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Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood / I. POTE in Autism Research, 12-4 (April 2019)
[article]
Titre : Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : I. POTE, Auteur ; S. WANG, Auteur ; V. SETHNA, Auteur ; A. BLASI, Auteur ; Eileen DALY, Auteur ; M. KUKLISOVA-MURGASOVA, Auteur ; S. LLOYD-FOX, Auteur ; E. MERCURE, Auteur ; P. BUSUULWA, Auteur ; V. STOENCHEVA, Auteur ; Tony CHARMAN, Auteur ; S. C. R. WILLIAMS, Auteur ; M. H. JOHNSON, Auteur ; D. G. M. MURPHY, Auteur ; G. M. MCALONAN, Auteur Article en page(s) : p.614-627 Langues : Anglais (eng) Mots-clés : autism spectrum disorder cerebellum familial risk infants magnetic resonance imaging-structural mother-infant interaction subcortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at a higher risk of developing autistic traits or an ASD diagnosis, when compared to those with typically developing siblings. Reports of differences in brain anatomy and function in high-risk infants which predict later autistic behaviors are emerging, but although cerebellar and subcortical brain regions have been frequently implicated in ASD, no high-risk study has examined these regions. Therefore, in this study, we compared regional MRI volumes across the whole brain in 4-6-month-old infants with (high-risk, n = 24) and without (low-risk, n = 26) a sibling with ASD. Within the high-risk group, we also examined whether any regional differences observed were associated with autistic behaviors at 36 months. We found that high-risk infants had significantly larger cerebellar and subcortical volumes at 4-6-months of age, relative to low-risk infants; and that larger volumes in high-risk infants were linked to more repetitive behaviors at 36 months. Our preliminary observations require replication in longitudinal studies of larger samples. If correct, they suggest that the early subcortex and cerebellum volumes may be predictive biomarkers for childhood repetitive behaviors. Autism Res 2019, 12: 614-627. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published byWiley Periodicals, Inc. LAY SUMMARY: Individuals with a family history of autism spectrum disorder (ASD) are at risk of ASD and related developmental difficulties. This study revealed that 4-6-month-old infants at high-risk of ASD have larger cerebellum and subcortical volumes than low-risk infants, and that larger volumes in high-risk infants are associated with more repetitive behaviors in childhood. En ligne : https://dx.doi.org/10.1002/aur.2083 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Autism Research > 12-4 (April 2019) . - p.614-627[article] Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood [Texte imprimé et/ou numérique] / I. POTE, Auteur ; S. WANG, Auteur ; V. SETHNA, Auteur ; A. BLASI, Auteur ; Eileen DALY, Auteur ; M. KUKLISOVA-MURGASOVA, Auteur ; S. LLOYD-FOX, Auteur ; E. MERCURE, Auteur ; P. BUSUULWA, Auteur ; V. STOENCHEVA, Auteur ; Tony CHARMAN, Auteur ; S. C. R. WILLIAMS, Auteur ; M. H. JOHNSON, Auteur ; D. G. M. MURPHY, Auteur ; G. M. MCALONAN, Auteur . - p.614-627.
Langues : Anglais (eng)
in Autism Research > 12-4 (April 2019) . - p.614-627
Mots-clés : autism spectrum disorder cerebellum familial risk infants magnetic resonance imaging-structural mother-infant interaction subcortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at a higher risk of developing autistic traits or an ASD diagnosis, when compared to those with typically developing siblings. Reports of differences in brain anatomy and function in high-risk infants which predict later autistic behaviors are emerging, but although cerebellar and subcortical brain regions have been frequently implicated in ASD, no high-risk study has examined these regions. Therefore, in this study, we compared regional MRI volumes across the whole brain in 4-6-month-old infants with (high-risk, n = 24) and without (low-risk, n = 26) a sibling with ASD. Within the high-risk group, we also examined whether any regional differences observed were associated with autistic behaviors at 36 months. We found that high-risk infants had significantly larger cerebellar and subcortical volumes at 4-6-months of age, relative to low-risk infants; and that larger volumes in high-risk infants were linked to more repetitive behaviors at 36 months. Our preliminary observations require replication in longitudinal studies of larger samples. If correct, they suggest that the early subcortex and cerebellum volumes may be predictive biomarkers for childhood repetitive behaviors. Autism Res 2019, 12: 614-627. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published byWiley Periodicals, Inc. LAY SUMMARY: Individuals with a family history of autism spectrum disorder (ASD) are at risk of ASD and related developmental difficulties. This study revealed that 4-6-month-old infants at high-risk of ASD have larger cerebellum and subcortical volumes than low-risk infants, and that larger volumes in high-risk infants are associated with more repetitive behaviors in childhood. En ligne : https://dx.doi.org/10.1002/aur.2083 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder / I. W. EISENBERG in Molecular Autism, (December 2015)
[article]
Titre : Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : I. W. EISENBERG, Auteur ; Gregory L. WALLACE, Auteur ; L. KENWORTHY, Auteur ; S. J. GOTTS, Auteur ; A. MARTIN, Auteur Article en page(s) : 54p. Langues : Anglais (eng) Mots-clés : Autism Insistence on sameness Mri Repetitive behavior Structural covariance Subcortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. METHODS: We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). RESULTS: We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. CONCLUSIONS: This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. TRIAL REGISTRATION: ClinicalTrials.gov NCT01031407. En ligne : http://dx.doi.org/10.1186/s13229-015-0047-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > (December 2015) . - 54p.[article] Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder [Texte imprimé et/ou numérique] / I. W. EISENBERG, Auteur ; Gregory L. WALLACE, Auteur ; L. KENWORTHY, Auteur ; S. J. GOTTS, Auteur ; A. MARTIN, Auteur . - 54p.
Langues : Anglais (eng)
in Molecular Autism > (December 2015) . - 54p.
Mots-clés : Autism Insistence on sameness Mri Repetitive behavior Structural covariance Subcortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. METHODS: We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). RESULTS: We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. CONCLUSIONS: This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. TRIAL REGISTRATION: ClinicalTrials.gov NCT01031407. En ligne : http://dx.doi.org/10.1186/s13229-015-0047-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328