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Assessing Autistic Traits in a Taiwan Preschool Population: Cross-Cultural Validation of the Social Responsiveness Scale (SRS) / Jessica WANG in Journal of Autism and Developmental Disorders, 42-11 (November 2012)
[article]
Titre : Assessing Autistic Traits in a Taiwan Preschool Population: Cross-Cultural Validation of the Social Responsiveness Scale (SRS) Type de document : Texte imprimé et/ou numérique Auteurs : Jessica WANG, Auteur ; Li-Ching LEE, Auteur ; Ying-Sheue CHEN, Auteur ; Ju-Wei HSU, Auteur Année de publication : 2012 Article en page(s) : p.2450-2459 Langues : Anglais (eng) Mots-clés : SRS Taiwan Cross-cultural Validity Autism spectrum disorder Index. décimale : PER Périodiques Résumé : The cross-cultural validity of the Mandarin-adaptation of the social responsiveness scale (SRS) was examined in a sample of N = 307 participants in Taiwan, 140 typically developing and 167 with clinically-diagnosed developmental disorders. This scale is an autism assessment tool that provides a quantitative rather than categorical measure of social impairment in the general population. SRS total and subscale scores distinguished significantly between autism spectrum disorder and other developmental disorders ( p < 0.01). Total SRS scores and sensitivity and specificity of the scale for diagnosing developmental disorders in the Taiwan study were similar to those observed in Western studies. These findings support the cross-cultural validity of the SRS scale for detecting autistic traits and for distinguishing between autism and other neuropsychiatric conditions. En ligne : http://dx.doi.org/10.1007/s10803-012-1499-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183
in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2450-2459[article] Assessing Autistic Traits in a Taiwan Preschool Population: Cross-Cultural Validation of the Social Responsiveness Scale (SRS) [Texte imprimé et/ou numérique] / Jessica WANG, Auteur ; Li-Ching LEE, Auteur ; Ying-Sheue CHEN, Auteur ; Ju-Wei HSU, Auteur . - 2012 . - p.2450-2459.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2450-2459
Mots-clés : SRS Taiwan Cross-cultural Validity Autism spectrum disorder Index. décimale : PER Périodiques Résumé : The cross-cultural validity of the Mandarin-adaptation of the social responsiveness scale (SRS) was examined in a sample of N = 307 participants in Taiwan, 140 typically developing and 167 with clinically-diagnosed developmental disorders. This scale is an autism assessment tool that provides a quantitative rather than categorical measure of social impairment in the general population. SRS total and subscale scores distinguished significantly between autism spectrum disorder and other developmental disorders ( p < 0.01). Total SRS scores and sensitivity and specificity of the scale for diagnosing developmental disorders in the Taiwan study were similar to those observed in Western studies. These findings support the cross-cultural validity of the SRS scale for detecting autistic traits and for distinguishing between autism and other neuropsychiatric conditions. En ligne : http://dx.doi.org/10.1007/s10803-012-1499-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 Atypical Laterality of Resting Gamma Oscillations in Autism Spectrum Disorders / Christina R. MAXWELL in Journal of Autism and Developmental Disorders, 45-2 (February 2015)
[article]
Titre : Atypical Laterality of Resting Gamma Oscillations in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Christina R. MAXWELL, Auteur ; Michele E. VILLALOBOS, Auteur ; Robert T. SCHULTZ, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Kerstin KONRAD, Auteur ; Gregor KOHLS, Auteur Article en page(s) : p.292-297 Langues : Anglais (eng) Mots-clés : Autism Gamma EEG SRS Resting state Laterality Index. décimale : PER Périodiques Résumé : Abnormal brain oscillatory activity has been found in autism spectrum disorders (ASD) and proposed as a potential biomarker. While several studies have investigated gamma oscillations in ASD, none have examined resting gamma power across multiple brain regions. This study investigated resting gamma power using EEG in 15 boys with ASD and 18 age and intelligence quotient matched typically developing controls. We found a decrease in resting gamma power at right