4 recherche sur le mot-clé 'Time Perception/physiology'

Correlations Between Audiovisual Temporal Processing and Sensory Responsiveness in Adolescents with Autistic Traits / Han-Yu ZHOU in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2450-2460 Titre : Correlations Between Audiovisual Temporal Processing and Sensory Responsiveness in Adolescents with Autistic Traits Type de document : texte imprimé Auteurs : Han-Yu ZHOU, Auteur ; Han-Xue YANG, Auteur ; Li-Juan SHI, Auteur ; Simon S.Y. LUI, Auteur ; Eric F.C. CHEUNG, Auteur ; Raymond C.K. CHAN, Auteur Article en page(s) : p.2450-2460 Langues : Anglais (eng) Mots-clés : Adolescent  Auditory Perception/physiology  Autism Spectrum Disorder/physiopathology  Female  Humans  Judgment  Male  Sensation/physiology  Sensory Thresholds  Task Performance and Analysis  Time Perception/physiology  Visual Perception/physiology  Audiovisual  Auditory  Autistic traits  Sensory responsiveness  Temporal acuity  Visual Index. décimale : PER Périodiques Résumé : Atypical sensory processing has recently gained much research interest as a key domain of autistic symptoms. Individuals with autism spectrum disorder (ASD) exhibit difficulties in processing the temporal aspects of sensory inputs, and show altered behavioural responses to sensory stimuli (i.e., sensory responsiveness). The present study examined the relation between sensory responsiveness (assessed by the Adult/Adolescent Sensory Profile) and audiovisual temporal integration (measured by unisensory temporal order judgement (TOJ) tasks and audiovisual simultaneity judgement (SJ) tasks) in typically-developing adolescents (n = 94). We found that adolescents with higher levels of autistic traits exhibited more difficulties in separating visual stimuli in time (i.e., larger visual TOJ threshold) and showed a stronger bias to perceive sound-leading audiovisual pairings as simultaneous. Regarding the associations between different measures of sensory function, reduced visual temporal acuity, but not auditory or multisensory temporal processing, was significantly correlated with more atypical patterns of sensory responsiveness. Furthermore, the positive correlation between visual TOJ thresholds and sensory avoidance was only found in adolescents with relatively high levels of autistic traits, but not in those with relatively low levels of autistic traits. These findings suggest that reduced visual temporal acuity may contribute to altered sensory experiences and may be linked to broader behavioural characteristics of ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04724-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Correlations Between Audiovisual Temporal Processing and Sensory Responsiveness in Adolescents with Autistic Traits [texte imprimé] / Han-Yu ZHOU, Auteur ; Han-Xue YANG, Auteur ; Li-Juan SHI, Auteur ; Simon S.Y. LUI, Auteur ; Eric F.C. CHEUNG, Auteur ; Raymond C.K. CHAN, Auteur . - p.2450-2460. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2450-2460 Mots-clés : Adolescent  Auditory Perception/physiology  Autism Spectrum Disorder/physiopathology  Female  Humans  Judgment  Male  Sensation/physiology  Sensory Thresholds  Task Performance and Analysis  Time Perception/physiology  Visual Perception/physiology  Audiovisual  Auditory  Autistic traits  Sensory responsiveness  Temporal acuity  Visual Index. décimale : PER Périodiques Résumé : Atypical sensory processing has recently gained much research interest as a key domain of autistic symptoms. Individuals with autism spectrum disorder (ASD) exhibit difficulties in processing the temporal aspects of sensory inputs, and show altered behavioural responses to sensory stimuli (i.e., sensory responsiveness). The present study examined the relation between sensory responsiveness (assessed by the Adult/Adolescent Sensory Profile) and audiovisual temporal integration (measured by unisensory temporal order judgement (TOJ) tasks and audiovisual simultaneity judgement (SJ) tasks) in typically-developing adolescents (n = 94). We found that adolescents with higher levels of autistic traits exhibited more difficulties in separating visual stimuli in time (i.e., larger visual TOJ threshold) and showed a stronger bias to perceive sound-leading audiovisual