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Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression / X. LIU in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
[article]
Titre : Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression Type de document : Texte imprimé et/ou numérique Auteurs : X. LIU, Auteur ; M. ZOU, Auteur ; C. SUN, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur Article en page(s) : p.522-539 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology Diet Dietary Supplements Female Folic Acid Humans Pregnancy Vitamins Autism spectrum disorder Folic acid Meta-analysis Meta-regression Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 ?g folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539[article] Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression [Texte imprimé et/ou numérique] / X. LIU, Auteur ; M. ZOU, Auteur ; C. SUN, Auteur ; L. WU, Auteur ; W. X. CHEN, Auteur . - p.522-539.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.522-539
Mots-clés : Autism Spectrum Disorder/chemically induced/epidemiology Diet Dietary Supplements Female Folic Acid Humans Pregnancy Vitamins Autism spectrum disorder Folic acid Meta-analysis Meta-regression Prenatal Index. décimale : PER Périodiques Résumé : We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring's ASD [OR 0.57, 95% CI 0.41-0.78]. The consumption of a daily amount of at least 400 ?g folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36-0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring's ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04951-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1(+/-) mouse model of autism spectrum disorders / Kevin LEE in Molecular Autism, 13 (2022)
[article]
Titre : Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1(+/-) mouse model of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Kevin LEE, Auteur ; Yewon JUNG, Auteur ; Yukti VYAS, Auteur ; Imogen SKELTON, Auteur ; Wickliffe C. ABRAHAM, Auteur ; Yi-Ping HSUEH, Auteur ; Johanna M. MONTGOMERY, Auteur Article en page(s) : 13 p. Langues : Anglais (eng) Mots-clés : Animals Autism Spectrum Disorder/genetics Dietary Supplements Disease Models, Animal Fear/physiology Humans Mice Microfilament Proteins/metabolism Nerve Tissue Proteins/genetics Receptors, N-Methyl-D-Aspartate Synapses/metabolism T-Box Domain Proteins/metabolism/pharmacology Zinc/metabolism/pharmacology Amygdala Autism spectrum disorder Dietary zinc supplementation Glutamatergic synapses N-methyl-D-aspartate receptors T-brain-1 Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by a dyad of behavioural symptoms-social and communication deficits and repetitive behaviours. Multiple aetiological genetic and environmental factors have been identified as causing or increasing the likelihood of ASD, including serum zinc deficiency. Our previous studies revealed that dietary zinc supplementation can normalise impaired social behaviours, excessive grooming, and heightened anxiety in a Shank3 mouse model of ASD, as well as the amelioration of synapse dysfunction. Here, we have examined the efficacy and breadth of dietary zinc supplementation as an effective therapeutic strategy utilising a non-Shank-related mouse model of ASD-mice with Tbr1 haploinsufficiency. METHODS: We performed behavioural assays, amygdalar slice whole-cell patch-clamp electrophysiology, and immunohistochemistry to characterise the synaptic mechanisms underlying the ASD-associated behavioural deficits observed in Tbr1(+/-) mice and the therapeutic potential of dietary zinc supplementation. Two-way analysis of variance (ANOVA) with ?ídák's post hoc test and one-way ANOVA with Tukey's post hoc multiple comparisons were performed for statistical analysis. RESULTS: Our data show that dietary zinc supplementation prevents impairments in auditory fear memory and social interaction, but not social novelty, in the Tbr1(+/-) mice. Tbr1 haploinsufficiency did not induce excessive grooming nor elevate anxiety in mice. At the synaptic level, dietary zinc supplementation reversed ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and N-methyl-D-aspartate receptor (NMDAR) hypofunction and normalised presynaptic function at thalamic-lateral amygdala (LA) synapses that are crucial for auditory fear memory. In addition, the zinc supplemented diet significantly restored the synaptic puncta density of the GluN1 subunit essential for functional NMDARs as well as SHANK3 expression in both the basal and lateral amygdala (BLA) of Tbr1(+/-) mice. LIMITATIONS: The therapeutic effect of dietary zinc supplementation observed in rodent models may not reproduce the same effects in human patients. The effect of dietary zinc supplementation on synaptic function in other brain structures affected by Tbr1 haploinsufficiency including olfactory bulb and anterior commissure will also need to be examined. CONCLUSIONS: Our data further the understanding of the molecular mechanisms underlying the effect of dietary zinc supplementation and verify the efficacy and breadth of its application as a potential treatment strategy for ASD. En ligne : http://dx.doi.org/10.1186/s13229-022-00494-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Molecular Autism > 13 (2022) . - 13 p.[article] Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1(+/-) mouse model of autism spectrum disorders [Texte imprimé et/ou numérique] / Kevin LEE, Auteur ; Yewon JUNG, Auteur ; Yukti VYAS, Auteur ; Imogen SKELTON, Auteur ; Wickliffe C. ABRAHAM, Auteur ; Yi-Ping HSUEH, Auteur ; Johanna M. MONTGOMERY, Auteur . - 13 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 13 p.
