17 recherche sur le mot-clé 'Toddler'

Sex differences in early autism screening using the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) / Sherief Y ELDEEB in Autism, 27-7 (October 2023)  

Public ISBD [article]  inAutism > 27-7 (October 2023) . - p.2112-2123 Titre : Sex differences in early autism screening using the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) Type de document : texte imprimé Auteurs : Sherief Y ELDEEB, Auteur ; Natasha N. LUDWIG, Auteur ; Andrea Trubanova WIECKOWSKI, Auteur ; Mary F.S. DIECKHAUS, Auteur ; Yasemin ALGUR, Auteur ; Victoria RYAN, Auteur ; Sarah DUFEK, Auteur ; Aubyn STAHMER, Auteur ; Diana L. ROBINS, Auteur Article en page(s) : p.2112-2123 Langues : Anglais (eng) Mots-clés : autism  screening  sex differences  toddler Index. décimale : PER Périodiques Résumé : Males are more likely to be diagnosed with autism than females, and at earlier ages, yet few studies examine sex differences in screening. This study explored sex differences in psychometric properties, recommended cutoff scores, and overall scores of the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up. Participants were 28,088 toddlers enrolled in four early detection of autism studies. Children (N=731) at high likelihood for autism attended evaluations after screening and/or primary care clinician concern. Females were less likely to screen at high likelihood for autism at each stage of screening and therefore less likely to be invited for evaluations. Positive predictive value was significantly lower among females than males, but sensitivity was similar. False positive females were likely to have another developmental delay. Cutoff scores for males and females matched recommended guidelines. Final scores on the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up did not differ between males and females diagnosed with autism, but did for the overall sample identified at high likelihood for autism. Our findings suggest that females are less likely to be referred for evaluations, but the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up accurately identifies both males and females with autism at established cutoffs. Future research should examine methods to reduce false positive in females.Lay abstractThis study examined a widely used autism screening tool, the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up to identify differences in screening for autism between toddler males and females. Examining sex differences in screening for autism in toddlerhood is important as it determines who will be referred for evaluations and receive diagnoses, which is critical for access to autism-specific early intervention. This study found that females were less likely to screen positive and be invited for evaluations compared with males. Females at high likelihood for autism were less likely to be diagnosed with autism, which decreases confidence in the screener?s results. Importantly, the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up accurately identified both males and females with autism. Future research should examine ways to improve accuracy in screening results for females. En ligne : http://dx.doi.org/10.1177/13623613231154728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Sex differences in early autism screening using the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) [texte imprimé] / Sherief Y ELDEEB, Auteur ; Natasha N. LUDWIG, Auteur ; Andrea Trubanova WIECKOWSKI, Auteur ; Mary F.S. DIECKHAUS, Auteur ; Yasemin ALGUR, Auteur ; Victoria RYAN, Auteur ; Sarah DUFEK, Auteur ; Aubyn STAHMER, Auteur ; Diana L. ROBINS, Auteur . - p.2112-2123. Langues : Anglais (eng) in Autism > 27-7 (October 2023) . - p.2112-2123 Mots-clés : autism  screening  sex differences  toddler Index. décimale : PER Périodiques Résumé : Males are more likely to be diagnosed with autism than females, and at earlier ages, yet few studies examine sex differences in screening. This study explored sex differences in psychometric properties, recommended cutoff scores, and overall scores of the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up. Participants were 28,088 toddlers enrolled in four early detection of autism studies. Children (N=731) at high likelihood for autism attended evaluations after screening and/or primary care clinician concern. Females were less likely to screen at high likelihood for autism at each stage of screening and therefore less likely to be invited for evaluations. Positive predictive value was significantly lower among females than males, but sensitivity was similar. False positive females were likely to have another developmental delay. Cutoff scores for males and females matched recommended guidelines. Final scores on the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up did not differ between males and females diagnosed with autism, but did for the overall sample identified at high likelihood for autism. Our findings suggest that females are less likely to be referred for evaluations, but the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up accurately identifies both males and females with autism at established cutoffs. Future research should examine methods to reduce false positive in females.Lay abstractThis study examined a widely used autism screening tool, the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up to identify differences in screening for autism between toddler males and females. Examining sex differences in screening for autism in toddlerhood is important as it determines who will be referred for evaluations and receive diagnoses, which is critical for access to autism-specific early intervention. This study found that females were less likely to screen positive and be invited for evaluations compared with males. Females at high likelihood for autism were less likely to be diagnosed with autism, which decreases confidence in the screener?s results. Importantly, the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up accurately identified both males and females with autism. Future research should examine ways to improve accuracy in screening results for females. En ligne : http://dx.doi.org/10.1177/13623613231154728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Association between the autistic traits, internalising and externalising traits, dysregulation, and competence in 18-36-months toddlers / Chiara MARTIS ; Luigia DUMA ; Flavia LECCISO in Research in Autism, 127 (September 2025)  

