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No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children / Karson T. F. KUNG in Molecular Autism, 7 (2016)
[article]
Titre : No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children Type de document : Texte imprimé et/ou numérique Auteurs : Karson T. F. KUNG, Auteur ; M. CONSTANTINESCU, Auteur ; W. V. BROWNE, Auteur ; R. M. NOORDERHAVEN, Auteur ; M. HINES, Auteur Article en page(s) : 15p. Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/metabolism/psychology Birth Weight Child Development Child, Preschool Female Humans Infant Male Maternal Age Parents/education Paternal Age Risk Factors Saliva/chemistry Siblings Surveys and Questionnaires Symptom Assessment Testosterone/analysis Autism Gender differences Postnatal development Sex differences Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Some previous research has suggested that testosterone prenatally contributes to gender differences in autistic traits, but little is known about the role of testosterone during early postnatal development (mini-puberty). Two prior studies found no sex difference in testosterone postnatally in saliva samples and detected little to no relationship between testosterone postnatally and autistic traits in toddlers. These findings may reflect late measurements of testosterone at 3 to 4 months of age, after the peak of mini-puberty at 1 to 3 months of age. The present study examined the relationship between testosterone at 1 to 3 months of age and autistic traits at 18 to 30 months of age. FINDINGS: Testosterone was measured in saliva samples collected from children at 1 to 3 months of age. When the children (40 boys, 47 girls) reached 18 to 30 months of age, parents completed the Quantitative Checklist for Autism in Toddlers (Q-CHAT). Boys had higher concentrations of testosterone postnatally and higher Q-CHAT scores than girls. However, testosterone did not correlate with Q-CHAT scores in boys, girls, or the entire sample. CONCLUSIONS: The current results suggest that testosterone during the early postnatal period does not contribute to later autistic traits. Given our relatively small samples and therefore limited power, however, further research could usefully examine if testosterone in saliva samples collected during the peak of mini-puberty in larger groups predicts autistic traits or other traits that show gender differences. En ligne : http://dx.doi.org/10.1186/s13229-016-0078-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 15p.[article] No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children [Texte imprimé et/ou numérique] / Karson T. F. KUNG, Auteur ; M. CONSTANTINESCU, Auteur ; W. V. BROWNE, Auteur ; R. M. NOORDERHAVEN, Auteur ; M. HINES, Auteur . - 15p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 15p.
Mots-clés : Adult Autism Spectrum Disorder/metabolism/psychology Birth Weight Child Development Child, Preschool Female Humans Infant Male Maternal Age Parents/education Paternal Age Risk Factors Saliva/chemistry Siblings Surveys and Questionnaires Symptom Assessment Testosterone/analysis Autism Gender differences Postnatal development Sex differences Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Some previous research has suggested that testosterone prenatally contributes to gender differences in autistic traits, but little is known about the role of testosterone during early postnatal development (mini-puberty). Two prior studies found no sex difference in testosterone postnatally in saliva samples and detected little to no relationship between testosterone postnatally and autistic traits in toddlers. These findings may reflect late measurements of testosterone at 3 to 4 months of age, after the peak of mini-puberty at 1 to 3 months of age. The present study examined the relationship between testosterone at 1 to 3 months of age and autistic traits at 18 to 30 months of age. FINDINGS: Testosterone was measured in saliva samples collected from children at 1 to 3 months of age. When the children (40 boys, 47 girls) reached 18 to 30 months of age, parents completed the Quantitative Checklist for Autism in Toddlers (Q-CHAT). Boys had higher concentrations of testosterone postnatally and higher Q-CHAT scores than girls. However, testosterone did not correlate with Q-CHAT scores in boys, girls, or the entire sample. CONCLUSIONS: The current results suggest that testosterone during the early postnatal period does not contribute to later autistic traits. Given our relatively small samples and therefore limited power, however, further research could usefully examine if testosterone in saliva samples collected during the peak of mini-puberty in larger groups predicts autistic traits or other traits that show gender differences. En ligne : http://dx.doi.org/10.1186/s13229-016-0078-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Changes in anxiety following a randomized control trial of a theatre-based intervention for youth with autism spectrum disorder / Blythe A. CORBETT in Autism, 21-3 (April 2017)
