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Reduced GABA and altered somatosensory function in children with autism spectrum disorder / Nicolaas A. J. PUTS in Autism Research, 10-4 (April 2017)
[article]
Titre : Reduced GABA and altered somatosensory function in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicolaas A. J. PUTS, Auteur ; Ericka L. WODKA, Auteur ; Ashley D. HARRIS, Auteur ; Deana CROCETTI, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur Article en page(s) : p.608-619 Langues : Anglais (eng) Mots-clés : autism somatosensory GABA magnetic resonance spectroscopy tactile MRS touch Index. décimale : PER Périodiques Résumé : Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA-edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with- and without the presence of a slowly increasing sub-threshold stimulus. Amplitude discrimination was measured with- and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub-threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. En ligne : http://dx.doi.org/10.1002/aur.1691 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307
in Autism Research > 10-4 (April 2017) . - p.608-619[article] Reduced GABA and altered somatosensory function in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Nicolaas A. J. PUTS, Auteur ; Ericka L. WODKA, Auteur ; Ashley D. HARRIS, Auteur ; Deana CROCETTI, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur . - p.608-619.
Langues : Anglais (eng)
in Autism Research > 10-4 (April 2017) . - p.608-619
Mots-clés : autism somatosensory GABA magnetic resonance spectroscopy tactile MRS touch Index. décimale : PER Périodiques Résumé : Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA-edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with- and without the presence of a slowly increasing sub-threshold stimulus. Amplitude discrimination was measured with- and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub-threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. En ligne : http://dx.doi.org/10.1002/aur.1691 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 The Role of Attention in Somatosensory Processing: A Multi-trait, Multi-method Analysis / Ericka L. WODKA in Journal of Autism and Developmental Disorders, 46-10 (October 2016)
[article]
Titre : The Role of Attention in Somatosensory Processing: A Multi-trait, Multi-method Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Ericka L. WODKA, Auteur ; Nicolaas A. J. PUTS, Auteur ; E. Mark MAHONE, Auteur ; Richard A. E. EDDEN, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur Article en page(s) : p.3232-3241 Langues : Anglais (eng) Mots-clés : Autism Sensory processing Attention Vibrotactile Somatosensory Index. décimale : PER Périodiques Résumé : Sensory processing abnormalities in autism have largely been described by parent report. This study used a multi-method (parent-report and measurement), multi-trait (tactile sensitivity and attention) design to evaluate somatosensory processing in ASD. Results showed multiple significant within-method (e.g., parent report of different traits)/cross-trait (e.g., attention and tactile sensitivity) correlations, suggesting that parent-reported tactile sensory dysfunction and performance-based tactile sensitivity describe different behavioral phenomena. Additionally, both parent-reported tactile functioning and performance-based tactile sensitivity measures were significantly associated with measures of attention. Findings suggest that sensory (tactile) processing abnormalities in ASD are multifaceted, and may partially reflect a more global deficit in behavioral regulation (including attention). Challenges of relying solely on parent-report to describe sensory difficulties faced by children/families with ASD are also highlighted. En ligne : http://dx.doi.org/10.1007/s10803-016-2866-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293
in Journal of Autism and Developmental Disorders > 46-10 (October 2016) . - p.3232-3241[article] The Role of Attention in Somatosensory Processing: A Multi-trait, Multi-method Analysis [Texte imprimé et/ou numérique] / Ericka L. WODKA, Auteur ; Nicolaas A. J. PUTS, Auteur ; E. Mark MAHONE, Auteur ; Richard A. E. EDDEN, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur . - p.3232-3241.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-10 (October 2016) . - p.3232-3241
Mots-clés : Autism Sensory processing Attention Vibrotactile Somatosensory Index. décimale : PER Périodiques Résumé : Sensory processing abnormalities in autism have largely been described by parent report. This study used a multi-method (parent-report and measurement), multi-trait (tactile sensitivity and attention) design to evaluate somatosensory processing in ASD. Results showed multiple significant within-method (e.g., parent report of different traits)/cross-trait (e.g., attention and tactile sensitivity) correlations, suggesting that parent-reported tactile sensory dysfunction and performance-based tactile sensitivity describe different behavioral phenomena. Additionally, both parent-reported tactile functioning and performance-based tactile sensitivity measures were significantly associated with measures of attention. Findings suggest that sensory (tactile) processing abnormalities in ASD are multifaceted, and may partially reflect a more global deficit in behavioral regulation (including attention). Challenges of relying solely on parent-report to describe sensory difficulties faced by children/families with ASD are also highlighted. En ligne : http://dx.doi.org/10.1007/s10803-016-2866-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 Hyper-responsiveness to touch mediates social dysfunction in adults with autism spectrum disorders / Lars-Olov LUNDQVIST in Research in Autism Spectrum Disorders, 9 (January 2015)
