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Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research / N. PEARSON in Autism Research, 11-12 (December 2018)
[article]
Titre : Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research Type de document : Texte imprimé et/ou numérique Auteurs : N. PEARSON, Auteur ; Tony CHARMAN, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur ; F. S. MCEWEN, Auteur Article en page(s) : p.1602-1620 Langues : Anglais (eng) Mots-clés : autism spectrum disorder developmental trajectories high-risk siblings infant regression Index. décimale : PER Périodiques Résumé : The way in which the behavioral manifestations of autism spectrum disorder (ASD) emerge in infancy is variable. Regression-loss of previously acquired skills-occurs in a subset of children. However, the etiology and significance of regression remains unclear. Until recently, investigation of regression relied on retrospective report by parents or examination of home videos from early in life. However, home videos and retrospective report of the nature and timing of regression, and association with factors such as illness or immunization, is potentially subject to bias. The advent of prospective studies of infant siblings at familial high-risk of ASD has the potential to document regression as it occurs. Recent research has suggested that subtle loss of skills occurs in a larger proportion of children with ASD than previously assumed; however, there are few reports of clear-cut regressions, such as that involving dramatic loss of language and other established skills, in the prospective literature. This could be because of the following: clear-cut regression occurs less commonly than parent report suggests, study design limits the potential to detect regression, or there are differences between multiplex and simplex families in the rate of de novo genetic mutations and therefore regression risk. This review will bring together literature from retrospective and prospective research and attempt to reconcile diverging findings, with a specific focus on methodological issues. Changing conceptualizations of regression will be discussed, as well as etiological factors that may be associated with regression. The main challenges that need to be addressed to measure regression in prospective studies will be set out. Autism Research 2018, 11: 1602-1620. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Regression-a loss of previously established skills-occurs in a subset of children with ASD. Parental recall is not always accurate but studying younger siblings of children with ASD, 10-20% of whom will develop ASD, should make it possible to measure regression as it occurs. Clear-cut regression, like loss of language, has not often been reported in infant sibling studies, but recent research suggests that gradual loss of social engagement might be more common. This review looks at the evidence for regression from infant sibling studies and asks how study design affects the likelihood of capturing regression. En ligne : http://dx.doi.org/10.1002/aur.2035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372
in Autism Research > 11-12 (December 2018) . - p.1602-1620[article] Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research [Texte imprimé et/ou numérique] / N. PEARSON, Auteur ; Tony CHARMAN, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur ; F. S. MCEWEN, Auteur . - p.1602-1620.
Langues : Anglais (eng)
in Autism Research > 11-12 (December 2018) . - p.1602-1620
Mots-clés : autism spectrum disorder developmental trajectories high-risk siblings infant regression Index. décimale : PER Périodiques Résumé : The way in which the behavioral manifestations of autism spectrum disorder (ASD) emerge in infancy is variable. Regression-loss of previously acquired skills-occurs in a subset of children. However, the etiology and significance of regression remains unclear. Until recently, investigation of regression relied on retrospective report by parents or examination of home videos from early in life. However, home videos and retrospective report of the nature and timing of regression, and association with factors such as illness or immunization, is potentially subject to bias. The advent of prospective studies of infant siblings at familial high-risk of ASD has the potential to document regression as it occurs. Recent research has suggested that subtle loss of skills occurs in a larger proportion of children with ASD than previously assumed; however, there are few reports of clear-cut regressions, such as that involving dramatic loss of language and other established skills, in the prospective literature. This could be because of the following: clear-cut regression occurs less commonly than parent report suggests, study design limits the potential to detect regression, or there are differences between multiplex and simplex families in the rate of de novo genetic mutations and therefore regression risk. This review will bring together literature from retrospective and prospective research and attempt to reconcile diverging findings, with a specific focus on methodological issues. Changing conceptualizations of regression will be discussed, as well as etiological factors that may be associated with regression. The main challenges that need to be addressed to measure regression in prospective studies will be set out. Autism Research 2018, 11: 1602-1620. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Regression-a loss of previously established skills-occurs in a subset of children with ASD. Parental recall is not always accurate but studying younger siblings of children with ASD, 10-20% of whom will develop ASD, should make it possible to measure regression as it occurs. Clear-cut regression, like loss of language, has not often been reported in infant sibling studies, but recent research suggests that gradual loss of social engagement might be more common. This review looks at the evidence for regression from infant sibling studies and asks how study design affects the likelihood of capturing regression. En ligne : http://dx.doi.org/10.1002/aur.2035 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=372 Bayonet-shaped language development in autism with regression: a retrospective study / D. GAGNON in Molecular Autism, 12 (2021)