lateral electrodes in ASD. We further explored associations between gamma and ASD severity as measured by the Social Responsiveness Scale (SRS) and found a negative correlation between SRS and gamma power. We believe that our findings give further support of gamma oscillations as a potential biomarker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1842-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.292-297[article] Atypical Laterality of Resting Gamma Oscillations in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Christina R. MAXWELL, Auteur ; Michele E. VILLALOBOS, Auteur ; Robert T. SCHULTZ, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Kerstin KONRAD, Auteur ; Gregor KOHLS, Auteur . - p.292-297.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.292-297
Mots-clés : Autism Gamma EEG SRS Resting state Laterality Index. décimale : PER Périodiques Résumé : Abnormal brain oscillatory activity has been found in autism spectrum disorders (ASD) and proposed as a potential biomarker. While several studies have investigated gamma oscillations in ASD, none have examined resting gamma power across multiple brain regions. This study investigated resting gamma power using EEG in 15 boys with ASD and 18 age and intelligence quotient matched typically developing controls. We found a decrease in resting gamma power at right lateral electrodes in ASD. We further explored associations between gamma and ASD severity as measured by the Social Responsiveness Scale (SRS) and found a negative correlation between SRS and gamma power. We believe that our findings give further support of gamma oscillations as a potential biomarker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1842-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 Is it Possible to Assess the Two-Domain Definition of the Broad Autism Phenotype Using the Available Measurement Tools? / M. GODOY-GIMENEZ in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
[article]
Titre : Is it Possible to Assess the Two-Domain Definition of the Broad Autism Phenotype Using the Available Measurement Tools? Type de document : Texte imprimé et/ou numérique Auteurs : M. GODOY-GIMENEZ, Auteur ; A. GONZALEZ-RODRIGUEZ, Auteur ; F. CANADAS, Auteur ; A. F. ESTEVEZ, Auteur ; P. SAYANS-JIMENEZ, Auteur Article en page(s) : p.2884-2895 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder/diagnosis Humans Phenotype Research Design Surveys and Questionnaires Aq Bapq Broad autism phenotype Expert judgment Srs Test content content of this article. Index. décimale : PER Périodiques Résumé : Although, the operationalization of the autism spectrum disorder has been updated around two domains, the broad autism phenotype (BAP) one has not. Additionally, the items of the three common BAP measures, the Broad Autism Phenotype Questionnaire (BAPQ), the Autism Quotient, and the Social Responsiveness Scale (SRS), remain organized around a non-consensual number of factors. We explored whether the items of these measures matched with the two-domain operationalization through a parallel analysis, which has suggested two main components, and two expert judgments which have assessed item wording, relevance, and construct representativeness. A remaining pool of 48 BAP-relevant items suggested a possible under-representation of two subdomains. Despite the relevance of all the BAPQ items, only the SRS ones tapped in all subdomains. En ligne : http://dx.doi.org/10.1007/s10803-021-05158-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.2884-2895[article] Is it Possible to Assess the Two-Domain Definition of the Broad Autism Phenotype Using the Available Measurement Tools? [Texte imprimé et/ou numérique] / M. GODOY-GIMENEZ, Auteur ; A. GONZALEZ-RODRIGUEZ, Auteur ; F. CANADAS, Auteur ; A. F. ESTEVEZ, Auteur ; P. SAYANS-JIMENEZ, Auteur . - p.2884-2895.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.2884-2895