Mots-clés : Animals Autism Spectrum Disorder/genetics Dietary Supplements Disease Models, Animal Fear/physiology Humans Mice Microfilament Proteins/metabolism Nerve Tissue Proteins/genetics Receptors, N-Methyl-D-Aspartate Synapses/metabolism T-Box Domain Proteins/metabolism/pharmacology Zinc/metabolism/pharmacology Amygdala Autism spectrum disorder Dietary zinc supplementation Glutamatergic synapses N-methyl-D-aspartate receptors T-brain-1 Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by a dyad of behavioural symptoms-social and communication deficits and repetitive behaviours. Multiple aetiological genetic and environmental factors have been identified as causing or increasing the likelihood of ASD, including serum zinc deficiency. Our previous studies revealed that dietary zinc supplementation can normalise impaired social behaviours, excessive grooming, and heightened anxiety in a Shank3 mouse model of ASD, as well as the amelioration of synapse dysfunction. Here, we have examined the efficacy and breadth of dietary zinc supplementation as an effective therapeutic strategy utilising a non-Shank-related mouse model of ASD-mice with Tbr1 haploinsufficiency. METHODS: We performed behavioural assays, amygdalar slice whole-cell patch-clamp electrophysiology, and immunohistochemistry to characterise the synaptic mechanisms underlying the ASD-associated behavioural deficits observed in Tbr1(+/-) mice and the therapeutic potential of dietary zinc supplementation. Two-way analysis of variance (ANOVA) with ?ídák's post hoc test and one-way ANOVA with Tukey's post hoc multiple comparisons were performed for statistical analysis. RESULTS: Our data show that dietary zinc supplementation prevents impairments in auditory fear memory and social interaction, but not social novelty, in the Tbr1(+/-) mice. Tbr1 haploinsufficiency did not induce excessive grooming nor elevate anxiety in mice. At the synaptic level, dietary zinc supplementation reversed ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and N-methyl-D-aspartate receptor (NMDAR) hypofunction and normalised presynaptic function at thalamic-lateral amygdala (LA) synapses that are crucial for auditory fear memory. In addition, the zinc supplemented diet significantly restored the synaptic puncta density of the GluN1 subunit essential for functional NMDARs as well as SHANK3 expression in both the basal and lateral amygdala (BLA) of Tbr1(+/-) mice. LIMITATIONS: The therapeutic effect of dietary zinc supplementation observed in rodent models may not reproduce the same effects in human patients. The effect of dietary zinc supplementation on synaptic function in other brain structures affected by Tbr1 haploinsufficiency including olfactory bulb and anterior commissure will also need to be examined. CONCLUSIONS: Our data further the understanding of the molecular mechanisms underlying the effect of dietary zinc supplementation and verify the efficacy and breadth of its application as a potential treatment strategy for ASD. En ligne : http://dx.doi.org/10.1186/s13229-022-00494-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Editorial: Diet and children's behaviour problems – disentangling urban myth from clinical reality / Edmund J. S. SONUGA-BARKE in Journal of Child Psychology and Psychiatry, 56-5 (May 2015)
[article]
Titre : Editorial: Diet and children's behaviour problems – disentangling urban myth from clinical reality Type de document : Texte imprimé et/ou numérique Auteurs : Edmund J. S. SONUGA-BARKE, Auteur Article en page(s) : p.497-499 Langues : Anglais (eng) Mots-clés : Diet dietary supplements artificial colours and preservatives children's behaviour problems ADHD omega-3, PUFA Index. décimale : PER Périodiques Résumé : This Editorial focuses on diet and behaviour problems - seeking to disentangle the modern urban myth of the toxic effects of the modern diet on children's brains from the reality of its actual effects on behaviour. It suggests we need to navigate a course between these two opposing extremes, seeing the proposed diet–behaviour link more as a hypothesis to test, than a truth to defend or a myth to debunk. It summarises the history and standing of the current diet-behaviour hypothesis and the use of dietary exclusions and dietary supplements for behaviour problems, in the light of current empirical evidence and the impetus this provides for further research in this field. En ligne : http://dx.doi.org/10.1111/jcpp.12418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.497-499[article] Editorial: Diet and children's behaviour problems – disentangling urban myth from clinical reality [Texte imprimé et/ou numérique] / Edmund J. S. SONUGA-BARKE, Auteur . - p.497-499.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.497-499
