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Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder / Jiang ZHU in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
[article]
Titre : Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jiang ZHU, Auteur ; Xueying HUA, Auteur ; Ting YANG, Auteur ; Min GUO, Auteur ; Qiu LI, Auteur ; Lu XIAO, Auteur ; Ling LI, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.3116-3128 Langues : Anglais (eng) Mots-clés : Amino Acids/metabolism Autism Spectrum Disorder/diagnosis Child Humans Intestines Metabolome Metabolomics/methods Vitamins Autism Children Metabolism Metabolomics Symptoms Vitamin Index. décimale : PER Périodiques Résumé : Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05066-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3116-3128[article] Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jiang ZHU, Auteur ; Xueying HUA, Auteur ; Ting YANG, Auteur ; Min GUO, Auteur ; Qiu LI, Auteur ; Lu XIAO, Auteur ; Ling LI, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur . - p.3116-3128.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3116-3128
Mots-clés : Amino Acids/metabolism Autism Spectrum Disorder/diagnosis Child Humans Intestines Metabolome Metabolomics/methods Vitamins Autism Children Metabolism Metabolomics Symptoms Vitamin Index. décimale : PER Périodiques Résumé : Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05066-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED) / Lisa D. WIGGINS in Journal of Autism and Developmental Disorders, 45-10 (October 2015)
[article]
Titre : Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED) Type de document : Texte imprimé et/ou numérique Auteurs : Lisa D. WIGGINS, Auteur ; Susan E. LEVY, Auteur ; Julie L. DANIELS, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa A. CROEN, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Lisa BLASKEY, Auteur ; Ellen GIARELLI, Auteur ; Li-Ching LEE, Auteur ; Jennifer PINTO-MARTIN, Auteur ; Ann REYNOLDS, Auteur ; Catherine RICE, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur ; Patrick THOMPSON, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Lisa YOUNG, Auteur ; Diana SCHENDEL, Auteur Article en page(s) : p.3183-3194 Langues : Anglais (eng) Mots-clés : Autism Etiology Symptoms Phenotype Study to Explore Early Development Index. décimale : PER Périodiques Résumé : This study examined the phenotypic profiles of children aged 30–68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses. En ligne : http://dx.doi.org/10.1007/s10803-015-2476-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3183-3194[article] Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED) [Texte imprimé et/ou numérique] / Lisa D. WIGGINS, Auteur ; Susan E. LEVY, Auteur ; Julie L. DANIELS, Auteur ; Laura A. SCHIEVE, Auteur ; Lisa A. CROEN, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Lisa BLASKEY, Auteur ; Ellen GIARELLI, Auteur ; Li-Ching LEE, Auteur ; Jennifer PINTO-MARTIN, Auteur ; Ann REYNOLDS, Auteur ; Catherine RICE, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur ; Patrick THOMPSON, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Lisa YOUNG, Auteur ; Diana SCHENDEL, Auteur . - p.3183-3194.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3183-3194
Mots-clés : Autism Etiology Symptoms Phenotype Study to Explore Early Development Index. décimale : PER Périodiques Résumé : This study examined the phenotypic profiles of children aged 30–68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses. En ligne : http://dx.doi.org/10.1007/s10803-015-2476-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 Homotypic and heterotypic continuity of symptoms of psychiatric disorders from age 4 to 10 years: a dynamic panel model / Lars WICHSTRØM in Journal of Child Psychology and Psychiatry, 58-11 (November 2017)
[article]
Titre : Homotypic and heterotypic continuity of symptoms of psychiatric disorders from age 4 to 10 years: a dynamic panel model Type de document : Texte imprimé et/ou numérique Auteurs : Lars WICHSTRØM, Auteur ; Jay BELSKY, Auteur ; Silje STEINSBEKK, Auteur Article en page(s) : p.1239-1247 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder anxiety conduct disorder continuity depression fixed effects heterotypic homotypic longitudinal life-events oppositional defiant disorder prospective psychiatric disorder symptoms Index. décimale : PER Périodiques Résumé : Background Childhood psychiatric disorders and their symptoms evince both within-disorder (homotypic) and between-disorder (heterotypic) continuities. These continuities may be due to earlier symptoms causing later symptoms or, alternatively, that the same (unknown) causes (e.g., genetics) are operating across time. Applying a novel data analytic approach, we disentangle these two explanations. Methods Participants in a Norwegian community study were assessed biennially from 4 to 10 years of age with clinical interviews (n = 1,042). Prospective reciprocal relations between symptoms of disorders were analyzed with a dynamic panel model within a structural equation framework, adjusting for all unmeasured time-invariant confounders and time-varying negative life-events. Results Homotypic continuities in symptoms characterized all disorders; strongest for attention-deficit/hyperactivity disorder (ADHD) (r = .32–.62), moderate for behavioral disorders (r = .31–.48) and for anxiety and depression (r = .15–.40), and stronger between 8 and 10 than between 4 and 6 years. Heterotypic continuity also characterized all disorders. A dynamic panel model showed that most continuities were due to unmeasured time-invariant