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Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention / Hsing-Chang NI in Autism, 25-5 (July 2021)
[article]
Titre : Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention Type de document : Texte imprimé et/ou numérique Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.1279-1294 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy Child Double-Blind Method Humans Single-Blind Method Temporal Lobe Transcranial Magnetic Stimulation Treatment Outcome autism spectrum disorder children and adolescents intervention posterior superior temporal sulcus theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8?weeks. Those in the sham group received two-session/week sham stimulations in the first 4?weeks and then active intervention for the following 4?weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475
in Autism > 25-5 (July 2021) . - p.1279-1294[article] Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention [Texte imprimé et/ou numérique] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur . - p.1279-1294.
Langues : Anglais (eng)
in Autism > 25-5 (July 2021) . - p.1279-1294
Mots-clés : Autism Spectrum Disorder/therapy Child Double-Blind Method Humans Single-Blind Method Temporal Lobe Transcranial Magnetic Stimulation Treatment Outcome autism spectrum disorder children and adolescents intervention posterior superior temporal sulcus theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8?weeks. Those in the sham group received two-session/week sham stimulations in the first 4?weeks and then active intervention for the following 4?weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention / Hsing-Chang NI in Autism, 26-5 (July 2022)
[article]
Titre : Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention Type de document : Texte imprimé et/ou numérique Auteurs : Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur Article en page(s) : p.1279-1294 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy Child Double-Blind Method Humans Single-Blind Method Temporal Lobe Transcranial Magnetic Stimulation Treatment Outcome autism spectrum disorder children and adolescents intervention posterior superior temporal sulcus theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8weeks. Those in the sham group received two-session/week sham stimulations in the first 4weeks and then active intervention for the following 4weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483
in Autism > 26-5 (July 2022) . - p.1279-1294[article] Intermittent theta burst stimulation over the posterior superior temporal sulcus for children with autism spectrum disorder: A 4-week randomized blinded controlled trial followed by another 4-week open-label intervention [Texte imprimé et/ou numérique] / Hsing-Chang NI, Auteur ; Yi-Lung CHEN, Auteur ; Yi-Ping CHAO, Auteur ; Chen-Te WU, Auteur ; Yu-Yu WU, Auteur ; Sophie Hsin-Yi LIANG, Auteur ; Wei-Chih CHIN, Auteur ; Tai-Li CHOU, Auteur ; Susan Shur-Fen GAU, Auteur ; Ying-Zu HUANG, Auteur ; Hsiang-Yuan LIN, Auteur . - p.1279-1294.
Langues : Anglais (eng)
in Autism > 26-5 (July 2022) . - p.1279-1294
Mots-clés : Autism Spectrum Disorder/therapy Child Double-Blind Method Humans Single-Blind Method Temporal Lobe Transcranial Magnetic Stimulation Treatment Outcome autism spectrum disorder children and adolescents intervention posterior superior temporal sulcus theta burst stimulation Index. décimale : PER Périodiques Résumé : Intermittent theta burst stimulation is a varied form of repetitive transcranial magnetic non-invasive brain stimulation technique used to treat several neurological and psychiatric disorders. Its feasibility and therapeutic effects on the bilateral posterior superior temporal sulcus in children with autism are unknown. We conducted a single-blind, sham-controlled parallel randomized clinical trial in a hitherto largest sample of intellectually able children with autism (N=78). Participants randomized to the active group received two-session/week intermittent theta burst stimulation for continuous 8weeks. Those in the sham group received two-session/week sham stimulations in the first 4weeks and then active intervention for the following 4weeks after unblinding. First, we found that continuous 8-week intermittent theta burst stimulation on the bilateral posterior superior temporal sulcus in children with autism is safe and tolerable. Second, we found that 8-week intermittent theta burst stimulation produced greater therapeutic efficacy, although we did not find any significant effects of 4-week intermittent theta burst stimulation on core symptoms and social cognitive performances in autism. Further analysis revealed that participants with higher intelligence and better social cognitive performance, alongside less attention-deficit hyperactivity disorder severity at baseline, were more likely to be responders. This study identified that the factors contribute to responders and the results suggest that longer courses of non-invasive brain stimulation may be needed to produce therapeutic benefits in autism, with consideration of heterogeneous responses. En ligne : http://dx.doi.org/10.1177/1362361321990534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 Altered gaze following during live interaction in infants at risk for autism: an eye tracking study / E. THORUP in Molecular Autism, 7 (2016)
