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Does the cognitive architecture of simplex and multiplex ASD families differ? / Anoek M. OERLEMANS in Journal of Autism and Developmental Disorders, 46-2 (February 2016)
[article]
Titre : Does the cognitive architecture of simplex and multiplex ASD families differ? Type de document : Texte imprimé et/ou numérique Auteurs : Anoek M. OERLEMANS, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur Année de publication : 2016 Article en page(s) : p.489-501 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder (ASD) Simplex-multiplex stratification Family Unaffected siblings Cognition Index. décimale : PER Périodiques Résumé : Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2572-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.489-501[article] Does the cognitive architecture of simplex and multiplex ASD families differ? [Texte imprimé et/ou numérique] / Anoek M. OERLEMANS, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur . - 2016 . - p.489-501.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.489-501
Mots-clés : Autism Spectrum Disorder (ASD) Simplex-multiplex stratification Family Unaffected siblings Cognition Index. décimale : PER Périodiques Résumé : Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2572-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 Cognitive impairments are different in single-incidence and multi-incidence ADHD families / Anoek M. OERLEMANS in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)
[article]
Titre : Cognitive impairments are different in single-incidence and multi-incidence ADHD families Type de document : Texte imprimé et/ou numérique Auteurs : Anoek M. OERLEMANS, Auteur ; Catharina A. HARTMAN, Auteur ; Yvette G. E. DE BRUIJN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur Article en page(s) : p.782-791 Langues : Anglais (eng) Mots-clés : Attention-Deficit/Hyperactivity Disorder (ADHD) simplex-multiplex stratification family unaffected relative endophenotype Index. décimale : PER Périodiques Résumé : Background We may improve our understanding of the role of common versus unique risk factors in attention-deficit/hyperactivity disorder (ADHD) by examining ADHD-related cognitive deficits in single- (SPX), and multi-incidence (MPX) families. Given that individuals from multiplex (MPX) families are likely to share genetic vulnerability for the disorder, whereas simplex (SPX) ADHD may be the result of sporadic (non-)genetic causes unique to the patient, we hypothesized that cognitive impairments may be different in SPX and MPX ADHD as indicated by (a) the presence of cognitive deficits in MPX, but not SPX unaffected siblings and (b) dissimilar cognitive profiles in SPX and MPX ADHD patients. Methods Tasks measuring total IQ, verbal attention, executive functioning, motor functioning, and time estimation were administered to 31 SPX/264 MPX ADHD probands, 47 SPX/123 MPX unaffected siblings, and 263 controls, aged 6–19 years. Results SPX unaffected siblings were unimpaired compared to controls, except for verbal working memory, whereas MPX unaffected siblings showed impairments on most cognitive domains. The cognitive profiles of SPX and MPX probands were highly similar, except that verbal attention, response inhibition and motor control deficits were more pronounced in MPX probands, and -compared to their unaffected siblings- impairments in IQ, visual working memory and timing abilities were more pronounced in SPX cases. Conclusions Our results support the hypothesis that a partly different cognitive architecture may underlie SPX and MPX forms of ADHD, which becomes evident when contrasting cognitive performances within families. Cognitive factors underlying MPX forms of ADHD are familial, whereas nonfamilial in SPX ADHD. SPX-MPX stratification may be a step forward in unraveling diverse causal pathways. En ligne : http://dx.doi.org/10.1111/jcpp.12349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.782-791[article] Cognitive impairments are different in single-incidence and multi-incidence ADHD families [Texte imprimé et/ou numérique] / Anoek M. OERLEMANS, Auteur ; Catharina A. HARTMAN, Auteur ; Yvette G. E. DE BRUIJN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur . - p.782-791.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.782-791
Mots-clés : Attention-Deficit/Hyperactivity Disorder (ADHD) simplex-multiplex stratification family unaffected relative endophenotype Index. décimale : PER Périodiques Résumé : Background We may improve our understanding of the role of common versus unique risk factors in attention-deficit/hyperactivity disorder (ADHD) by examining ADHD-related cognitive deficits in single- (SPX), and multi-incidence (MPX) families. Given that individuals from multiplex (MPX) families are likely to share genetic vulnerability for the disorder, whereas simplex (SPX) ADHD may be the result of sporadic (non-)genetic causes unique to the patient, we hypothesized that cognitive impairments may be different in SPX and MPX ADHD as indicated by (a) the presence of cognitive deficits in MPX, but not SPX unaffected siblings and (b) dissimilar cognitive profiles in SPX and MPX ADHD patients. Methods Tasks measuring total IQ, verbal attention, executive functioning, motor functioning, and time estimation were administered to 31 SPX/264 MPX ADHD probands, 47 SPX/123 MPX unaffected siblings, and 263 controls, aged 6–19 years. Results SPX unaffected siblings were unimpaired compared to controls, except for verbal working memory, whereas MPX unaffected siblings showed impairments on most cognitive domains. The cognitive profiles of SPX and MPX probands were highly similar, except that verbal attention, response inhibition and motor control deficits were more pronounced in MPX probands, and -compared to their unaffected siblings- impairments in IQ, visual working memory and timing abilities were more pronounced in SPX cases. Conclusions Our results support the hypothesis that a partly different cognitive architecture may underlie SPX and MPX forms of ADHD, which becomes evident when contrasting cognitive performances within families. Cognitive factors underlying MPX forms of ADHD are familial, whereas nonfamilial in SPX ADHD. SPX-MPX stratification may be a step forward in unraveling diverse causal pathways. En ligne : http://dx.doi.org/10.1111/jcpp.12349 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260