factors rather than effects of earlier symptoms on later symptoms, although symptoms of behavioral disorders, which evinced two-year homotypic continuity (B = .14, 95% CI: .04, .25), did influence later symptoms of ADHD (B = .13, CI: .03, .23), and earlier ADHD symptoms influenced later anxiety disorder symptoms (B = .07, CI: .01, .12). Conclusions Homotypic and heterotypic continuities of symptoms of childhood psychiatric disorders are mostly due to unobserved time-invariant factors. Nonetheless, symptoms of earlier behavioral disorders may affect later symptoms of such disorders and of ADHD, and ADHD may increase the risk of later anxiety. Thus, even if interventions do not alter basic etiological factors, symptom reduction may itself cause later symptom reduction. En ligne : http://dx.doi.org/10.1111/jcpp.12754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326
in Journal of Child Psychology and Psychiatry > 58-11 (November 2017) . - p.1239-1247[article] Homotypic and heterotypic continuity of symptoms of psychiatric disorders from age 4 to 10 years: a dynamic panel model [Texte imprimé et/ou numérique] / Lars WICHSTRØM, Auteur ; Jay BELSKY, Auteur ; Silje STEINSBEKK, Auteur . - p.1239-1247.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-11 (November 2017) . - p.1239-1247
Mots-clés : Attention-deficit/hyperactivity disorder anxiety conduct disorder continuity depression fixed effects heterotypic homotypic longitudinal life-events oppositional defiant disorder prospective psychiatric disorder symptoms Index. décimale : PER Périodiques Résumé : Background Childhood psychiatric disorders and their symptoms evince both within-disorder (homotypic) and between-disorder (heterotypic) continuities. These continuities may be due to earlier symptoms causing later symptoms or, alternatively, that the same (unknown) causes (e.g., genetics) are operating across time. Applying a novel data analytic approach, we disentangle these two explanations. Methods Participants in a Norwegian community study were assessed biennially from 4 to 10 years of age with clinical interviews (n = 1,042). Prospective reciprocal relations between symptoms of disorders were analyzed with a dynamic panel model within a structural equation framework, adjusting for all unmeasured time-invariant confounders and time-varying negative life-events. Results Homotypic continuities in symptoms characterized all disorders; strongest for attention-deficit/hyperactivity disorder (ADHD) (r = .32–.62), moderate for behavioral disorders (r = .31–.48) and for anxiety and depression (r = .15–.40), and stronger between 8 and 10 than between 4 and 6 years. Heterotypic continuity also characterized all disorders. A dynamic panel model showed that most continuities were due to unmeasured time-invariant factors rather than effects of earlier symptoms on later symptoms, although symptoms of behavioral disorders, which evinced two-year homotypic continuity (B = .14, 95% CI: .04, .25), did influence later symptoms of ADHD (B = .13, CI: .03, .23), and earlier ADHD symptoms influenced later anxiety disorder symptoms (B = .07, CI: .01, .12). Conclusions Homotypic and heterotypic continuities of symptoms of childhood psychiatric disorders are mostly due to unobserved time-invariant factors. Nonetheless, symptoms of earlier behavioral disorders may affect later symptoms of such disorders and of ADHD, and ADHD may increase the risk of later anxiety. Thus, even if interventions do not alter basic etiological factors, symptom reduction may itself cause later symptom reduction. En ligne : http://dx.doi.org/10.1111/jcpp.12754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 Measurement Tools and Target Symptoms/Skills Used to Assess Treatment Response for Individuals with Autism Spectrum Disorder / Erin Elizabeth BOLTE in Journal of Autism and Developmental Disorders, 43-11 (November 2013)
[article]
Titre : Measurement Tools and Target Symptoms/Skills Used to Assess Treatment Response for Individuals with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Erin Elizabeth BOLTE, Auteur ; Joshua John DIEHL, Auteur Article en page(s) : p.2491-2501 Langues : Anglais (eng) Mots-clés : Autism Intervention Treatment Behavior Symptoms Measures Index. décimale : PER Périodiques Résumé : This study examined the measurement tools and target symptoms/skills used to assess treatment response during Autism Spectrum Disorder (ASD) intervention trials from 2001 through 2010. Data from 195 prospective trials were analyzed. There were 289 unique measurement tools, of which 61.6 % were used only once, and 20.8 % were investigator-designed. Only three tools were used in more than 2 % of the studies, and none were used in more than 7 % of studies. Studies investigated an average of 11.4 tool-symptom combinations per trial, with as many as 45 in one study. These results represent a lack of consistency in outcome measurements in ASD intervention trials. These findings highlight the need to set guidelines for appropriate outcome measurement in the ASD field. En ligne : http://dx.doi.org/10.1007/s10803-013-1798-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217
in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2491-2501[article] Measurement Tools and Target Symptoms/Skills Used to Assess Treatment Response for Individuals with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Erin Elizabeth BOLTE, Auteur ; Joshua John DIEHL, Auteur . - p.2491-2501.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2491-2501