pairings as simultaneous. Regarding the associations between different measures of sensory function, reduced visual temporal acuity, but not auditory or multisensory temporal processing, was significantly correlated with more atypical patterns of sensory responsiveness. Furthermore, the positive correlation between visual TOJ thresholds and sensory avoidance was only found in adolescents with relatively high levels of autistic traits, but not in those with relatively low levels of autistic traits. These findings suggest that reduced visual temporal acuity may contribute to altered sensory experiences and may be linked to broader behavioural characteristics of ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04724-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Learning impairments in Fmr1(-/-)mice on an audio-visual temporal pattern discrimination task / William MOL in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Learning impairments in Fmr1(-/-)mice on an audio-visual temporal pattern discrimination task Type de document : texte imprimé Auteurs : William MOL, Auteur ; Sam POST, Auteur ; Megan LEE, Auteur ; Ritika THAPA, Auteur ; Michael ERICKSON, Auteur ; Anubhuti GOEL, Auteur Langues : Anglais (eng) Mots-clés : Animals  Fragile X Mental Retardation Protein/genetics  Mice  Male  Fragile X Syndrome/genetics/physiopathology  Disease Models, Animal  Mice, Knockout  Auditory Perception/physiology  Mice, Inbred C57BL  Learning Disabilities/genetics/physiopathology  Discrimination Learning/physiology  Time Perception/physiology  Acoustic Stimulation  Discrimination, Psychological/physiology  Visual Perception/physiology  Photic Stimulation Index. décimale : PER Périodiques Résumé : Estimating time and making predictions is integral to our experience of the world. Given the importance of timing to most behaviors, disruptions in temporal processing and timed performance are reported in a number of neuropsychiatric disorders such as Schizophrenia, Autism Spectrum Disorder (ASD), Fragile X Syndrome (FXS), and Attention-deficit Hyperactivity Disorder (ADHD). Symptoms that implicitly include disruption in timing are atypical turn-taking during social interactions, unusual verbal intonations, poor reading, speech and language skills, inattention, delays in learning, and difficulties making predictions. Currently, there are no viable treatments for these symptoms, the reason being the underlying neural dysfunction that contributes to timing deficits in neuropsychiatric disorders is unknown. To address this unknown, we have designed a novel Temporal Pattern Sensory Discrimination Task (TPSD) for awake-behaving mice. Stimuli consist of paired audiovisual stimuli that differ in duration. Compared to Wild-Type (WT) mice, Fmr1(-/-) mice, a well-established mouse model of FXS, showed significant impairment in learning the TPSD task, as evidenced by reduced discriminability indices and atypical licking patterns. Often sensory information is multimodal and, indeed, studies show that learning in humans and rodents improves with multimodal stimuli than with unimodal stimuli. To test how the multimodal nature of stimuli impacted performance of Fmr1(-/-) mice, following training on the audiovisual stimuli, we tested mice on audio-only or visual-only stimuli. While WT mice showed significant disruption in performance when tested on unimodal stimuli, Fmr1(-/-) mice displayed equivalent performance on visual-only stimuli when compared to the multimodal task. Our novel task captures timing difficulties and multisensory integration issues in Fmr1(-/-) mice and provides an assay to examine the associated neural dysfunction. En ligne : https://dx.doi.org/10.1186/s11689-025-09638-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Learning impairments in Fmr1(-/-)mice on an audio-visual temporal pattern discrimination task [texte imprimé] / William MOL, Auteur ; Sam POST, Auteur ; Megan LEE, Auteur ; Ritika THAPA, Auteur ; Michael ERICKSON, Auteur ; Anubhuti GOEL, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Animals  Fragile X Mental Retardation Protein/genetics  Mice  Male  Fragile X Syndrome/genetics/physiopathology  Disease Models, Animal  Mice, Knockout  Auditory Perception/physiology  Mice, Inbred C57BL  