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Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders / Rabindra TIROUVANZIAM in Journal of Autism and Developmental Disorders, 42-5 (May 2012)
[article]
Titre : Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Rabindra TIROUVANZIAM, Auteur ; Tetyana V. OBUKHANYCH, Auteur ; Julie LAVAL, Auteur ; Pavel A. ARONOV, Auteur ; Robin LIBOVE, Auteur ; Arpita GOSWAMI BANERJEE, Auteur ; Karen J. PARKER, Auteur ; Ruth O’HARA, Auteur ; Leonard A. HERZENBERG, Auteur ; Leonore A. HERZENBERG, Auteur ; Antonio Y. HARDAN, Auteur Année de publication : 2012 Article en page(s) : p.827-836 Langues : Anglais (eng) Mots-clés : Blood Predictive value Polar neutral amino acids Leucine Glutamate Index. décimale : PER Périodiques Résumé : The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1314-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154
in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.827-836[article] Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Rabindra TIROUVANZIAM, Auteur ; Tetyana V. OBUKHANYCH, Auteur ; Julie LAVAL, Auteur ; Pavel A. ARONOV, Auteur ; Robin LIBOVE, Auteur ; Arpita GOSWAMI BANERJEE, Auteur ; Karen J. PARKER, Auteur ; Ruth O’HARA, Auteur ; Leonard A. HERZENBERG, Auteur ; Leonore A. HERZENBERG, Auteur ; Antonio Y. HARDAN, Auteur . - 2012 . - p.827-836.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.827-836
Mots-clés : Blood Predictive value Polar neutral amino acids Leucine Glutamate Index. décimale : PER Périodiques Résumé : The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1314-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154