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Social Responsiveness and Competence in Prader-Willi Syndrome: Direct Comparison to Autism Spectrum Disorder / Anastasia DIMITROPOULOS in Journal of Autism and Developmental Disorders, 43-1 (January 2013)
[article]
Titre : Social Responsiveness and Competence in Prader-Willi Syndrome: Direct Comparison to Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Anastasia DIMITROPOULOS, Auteur ; Alan HO, Auteur ; Benjamin FELDMAN, Auteur Année de publication : 2013 Article en page(s) : p.103-113 Langues : Anglais (eng) Mots-clés : Prader-Willi syndrome Social deficit Social responsiveness Social competence Autism spectrum disorder Maternal uniparental disomy Index. décimale : PER Périodiques Résumé : Prader-Willi syndrome (PWS), a neurodevelopmental disorder primarily characterized by hyperphagia and food preoccupations, is caused by the absence of expression of the paternally active genes in the proximal arm of chromosome 15. Although maladaptive behavior and the cognitive profile in PWS have been well characterized, social functioning has only more recently been systematically examined. Findings to date indicate the social impairment exhibited may reflect specific difficulty interpreting and using social information effectively. In addition, evidence suggests that there is an increased risk of social deficits in people with the maternally-derived uniparental disomy (mUPD) subtype of PWS in comparison to those with 15q11'13 paternal deletion (DEL). Using the Social Responsiveness Scale (SRS) and the Social Competence Inventory, our goal was to compare social functioning in PWS to individuals with autism spectrum disorder (ASD). Participants with mUPD scored similarly to the ASD group across most SRS domains. All groups had difficulty with social competence, although the DEL group scored highest on prosocial behavior. Findings suggest further characterization of social behavior in PWS is necessary to aid in advancing the understanding of the contributions of genes in the 15q11'13 critical region to ASD susceptibility, particularly with respect to the overexpression of maternally expressed genes in this region, as well as aiding in awareness and development/implementation of interventions. En ligne : http://dx.doi.org/10.1007/s10803-012-1547-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.103-113[article] Social Responsiveness and Competence in Prader-Willi Syndrome: Direct Comparison to Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Anastasia DIMITROPOULOS, Auteur ; Alan HO, Auteur ; Benjamin FELDMAN, Auteur . - 2013 . - p.103-113.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.103-113
Mots-clés : Prader-Willi syndrome Social deficit Social responsiveness Social competence Autism spectrum disorder Maternal uniparental disomy Index. décimale : PER Périodiques Résumé : Prader-Willi syndrome (PWS), a neurodevelopmental disorder primarily characterized by hyperphagia and food preoccupations, is caused by the absence of expression of the paternally active genes in the proximal arm of chromosome 15. Although maladaptive behavior and the cognitive profile in PWS have been well characterized, social functioning has only more recently been systematically examined. Findings to date indicate the social impairment exhibited may reflect specific difficulty interpreting and using social information effectively. In addition, evidence suggests that there is an increased risk of social deficits in people with the maternally-derived uniparental disomy (mUPD) subtype of PWS in comparison to those with 15q11'13 paternal deletion (DEL). Using the Social Responsiveness Scale (SRS) and the Social Competence Inventory, our goal was to compare social functioning in PWS to individuals with autism spectrum disorder (ASD). Participants with mUPD scored similarly to the ASD group across most SRS domains. All groups had difficulty with social competence, although the DEL group scored highest on prosocial behavior. Findings suggest further characterization of social behavior in PWS is necessary to aid in advancing the understanding of the contributions of genes in the 15q11'13 critical region to ASD susceptibility, particularly with respect to the overexpression of maternally expressed genes in this region, as well as aiding in awareness and development/implementation of interventions. En ligne : http://dx.doi.org/10.1007/s10803-012-1547-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 Brief Report: Theory of Mind, Relational Reasoning, and Social Responsiveness in Children With and Without Autism: Demonstration of Feasibility for a Larger-Scale Study / John R PRUETT in Journal of Autism and Developmental Disorders, 45-7 (July 2015)