Mots-clés : Autism Intervention Treatment Behavior Symptoms Measures Index. décimale : PER Périodiques Résumé : This study examined the measurement tools and target symptoms/skills used to assess treatment response during Autism Spectrum Disorder (ASD) intervention trials from 2001 through 2010. Data from 195 prospective trials were analyzed. There were 289 unique measurement tools, of which 61.6 % were used only once, and 20.8 % were investigator-designed. Only three tools were used in more than 2 % of the studies, and none were used in more than 7 % of studies. Studies investigated an average of 11.4 tool-symptom combinations per trial, with as many as 45 in one study. These results represent a lack of consistency in outcome measurements in ASD intervention trials. These findings highlight the need to set guidelines for appropriate outcome measurement in the ASD field. En ligne : http://dx.doi.org/10.1007/s10803-013-1798-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 A Multi-Rater Study on Being Teased Among Children/Adolescents With Autism Spectrum Disorder (ASD) and Their Typically Developing Siblings: Associations With ASD Symptoms / Kerri P. NOWELL in Focus on Autism and Other Developmental Disabilities, 29-4 (December 2014)
[article]
Titre : A Multi-Rater Study on Being Teased Among Children/Adolescents With Autism Spectrum Disorder (ASD) and Their Typically Developing Siblings: Associations With ASD Symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Kerri P. NOWELL, Auteur ; Christie M. BREWTON, Auteur ; Robin P. GOIN-KOCHEL, Auteur Article en page(s) : p.195-205 Langues : Anglais (eng) Mots-clés : autism spectrum disorders symptoms bullying teasing Index. décimale : PER Périodiques Résumé : The study examined teasing experiences among 74 individuals with autism spectrum disorder (ASD; M age = 115.7 months [9.6 years]; 83.8% male). Experiences were examined from parent, teacher, and child’s own perspectives. Factors potentially associated with being teased were investigated. Comparison data were ascertained on typically developing siblings (n = 68; M age = 116.5 months [9.7 years]; 52.9% male). Select items on the Child Behavior Checklist 6–18 and the Teacher Report Form 6–18 were utilized to calculate the prevalence of being teased; qualitative data from a subgroup of verbally fluent children with ASD (n = 50) were analyzed to provide child self-report teasing data. Children with ASD were more likely to be teased than their typically developing siblings. Characteristics that were significantly associated with being teased included higher cognitive functioning, less severe ASD symptomatology, and more time spent in inclusive educational settings. Clinical implications are discussed. En ligne : http://dx.doi.org/10.1177/1088357614522292 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=244
in Focus on Autism and Other Developmental Disabilities > 29-4 (December 2014) . - p.195-205[article] A Multi-Rater Study on Being Teased Among Children/Adolescents With Autism Spectrum Disorder (ASD) and Their Typically Developing Siblings: Associations With ASD Symptoms [Texte imprimé et/ou numérique] / Kerri P. NOWELL, Auteur ; Christie M. BREWTON, Auteur ; Robin P. GOIN-KOCHEL, Auteur . - p.195-205.
Langues : Anglais (eng)
in Focus on Autism and Other Developmental Disabilities > 29-4 (December 2014) . - p.195-205
Mots-clés : autism spectrum disorders symptoms bullying teasing Index. décimale : PER Périodiques Résumé : The study examined teasing experiences among 74 individuals with autism spectrum disorder (ASD; M age = 115.7 months [9.6 years]; 83.8% male). Experiences were examined from parent, teacher, and child’s own perspectives. Factors potentially associated with being teased were investigated. Comparison data were ascertained on typically developing siblings (n = 68; M age = 116.5 months [9.7 years]; 52.9% male). Select items on the Child Behavior Checklist 6–18 and the Teacher Report Form 6–18 were utilized to calculate the prevalence of being teased; qualitative data from a subgroup of verbally fluent children with ASD (n = 50) were analyzed to provide child self-report teasing data. Children with ASD were more likely to be teased than their typically developing siblings. Characteristics that were significantly associated with being teased included higher cognitive functioning, less severe ASD symptomatology, and more time spent in inclusive educational settings. Clinical implications are discussed. En ligne : http://dx.doi.org/10.1177/1088357614522292 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=244 A multinational study examining the cross cultural differences in reported symptoms of autism spectrum disorders: Israel, South Korea, the United Kingdom, and the United States of America / Johnny L. MATSON in Research in Autism Spectrum Disorders, 5-4 (October-December 2011)
PermalinkPredicting improvement in social–communication symptoms of autism spectrum disorders using retrospective treatment data / Micah O. MAZUREK in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)
PermalinkThe Structure of Autism Symptoms as Measured by the Autism Diagnostic Observation Schedule / Megan NORRIS in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
Permalink''They don?t understand how bad I feel'': Inconsistencies between mother-rated and self-rated symptoms of depression in autistic girls / Vicki BITSIKA in Research in Autism Spectrum Disorders, 104 (June 2023)
PermalinkExecutive functions in girls with and without childhood ADHD: developmental trajectories and associations with symptom change / Meghan MILLER in Journal of Child Psychology and Psychiatry, 54-9 (September 2013)
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