Learning Disabilities/genetics/physiopathology  Discrimination Learning/physiology  Time Perception/physiology  Acoustic Stimulation  Discrimination, Psychological/physiology  Visual Perception/physiology  Photic Stimulation Index. décimale : PER Périodiques Résumé : Estimating time and making predictions is integral to our experience of the world. Given the importance of timing to most behaviors, disruptions in temporal processing and timed performance are reported in a number of neuropsychiatric disorders such as Schizophrenia, Autism Spectrum Disorder (ASD), Fragile X Syndrome (FXS), and Attention-deficit Hyperactivity Disorder (ADHD). Symptoms that implicitly include disruption in timing are atypical turn-taking during social interactions, unusual verbal intonations, poor reading, speech and language skills, inattention, delays in learning, and difficulties making predictions. Currently, there are no viable treatments for these symptoms, the reason being the underlying neural dysfunction that contributes to timing deficits in neuropsychiatric disorders is unknown. To address this unknown, we have designed a novel Temporal Pattern Sensory Discrimination Task (TPSD) for awake-behaving mice. Stimuli consist of paired audiovisual stimuli that differ in duration. Compared to Wild-Type (WT) mice, Fmr1(-/-) mice, a well-established mouse model of FXS, showed significant impairment in learning the TPSD task, as evidenced by reduced discriminability indices and atypical licking patterns. Often sensory information is multimodal and, indeed, studies show that learning in humans and rodents improves with multimodal stimuli than with unimodal stimuli. To test how the multimodal nature of stimuli impacted performance of Fmr1(-/-) mice, following training on the audiovisual stimuli, we tested mice on audio-only or visual-only stimuli. While WT mice showed significant disruption in performance when tested on unimodal stimuli, Fmr1(-/-) mice displayed equivalent performance on visual-only stimuli when compared to the multimodal task. Our novel task captures timing difficulties and multisensory integration issues in Fmr1(-/-) mice and provides an assay to examine the associated neural dysfunction. En ligne : https://dx.doi.org/10.1186/s11689-025-09638-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Quantifying the resolution of spatial and temporal representation in children with 22q11.2 deletion syndrome / Kathryn L. MCCABE in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 40 Titre : Quantifying the resolution of spatial and temporal representation in children with 22q11.2 deletion syndrome Type de document : texte imprimé Auteurs : Kathryn L. MCCABE, Auteur ; Abbie M. POPA, Auteur ; Courtney DURDLE, Auteur ; Michele AMATO, Auteur ; Margarita H. CABARAL, Auteur ; Joshua CRUZ, Auteur ; Ling M. WONG, Auteur ; Danielle HARVEY, Auteur ; Nicole TARTAGLIA, Auteur ; Tony J. SIMON, Auteur Article en page(s) : 40 Langues : Anglais (eng) Mots-clés : Adolescent  Attention/physiology  Auditory Perception/physiology  Child  DiGeorge Syndrome/complications/physiopathology  Female  Humans  Male  Mathematical Concepts  Perceptual Disorders/etiology/physiopathology  Sex Chromosome Aberrations  Space Perception/physiology  Time Perception/physiology  Visual Perception/physiology  22q11.2 deletion syndrome (22q11DS)  Attention  Children  Magnitude processing  Spatiotemporal attention Index. décimale : PER Périodiques Résumé : OBJECTIVES: Our ability to generate mental representation of magnitude from sensory information affects how we perceive and experience the world. Reduced resolution of the mental representations formed from sensory inputs may generate impairment in the proximal and distal information processes that utilize these representations. Impairment of spatial and temporal information processing likely underpins the non-verbal cognitive impairments observed in 22q11.2 deletion syndrome (22q11DS). The present study builds on prior research by seeking to quantify the resolution of spatial and temporal representation in children with 22q11DS, sex chromosome aneuploidy (SCA), and a typically developing (TD) control group. PARTICIPANTS AND METHODS: Children (22q11DS = 70, SCA = 49, TD = 46) responded to visual or