[article]
Titre : Brief Report: Theory of Mind, Relational Reasoning, and Social Responsiveness in Children With and Without Autism: Demonstration of Feasibility for a Larger-Scale Study Type de document : Texte imprimé et/ou numérique Auteurs : John R PRUETT, Auteur ; Sridhar KANDALA, Auteur ; Steven E. PETERSEN, Auteur ; Daniel J. POVINELLI, Auteur Année de publication : 2015 Article en page(s) : p.2243-2251 Langues : Anglais (eng) Mots-clés : Theory of mind Relational reasoning Analogical reasoning Social responsiveness Autism Cognition Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-015-2357-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261
in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2243-2251[article] Brief Report: Theory of Mind, Relational Reasoning, and Social Responsiveness in Children With and Without Autism: Demonstration of Feasibility for a Larger-Scale Study [Texte imprimé et/ou numérique] / John R PRUETT, Auteur ; Sridhar KANDALA, Auteur ; Steven E. PETERSEN, Auteur ; Daniel J. POVINELLI, Auteur . - 2015 . - p.2243-2251.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2243-2251
Mots-clés : Theory of mind Relational reasoning Analogical reasoning Social responsiveness Autism Cognition Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-015-2357-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 Mothers of children with autism spectrum disorders: Play behaviors with infant siblings and social responsiveness / A. J. SCHWICHTENBERG in Autism, 23-4 (May 2019)
[article]
Titre : Mothers of children with autism spectrum disorders: Play behaviors with infant siblings and social responsiveness Type de document : Texte imprimé et/ou numérique Auteurs : A. J. SCHWICHTENBERG, Auteur ; A. M. KELLERMAN, Auteur ; Gregory S. YOUNG, Auteur ; M. MILLER, Auteur ; S. OZONOFF, Auteur Article en page(s) : p.821-833 Langues : Anglais (eng) Mots-clés : autism spectrum disorder infant sibling mother-infant interaction parent-mediated intervention social responsiveness Index. décimale : PER Périodiques Résumé : Mother-infant interactions are a proximal process in early development and may be especially salient for children who are at risk for social difficulties (i.e. infant siblings of children with autism spectrum disorder). To inform how indices of maternal behaviors may improve parent-mediated interventions designed to mitigate autism spectrum disorder risk, the present study explored maternal social responsiveness ratings and social behaviors during dyadic play interactions. Dyads were recruited from families with at least one older child with autism spectrum disorder (high-risk group, n = 90) or families with no history of autism spectrum disorder (low-risk group, n = 62). As part of a prospective study, interactions were coded when infant siblings were 6, 9, and 12 months of age, for gaze, affect, vocalizations, and multimodal bids or responses (i.e. social smiles). Maternal social responsiveness was indexed via the Social Responsiveness Scale. Mothers in both risk groups had comparable Social Responsiveness Scale scores and social behaviors during play. Two maternal behaviors emerged as positive correlates of infant social behaviors and are thus of high relevance to parent-mediated interventions. Specifically, more maternal positive affect and the use of multimodal bids or responses were associated with more infant positive affect, vocalizations, gaze to face, and multimodal bids or responses. En ligne : http://dx.doi.org/10.1177/1362361318782220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397
in Autism > 23-4 (May 2019) . - p.821-833[article] Mothers of children with autism spectrum disorders: Play behaviors with infant siblings and social responsiveness [Texte imprimé et/ou numérique] / A. J. SCHWICHTENBERG, Auteur ; A. M. KELLERMAN, Auteur ; Gregory S. YOUNG, Auteur ; M. MILLER, Auteur ; S. OZONOFF, Auteur . - p.821-833.
