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Predictive Value of Morphological Features in Patients with Autism versus Normal Controls / Heval M. OZGEN in Journal of Autism and Developmental Disorders, 43-1 (January 2013)
[article]
Titre : Predictive Value of Morphological Features in Patients with Autism versus Normal Controls Type de document : Texte imprimé et/ou numérique Auteurs : Heval M. OZGEN, Auteur ; Gerhard S. HELLEMANN, Auteur ; M. V. JONGE, Auteur ; Frits A. BEEMER, Auteur ; Herman VAN ENGELAND, Auteur Article en page(s) : p.147-155 Langues : Anglais (eng) Mots-clés : Autism Common variant Endophenotype Morphology Minor anomaly Predictive value ROC Recursive partitioning Index. décimale : PER Périodiques Résumé : We investigated the predictive power of morphological features in 224 autistic patients and 224 matched-pairs controls. To assess the relationship between the morphological features and autism, we used the receiver operator curves (ROC). In addition, we used recursive partitioning (RP) to determine a specific pattern of abnormalities that is characteristic for the difference between autistic children and typically developing controls. The present findings showed that morphological features are significantly increased in patients with autism. Using ROC and RP, some of the morphological measures also led to strong predictive accuracy. Facial asymmetry, multiple hair whorls and prominent forehead significantly differentiated patients with autism from controls. Future research on multivariable risk prediction models may benefit from the use of morphological features. En ligne : http://dx.doi.org/10.1007/s10803-012-1554-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.147-155[article] Predictive Value of Morphological Features in Patients with Autism versus Normal Controls [Texte imprimé et/ou numérique] / Heval M. OZGEN, Auteur ; Gerhard S. HELLEMANN, Auteur ; M. V. JONGE, Auteur ; Frits A. BEEMER, Auteur ; Herman VAN ENGELAND, Auteur . - p.147-155.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.147-155
Mots-clés : Autism Common variant Endophenotype Morphology Minor anomaly Predictive value ROC Recursive partitioning Index. décimale : PER Périodiques Résumé : We investigated the predictive power of morphological features in 224 autistic patients and 224 matched-pairs controls. To assess the relationship between the morphological features and autism, we used the receiver operator curves (ROC). In addition, we used recursive partitioning (RP) to determine a specific pattern of abnormalities that is characteristic for the difference between autistic children and typically developing controls. The present findings showed that morphological features are significantly increased in patients with autism. Using ROC and RP, some of the morphological measures also led to strong predictive accuracy. Facial asymmetry, multiple hair whorls and prominent forehead significantly differentiated patients with autism from controls. Future research on multivariable risk prediction models may benefit from the use of morphological features. En ligne : http://dx.doi.org/10.1007/s10803-012-1554-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 The Predictive Value of the AQ and the SRS-A in the Diagnosis of ASD in Adults in Clinical Practice / M. L. BEZEMER in Journal of Autism and Developmental Disorders, 51-7 (July 2021)
[article]
Titre : The Predictive Value of the AQ and the SRS-A in the Diagnosis of ASD in Adults in Clinical Practice Type de document : Texte imprimé et/ou numérique Auteurs : M. L. BEZEMER, Auteur ; E. M. A. BLIJD-HOOGEWYS, Auteur ; M. MEEK-HEEKELAAR, Auteur Article en page(s) : p.2402-2415 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/diagnosis Female Humans Male Neuropsychological Tests/standards/statistics & numerical data Predictive Value of Tests Psychiatric Status Rating Scales/standards/statistics & numerical data Psychometrics Referral and Consultation Reproducibility of Results Sensitivity and Specificity Surveys and Questionnaires/standards/statistics & numerical data Aq Asd Predictive value Srs-a Index. décimale : PER Périodiques Résumé : Questionnaires are widely used in autism assessment. However, their psychometric properties are generally not evaluated in clinical practice, and the comparability and applicability of such research is limited because questionnaires are often not simultaneously evaluated. This certainly pertains to predictive values which are highly population and setting specific. This study evaluated the power of AQ and SRS-A in predicting an ASD diagnosis within the same clinical population. The patient records of 92 adults, referred for autism assessment, were analyzed. The AQ proved somewhat better than the SRS-A at discriminating and predicting autism. The predictive values of both questionnaires were lower than reported in general population studies. Psychometric results in core publications appear less representative for clinical practice. En ligne : http://dx.doi.org/10.1007/s10803-020-04699-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2402-2415[article] The Predictive Value of the AQ and the SRS-A in the Diagnosis of ASD in Adults in Clinical Practice [Texte imprimé et/ou numérique] / M. L. BEZEMER, Auteur ; E. M. A. BLIJD-HOOGEWYS, Auteur ; M. MEEK-HEEKELAAR, Auteur . - p.2402-2415.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2402-2415
Mots-clés : Adult Autism Spectrum Disorder/diagnosis Female Humans Male Neuropsychological Tests/standards/statistics & numerical data Predictive Value of Tests Psychiatric Status Rating Scales/standards/statistics & numerical data Psychometrics Referral and Consultation Reproducibility of Results Sensitivity and Specificity Surveys and Questionnaires/standards/statistics & numerical data Aq Asd Predictive value Srs-a Index. décimale : PER Périodiques Résumé : Questionnaires are widely used in autism assessment. However, their psychometric properties are generally not evaluated in clinical practice, and the comparability and applicability of such research is limited because questionnaires are often not simultaneously evaluated. This certainly pertains to predictive values which are highly population and setting specific. This study evaluated the power of AQ and SRS-A in predicting an ASD diagnosis within the same clinical population. The patient records of 92 adults, referred for autism assessment, were analyzed. The AQ proved somewhat better than the SRS-A at discriminating and predicting autism. The predictive values of both questionnaires were lower than reported in general population studies. Psychometric results in core publications appear less representative for clinical practice. En ligne : http://dx.doi.org/10.1007/s10803-020-04699-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders / Rabindra TIROUVANZIAM in Journal of Autism and Developmental Disorders, 42-5 (May 2012)
[article]
Titre : Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Rabindra TIROUVANZIAM, Auteur ; Tetyana V. OBUKHANYCH, Auteur ; Julie LAVAL, Auteur ; Pavel A. ARONOV, Auteur ; Robin LIBOVE, Auteur ; Arpita GOSWAMI BANERJEE, Auteur ; Karen J. PARKER, Auteur ; Ruth O’HARA, Auteur ; Leonard A. HERZENBERG, Auteur ; Leonore A. HERZENBERG, Auteur ; Antonio Y. HARDAN, Auteur Année de publication : 2012 Article en page(s) : p.827-836 Langues : Anglais (eng) Mots-clés : Blood Predictive value Polar neutral amino acids Leucine Glutamate Index. décimale : PER Périodiques Résumé : The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1314-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154
in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.827-836[article] Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Rabindra TIROUVANZIAM, Auteur ; Tetyana V. OBUKHANYCH, Auteur ; Julie LAVAL, Auteur ; Pavel A. ARONOV, Auteur ; Robin LIBOVE, Auteur ; Arpita GOSWAMI BANERJEE, Auteur ; Karen J. PARKER, Auteur ; Ruth O’HARA, Auteur ; Leonard A. HERZENBERG, Auteur ; Leonore A. HERZENBERG, Auteur ; Antonio Y. HARDAN, Auteur . - 2012 . - p.827-836.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.827-836
Mots-clés : Blood Predictive value Polar neutral amino acids Leucine Glutamate Index. décimale : PER Périodiques Résumé : The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1314-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154