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder/diagnosis Humans Phenotype Research Design Surveys and Questionnaires Aq Bapq Broad autism phenotype Expert judgment Srs Test content content of this article. Index. décimale : PER Périodiques Résumé : Although, the operationalization of the autism spectrum disorder has been updated around two domains, the broad autism phenotype (BAP) one has not. Additionally, the items of the three common BAP measures, the Broad Autism Phenotype Questionnaire (BAPQ), the Autism Quotient, and the Social Responsiveness Scale (SRS), remain organized around a non-consensual number of factors. We explored whether the items of these measures matched with the two-domain operationalization through a parallel analysis, which has suggested two main components, and two expert judgments which have assessed item wording, relevance, and construct representativeness. A remaining pool of 48 BAP-relevant items suggested a possible under-representation of two subdomains. Despite the relevance of all the BAPQ items, only the SRS ones tapped in all subdomains. En ligne : http://dx.doi.org/10.1007/s10803-021-05158-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry / R. M. POLLAK in Molecular Autism, 10 (2019)
[article]
Titre : Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry Type de document : Texte imprimé et/ou numérique Auteurs : R. M. POLLAK, Auteur ; M. M. MURPHY, Auteur ; M. P. EPSTEIN, Auteur ; M. E. ZWICK, Auteur ; C. KLAIMAN, Auteur ; Celine A. SAULNIER, Auteur ; J. G. MULLE, Auteur Article en page(s) : 30 p. Langues : Anglais (eng) Mots-clés : 3q29 deletion Autism Copy number variants Developmental delay Genomic disorder Psychiatric genetics SRS Vineland-3 Index. décimale : PER Périodiques Résumé : Background: The 1.6 Mb 3q29 deletion is associated with neurodevelopmental and psychiatric phenotypes, including increased risk for autism spectrum disorder (ASD) and a 20 to 40-fold increased risk for schizophrenia. However, the phenotypic spectrum of the deletion, particularly with respect to ASD, remains poorly described. Methods: We ascertained individuals with 3q29 deletion syndrome (3q29Del, "cases," n = 93, 58.1% male) and typically developing controls (n = 64, 51.6% male) through the 3q29 registry (https://3q29deletion.patientcrossroads.org). Self-report of neuropsychiatric illness was evaluated for 93 cases. Subsets of participants were evaluated with the Social Responsiveness Scale (SRS, n = 48 cases, 56 controls), Social Communication Questionnaire (n = 33 cases, 46 controls), Autism Spectrum Screening Questionnaire (n = 24 cases, 35 controls), and Achenbach Behavior Checklists (n = 48 cases, 57 controls). Results: 3q29Del cases report a higher prevalence of autism diagnoses versus the general population (29.0% vs. 1.47%, p < 2.2E- 16). Notably, 3q29 deletion confers a greater influence on risk for ASD in females (OR = 41.8, p = 4.78E- 05) than in males (OR = 24.6, p = 6.06E- 09); this is aligned with the reduced male:female bias from 4:1 in the general population to 2:1 in our study sample. Although 71% of cases do not report a diagnosis of ASD, there is evidence of significant social disability (3q29Del SRS T-score = 71.8, control SRS T-score = 45.9, p = 2.16E- 13). Cases also report increased frequency of generalized anxiety disorder compared to controls (28.0% vs. 6.2%, p = 0.001), which is mirrored by elevated mean scores on the Achenbach diagnostic and statistical manual-oriented sub-scales (p < 0.001). Finally, cases show a distinct constellation of ASD features on the SRS as compared to idiopathic ASD, with substantially elevated Restricted Interests and Repetitive Behaviors, but only mild impairment in Social Motivation. Conclusions: Our sample of 3q29Del is significantly enriched for ASD diagnosis, especially among females, and features of autism may be present even when an ASD diagnosis is not reported. Further, the constellation of ASD features in this population is distinct from idiopathic ASD, with substantially less impaired social motivation. Our study implies that ASD evaluation should be the standard of care for individuals with 3q29Del. From a research perspective, the distinct ASD subtype present in 3q29Del is an ideal entry point for expanding understanding of ASD. En ligne : https://dx.doi.org/10.1186/s13229-019-0281-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408
in Molecular Autism > 10 (2019) . - 30 p.[article] Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry [Texte imprimé et/ou numérique] / R. M. POLLAK, Auteur ; M. M. MURPHY, Auteur ; M. P. EPSTEIN, Auteur ; M. E. ZWICK, Auteur ; C. KLAIMAN, Auteur ; Celine A. SAULNIER, Auteur ; J. G. MULLE, Auteur . - 30 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 30 p.