Langues : Anglais (eng)
in Autism > 23-4 (May 2019) . - p.821-833
Mots-clés : autism spectrum disorder infant sibling mother-infant interaction parent-mediated intervention social responsiveness Index. décimale : PER Périodiques Résumé : Mother-infant interactions are a proximal process in early development and may be especially salient for children who are at risk for social difficulties (i.e. infant siblings of children with autism spectrum disorder). To inform how indices of maternal behaviors may improve parent-mediated interventions designed to mitigate autism spectrum disorder risk, the present study explored maternal social responsiveness ratings and social behaviors during dyadic play interactions. Dyads were recruited from families with at least one older child with autism spectrum disorder (high-risk group, n = 90) or families with no history of autism spectrum disorder (low-risk group, n = 62). As part of a prospective study, interactions were coded when infant siblings were 6, 9, and 12 months of age, for gaze, affect, vocalizations, and multimodal bids or responses (i.e. social smiles). Maternal social responsiveness was indexed via the Social Responsiveness Scale. Mothers in both risk groups had comparable Social Responsiveness Scale scores and social behaviors during play. Two maternal behaviors emerged as positive correlates of infant social behaviors and are thus of high relevance to parent-mediated interventions. Specifically, more maternal positive affect and the use of multimodal bids or responses were associated with more infant positive affect, vocalizations, gaze to face, and multimodal bids or responses. En ligne : http://dx.doi.org/10.1177/1362361318782220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 Social Behaviors Increase More When Children With ASD Are Imitated by Their Mother vs. an Unfamiliar Adult / Virginia SLAUGHTER in Autism Research, 7-5 (October 2014)
[article]
Titre : Social Behaviors Increase More When Children With ASD Are Imitated by Their Mother vs. an Unfamiliar Adult Type de document : Texte imprimé et/ou numérique Auteurs : Virginia SLAUGHTER, Auteur ; Su Sen ONG, Auteur Article en page(s) : p.582-589 Langues : Anglais (eng) Mots-clés : autism spectrum disorders imitation mother–child interaction intervention social responsiveness Index. décimale : PER Périodiques Résumé : Previous research suggests that being imitated by an adult increases the social behaviors of children with an autism spectrum disorder (ASD). In the current study, we examined whether familiarity with the imitating social partner modulates this effect. Ten children with ASD and their mothers participated. The children's social behaviors were observed prior to and following a 3-min period in which an adult social partner imitated everything they did. In one condition the partner was the child's mother, and in the other condition the partner was an unfamiliar experimenter. The results revealed significant increases in distal social behaviors (gazes toward the adult, vocalizing) following imitation by both partners. There was a significantly greater increase in proximal social behaviors (including approach, being physically close, and touching) and a greater decrease in playing alone when the imitator was the child's mother as opposed to the experimenter. The findings suggest that the experience of being imitated creates an atmosphere of mutuality and rapport between children with ASD and their social partners, which increases their sociability even in interactions with already familiar adults. Autism Res 2014, 7: 582–589. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1392 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Autism Research > 7-5 (October 2014) . - p.582-589[article] Social Behaviors Increase More When Children With ASD Are Imitated by Their Mother vs. an Unfamiliar Adult [Texte imprimé et/ou numérique] / Virginia SLAUGHTER, Auteur ; Su Sen ONG, Auteur . - p.582-589.
Langues : Anglais (eng)
in Autism Research > 7-5 (October 2014) . - p.582-589
Mots-clés : autism spectrum disorders imitation mother–child interaction intervention social responsiveness Index. décimale : PER Périodiques Résumé : Previous research suggests that being imitated by an adult increases the social behaviors of children with an autism spectrum disorder (ASD). In the current study, we examined whether familiarity with the imitating social partner modulates this effect. Ten children with ASD and their mothers participated. The children's social behaviors were observed prior to and following a 3-min period in which an adult social partner imitated everything they did. In one condition the partner was the child's mother, and in the other condition the partner was an unfamiliar experimenter. The results revealed significant increases in distal social behaviors (gazes toward the adult, vocalizing) following imitation by both partners. There was a significantly greater increase in proximal social behaviors (including approach, being physically close, and touching) and a greater decrease in playing alone when the imitator was the child's mother as opposed to the experimenter. The findings suggest that the experience of being imitated creates an atmosphere of mutuality and rapport between children with ASD and their social partners, which increases their sociability even in interactions with already familiar adults. Autism Res 2014, 7: 582–589. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1392 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up / Sylvie BERNAERTS in Molecular Autism, 11 (2020)
[article]