auditory stimuli with varying difference ratios. The participant's task was to identify which of two sequentially presented stimuli was of larger magnitude in terms of, size, duration, or auditory frequency. Detection threshold was calculated as the minimum difference ratio between the "standard" and the "target" stimuli required to achieve 75% accuracy in detecting that the two stimuli were different. RESULTS: Children with 22q11DS required larger magnitude difference between spatial stimuli for accurate identification compared with both the SCA and TD groups (% difference from standard: 22q11DS = 14; SCA = 8; TD: 7; F = 8.42, p < 0.001). Temporal detection threshold was also higher for the 22q11DS group to both visual (% difference from standard: 22q11DS = 14; SCA = 8; TD = 7; F = 8.33, p < 0.001) and auditory (% difference from standard: 22q11DS = 23; SCA = 12; TD: 8; F = 8.99, p < 0.001) stimuli compared with both the SCA and TD groups, while the SCA and TD groups displayed equivalent performance on these measures (p's > 0.05). Pitch detection threshold did not differ among the groups (p's > 0.05). CONCLUSIONS: The observation of higher detection thresholds to spatial and temporal stimuli indicates further evidence for reduced resolution in both spatial and temporal magnitude representation in 22q11DS, that does not extend to frequency magnitude representation (pitch detection), and which is not explained by generalized cognitive impairment alone. These findings generate further support for the hypothesis that spatiotemporal hypergranularity of mental representations contributes to the non-verbal cognitive impairment seen in 22q11DS. En ligne : https://dx.doi.org/10.1186/s11689-019-9301-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Quantifying the resolution of spatial and temporal representation in children with 22q11.2 deletion syndrome [texte imprimé] / Kathryn L. MCCABE, Auteur ; Abbie M. POPA, Auteur ; Courtney DURDLE, Auteur ; Michele AMATO, Auteur ; Margarita H. CABARAL, Auteur ; Joshua CRUZ, Auteur ; Ling M. WONG, Auteur ; Danielle HARVEY, Auteur ; Nicole TARTAGLIA, Auteur ; Tony J. SIMON, Auteur . - 40. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 40 Mots-clés : Adolescent  Attention/physiology  Auditory Perception/physiology  Child  DiGeorge Syndrome/complications/physiopathology  Female  Humans  Male  Mathematical Concepts  Perceptual Disorders/etiology/physiopathology  Sex Chromosome Aberrations  Space Perception/physiology  Time Perception/physiology  Visual Perception/physiology  22q11.2 deletion syndrome (22q11DS)  Attention  Children  Magnitude processing  Spatiotemporal attention Index. décimale : PER Périodiques Résumé : OBJECTIVES: Our ability to generate mental representation of magnitude from sensory information affects how we perceive and experience the world. Reduced resolution of the mental representations formed from sensory inputs may generate impairment in the proximal and distal information processes that utilize these representations. Impairment of spatial and temporal information processing likely underpins the non-verbal cognitive impairments observed in 22q11.2 deletion syndrome (22q11DS). The present study builds on prior research by seeking to quantify the resolution of spatial and temporal representation in children with 22q11DS, sex chromosome aneuploidy (SCA), and a typically developing (TD) control group. PARTICIPANTS AND METHODS: Children (22q11DS = 70, SCA = 49, TD = 46) responded to visual or auditory stimuli with varying difference ratios. The participant's task was to identify which of two sequentially presented stimuli was of larger magnitude in terms of, size, duration, or auditory frequency. Detection threshold was calculated as the minimum difference ratio between the "standard" and the "target" stimuli required to achieve 75% accuracy in detecting that the two stimuli were different. RESULTS: Children with 22q11DS required larger magnitude difference between spatial stimuli for accurate identification compared with both the SCA and TD groups (% difference from standard: 22q11DS = 14; SCA = 8; TD: 7; F = 8.42, p < 0.001). Temporal detection threshold was also higher for the 22q11DS group to both visual (% difference from standard: 