Mots-clés : 3q29 deletion Autism Copy number variants Developmental delay Genomic disorder Psychiatric genetics SRS Vineland-3 Index. décimale : PER Périodiques Résumé : Background: The 1.6 Mb 3q29 deletion is associated with neurodevelopmental and psychiatric phenotypes, including increased risk for autism spectrum disorder (ASD) and a 20 to 40-fold increased risk for schizophrenia. However, the phenotypic spectrum of the deletion, particularly with respect to ASD, remains poorly described. Methods: We ascertained individuals with 3q29 deletion syndrome (3q29Del, "cases," n = 93, 58.1% male) and typically developing controls (n = 64, 51.6% male) through the 3q29 registry (https://3q29deletion.patientcrossroads.org). Self-report of neuropsychiatric illness was evaluated for 93 cases. Subsets of participants were evaluated with the Social Responsiveness Scale (SRS, n = 48 cases, 56 controls), Social Communication Questionnaire (n = 33 cases, 46 controls), Autism Spectrum Screening Questionnaire (n = 24 cases, 35 controls), and Achenbach Behavior Checklists (n = 48 cases, 57 controls). Results: 3q29Del cases report a higher prevalence of autism diagnoses versus the general population (29.0% vs. 1.47%, p < 2.2E- 16). Notably, 3q29 deletion confers a greater influence on risk for ASD in females (OR = 41.8, p = 4.78E- 05) than in males (OR = 24.6, p = 6.06E- 09); this is aligned with the reduced male:female bias from 4:1 in the general population to 2:1 in our study sample. Although 71% of cases do not report a diagnosis of ASD, there is evidence of significant social disability (3q29Del SRS T-score = 71.8, control SRS T-score = 45.9, p = 2.16E- 13). Cases also report increased frequency of generalized anxiety disorder compared to controls (28.0% vs. 6.2%, p = 0.001), which is mirrored by elevated mean scores on the Achenbach diagnostic and statistical manual-oriented sub-scales (p < 0.001). Finally, cases show a distinct constellation of ASD features on the SRS as compared to idiopathic ASD, with substantially elevated Restricted Interests and Repetitive Behaviors, but only mild impairment in Social Motivation. Conclusions: Our sample of 3q29Del is significantly enriched for ASD diagnosis, especially among females, and features of autism may be present even when an ASD diagnosis is not reported. Further, the constellation of ASD features in this population is distinct from idiopathic ASD, with substantially less impaired social motivation. Our study implies that ASD evaluation should be the standard of care for individuals with 3q29Del. From a research perspective, the distinct ASD subtype present in 3q29Del is an ideal entry point for expanding understanding of ASD. En ligne : https://dx.doi.org/10.1186/s13229-019-0281-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 The Effect of Gestational Age on Symptom Severity in Children with Autism Spectrum Disorder / Tammy MOVSAS in Journal of Autism and Developmental Disorders, 42-11 (November 2012)
[article]
Titre : The Effect of Gestational Age on Symptom Severity in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tammy MOVSAS, Auteur ; Nigel PANETH, Auteur Année de publication : 2012 Article en page(s) : p.2431-2439 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder symptoms Preterm Post-term Post-mature SCQ SRS Index. décimale : PER Périodiques Résumé : Between 2006 and 2010, two research-validated instruments, Social Communication Questionnaire (SCQ) and Social Responsiveness Scale (SRS) were filled out online by 4,188 mothers of Autism Spectrum Disorder (ASD) children, aged 4–21, as part of voluntary parental participation in a large web-based registry. Univariate and multivariate linear regression analysis (adjusted for child’s sex, ability to verbalize, categorical IQ score, and fetal growth rate) demonstrated significantly higher SCQ and SRS scores for ASD children of both preterm (<37 weeks) and post-term (>42 weeks) gestational age (GA) compared to ASD children of normal GA, thus indicating that both preterm and post-term children manifest increased ASD symptomatology. Normal GA at birth appears to mitigate the severity of autistic social impairment in ASD children. En ligne : http://dx.doi.org/10.1007/s10803-012-1501-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183
in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2431-2439[article] The Effect of Gestational Age on Symptom Severity in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Tammy MOVSAS, Auteur ; Nigel PANETH, Auteur . - 2012 . - p.2431-2439.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2431-2439
Mots-clés : Autism Spectrum Disorder symptoms Preterm Post-term Post-mature SCQ SRS Index. décimale : PER Périodiques Résumé : Between 2006 and 2010, two research-validated instruments, Social Communication Questionnaire (SCQ) and Social Responsiveness Scale (SRS) were filled out online by 4,188 mothers of Autism Spectrum Disorder (ASD) children, aged 4–21, as part of voluntary parental participation in a large web-based registry. Univariate and multivariate linear regression analysis (adjusted for child’s sex, ability to verbalize, categorical IQ score, and fetal growth rate) demonstrated significantly higher SCQ and SRS scores for ASD children of both preterm (<37 weeks) and post-term (>42 weeks) gestational age (GA) compared to ASD children of normal GA, thus indicating that both preterm and post-term children manifest increased ASD symptomatology. Normal GA at birth appears to mitigate the severity of autistic social impairment in ASD children. En ligne : http://dx.doi.org/10.1007/s10803-012-1501-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 Autism Spectrum Disorder Profile in Neurofibromatosis Type I / Shruti GARG in Journal of Autism and Developmental Disorders, 45-6 (June 2015)
PermalinkHoning in on the Social Phenotype in Williams Syndrome Using Multiple Measures and Multiple Raters / Bonita P. KLEIN-TASMAN in Journal of Autism and Developmental Disorders, 41-3 (March 2011)
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