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Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder / I. W. EISENBERG in Molecular Autism, (December 2015)
[article]
Titre : Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : I. W. EISENBERG, Auteur ; Gregory L. WALLACE, Auteur ; L. KENWORTHY, Auteur ; S. J. GOTTS, Auteur ; A. MARTIN, Auteur Article en page(s) : 54p. Langues : Anglais (eng) Mots-clés : Autism Insistence on sameness Mri Repetitive behavior Structural covariance Subcortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. METHODS: We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). RESULTS: We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. CONCLUSIONS: This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. TRIAL REGISTRATION: ClinicalTrials.gov NCT01031407. En ligne : http://dx.doi.org/10.1186/s13229-015-0047-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > (December 2015) . - 54p.[article] Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder [Texte imprimé et/ou numérique] / I. W. EISENBERG, Auteur ; Gregory L. WALLACE, Auteur ; L. KENWORTHY, Auteur ; S. J. GOTTS, Auteur ; A. MARTIN, Auteur . - 54p.
Langues : Anglais (eng)
in Molecular Autism > (December 2015) . - 54p.
Mots-clés : Autism Insistence on sameness Mri Repetitive behavior Structural covariance Subcortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. METHODS: We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). RESULTS: We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. CONCLUSIONS: This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. TRIAL REGISTRATION: ClinicalTrials.gov NCT01031407. En ligne : http://dx.doi.org/10.1186/s13229-015-0047-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Mapping the structural organization of the brain in conduct disorder: replication of findings in two independent samples / Graeme FAIRCHILD in Journal of Child Psychology and Psychiatry, 57-9 (September 2016)
[article]
Titre : Mapping the structural organization of the brain in conduct disorder: replication of findings in two independent samples Type de document : Texte imprimé et/ou numérique Auteurs : Graeme FAIRCHILD, Auteur ; Nicola TOSCHI, Auteur ; Kate SULLY, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Cindy C. HAGAN, Auteur ; Stefano DICIOTTI, Auteur ; Ian M. GOODYER, Auteur ; Andrew J. CALDER, Auteur ; Luca PASSAMONTI, Auteur Article en page(s) : p.1018-1026 Langues : Anglais (eng) Mots-clés : Cortical thickness structural covariance conduct disorder antisocial behavior developmental taxonomic theory Index. décimale : PER Périodiques Résumé : Background Neuroimaging methods that allow researchers to investigate structural covariance between brain regions are increasingly being used to study psychiatric disorders. Structural covariance analyses are particularly well suited for studying disorders with putative neurodevelopmental origins as they appear sensitive to changes in the synchronized maturation of different brain regions. We assessed interregional correlations in cortical thickness as a measure of structural covariance, and applied this method to investigate the coordinated development of different brain regions in conduct disorder (CD). We also assessed whether structural covariance measures could differentiate between the childhood-onset (CO-CD) and adolescence-onset (AO-CD) subtypes of CD, which may differ in terms of etiology and adult outcomes. Methods We examined interregional correlations in cortical thickness in male youths with CO-CD or AO-CD relative to healthy controls (HCs) in two independent datasets. The age range in the Cambridge sample was 16–21 years (mean: 18.0), whereas the age range of the Southampton sample was 13–18 years (mean: 16.7). We used FreeSurfer to perform segmentations and applied structural covariance methods to the resulting parcellations. Results In both samples, CO-CD participants displayed a strikingly higher number of significant cross-cortical correlations compared to HC or AO-CD participants, whereas AO-CD participants presented fewer significant correlations than HCs. Group differences in the strength of the interregional correlations were observed in both samples, and each set of results remained significant when controlling for IQ and comorbid attention-deficit/hyperactivity disorder symptoms. Conclusions This study provides new evidence for quantitative differences in structural brain organization between the CO-CD and AO-CD subtypes, and supports the hypothesis that both subtypes of CD have neurodevelopmental origins. En ligne : http://dx.doi.org/10.1111/jcpp.12581 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.1018-1026[article] Mapping the structural organization of the brain in conduct disorder: replication of findings in two independent samples [Texte imprimé et/ou numérique] / Graeme FAIRCHILD, Auteur ; Nicola TOSCHI, Auteur ; Kate SULLY, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Cindy C. HAGAN, Auteur ; Stefano DICIOTTI, Auteur ; Ian M. GOODYER, Auteur ; Andrew J. CALDER, Auteur ; Luca PASSAMONTI, Auteur . - p.1018-1026.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-9 (September 2016) . - p.1018-1026
Mots-clés : Cortical thickness structural covariance conduct disorder antisocial behavior developmental taxonomic theory Index. décimale : PER Périodiques Résumé : Background Neuroimaging methods that allow researchers to investigate structural covariance between brain regions are increasingly being used to study psychiatric disorders. Structural covariance analyses are particularly well suited for studying disorders with putative neurodevelopmental origins as they appear sensitive to changes in the synchronized maturation of different brain regions. We assessed interregional correlations in cortical thickness as a measure of structural covariance, and applied this method to investigate the coordinated development of different brain regions in conduct disorder (CD). We also assessed whether structural covariance measures could differentiate between the childhood-onset (CO-CD) and adolescence-onset (AO-CD) subtypes of CD, which may differ in terms of etiology and adult