Titre : Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up Type de document : Texte imprimé et/ou numérique Auteurs : Sylvie BERNAERTS, Auteur ; Bart BOETS, Auteur ; Guy BOSMANS, Auteur ; Jean STEYAERT, Auteur ; Kaat ALAERTS, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Attachment Autism spectrum disorder Oxytocin Repetitive and restricted behavior Social responsiveness Index. décimale : PER Périodiques Résumé : BACKGROUND: Intranasal administration of the "prosocial" neuropeptide oxytocin is increasingly explored as a potential treatment for targeting the core characteristics of autism spectrum disorder (ASD). However, long-term follow-up studies, evaluating the possibility of long-lasting retention effects, are currently lacking. METHODS: Using a double-blind, randomized, placebo-controlled, parallel design, this pilot clinical trial explored the possibility of long-lasting behavioral effects of 4 weeks of intranasal oxytocin treatment (24 International Units once daily in the morning) in 40 adult men with ASD. To do so, self-report and informant-based questionnaires assessing core autism symptoms and characterizations of attachment were administered at baseline, immediately after 4 weeks of treatment (approximately 24 h after the last nasal spray administration), and at two follow-up sessions, 4 weeks and 1 year post-treatment. RESULTS: No treatment-specific effects were identified in the primary outcome assessing social symptoms (Social Responsiveness Scale, self- and informant-rated). In particular, with respect to self-reported social responsiveness, improvements were evident both in the oxytocin and in the placebo group, yielding no significant between-group difference (p = .37). Also informant-rated improvements in social responsiveness were not significantly larger in the oxytocin, compared to the placebo group (between-group difference: p = .19). Among the secondary outcome measures, treatment-specific improvements were identified in the Repetitive Behavior Scale and State Adult Attachment Measure, indicating reductions in self-reported repetitive behaviors (p = .04) and reduced feelings of avoidance toward others (p = .03) in the oxytocin group compared to the placebo group, up to 1 month and even 1 year post-treatment. Treatment-specific effects were also revealed in screenings of mood states (Profile of Mood States), indicating higher reports of "vigor" (feeling energetic, active, lively) in the oxytocin, compared to the placebo group (p = .03). CONCLUSIONS: While no treatment-specific improvements were evident in terms of core social symptoms, the current observations of long-term beneficial effects on repetitive behaviors and feelings of avoidance are promising and suggestive of a therapeutic potential of oxytocin treatment for ASD. However, given the exploratory nature of this pilot study, future studies are warranted to evaluate the long-term effects of OT administration further. TRIAL REGISTRATION: The trial was registered with the European Clinical Trial Registry (Eudract 2014-000586-45) on January 22, 2014 (https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-000586-45/BE). En ligne : http://dx.doi.org/10.1186/s13229-020-0313-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 6 p.[article] Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up [Texte imprimé et/ou numérique] / Sylvie BERNAERTS, Auteur ; Bart BOETS, Auteur ; Guy BOSMANS, Auteur ; Jean STEYAERT, Auteur ; Kaat ALAERTS, Auteur . - 6 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 6 p.
Mots-clés : Attachment Autism spectrum disorder Oxytocin Repetitive and restricted behavior Social responsiveness Index. décimale : PER Périodiques Résumé : BACKGROUND: Intranasal administration of the "prosocial" neuropeptide oxytocin is increasingly explored as a potential treatment for targeting the core characteristics of autism spectrum disorder (ASD). However, long-term follow-up studies, evaluating the possibility of long-lasting retention effects, are currently lacking. METHODS: Using a double-blind, randomized, placebo-controlled, parallel design, this pilot clinical trial explored the possibility of long-lasting behavioral effects of 4 weeks of intranasal oxytocin treatment (24 International Units once daily in the morning) in 40 adult men with ASD. To do so, self-report and informant-based questionnaires assessing core autism symptoms and characterizations of attachment were administered at baseline, immediately after 4 weeks of treatment (approximately 24 h after the last nasal spray administration), and at two follow-up sessions, 4 weeks and 1 year post-treatment. RESULTS: No treatment-specific effects were identified in the primary outcome assessing social symptoms (Social Responsiveness Scale, self- and informant-rated). In particular, with respect to self-reported social responsiveness, improvements were evident both in the oxytocin and in the placebo group, yielding no significant between-group difference (p = .37). Also informant-rated improvements in social responsiveness were not significantly larger in the oxytocin, compared to the placebo group (between-group difference: p = .19). Among the secondary outcome measures, treatment-specific improvements were identified in the Repetitive Behavior Scale and State Adult Attachment Measure, indicating reductions in self-reported repetitive behaviors (p = .04) and reduced feelings of avoidance toward others (p = .03) in the oxytocin group compared to the placebo group, up to 1 month and even 1 year post-treatment. Treatment-specific effects were also revealed in screenings of mood states (Profile of Mood States), indicating higher reports of "vigor" (feeling energetic, active, lively) in the oxytocin, compared to the placebo group (p = .03). CONCLUSIONS: While no treatment-specific improvements were evident in terms of core social symptoms, the current observations of long-term beneficial effects on repetitive behaviors and feelings of avoidance are promising and suggestive of a therapeutic potential of oxytocin treatment for ASD. However, given the exploratory nature of this pilot study, future studies are warranted to evaluate the long-term effects of OT administration further. TRIAL REGISTRATION: The trial was registered with the European Clinical Trial Registry (Eudract 2014-000586-45) on January 22, 2014 (https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-000586-45/BE). En ligne : http://dx.doi.org/10.1186/s13229-020-0313-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Extending the ‘cross-disorder’ relevance of executive functions to dimensional neuropsychiatric traits in youth / Lauren M. MCGRATH in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)
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