[article]
Titre : Altered gaze following during live interaction in infants at risk for autism: an eye tracking study Type de document : Texte imprimé et/ou numérique Auteurs : E. THORUP, Auteur ; P. NYSTROM, Auteur ; G. GREDEBACK, Auteur ; Sven BÖLTE, Auteur ; T. FALCK-YTTER, Auteur Article en page(s) : 12p. Langues : Anglais (eng) Mots-clés : Attention/physiology Autism Spectrum Disorder/diagnosis/epidemiology/physiopathology Cues Early Diagnosis Eye Movements Family Health Female Fixation, Ocular/physiology Head Movements Humans Imitative Behavior/physiology Infant Male Pursuit, Smooth/physiology Risk Single-Blind Method Social Behavior Social Perception Autism Communication Early development Gaze following Joint attention Neurodevelopmental disorders Social cognition Younger siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: The ability to follow gaze is an important prerequisite for joint attention, which is often compromised in children with autism spectrum disorder (ASD). The direction of both the head and eyes provides cues to other people's attention direction, but previous studies have not separated these factors and their relation to ASD susceptibility. Development of gaze following typically occurs before ASD diagnosis is possible, and studies of high-risk populations are therefore important. METHODS: Eye tracking was used to assess gaze following during interaction in a group of 10-month-old infants at high familial risk for ASD (high-risk group) as well as a group of infants with no family history of ASD (low-risk group). The infants watched an experimenter gaze at objects in the periphery. Performance was compared across two conditions: one in which the experimenter moved both the eyes and head toward the objects (Eyes and Head condition) and one that involved movement of the eyes only (Eyes Only condition). RESULTS: A group by condition interaction effect was found. Specifically, whereas gaze following accuracy was comparable across the two conditions in the low-risk group, infants in the high-risk group were more likely to follow gaze in the Eyes and Head condition than in the Eyes Only condition. CONCLUSIONS: In an ecologically valid social situation, responses to basic non-verbal orienting cues were found to be altered in infants at risk for ASD. The results indicate that infants at risk for ASD may rely disproportionally on information from the head when following gaze and point to the importance of separating information from the eyes and the head when studying social perception in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0069-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 12p.[article] Altered gaze following during live interaction in infants at risk for autism: an eye tracking study [Texte imprimé et/ou numérique] / E. THORUP, Auteur ; P. NYSTROM, Auteur ; G. GREDEBACK, Auteur ; Sven BÖLTE, Auteur ; T. FALCK-YTTER, Auteur . - 12p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 12p.
Mots-clés : Attention/physiology Autism Spectrum Disorder/diagnosis/epidemiology/physiopathology Cues Early Diagnosis Eye Movements Family Health Female Fixation, Ocular/physiology Head Movements Humans Imitative Behavior/physiology Infant Male Pursuit, Smooth/physiology Risk Single-Blind Method Social Behavior Social Perception Autism Communication Early development Gaze following Joint attention Neurodevelopmental disorders Social cognition Younger siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: The ability to follow gaze is an important prerequisite for joint attention, which is often compromised in children with autism spectrum disorder (ASD). The direction of both the head and eyes provides cues to other people's attention direction, but previous studies have not separated these factors and their relation to ASD susceptibility. Development of gaze following typically occurs before ASD diagnosis is possible, and studies of high-risk populations are therefore important. METHODS: Eye tracking was used to assess gaze following during interaction in a group of 10-month-old infants at high familial risk for ASD (high-risk group) as well as a group of infants with no family history of ASD (low-risk group). The infants watched an experimenter gaze at objects in the periphery. Performance was compared across two conditions: one in which the experimenter moved both the eyes and head toward the objects (Eyes and Head condition) and one that involved movement of the eyes only (Eyes Only condition). RESULTS: A group by condition interaction effect was found. Specifically, whereas gaze following accuracy was comparable across the two conditions in the low-risk group, infants in the high-risk group were more likely to follow gaze in the Eyes and Head condition than in the Eyes Only condition. CONCLUSIONS: In an ecologically valid social situation, responses to basic non-verbal orienting cues were found to be altered in infants at risk for ASD. The results indicate that infants at risk for ASD may rely disproportionally on information from the head when following gaze and point to the importance of separating information from the eyes and the head when studying social perception in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0069-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329