outcomes. Methods We examined interregional correlations in cortical thickness in male youths with CO-CD or AO-CD relative to healthy controls (HCs) in two independent datasets. The age range in the Cambridge sample was 16–21 years (mean: 18.0), whereas the age range of the Southampton sample was 13–18 years (mean: 16.7). We used FreeSurfer to perform segmentations and applied structural covariance methods to the resulting parcellations. Results In both samples, CO-CD participants displayed a strikingly higher number of significant cross-cortical correlations compared to HC or AO-CD participants, whereas AO-CD participants presented fewer significant correlations than HCs. Group differences in the strength of the interregional correlations were observed in both samples, and each set of results remained significant when controlling for IQ and comorbid attention-deficit/hyperactivity disorder symptoms. Conclusions This study provides new evidence for quantitative differences in structural brain organization between the CO-CD and AO-CD subtypes, and supports the hypothesis that both subtypes of CD have neurodevelopmental origins. En ligne : http://dx.doi.org/10.1111/jcpp.12581 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity / Edward T. BULLMORE ; Raymond J. DOLAN ; Peter FONAGY ; Nadia GONZÁLEZ-GARCÍA ; Ian GOODYER ; Peter B. JONES ; Sol LIM ; Laura MORENO-LÓPEZ ; Rafael ROMERO-GARCIA ; Samantha N. SALLIE ; Maximilian SCHEUPLEIN ; Franti?ek VÁ?A ; Kirstie J. WHITAKER ; Anne-Laura VAN HARMELEN in Development and Psychopathology, 35-5 (December 2023)
[article]
Titre : Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity Type de document : Texte imprimé et/ou numérique Auteurs : Edward T. BULLMORE, Auteur ; Raymond J. DOLAN, Auteur ; Peter FONAGY, Auteur ; Nadia GONZÁLEZ-GARCÍA, Auteur ; Ian GOODYER, Auteur ; Peter B. JONES, Auteur ; Sol LIM, Auteur ; Laura MORENO-LÓPEZ, Auteur ; Rafael ROMERO-GARCIA, Auteur ; Samantha N. SALLIE, Auteur ; Maximilian SCHEUPLEIN, Auteur ; Franti?ek VÁ?A, Auteur ; Kirstie J. WHITAKER, Auteur ; Anne-Laura VAN HARMELEN, Auteur Article en page(s) : p.2253-2263 Mots-clés : adolescence brain networks childhood adversity resilience structural covariance Index. décimale : PER Périodiques Résumé : Childhood adversity is one of the strongest predictors of adolescent mental illness. Therefore, it is critical that the mechanisms that aid resilient functioning in individuals exposed to childhood adversity are better understood. Here, we examined whether resilient functioning was related to structural brain network topology. We quantified resilient functioning at the individual level as psychosocial functioning adjusted for the severity of childhood adversity in a large sample of adolescents (N = 2406, aged 14?24). Next, we examined nodal degree (the number of connections that brain regions have in a network) using brain-wide cortical thickness measures in a representative subset (N = 275) using a sliding window approach. We found that higher resilient functioning was associated with lower nodal degree of multiple regions including the dorsolateral prefrontal cortex, the medial prefrontal cortex, and the posterior superior temporal sulcus (z > 1.645). During adolescence, decreases in nodal degree are thought to reflect a normative developmental process that is part of the extensive remodeling of structural brain network topology. Prior findings in this sample showed that decreased nodal degree was associated with age, as such our findings of negative associations between nodal degree and resilient functioning may therefore potentially resemble a more mature structural network configuration in individuals with higher resilient functioning. En ligne : https://dx.doi.org/10.1017/S0954579423000901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519
in Development and Psychopathology > 35-5 (December 2023) . - p.2253-2263[article] Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity [Texte imprimé et/ou numérique] / Edward T. BULLMORE, Auteur ; Raymond J. DOLAN, Auteur ; Peter FONAGY, Auteur ; Nadia GONZÁLEZ-GARCÍA, Auteur ; Ian GOODYER, Auteur ; Peter B. JONES, Auteur ; Sol LIM, Auteur ; Laura MORENO-LÓPEZ, Auteur ; Rafael ROMERO-GARCIA, Auteur ; Samantha N. SALLIE, Auteur ; Maximilian SCHEUPLEIN, Auteur ; Franti?ek VÁ?A, Auteur ; Kirstie J. WHITAKER, Auteur ; Anne-Laura VAN HARMELEN, Auteur . - p.2253-2263.
in Development and Psychopathology > 35-5 (December 2023) . - p.2253-2263
Mots-clés : adolescence brain networks childhood adversity resilience structural covariance Index. décimale : PER Périodiques Résumé : Childhood adversity is one of the strongest predictors of adolescent mental illness. Therefore, it is critical that the mechanisms that aid resilient functioning in individuals exposed to childhood adversity are better understood. Here, we examined whether resilient functioning was related to structural brain network topology. We quantified resilient functioning at the individual level as psychosocial functioning adjusted for the severity of childhood adversity in a large sample of adolescents (N = 2406, aged 14?24). Next, we examined nodal degree (the number of connections that brain regions have in a network) using brain-wide cortical thickness measures in a representative subset (N = 275) using a sliding window approach. We found that higher resilient functioning was associated with lower nodal degree of multiple regions including the dorsolateral prefrontal cortex, the medial prefrontal cortex, and the posterior superior temporal sulcus (z > 1.645). During adolescence, decreases in nodal degree are thought to reflect a normative developmental process that is part of the extensive remodeling of structural brain network topology. Prior findings in this sample showed that decreased nodal degree was associated with age, as such our findings of negative associations between nodal degree and resilient functioning may therefore potentially resemble a more mature structural network configuration in individuals with higher resilient functioning. En ligne : https://dx.doi.org/10.1017/S0954579423000901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519