Public ISBD [article]  inResearch in Autism > 127 (September 2025) . - p.202679 Titre : Association between the autistic traits, internalising and externalising traits, dysregulation, and competence in 18-36-months toddlers Type de document : texte imprimé Auteurs : Chiara MARTIS, Auteur ; Luigia DUMA, Auteur ; Flavia LECCISO, Auteur Article en page(s) : p.202679 Langues : Anglais (eng) Mots-clés : Autistic trait  Internalising trait  Externalising trait  Dysregulation  Competence  Toddler Index. décimale : PER Périodiques En ligne : https://doi.org/10.1016/j.reia.2025.202679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Association between the autistic traits, internalising and externalising traits, dysregulation, and competence in 18-36-months toddlers [texte imprimé] / Chiara MARTIS, Auteur ; Luigia DUMA, Auteur ; Flavia LECCISO, Auteur . - p.202679. Langues : Anglais (eng) in Research in Autism > 127 (September 2025) . - p.202679 Mots-clés : Autistic trait  Internalising trait  Externalising trait  Dysregulation  Competence  Toddler Index. décimale : PER Périodiques En ligne : https://doi.org/10.1016/j.reia.2025.202679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence from the Brain Imaging Abnormalities in 2–3 Years Old Toddlers / Zhou XIAO in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1633-1640 Titre : Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence from the Brain Imaging Abnormalities in 2–3 Years Old Toddlers Type de document : texte imprimé Auteurs : Zhou XIAO, Auteur ; Ting QIU, Auteur ; Xiaoyan KE, Auteur ; Xiang XIAO, Auteur ; Ting XIAO, Auteur ; Fengjing LIANG, Auteur ; Bing ZOU, Auteur ; Haiqing HUANG, Auteur ; Hui FANG, Auteur ; Kangkang CHU, Auteur ; Jiuping ZHANG, Auteur ; Yijun LIU, Auteur Article en page(s) : p.1633-1640 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Toddler  Magnetic resonance imaging  Voxel based morphometry  Diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that occurs within the first 3 years of life, which is marked by social skills and communication deficits along with stereotyped repetitive behavior. Although great efforts have been made to clarify the underlying neuroanatomical abnormalities and brain-behavior relationships in adolescents and adults with ASD, literature is still limited in information about the neurobiology of ASD in the early age of life. Brain images of 50 toddlers with ASD and 28 age, gender, and developmental quotient matched toddlers with developmental delay (DD) (control group) between ages 2 and 3 years were captured using combined magnetic resonance-based structural imaging and diffusion tensor imaging (DTI). Structural magnetic resonance imaging was applied to assess overall gray matter (GM) and white matter (WM) volumes, and regional alterations were assessed by voxel-based morphometry. DTI was used to investigate the white matter tract integrity. Compared with DD, significant increases were observed in ASD, primarily in global GM and WM volumes and in right superior temporal gyrus regional GM and WM volumes. Higher fractional anisotropy value was also observed in the corpus callosum, posterior cingulate cortex, and limbic lobes of ASD. The converging findings of structural and white matter abnormalities in ASD suggest that alterations in neural-anatomy of different brain regions may be involved in behavioral and cognitive deficits associated with ASD, especially in an early age of 2–3 years old toddlers. En ligne : http://dx.doi.org/10.1007/s10803-014-2033-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence from the Brain Imaging Abnormalities in 2–3 Years Old Toddlers [texte imprimé] / Zhou XIAO, Auteur ; Ting QIU, Auteur ; Xiaoyan KE, Auteur ; Xiang XIAO, Auteur ; Ting XIAO, Auteur ; Fengjing LIANG, Auteur ; Bing ZOU, Auteur ; Haiqing HUANG, Auteur ; Hui FANG, Auteur ; Kangkang CHU, Auteur ; Jiuping ZHANG, Auteur ; Yijun LIU, Auteur . - p.1633-1640. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1633-1640 Mots-clés : Autism spectrum disorder  Toddler  Magnetic resonance imaging  Voxel based morphometry  Diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that occurs within the first 3 years of life, which is marked by social skills and communication deficits along with stereotyped repetitive behavior. Although great efforts have been made to clarify the underlying neuroanatomical abnormalities and brain-behavior relationships in adolescents and adults with ASD, literature is still limited in information about the neurobiology of ASD in the early age of life. Brain images of 50 toddlers with ASD and 28 age, gender, and developmental quotient matched toddlers with developmental delay (DD) (control group) between ages 2 and 3 years were captured using combined magnetic resonance-based structural imaging and diffusion tensor imaging (DTI). Structural magnetic resonance imaging was applied to assess overall gray matter (GM) and white matter (WM) volumes, and regional alterations were assessed by voxel-based morphometry. DTI was used to investigate the white matter tract integrity. Compared with DD, significant increases were observed in ASD, primarily in global GM and WM volumes and in right superior temporal gyrus regional GM and WM volumes. Higher fractional anisotropy value was also observed in the corpus callosum, posterior cingulate cortex, and limbic lobes of ASD. The converging findings of structural and white matter abnormalities in ASD suggest that alterations in neural-anatomy of different brain regions may be involved in behavioral and cognitive deficits associated with ASD, especially in an early age of 2–3 years old toddlers. En ligne : http://dx.doi.org/10.1007/s10803-014-2033-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