[article]
Titre : Bayonet-shaped language development in autism with regression: a retrospective study Type de document : Texte imprimé et/ou numérique Auteurs : D. GAGNON, Auteur ; A. ZERIBI, Auteur ; É DOUARD, Auteur ; V. COURCHESNE, Auteur ; B. RODRÍGUEZ-HERREROS, Auteur ; G. HUGUET, Auteur ; S. JACQUEMONT, Auteur ; M. A. LOUM, Auteur ; L. MOTTRON, Auteur Article en page(s) : 35 p. Langues : Anglais (eng) Mots-clés : Autism Heterogeneity Language Regression Speech Index. décimale : PER Périodiques Résumé : BACKGROUND: Language delay is one of the major referral criteria for an autism evaluation. Once an autism spectrum diagnosis is established, the language prognosis is among the main parental concerns. Early language regression (ELR) is observed by 10-50% of parents but its relevance to late language level and socio-communicative ability is uncertain. This study aimed to establish the predictive value of ELR on the progression of language development and socio-communicative outcomes to guide clinicians in addressing parents' concerns at the time of diagnosis. METHODS: We used socio-communicative, language, and cognitive data of 2,047 autism spectrum participants from the Simons Simplex Collection, aged 4-18 years (mean?=?9 years; SD?=?3.6). Cox proportional hazard and logistic regression models were used to evaluate the effect of ELR on language milestones and the probability of using complex and flexible language, as defined by the choice of ADOS module at enrollment. Linear models were then used to evaluate the relationship of ELR and non-verbal IQ with socio-communicative and language levels. RESULTS: ELR is associated with earlier language milestones but delayed attainment of fluent, complex, and flexible language. However, this language outcome can be expected for almost all autistic children without intellectual disability at 18 years of age. It is mostly influenced by non-verbal IQ, not ELR. The language and socio-communicative level of participants with flexible language, as measured by the Vineland and ADOS socio-communicative subscales, was not affected by ELR. LIMITATIONS: This study is based on a relatively coarse measure of ultimate language level and relies on retrospective reporting of early language milestones and ELR. It does not prospectively document the age at which language catches up, the relationship between ELR and other behavioral areas of regression, nor the effects of intervention. CONCLUSIONS: For autistic individuals with ELR and a normal level of non-verbal intelligence, language development follows a "bayonet shape" trajectory: early first words followed by regression, a plateau with limited progress, and then language catch up. En ligne : http://dx.doi.org/10.1186/s13229-021-00444-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 35 p.[article] Bayonet-shaped language development in autism with regression: a retrospective study [Texte imprimé et/ou numérique] / D. GAGNON, Auteur ; A. ZERIBI, Auteur ; É DOUARD, Auteur ; V. COURCHESNE, Auteur ; B. RODRÍGUEZ-HERREROS, Auteur ; G. HUGUET, Auteur ; S. JACQUEMONT, Auteur ; M. A. LOUM, Auteur ; L. MOTTRON, Auteur . - 35 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 35 p.
Mots-clés : Autism Heterogeneity Language Regression Speech Index. décimale : PER Périodiques Résumé : BACKGROUND: Language delay is one of the major referral criteria for an autism evaluation. Once an autism spectrum diagnosis is established, the language prognosis is among the main parental concerns. Early language regression (ELR) is observed by 10-50% of parents but its relevance to late language level and socio-communicative ability is uncertain. This study aimed to establish the predictive value of ELR on the progression of language development and socio-communicative outcomes to guide clinicians in addressing parents' concerns at the time of diagnosis. METHODS: We used socio-communicative, language, and cognitive data of 2,047 autism spectrum participants from the Simons Simplex Collection, aged 4-18 years (mean?=?9 years; SD?=?3.6). Cox proportional hazard and logistic regression models were used to evaluate the effect of ELR on language milestones and the probability of using complex and flexible language, as defined by the choice of ADOS module at enrollment. Linear models were then used to evaluate the relationship of ELR and non-verbal IQ with socio-communicative and language levels. RESULTS: ELR is associated with earlier language milestones but delayed attainment of fluent, complex, and flexible language. However, this language outcome can be expected for almost all autistic children without intellectual disability at 18 years of age. It is mostly influenced by non-verbal IQ, not ELR. The language and socio-communicative level of participants with flexible language, as measured by the Vineland and ADOS socio-communicative subscales, was not affected by ELR. LIMITATIONS: This study is based on a relatively coarse measure of ultimate language level and relies on retrospective reporting of early language milestones and ELR. It does not prospectively document the age at which language catches up, the relationship between ELR and other behavioral areas of regression, nor the effects of intervention. CONCLUSIONS: For autistic individuals with ELR and a normal level of non-verbal intelligence, language development follows a "bayonet shape" trajectory: early first words followed by regression, a plateau with limited progress, and then language catch up. En ligne : http://dx.doi.org/10.1186/s13229-021-00444-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Brief Report: Regression Timing and Associated Features in MECP2 Duplication Syndrome / S. U. PETERS in Journal of Autism and Developmental Disorders, 43-10 (October 2013)
[article]
Titre : Brief Report: Regression Timing and Associated Features in MECP2 Duplication Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : S. U. PETERS, Auteur ; Rachel J. HUNDLEY, Auteur ; A. K. WILSON, Auteur ; Claudia M. B. CARVALHO, Auteur ; James R. LUPSKI, Auteur ; M. B. RAMOCKI, Auteur Article en page(s) : p.2484-2490 Langues : Anglais (eng) Mots-clés : Regression MECP2 Seizures Index. décimale : PER Périodiques Résumé : The aim of this study was to determine the frequency, timing, and associated features of developmental regression in MECP2 duplication syndrome. We also examined whether duplication size was associated with regression. Comprehensive psychological evaluations were used to assess 17 boys with MECP2 duplication syndrome. Information about regression was gathered via parent report. Eight of 17 boys exhibited regression in language skills, while seven of 17 exhibited regression in other skill areas. Regression in “other skill” areas coincided with seizure onset and with a prior autism diagnosis in six of seven participants. Regression was not associated with duplication size. Questions remain as to why some boys regress, and future work is necessary to understand the underlying mechanism(s) that causes regression. En ligne : http://dx.doi.org/10.1007/s10803-013-1796-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215
in Journal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2484-2490[article] Brief Report: Regression Timing and Associated Features in MECP2 Duplication Syndrome [Texte imprimé et/ou numérique] / S. U. PETERS, Auteur ; Rachel J. HUNDLEY, Auteur ; A. K. WILSON, Auteur ; Claudia M. B. CARVALHO, Auteur ; James R. LUPSKI, Auteur ; M. B. RAMOCKI, Auteur . - p.2484-2490.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2484-2490
Mots-clés : Regression MECP2 Seizures Index. décimale : PER Périodiques Résumé : The aim of this study was to determine the frequency, timing, and associated features of developmental regression in MECP2 duplication syndrome. We also examined whether duplication size was associated with regression. Comprehensive psychological evaluations were used to assess 17 boys with MECP2 duplication syndrome. Information about regression was gathered via parent report. Eight of 17 boys exhibited regression in language skills, while seven of 17 exhibited regression in other skill areas. Regression in “other skill” areas coincided with seizure onset and with a prior autism diagnosis in six of seven participants. Regression was not associated with duplication size. Questions remain as to why some boys regress, and future work is necessary to understand the underlying mechanism(s) that causes regression. En ligne : http://dx.doi.org/10.1007/s10803-013-1796-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215 Characteristics, Early Development and Outcome of Parent-Reported Regression in Autism Spectrum Disorder / S. BOTERBERG in Journal of Autism and Developmental Disorders, 49-11 (November 2019)
[article]
Titre : Characteristics, Early Development and Outcome of Parent-Reported Regression in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. BOTERBERG, Auteur ; R. VAN COSTER, Auteur ; H. ROEYERS, Auteur Article en page(s) : p.4603-4625 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Early development Onset patterns Outcome Regression Index. décimale : PER Périodiques Résumé : This study explored regression patterns in 100 children with ASD (3-11 years) using several approaches to enhance the validity of retrospective parent report. Both early development and outcome were examined in regression groups defined by 36 months age cut-off and two underlying empirical patterns based on type and onset age. Results over regression groups were generally consistent. During early development, children with regression showed a similar amount of social atypicalities and stereotyped behaviour as compared to children without regression. However, parents indicated less communication skills which could be a valuable predictor of regression. Development after regression was characterised by early language delay and more restricted and repetitive behaviour. The findings provide insight into the diagnosis and prognosis of regression in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04183-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408
in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4603-4625[article] Characteristics, Early Development and Outcome of Parent-Reported Regression in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. BOTERBERG, Auteur ; R. VAN COSTER, Auteur ; H. ROEYERS, Auteur . - p.4603-4625.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4603-4625