[article]
Titre : Hyper-responsiveness to touch mediates social dysfunction in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lars-Olov LUNDQVIST, Auteur Année de publication : 2015 Article en page(s) : p.13-20 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Touch Tactile Somatosensory Sensory processing Index. décimale : PER Périodiques Résumé : Abstract This study investigated whether hyper-responsiveness to touch serves as a mediating variable that predicts social dysfunction in adults with autism spectrum disorders (ASD). Data were obtained from all adults with administratively defined intellectual disability in a region in Sweden (n = 915, where 143 had ASD). A multiple mediation modeling analysis revealed a well-fitted model (Satorra–Bentler scaled chi-square = 10.91, df = 7, p = 0.14, CFI = 0.99, RMSEA = 0.025), demonstrating that social dysfunction among adults with ASD was completely mediated by hyper-responsiveness to touch followed by impairment of speech and aggressive/destructive behavior. The results demonstrated that in adulthood, the tactile sensory system is foundational for social functioning in people with ASD, with diagnosis and intervention implications. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.13-20[article] Hyper-responsiveness to touch mediates social dysfunction in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Lars-Olov LUNDQVIST, Auteur . - 2015 . - p.13-20.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.13-20
Mots-clés : Autism spectrum disorders Touch Tactile Somatosensory Sensory processing Index. décimale : PER Périodiques Résumé : Abstract This study investigated whether hyper-responsiveness to touch serves as a mediating variable that predicts social dysfunction in adults with autism spectrum disorders (ASD). Data were obtained from all adults with administratively defined intellectual disability in a region in Sweden (n = 915, where 143 had ASD). A multiple mediation modeling analysis revealed a well-fitted model (Satorra–Bentler scaled chi-square = 10.91, df = 7, p = 0.14, CFI = 0.99, RMSEA = 0.025), demonstrating that social dysfunction among adults with ASD was completely mediated by hyper-responsiveness to touch followed by impairment of speech and aggressive/destructive behavior. The results demonstrated that in adulthood, the tactile sensory system is foundational for social functioning in people with ASD, with diagnosis and intervention implications. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 Self-reported Sensory Hypersensitivity Moderates Association Between Tactile Psychophysical Performance and Autism-Related Traits in Neurotypical Adults / Lauren K. BRYANT in Journal of Autism and Developmental Disorders, 49-8 (August 2019)
[article]
Titre : Self-reported Sensory Hypersensitivity Moderates Association Between Tactile Psychophysical Performance and Autism-Related Traits in Neurotypical Adults Type de document : Texte imprimé et/ou numérique Auteurs : Lauren K. BRYANT, Auteur ; Tiffany G. WOYNAROSKI, Auteur ; Mark T. WALLACE, Auteur ; Carissa J. CASCIO, Auteur Article en page(s) : p.3159-3172 Langues : Anglais (eng) Mots-clés : Autism Broader phenotype Dynamic range Psychophysics Somatosensory Tactile Index. décimale : PER Périodiques Résumé : Atypical responses to tactile stimulation have been linked to core domains of dysfunction in individuals with autism spectrum disorder (ASD) and phenotypic traits associated with ASD in neurotypical individuals. We investigated (a) the extent to which two psychophysically derived measures of tactile sensitivity-detection threshold and dynamic range-relate to traits associated with ASD and (b) whether those relations vary according to the presence of self-reported sensory hypersensitivities in neurotypical individuals. A narrow dynamic range was associated with increased autism-related traits in individuals who reported greater sensory hypersensitivity. In contrast, in individuals less prone to sensory hypersensitivity, a narrow dynamic range was associated with reduced autism-related traits. Findings highlight the potential importance of considering dynamic psychophysical metrics in future studies. En ligne : http://dx.doi.org/10.1007/s10803-019-04043-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403
in Journal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3159-3172[article] Self-reported Sensory Hypersensitivity Moderates Association Between Tactile Psychophysical Performance and Autism-Related Traits in Neurotypical Adults [Texte imprimé et/ou numérique] / Lauren K. BRYANT, Auteur ; Tiffany G. WOYNAROSKI, Auteur ; Mark T. WALLACE, Auteur ; Carissa J. CASCIO, Auteur . - p.3159-3172.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3159-3172