Diagnostic model generated by MRI-derived brain features in toddlers with autism spectrum disorder / Xiang XIAO in Autism Research, 10-4 (April 2017)  

Public ISBD [article]  inAutism Research > 10-4 (April 2017) . - p.620-630 Titre : Diagnostic model generated by MRI-derived brain features in toddlers with autism spectrum disorder Type de document : texte imprimé Auteurs : Xiang XIAO, Auteur ; Hui FANG, Auteur ; Jiansheng WU, Auteur ; ChaoYong XIAO, Auteur ; Ting XIAO, Auteur ; Lu QIAN, Auteur ; Fengjing LIANG, Auteur ; Zhou XIAO, Auteur ; Kangkang CHU, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.620-630 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  toddler  magnetic resonance imaging  cortical thickness  predictive model Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder mainly showed atypical social interaction, communication, and restricted, repetitive patterns of behavior, interests and activities. Now clinic diagnosis of ASD is mostly based on psychological evaluation, clinical observation and medical history. All these behavioral indexes could not avoid defects such as subjectivity and reporter-dependency. Therefore researchers devoted themselves to seek relatively stable biomarkers of ASD as supplementary diagnostic evidence. The goal of present study is to generate relatively stable predictive model based on anatomical brain features by using machine learning technique. Forty-six ASD children and thirty-nine development delay children aged from 18 to 37 months were evolved in. As a result, the predictive model generated by regional average cortical thickness of regions with top 20 highest importance of random forest classifier showed best diagnostic performance. And random forest was proved to be the optimal approach for neuroimaging data mining in small size set and thickness-based classification outperformed volume-based classification and surface area-based classification in ASD. The brain regions selected by the models might attract attention and the idea of considering biomarkers as a supplementary evidence of ASD diagnosis worth exploring. En ligne : http://dx.doi.org/10.1002/aur.1711 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Diagnostic model generated by MRI-derived brain features in toddlers with autism spectrum disorder [texte imprimé] / Xiang XIAO, Auteur ; Hui FANG, Auteur ; Jiansheng WU, Auteur ; ChaoYong XIAO, Auteur ; Ting XIAO, Auteur ; Lu QIAN, Auteur ; Fengjing LIANG, Auteur ; Zhou XIAO, Auteur ; Kangkang CHU, Auteur ; Xiaoyan KE, Auteur . - p.620-630. Langues : Anglais (eng) in Autism Research > 10-4 (April 2017) . - p.620-630 Mots-clés : autism spectrum disorder  toddler  magnetic resonance imaging  cortical thickness  predictive model Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder mainly showed atypical social interaction, communication, and restricted, repetitive patterns of behavior, interests and activities. Now clinic diagnosis of ASD is mostly based on psychological evaluation, clinical observation and medical history. All these behavioral indexes could not avoid defects such as subjectivity and reporter-dependency. Therefore researchers devoted themselves to seek relatively stable biomarkers of ASD as supplementary diagnostic evidence. The goal of present study is to generate relatively stable predictive model based on anatomical brain features by using machine learning technique. Forty-six ASD children and thirty-nine development delay children aged from 18 to 37 months were evolved in. As a result, the predictive model generated by regional average cortical thickness of regions with top 20 highest importance of random forest classifier showed best diagnostic performance. And random forest was proved to be the optimal approach for neuroimaging data mining in small size set and thickness-based classification outperformed volume-based classification and surface area-based classification in ASD. The brain regions selected by the models might attract attention and the idea of considering biomarkers as a supplementary evidence of ASD diagnosis worth exploring. En ligne : http://dx.doi.org/10.1002/aur.1711 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Effects of Parent-Implemented Early Start Denver Model Intervention on Chinese Toddlers with Autism Spectrum Disorder: A Non-Randomized Controlled Trial / Bingrui ZHOU in Autism Research, 11-4 (April 2018)  