Mots-clés : Diet dietary supplements artificial colours and preservatives children's behaviour problems ADHD omega-3, PUFA Index. décimale : PER Périodiques Résumé : This Editorial focuses on diet and behaviour problems - seeking to disentangle the modern urban myth of the toxic effects of the modern diet on children's brains from the reality of its actual effects on behaviour. It suggests we need to navigate a course between these two opposing extremes, seeing the proposed diet–behaviour link more as a hypothesis to test, than a truth to defend or a myth to debunk. It summarises the history and standing of the current diet-behaviour hypothesis and the use of dietary exclusions and dietary supplements for behaviour problems, in the light of current empirical evidence and the impetus this provides for further research in this field. En ligne : http://dx.doi.org/10.1111/jcpp.12418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder / Sarah A. KEIM in Journal of Autism and Developmental Disorders, 52-12 (December 2022)
[article]
Titre : Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sarah A. KEIM, Auteur ; Abigail JUDE, Auteur ; Katie SMITH, Auteur ; Aiman Q. KHAN, Auteur ; Daniel L. COURY, Auteur ; Joseph RAUSCH, Auteur ; Shivika UDAIPURIA, Auteur ; Megan NORRIS, Auteur ; Lindsay R. BARTRAM, Auteur ; Anita R. NARAYANAN, Auteur ; Lynette K. ROGERS, Auteur Année de publication : 2022 Article en page(s) : p.5342-5355 Langues : Anglais (eng) Mots-clés : Child Child, Preschool Humans Autism Spectrum Disorder/drug therapy Biomarkers Dietary Supplements Double-Blind Method Fatty Acids, Omega-3/therapeutic use Fatty Acids, Omega-6/therapeutic use Interleukin-2/metabolism Autism spectrum disorder Il-2 Inflammation Omega-3 fatty acids Omega-6 fatty acids Young child the content of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Nordic Naturals provided the investigational product at no cost and Welsh, Holme, & Clark Co., Inc. provided canola oil at no cost. Neither the study sponsors nor product providers had a role in the study design the collection, analysis, and interpretation of data writing of this report or the decision to submit the manuscript for publication. Index. décimale : PER Périodiques Résumé : This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6Â years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90Â days based on participant weight. Erythrocyte FAs and the cytokines, IL-1Î2, IL-2, IFNÎ3, were measured in plasma obtained from serial blood collections. Treatment increased omega-3 and omega-6 FA levels (1.40Â mol% for EPA and 1.62Â mol% for DHA) and reduced IL-2 levels compared to placebo (-Â 0.17Â pg/mL, 95% CI -Â 0.31, -Â 0.02, d=-Â 0.62). Omega 3-6 treatment was tolerable and adherence was greater than 70%. Future research will assess the effects of Omega 3-6 treatment on ASD symptoms. Registered on 06/08/2018 with ClinicalTrials.gov: NCT03550209. En ligne : http://dx.doi.org/10.1007/s10803-021-05396-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5342-5355[article] Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sarah A. KEIM, Auteur ; Abigail JUDE, Auteur ; Katie SMITH, Auteur ; Aiman Q. KHAN, Auteur ; Daniel L. COURY, Auteur ; Joseph RAUSCH, Auteur ; Shivika UDAIPURIA, Auteur ; Megan NORRIS, Auteur ; Lindsay R. BARTRAM, Auteur ; Anita R. NARAYANAN, Auteur ; Lynette K. ROGERS, Auteur . - 2022 . - p.5342-5355.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5342-5355
Mots-clés : Child Child, Preschool Humans Autism Spectrum Disorder/drug therapy Biomarkers Dietary Supplements Double-Blind Method Fatty Acids, Omega-3/therapeutic use Fatty Acids, Omega-6/therapeutic use Interleukin-2/metabolism Autism spectrum disorder Il-2 Inflammation Omega-3 fatty acids Omega-6 fatty acids Young child the content of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Nordic Naturals provided the investigational product at no cost and Welsh, Holme, & Clark Co., Inc. provided canola oil at no cost. Neither the study sponsors nor product providers had a role in the study design the collection, analysis, and interpretation of data writing of this report or the decision to submit the manuscript for publication. Index. décimale : PER Périodiques Résumé : This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6Â years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90Â days based on participant weight. Erythrocyte FAs and the cytokines, IL-1Î2, IL-2, IFNÎ3, were measured in plasma obtained from serial blood collections. Treatment increased omega-3 and omega-6 FA levels (1.40Â mol% for EPA and 1.62Â mol% for DHA) and reduced IL-2 levels compared to placebo (-Â 0.17Â pg/mL, 95% CI -Â 0.31, -Â 0.02, d=-Â 0.62). Omega 3-6 treatment was tolerable and adherence was greater than 70%. Future research will assess the effects of Omega 3-6 treatment on ASD symptoms. Registered on 06/08/2018 with ClinicalTrials.gov: NCT03550209. En ligne : http://dx.doi.org/10.1007/s10803-021-05396-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489