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Characterizing intrinsic functional connectivity in relation to impaired self-regulation in intellectually able male youth with autism spectrum disorder / Hsiang-Yuan LIN in Autism, 24-5 (July 2020)
[article]
Titre : Characterizing intrinsic functional connectivity in relation to impaired self-regulation in intellectually able male youth with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hsiang-Yuan LIN, Auteur ; Hsing-Chang NI, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1201-1216 Langues : Anglais (eng) Mots-clés : Child Behavior Checklist autism spectrum disorder connectivity connectome-wide association study dysregulation resting-state fMRI Index. décimale : PER Périodiques Résumé : Impaired self-regulation (i.e., dysregulation in affective, behavioral, and cognitive control), is commonly present in young people with autism spectrum disorder (ASD). However, little is known about what is happening in people's brains when self-regulation is impaired in young people with ASD. We used a technique called functional MRI (which measures brain activity by detecting changes associated with blood flow) at a resting state (when participants are not asked to do anything) to research this in intellectually able young people with ASD. We found that brains with more connections, especially between regions involved in sensorimotor processing and regions involved in the processes that enable peoples to focus their attention on the most pertinent features from the sensory environment (salience processing), were related to more impaired self-regulation in young people with and without ASD. We also found that impaired self-regulation was related to increased communication within the brain system involved in voluntary orienting attention to a sensory cue (the dorsal attention network) in young people with ASD. These results highlight how different people have different degrees of dysregulation, which has been largely overlooked in the earlier brain imaging reports on ASD. This might contribute to understanding some of the inconsistencies in the existing published literature on this topic. En ligne : http://dx.doi.org/10.1177/1362361319888104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Autism > 24-5 (July 2020) . - p.1201-1216[article] Characterizing intrinsic functional connectivity in relation to impaired self-regulation in intellectually able male youth with autism spectrum disorder [Texte imprimé et/ou numérique] / Hsiang-Yuan LIN, Auteur ; Hsing-Chang NI, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1201-1216.
Langues : Anglais (eng)
in Autism > 24-5 (July 2020) . - p.1201-1216
Mots-clés : Child Behavior Checklist autism spectrum disorder connectivity connectome-wide association study dysregulation resting-state fMRI Index. décimale : PER Périodiques Résumé : Impaired self-regulation (i.e., dysregulation in affective, behavioral, and cognitive control), is commonly present in young people with autism spectrum disorder (ASD). However, little is known about what is happening in people's brains when self-regulation is impaired in young people with ASD. We used a technique called functional MRI (which measures brain activity by detecting changes associated with blood flow) at a resting state (when participants are not asked to do anything) to research this in intellectually able young people with ASD. We found that brains with more connections, especially between regions involved in sensorimotor processing and regions involved in the processes that enable peoples to focus their attention on the most pertinent features from the sensory environment (salience processing), were related to more impaired self-regulation in young people with and without ASD. We also found that impaired self-regulation was related to increased communication within the brain system involved in voluntary orienting attention to a sensory cue (the dorsal attention network) in young people with ASD. These results highlight how different people have different degrees of dysregulation, which has been largely overlooked in the earlier brain imaging reports on ASD. This might contribute to understanding some of the inconsistencies in the existing published literature on this topic. En ligne : http://dx.doi.org/10.1177/1362361319888104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427