Public ISBD [article]  inAutism Research > 11-4 (April 2018) . - p.654-666 Titre : Effects of Parent-Implemented Early Start Denver Model Intervention on Chinese Toddlers with Autism Spectrum Disorder: A Non-Randomized Controlled Trial Type de document : texte imprimé Auteurs : Bingrui ZHOU, Auteur ; Qiong XU, Auteur ; Huiping LI, Auteur ; Ying ZHANG, Auteur ; Yao WANG, Auteur ; Sally J. ROGERS, Auteur ; Xiu XU, Auteur Année de publication : 2018 Article en page(s) : p.654-666 Langues : Anglais (eng) Mots-clés : Parent-implemented Early Start Denver Model (P-ESDM)  autism spectrum disorder  early intervention  parenting stress  toddler Index. décimale : PER Périodiques Résumé : To evaluate the effects of a 26-week, high-intensity, parent-implemented Early Start Denver Model (P-ESDM) intervention on developmental outcomes, severity of autism spectrum disorder (ASD), and parental stress of ASD toddlers in China. Subjects in P-ESDM group (n = 23) were recruited from 1.5- to 2.5-year-old toddlers who were screened positive in Xuhui and Minhang Districts and were diagnosed with ASD. A community (comparison) group of age-matched toddlers with ASD (n = 20) was recruited from other areas. Subjects of the P-ESDM group attended 1.5-hr parent coaching per week for 26 weeks, and those in the community group received interventions available from communities. Assessments were conducted at baseline (T1) and 26 weeks later (T2). After adjusting for baseline differences between the two groups, P-ESDM group demonstrated greater improvement than the community group in general development, especially in Language domain. Neither group demonstrated significant change in ASD severity, but the P-ESDM group showed greater improvement in social affect, parent-reported social communication and symbolic play than community group did. Finally, parents in P-ESDM group experienced decreased parenting stress while those in community group showed an opposite trend, though the differences did not reach significant association with the P-ESDM intervention. Chinese toddlers with ASD receiving 26 weeks of P-ESDM via regular coaching sessions showed significant greater improvement than those receiving community interventions in multiple aspects of development including social communications. These findings add support to the importance of providing early screening, diagnosis, and immediate referral for evidence-based interventions to improve outcome of young children with ASD. Autism Res 2018, 11: 654-666. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The development of early screening and diagnosis of autism spectrum disorder (ASD) in China has highlighted the importance of early intervention for young children with ASD. Our current study demonstrated that parent-implemented Early Start Denver Model (P-ESDM) via coaching from professionals improved developmental outcomes, especially in the language domain, and social communicational behaviors of Chinese toddlers with ASD. P-ESDM may help parents in China provide effective early intervention to their children with ASD via improving their skills when they are still at a waiting list for services or lack access to intervention, and has the potential to alleviate their parenting stress. En ligne : http://dx.doi.org/10.1002/aur.1917 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] Effects of Parent-Implemented Early Start Denver Model Intervention on Chinese Toddlers with Autism Spectrum Disorder: A Non-Randomized Controlled Trial [texte imprimé] / Bingrui ZHOU, Auteur ; Qiong XU, Auteur ; Huiping LI, Auteur ; Ying ZHANG, Auteur ; Yao WANG, Auteur ; Sally J. ROGERS, Auteur ; Xiu XU, Auteur . - 2018 . - p.654-666. Langues : Anglais (eng) in Autism Research > 11-4 (April 2018) . - p.654-666 Mots-clés : Parent-implemented Early Start Denver Model (P-ESDM)  autism spectrum disorder  early intervention  parenting stress  toddler