Mots-clés : Autism spectrum disorder Early development Onset patterns Outcome Regression Index. décimale : PER Périodiques Résumé : This study explored regression patterns in 100 children with ASD (3-11 years) using several approaches to enhance the validity of retrospective parent report. Both early development and outcome were examined in regression groups defined by 36 months age cut-off and two underlying empirical patterns based on type and onset age. Results over regression groups were generally consistent. During early development, children with regression showed a similar amount of social atypicalities and stereotyped behaviour as compared to children without regression. However, parents indicated less communication skills which could be a valuable predictor of regression. Development after regression was characterised by early language delay and more restricted and repetitive behaviour. The findings provide insight into the diagnosis and prognosis of regression in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04183-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 Childhood Disintegrative Disorder (CDD): Symptomatology of the Norwegian Patient Population and Parents' Experiences of Patient Regression / Martin John ELLIS in Journal of Autism and Developmental Disorders, 52-4 (April 2022)
[article]
Titre : Childhood Disintegrative Disorder (CDD): Symptomatology of the Norwegian Patient Population and Parents' Experiences of Patient Regression Type de document : Texte imprimé et/ou numérique Auteurs : Martin John ELLIS, Auteur ; Kenneth LARSEN, Auteur ; Sophie Seychelle HAVIGHURST, Auteur Article en page(s) : p.1495-1506 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Child Development Disorders, Pervasive/diagnosis Child, Preschool Humans Language Norway Parents Autism Cdd Childhood Disintegrative Disorder Heller Syndrome Regression financial or non-financial conflicts of interest to disclose. Index. décimale : PER Périodiques Résumé : Childhood Disintegrative Disorder (CDD) is a rare and little researched developmental disorder characterised by regression in language and social skills after a period of seemingly normal development until at least the age of 2 years. The study contacted all parents of CDD patients in Norway to assess patient symptomatology and parents' experiences of regression via questionnaire or interview. There were 12 participants. Symptomatology was in-line with previous studies, with universal regression in language and social skills and onset predominantly at 2-4 years. Regression was connected to feelings of 'loss' and uncertainty over the prognosis for CDD patients. The study supported CDD diagnostic criteria and showed that CDD patient regression has profound implications for parental well-being. En ligne : http://dx.doi.org/10.1007/s10803-021-05023-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475
in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1495-1506[article] Childhood Disintegrative Disorder (CDD): Symptomatology of the Norwegian Patient Population and Parents' Experiences of Patient Regression [Texte imprimé et/ou numérique] / Martin John ELLIS, Auteur ; Kenneth LARSEN, Auteur ; Sophie Seychelle HAVIGHURST, Auteur . - p.1495-1506.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1495-1506
Mots-clés : Autism Spectrum Disorder Child Child Development Disorders, Pervasive/diagnosis Child, Preschool Humans Language Norway Parents Autism Cdd Childhood Disintegrative Disorder Heller Syndrome Regression financial or non-financial conflicts of interest to disclose. Index. décimale : PER Périodiques Résumé : Childhood Disintegrative Disorder (CDD) is a rare and little researched developmental disorder characterised by regression in language and social skills after a period of seemingly normal development until at least the age of 2 years. The study contacted all parents of CDD patients in Norway to assess patient symptomatology and parents' experiences of regression via questionnaire or interview. There were 12 participants. Symptomatology was in-line with previous studies, with universal regression in language and social skills and onset predominantly at 2-4 years. Regression was connected to feelings of 'loss' and uncertainty over the prognosis for CDD patients. The study supported CDD diagnostic criteria and showed that CDD patient regression has profound implications for parental well-being. En ligne : http://dx.doi.org/10.1007/s10803-021-05023-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 Children with ASD and Communication Regression: Examining Pre-Loss Skills and Later Language Outcomes Through the Preschool Years / Kathryn E. PRESCOTT in Journal of Autism and Developmental Disorders, 52-5 (May 2022)
PermalinkDevelopmental regression among children with autism spectrum disorder: Onset, duration, and effects on functional outcomes / Robin P. GOIN-KOCHEL in Research in Autism Spectrum Disorders, 8-7 (July 2014)
PermalinkEarly Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample / Jeremy R. PARR in Journal of Autism and Developmental Disorders, 41-3 (March 2011)
PermalinkGastrointestinal symptoms have a non-temporal association with regression in a cohort with autism spectrum disorder using the simons simplex collection / Adriana BAGOS-ESTEVEZ ; LeeAnne Green SNYDER ; Athanasios TSALATSANIS ; Amelia BOEHME ; Jennifer M. BAIN in Research in Autism Spectrum Disorders, 111 (March 2024)
PermalinkGene Disrupting Mutations Associated with Regression in Autism Spectrum Disorder / R. P. GOIN-KOCHEL in Journal of Autism and Developmental Disorders, 47-11 (November 2017)
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