Mots-clés : Autism Broader phenotype Dynamic range Psychophysics Somatosensory Tactile Index. décimale : PER Périodiques Résumé : Atypical responses to tactile stimulation have been linked to core domains of dysfunction in individuals with autism spectrum disorder (ASD) and phenotypic traits associated with ASD in neurotypical individuals. We investigated (a) the extent to which two psychophysically derived measures of tactile sensitivity-detection threshold and dynamic range-relate to traits associated with ASD and (b) whether those relations vary according to the presence of self-reported sensory hypersensitivities in neurotypical individuals. A narrow dynamic range was associated with increased autism-related traits in individuals who reported greater sensory hypersensitivity. In contrast, in individuals less prone to sensory hypersensitivity, a narrow dynamic range was associated with reduced autism-related traits. Findings highlight the potential importance of considering dynamic psychophysical metrics in future studies. En ligne : http://dx.doi.org/10.1007/s10803-019-04043-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 Tactile responsiveness patterns and their association with core features in autism spectrum disorders / Jennifer H. FOSS-FEIG in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)
[article]
Titre : Tactile responsiveness patterns and their association with core features in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Carissa J. CASCIO, Auteur Année de publication : 2012 Article en page(s) : p.337-344 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Sensory Tactile Symptoms Somatosensory Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are often associated with aberrant responses to sensory stimuli, which are thought to contribute to the social, communication, and repetitive behavior deficits that define ASD. However, there are few studies that separate aberrant sensory responses by individual sensory modality to assess modality-specific associations between sensory features and core symptoms. Differences in response to tactile stimuli are prevalent in ASD, and tactile contact early in infancy is a foundation for the development of social and communication skills affected by ASD. We assessed the association between three aberrant patterns of tactile responsiveness (hyper-responsiveness, hypo-responsiveness, sensory seeking) and core symptoms of ASD. Both sensory and core features were measured with converging methods including both parent-report and direct observation. Our results demonstrate that for the tactile modality, sensory hypo-responsiveness correlates strongly with increased social and communication impairments, and to a lesser degree, repetitive behaviors. Sensory seeking was found to correlate strongly with social impairment, nonverbal communication impairment, and repetitive behaviors. Surprisingly, tactile hyper-responsiveness did not significantly correlate with any core features of ASD. This differential association between specific tactile processing patterns and core features provides an important step in defining the significance of sensory symptoms in ASD, and may be useful in the development of sensory-based approaches for early detection and intervention. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.06.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146
in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.337-344[article] Tactile responsiveness patterns and their association with core features in autism spectrum disorders [Texte imprimé et/ou numérique] / Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Carissa J. CASCIO, Auteur . - 2012 . - p.337-344.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.337-344
Mots-clés : Autism spectrum disorders Sensory Tactile Symptoms Somatosensory Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are often associated with aberrant responses to sensory stimuli, which are thought to contribute to the social, communication, and repetitive behavior deficits that define ASD. However, there are few studies that separate aberrant sensory responses by individual sensory modality to assess modality-specific associations between sensory features and core symptoms. Differences in response to tactile stimuli are prevalent in ASD, and tactile contact early in infancy is a foundation for the development of social and communication skills affected by ASD. We assessed the association between three aberrant patterns of tactile responsiveness (hyper-responsiveness, hypo-responsiveness, sensory seeking) and core symptoms of ASD. Both sensory and core features were measured with converging methods including both parent-report and direct observation. Our results demonstrate that for the tactile modality, sensory hypo-responsiveness correlates strongly with increased social and communication impairments, and to a lesser degree, repetitive behaviors. Sensory seeking was found to correlate strongly with social impairment, nonverbal communication impairment, and repetitive behaviors. Surprisingly, tactile hyper-responsiveness did not significantly correlate with any core features of ASD. This differential association between specific tactile processing patterns and core features provides an important step in defining the significance of sensory symptoms in ASD, and may be useful in the development of sensory-based approaches for early detection and intervention. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.06.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146