Index. décimale : PER Périodiques Résumé : To evaluate the effects of a 26-week, high-intensity, parent-implemented Early Start Denver Model (P-ESDM) intervention on developmental outcomes, severity of autism spectrum disorder (ASD), and parental stress of ASD toddlers in China. Subjects in P-ESDM group (n = 23) were recruited from 1.5- to 2.5-year-old toddlers who were screened positive in Xuhui and Minhang Districts and were diagnosed with ASD. A community (comparison) group of age-matched toddlers with ASD (n = 20) was recruited from other areas. Subjects of the P-ESDM group attended 1.5-hr parent coaching per week for 26 weeks, and those in the community group received interventions available from communities. Assessments were conducted at baseline (T1) and 26 weeks later (T2). After adjusting for baseline differences between the two groups, P-ESDM group demonstrated greater improvement than the community group in general development, especially in Language domain. Neither group demonstrated significant change in ASD severity, but the P-ESDM group showed greater improvement in social affect, parent-reported social communication and symbolic play than community group did. Finally, parents in P-ESDM group experienced decreased parenting stress while those in community group showed an opposite trend, though the differences did not reach significant association with the P-ESDM intervention. Chinese toddlers with ASD receiving 26 weeks of P-ESDM via regular coaching sessions showed significant greater improvement than those receiving community interventions in multiple aspects of development including social communications. These findings add support to the importance of providing early screening, diagnosis, and immediate referral for evidence-based interventions to improve outcome of young children with ASD. Autism Res 2018, 11: 654-666. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The development of early screening and diagnosis of autism spectrum disorder (ASD) in China has highlighted the importance of early intervention for young children with ASD. Our current study demonstrated that parent-implemented Early Start Denver Model (P-ESDM) via coaching from professionals improved developmental outcomes, especially in the language domain, and social communicational behaviors of Chinese toddlers with ASD. P-ESDM may help parents in China provide effective early intervention to their children with ASD via improving their skills when they are still at a waiting list for services or lack access to intervention, and has the potential to alleviate their parenting stress. En ligne : http://dx.doi.org/10.1002/aur.1917 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

Imitation in ASD: Performance on an imitation choice task / Joanna L. MUSSEY in Research in Autism Spectrum Disorders, 73 (May 2019)  

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Individual and Environmental Factors Affecting Adaptive Behavior of Toddlers with Autism Spectrum Disorder: Role of Parents' Socio-cultural Level / Giulia BALBONI in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

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Intervening in infancy: implications for autism spectrum disorders / Katherine S. WALLACE in Journal of Child Psychology and Psychiatry, 51-12 (December 2010)  

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Interventions for toddlers with autism spectrum disorder: A meta-analysis of single-subject experimental studies / Ellen DEBODINANCE in Research in Autism Spectrum Disorders, 36 (April 2017)  

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Limited Effect of Masking During COVID-19 Pandemic on ADOS-2 Algorithm Scores in Toddlers With and Without Autism / Morgan CHELSEA ; Powell KELLY ; Suzanne L. MACARI ; Katarzyna CHAWARSKA in Autism Research, 18-6 (June 2025)  

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