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Understanding environmental contributions to autism: Causal concepts and the state of science / I. HERTZ-PICCIOTTO in Autism Research, 11-4 (April 2018)
[article]
Titre : Understanding environmental contributions to autism: Causal concepts and the state of science Type de document : Texte imprimé et/ou numérique Auteurs : I. HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; P. KRAKOWIAK, Auteur Article en page(s) : p.554-586 Langues : Anglais (eng) Mots-clés : autism spectrum disorder causal inference diabetes environmental risk factors epigenetics gene-environment interaction nutrition pesticides pre- and peri-natal risk factors Index. décimale : PER Périodiques Résumé : The complexity of neurodevelopment, the rapidity of early neurogenesis, and over 100 years of research identifying environmental influences on neurodevelopment serve as backdrop to understanding factors that influence risk and severity of autism spectrum disorder (ASD). This Keynote Lecture, delivered at the May 2016 annual meeting of the International Society for Autism Research, describes concepts of causation, outlines the trajectory of research on nongenetic factors beginning in the 1960s, and briefly reviews the current state of this science. Causal concepts are introduced, including root causes; pitfalls in interpreting time trends as clues to etiologic factors; susceptible time windows for exposure; and implications of a multi-factorial model of ASD. An historical background presents early research into the origins of ASD. The epidemiologic literature from the last fifteen years is briefly but critically reviewed for potential roles of, for example, air pollution, pesticides, plastics, prenatal vitamins, lifestyle and family factors, and maternal obstetric and metabolic conditions during her pregnancy. Three examples from the case-control CHildhood Autism Risks from Genes and the Environment Study are probed to illustrate methodological approaches to central challenges in observational studies: capturing environmental exposure; causal inference when a randomized controlled clinical trial is either unethical or infeasible; and the integration of genetic, epigenetic, and environmental influences on development. We conclude with reflections on future directions, including exposomics, new technologies, the microbiome, gene-by-environment interaction in the era of -omics, and epigenetics as the interface of those two. As the environment is malleable, this research advances the goal of a productive and fulfilling life for all children, teen-agers and adults. Autism Res 2018, 11: 554-586. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This Keynote Lecture, delivered at the 2016 meeting of the International Society for Autism Research, discusses evidence from human epidemiologic studies of prenatal factors contributing to autism, such as pesticides, maternal nutrition and her health. There is no single cause for autism. Examples highlight the features of a high-quality epidemiology study, and what comprises a compelling case for causation. Emergent research directions hold promise for identifying potential interventions to reduce disabilities, enhance giftedness, and improve lives of those with ASD. En ligne : http://dx.doi.org/10.1002/aur.1938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358
in Autism Research > 11-4 (April 2018) . - p.554-586[article] Understanding environmental contributions to autism: Causal concepts and the state of science [Texte imprimé et/ou numérique] / I. HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; P. KRAKOWIAK, Auteur . - p.554-586.
Langues : Anglais (eng)
in Autism Research > 11-4 (April 2018) . - p.554-586
Mots-clés : autism spectrum disorder causal inference diabetes environmental risk factors epigenetics gene-environment interaction nutrition pesticides pre- and peri-natal risk factors Index. décimale : PER Périodiques Résumé : The complexity of neurodevelopment, the rapidity of early neurogenesis, and over 100 years of research identifying environmental influences on neurodevelopment serve as backdrop to understanding factors that influence risk and severity of autism spectrum disorder (ASD). This Keynote Lecture, delivered at the May 2016 annual meeting of the International Society for Autism Research, describes concepts of causation, outlines the trajectory of research on nongenetic factors beginning in the 1960s, and briefly reviews the current state of this science. Causal concepts are introduced, including root causes; pitfalls in interpreting time trends as clues to etiologic factors; susceptible time windows for exposure; and implications of a multi-factorial model of ASD. An historical background presents early research into the origins of ASD. The epidemiologic literature from the last fifteen years is briefly but critically reviewed for potential roles of, for example, air pollution, pesticides, plastics, prenatal vitamins, lifestyle and family factors, and maternal obstetric and metabolic conditions during her pregnancy. Three examples from the case-control CHildhood Autism Risks from Genes and the Environment Study are probed to illustrate methodological approaches to central challenges in observational studies: capturing environmental exposure; causal inference when a randomized controlled clinical trial is either unethical or infeasible; and the integration of genetic, epigenetic, and environmental influences on development. We conclude with reflections on future directions, including exposomics, new technologies, the microbiome, gene-by-environment interaction in the era of -omics, and epigenetics as the interface of those two. As the environment is malleable, this research advances the goal of a productive and fulfilling life for all children, teen-agers and adults. Autism Res 2018, 11: 554-586. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This Keynote Lecture, delivered at the 2016 meeting of the International Society for Autism Research, discusses evidence from human epidemiologic studies of prenatal factors contributing to autism, such as pesticides, maternal nutrition and her health. There is no single cause for autism. Examples highlight the features of a high-quality epidemiology study, and what comprises a compelling case for causation. Emergent research directions hold promise for identifying potential interventions to reduce disabilities, enhance giftedness, and improve lives of those with ASD. En ligne : http://dx.doi.org/10.1002/aur.1938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 Early adversity and positive parenting: Association with cognitive outcomes in children with autism spectrum disorder / E. KUENZEL in Autism Research, 14-12 (December 2021)
[article]
Titre : Early adversity and positive parenting: Association with cognitive outcomes in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. KUENZEL, Auteur ; D. SEGUIN, Auteur ; R. NICOLSON, Auteur ; E. G. DUERDEN, Auteur Article en page(s) : p.2654-2662 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/complications Child Child, Preschool Cognition Executive Function Humans Parenting Peer Group Children Clinical Psychology Cognitive Neuroscience Environmental risk factors Neuropsychology Parent Training Pediatrics Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and repetitive behaviors. Children with ASD are statistically more likely to experience early adversity; however, little is known about the types of early adversity that place these children at risk, the role of parenting as a protective factor, and how this early life stress impacts cognitive outcomes. We assessed early adversity in 302 children (ASD = 98) aged 6-16?years old, using parent-based report. To identify protective factors, we assessed parenting styles using parent surveys. Executive functions were assessed in the children using the WISC-V. Children with ASD had an increased incidence of familial stressors compared to the typically developing (TD) group. Positive parenting was associated with a significant decrease in the incidence of familial adverse events for both children with ASD and TD children. Examining the relationship between adversity and cognitive outcomes, in young children (6-11?years) with ASD, environmental stressors were associated with cognitive impairments. Findings suggest children with ASD may be at higher risk for familial adversity than their TD peers. However, all children benefit from positive parenting styles, which may mitigate the adverse effects of family-based early life stress. LAY SUMMARY: Some key features of Autism Spectrum Disorder (ASD) include difficulties with communication and social impairments. This means that children with ASD may be more likely to experience early adversity (stressful social interactions which take place during childhood) than children without ASD. Research in typically developing (TD) children has shown that experiencing more stressful events in childhood can cause changes in the brain, which can potentially impact the child's memory, reasoning, and decision-making skills later in life. However, there is evidence to suggest that having a nurturing relationship with a parent can offset some of the negative impacts of childhood adversity. In our study, we found that children with ASD are more likely to experience family-related stress compared to TD children. Having a positive relationship with a parent, however, was linked to experiencing this type of stress less often for all children, regardless of whether they were diagnosed with ASD. We also found that stressors related to environmental factors like financial instability were associated with lower cognitive abilities in children with ASD under 12?years of age. Understanding how these factors interact and differ in children with ASD can help to build stronger families and help children with ASD to thrive throughout their development. En ligne : http://dx.doi.org/10.1002/aur.2613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-12 (December 2021) . - p.2654-2662[article] Early adversity and positive parenting: Association with cognitive outcomes in children with autism spectrum disorder [Texte imprimé et/ou numérique] / E. KUENZEL, Auteur ; D. SEGUIN, Auteur ; R. NICOLSON, Auteur ; E. G. DUERDEN, Auteur . - p.2654-2662.