[article]
Titre : Changes in anxiety following a randomized control trial of a theatre-based intervention for youth with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Scott D. BLAIN, Auteur ; Sara IOANNOU, Auteur ; Maddie BALSER, Auteur Article en page(s) : p.333-343 Langues : Anglais (eng) Mots-clés : Adolescent Anxiety/ epidemiology/etiology Autism Spectrum Disorder/psychology/ therapy Child Female Humans Hydrocortisone/analysis Male Psychodrama/methods Saliva/chemistry anxiety autism spectrum disorders competence cortisol stress theatre Index. décimale : PER Périodiques Résumé : Increased anxiety and stress are frequently found in children with autism spectrum disorder and are associated with social challenges. Recently, we reported changes in social competence following peer-mediated, theatre-based intervention. The purpose of this study was to examine the impact of the intervention on reducing anxiety and stress. Participants included 30 youth with autism spectrum disorder (8-14?years old) randomly assigned to the experimental (17) or waitlist control (13) group. Pretest adjusted, between-group differences were analyzed for state-anxiety, trait-anxiety, play-based cortisol, and diurnal cortisol. Pearson correlations were conducted between anxiety, cortisol, and group play. Significant pretest-adjusted between-group differences at posttest were observed on trait-anxiety (F(1, 27)=9.16, p=0.005) but not state-anxiety (F(1, 27)=0.03, p=0.86), showing lower trait-anxiety in the experimental group. There were no between-group differences on cortisol. There was a significant negative correlation between group play and trait-anxiety (r=-0.362, p=0.05). Playground cortisol correlated with group play, for the experimental group (r=0.55, p=0.03). The theatre-based, peer-mediated intervention not only contributes to improvement in social competence in youth with autism spectrum disorder but also contributes to reductions in trait-anxiety associated with more social interaction with peers. Results suggest that some degree of physiological arousal is essential for social interaction. En ligne : http://dx.doi.org/10.1177/1362361316643623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475
in Autism > 21-3 (April 2017) . - p.333-343[article] Changes in anxiety following a randomized control trial of a theatre-based intervention for youth with autism spectrum disorder [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Scott D. BLAIN, Auteur ; Sara IOANNOU, Auteur ; Maddie BALSER, Auteur . - p.333-343.
Langues : Anglais (eng)
in Autism > 21-3 (April 2017) . - p.333-343
Mots-clés : Adolescent Anxiety/ epidemiology/etiology Autism Spectrum Disorder/psychology/ therapy Child Female Humans Hydrocortisone/analysis Male Psychodrama/methods Saliva/chemistry anxiety autism spectrum disorders competence cortisol stress theatre Index. décimale : PER Périodiques Résumé : Increased anxiety and stress are frequently found in children with autism spectrum disorder and are associated with social challenges. Recently, we reported changes in social competence following peer-mediated, theatre-based intervention. The purpose of this study was to examine the impact of the intervention on reducing anxiety and stress. Participants included 30 youth with autism spectrum disorder (8-14?years old) randomly assigned to the experimental (17) or waitlist control (13) group. Pretest adjusted, between-group differences were analyzed for state-anxiety, trait-anxiety, play-based cortisol, and diurnal cortisol. Pearson correlations were conducted between anxiety, cortisol, and group play. Significant pretest-adjusted between-group differences at posttest were observed on trait-anxiety (F(1, 27)=9.16, p=0.005) but not state-anxiety (F(1, 27)=0.03, p=0.86), showing lower trait-anxiety in the experimental group. There were no between-group differences on cortisol. There was a significant negative correlation between group play and trait-anxiety (r=-0.362, p=0.05). Playground cortisol correlated with group play, for the experimental group (r=0.55, p=0.03). The theatre-based, peer-mediated intervention not only contributes to improvement in social competence in youth with autism spectrum disorder but also contributes to reductions in trait-anxiety associated with more social interaction with peers. Results suggest that some degree of physiological arousal is essential for social interaction. En ligne : http://dx.doi.org/10.1177/1362361316643623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475