires and biomarkers, are associated with risk of autism spectrum disorder and other non-typical development in the children. Food frequency questionnaires were used to estimate maternal polyunsaturated fatty acid intake during the first and second half of pregnancy. Gas chromatography measured maternal plasma polyunsaturated fatty acid concentrations in the third trimester. In all, 258 mother-child pairs from a prospective cohort were included. All mothers already had a child with autism spectrum disorder and were planning a pregnancy or pregnant with another child. Children were clinically assessed longitudinally and diagnosed at 36 months. For polyunsaturated fatty acid intake from questionnaires, we only found mothers consuming more omega-3 in the second half of pregnancy were 40% less likely to have children with autism spectrum disorder. For polyunsaturated fatty acid concentrations in the third-trimester plasma, we did not observe any statistical significance in relation to the risk of autism spectrum disorder. However, our study confirmed associations from previous studies between higher maternal docosahexaenoic acid and eicosapentaenoic acid plasma concentrations in the late pregnancy and reduced risk for non-typical development. This study markedly advanced understandings of whether and when maternal polyunsaturated fatty acid intake influences risk for autism spectrum disorder and sets the stage for prevention at the behavioral and educational level. En ligne : http://dx.doi.org/10.1177/1362361319877792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial / Adrian RAINE in Journal of Child Psychology and Psychiatry, 57-9 (September 2016)
[article]
Titre : Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial Type de document : Texte imprimé et/ou numérique Auteurs : Adrian RAINE, Auteur ; Rose A. CHENEY, Auteur ; Ringo HO, Auteur ; Jill PORTNOY, Auteur ; Jianghong LIU, Auteur ; Liana SOYFER, Auteur ; Joseph HIBBELN, Auteur ; Therese S. RICHMOND, Auteur Article en page(s) : p.1038-1046 Langues : Anglais (eng) Mots-clés : Aggression omega-3 cognitive behavioral therapy reactive callous nutrition externalizing Index. décimale : PER Périodiques Résumé : Background While some studies suggest that nutritional supplementation may reduce aggressive behavior in children, they have not examined whether its efficacy may be enhanced in conjunction with other treatment approaches. This study tests the hypothesis that a nutritional supplementation of omega-3, multivitamins, and minerals over 3 months, combined with cognitive behavior therapy, will reduce childhood aggression. Methods In this randomized, single-blind, stratified, factorial trial, a high-risk community sample of 290 children aged 11–12 years were randomized into Nutrition only, cognitive behavioral therapy (CBT) only, Nutrition + CBT, and Control groups. The primary outcome measures of child- and parent-reported aggressive and antisocial behavior were collected at 0 months (baseline), 3 months (end of treatment), 6 months (3 months posttreatment), and 12 months (9 months posttreatment). The trial (‘Healthy Brains & Behavior: Understanding and Treating Youth Aggression (HBB)’ was registered at ClinicalTrials.gov at https://clinicaltrials.gov/ct2/show/NCT00842439 Results For child self-reports, children in the Nutrition only group showed reduced externalizing behavior compared to Controls at 3 months. At 6 months, the Nutrition + CBT group scored lower on externalizing behavior compared to both CBT only and Control groups. Findings were more in evidence for an Aggressive-Reactive form of antisocial behavior than for a Callous-Proactive form. Effect sizes were in the small-to-medium range (d = ?.33 to ?.37). Group differences were not sustained 9 months posttreatment, and no other effects were significant. Conclusions Findings provide some limited support for the efficacy of omega-3, vitamin, and mineral supplementation in reducing aggressive behavior in children, and represent the first evaluation of nutritional supplements in conjunction with CBT. En ligne : http://dx.doi.org/10.1111/jcpp.12565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.1038-1046[article] Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial [Texte imprimé et/ou numérique] / Adrian RAINE, Auteur ; Rose A. CHENEY, Auteur ; Ringo HO, Auteur ; Jill PORTNOY, Auteur ; Jianghong LIU, Auteur ; Liana SOYFER, Auteur ; Joseph HIBBELN, Auteur ; Therese S. RICHMOND, Auteur . - p.1038-1046.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.1038-1046
Mots-clés : Aggression omega-3 cognitive behavioral therapy reactive callous nutrition externalizing Index. décimale : PER Périodiques Résumé : Background While some studies suggest that nutritional supplementation may reduce aggressive behavior in children, they have not examined whether its efficacy may be enhanced in conjunction with other treatment approaches. This study tests the hypothesis that a nutritional supplementation of omega-3, multivitamins, and minerals over 3 months, combined with cognitive behavior therapy, will reduce childhood aggression. Methods In this randomized, single-blind, stratified, factorial trial, a high-risk community sample of 290 children aged 11–12 years were randomized into Nutrition only, cognitive behavioral therapy (CBT) only, Nutrition + CBT, and Control groups. The primary outcome measures of child- and parent-reported aggressive and antisocial behavior were collected at 0 months (baseline), 3 months (end of treatment), 6 months (3 months posttreatment), and 12 months (9 months posttreatment). The trial (‘Healthy Brains & Behavior: Understanding and Treating Youth Aggression (HBB)’ was registered at ClinicalTrials.gov at https://clinicaltrials.gov/ct2/show/NCT00842439 Results For child self-reports, children in the Nutrition only group showed reduced externalizing behavior compared to Controls at 3 months. At 6 months, the Nutrition + CBT group scored lower on externalizing behavior compared to both CBT only and Control groups. Findings were more in evidence for an Aggressive-Reactive form of antisocial behavior than for a Callous-Proactive form. Effect sizes were in the small-to-medium range (d = ?.33 to ?.37). Group differences were not sustained 9 months posttreatment, and no other effects were significant. Conclusions Findings provide some limited support for the efficacy of omega-3, vitamin, and mineral supplementation in reducing aggressive behavior in children, and represent the first evaluation of nutritional supplements in conjunction with CBT. En ligne : http://dx.doi.org/10.1111/jcpp.12565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292