22q11DS = 14; SCA = 8; TD = 7; F = 8.33, p < 0.001) and auditory (% difference from standard: 22q11DS = 23; SCA = 12; TD: 8; F = 8.99, p < 0.001) stimuli compared with both the SCA and TD groups, while the SCA and TD groups displayed equivalent performance on these measures (p's > 0.05). Pitch detection threshold did not differ among the groups (p's > 0.05). CONCLUSIONS: The observation of higher detection thresholds to spatial and temporal stimuli indicates further evidence for reduced resolution in both spatial and temporal magnitude representation in 22q11DS, that does not extend to frequency magnitude representation (pitch detection), and which is not explained by generalized cognitive impairment alone. These findings generate further support for the hypothesis that spatiotemporal hypergranularity of mental representations contributes to the non-verbal cognitive impairment seen in 22q11DS. En ligne : https://dx.doi.org/10.1186/s11689-019-9301-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Temporal Coordination and Prosodic Structure in Autism Spectrum Disorder: Timing Across Speech and Non-speech Motor Domains / Kathryn FRANICH in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2929-2949 Titre : Temporal Coordination and Prosodic Structure in Autism Spectrum Disorder: Timing Across Speech and Non-speech Motor Domains Type de document : texte imprimé Auteurs : Kathryn FRANICH, Auteur ; Hung Yat WONG, Auteur ; Alan C.L. YU, Auteur ; Carol K.S. TO, Auteur Article en page(s) : p.2929-2949 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/complications/psychology  Female  Humans  Male  Speech/physiology  Speech Disorders/complications/psychology  Speech Perception/physiology  Time Perception/physiology  Young Adult  Autism  Motor control  Prosody  Speech timing  Temporal processing Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) often exhibit disordered speech prosody, but sources of disordered prosody remain poorly understood. We explored patterns of temporal alignment and prosodic grouping in a speech-based metronome repetition task as well as manual coordination in a drum tapping task among Cantonese speakers with ASD and normal nonverbal IQ and matched controls. Results indicate similar group results for prosodic grouping patterns, but significant differences in relative timing and longer syllable durations at phrase ends for the ASD group. Variability on the speech task was significantly correlated with variability on the drumming task, consistent with the view that impairment in both speech and non-speech motor domains can be linked with deficits in temporal processing. En ligne : http://dx.doi.org/10.1007/s10803-020-04758-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Temporal Coordination and Prosodic Structure in Autism Spectrum Disorder: Timing Across Speech and Non-speech Motor Domains [texte imprimé] / Kathryn FRANICH, Auteur ; Hung Yat WONG, Auteur ; Alan C.L. YU, Auteur ; Carol K.S. TO, Auteur . - p.2929-2949. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2929-2949 Mots-clés : Adult  Autism Spectrum Disorder/complications/psychology  Female  Humans  Male  Speech/physiology  Speech Disorders/complications/psychology  Speech Perception/physiology  Time Perception/physiology  Young Adult  Autism  Motor control  Prosody  Speech timing  Temporal processing Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) often exhibit disordered speech prosody, but sources of disordered prosody remain poorly understood. We explored patterns of temporal alignment and prosodic grouping in a speech-based metronome repetition task as well as manual coordination in a drum tapping task among Cantonese speakers with ASD and normal nonverbal IQ and matched controls. Results indicate similar group results for prosodic grouping patterns, but significant differences in relative timing and longer syllable durations at phrase ends for the ASD group. Variability on the speech task was significantly correlated with variability on the drumming task, consistent with the view that impairment in both speech and non-speech motor domains can be linked with deficits in temporal processing. En ligne : http://dx.doi.org/10.1007/s10803-020-04758-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453