Langues : Anglais (eng)
in Autism Research > 14-12 (December 2021) . - p.2654-2662
Mots-clés : Adolescent Autism Spectrum Disorder/complications Child Child, Preschool Cognition Executive Function Humans Parenting Peer Group Children Clinical Psychology Cognitive Neuroscience Environmental risk factors Neuropsychology Parent Training Pediatrics Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and repetitive behaviors. Children with ASD are statistically more likely to experience early adversity; however, little is known about the types of early adversity that place these children at risk, the role of parenting as a protective factor, and how this early life stress impacts cognitive outcomes. We assessed early adversity in 302 children (ASD = 98) aged 6-16?years old, using parent-based report. To identify protective factors, we assessed parenting styles using parent surveys. Executive functions were assessed in the children using the WISC-V. Children with ASD had an increased incidence of familial stressors compared to the typically developing (TD) group. Positive parenting was associated with a significant decrease in the incidence of familial adverse events for both children with ASD and TD children. Examining the relationship between adversity and cognitive outcomes, in young children (6-11?years) with ASD, environmental stressors were associated with cognitive impairments. Findings suggest children with ASD may be at higher risk for familial adversity than their TD peers. However, all children benefit from positive parenting styles, which may mitigate the adverse effects of family-based early life stress. LAY SUMMARY: Some key features of Autism Spectrum Disorder (ASD) include difficulties with communication and social impairments. This means that children with ASD may be more likely to experience early adversity (stressful social interactions which take place during childhood) than children without ASD. Research in typically developing (TD) children has shown that experiencing more stressful events in childhood can cause changes in the brain, which can potentially impact the child's memory, reasoning, and decision-making skills later in life. However, there is evidence to suggest that having a nurturing relationship with a parent can offset some of the negative impacts of childhood adversity. In our study, we found that children with ASD are more likely to experience family-related stress compared to TD children. Having a positive relationship with a parent, however, was linked to experiencing this type of stress less often for all children, regardless of whether they were diagnosed with ASD. We also found that stressors related to environmental factors like financial instability were associated with lower cognitive abilities in children with ASD under 12?years of age. Understanding how these factors interact and differ in children with ASD can help to build stronger families and help children with ASD to thrive throughout their development. En ligne : http://dx.doi.org/10.1002/aur.2613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study / A. S. E. LEE in Autism Research, 14-12 (December 2021)
[article]
Titre : Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur Article en page(s) : p.2533-2543 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder/epidemiology Birth Cohort Cohort Studies Female Humans Neurodevelopmental Disorders/epidemiology Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Selenium attention deficit-hyperactivity disorder children environmental risk factors epigenetics gene-environment interaction pediatrics pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-12 (December 2021) . - p.2533-2543[article] Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study [Texte imprimé et/ou numérique] / A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur . - p.2533-2543.
Langues : Anglais (eng)
in Autism Research > 14-12 (December 2021) . - p.2533-2543
Mots-clés : Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder/epidemiology Birth Cohort Cohort Studies Female Humans Neurodevelopmental Disorders/epidemiology Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Selenium attention deficit-hyperactivity disorder children environmental risk factors epigenetics gene-environment interaction pediatrics pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 The association of adverse life events and parental mental health with emotional and behavioral outcomes in young adults with autism spectrum disorder / M. J. HOLLOCKS in Autism Research, 14-8 (August 2021)
[article]
Titre : The association of adverse life events and parental mental health with emotional and behavioral outcomes in young adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. J. HOLLOCKS, Auteur ; R. MEISER-STEDMAN, Auteur ; R. KENT, Auteur ; S. LUKITO, Auteur ; Jackie BRISKMAN, Auteur ; D. STRINGER, Auteur ; C. LORD, Auteur ; A. PICKLES, Auteur ; Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur ; E. SIMONOFF, Auteur Article en page(s) : p.1724-1735 Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/complications Child Emotions Humans Longitudinal Studies Mental Health Parents Young Adult anxiety co-morbid conditions depression environmental risk factors stress Index. décimale : PER Périodiques Résumé : People with autism spectrum disorder (ASD) are at increased risk of developing co-occurring mental health difficulties across the lifespan. Exposure to adverse life events and parental mental health difficulties are known risk factors for developing a range of mental health difficulties. This study investigates the association of adverse life events, parental stress and mental health with emotional and behavioral problems in young adults with ASD. One hundred and fifteen young adults with ASD derived from a population-based longitudinal study were assessed at three time-points (12-, 16-, and 23-year) on questionnaire measures of emotional and behavioral problems. Parent-reported exposure to adverse life events and parental stress/mental health were measured at age 23. We used structural equation modeling to investigate the stability of emotional and behavioral problems over time, and the association between adverse life events and parental stress and mental health and emotional and behavioral outcomes at 23-year. Our results indicate that exposure to adverse life events was significantly associated with increased emotional and behavioral problems in young adults with ASD, while controlling for symptoms in childhood and adolescence. Higher reported parental stress and mental health difficulties were associated with a higher frequency of behavioral, but not emotional problems, and did not mediate the impact of adverse life events. These results suggest that child and adolescent emotional and behavioral problems, exposure to life events and parent stress and mental health are independently associated, to differing degrees, with emotional or behavioral outcomes in early adulthood. LAY SUMMARY: People with autism experience high rates of mental health difficulties throughout childhood and into adult life. Adverse life events and parental stress and mental health may contribute to poor mental health in adulthood. We used data at three time points (12-, 16-, and 23-year) to understand how these factors relate to symptoms at 23-year. We found that emotional and behavioral problems in childhood, adverse life events and parent mental health were all associated with increased emotional and behavioral problems in adulthood. En ligne : http://dx.doi.org/10.1002/aur.2548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-8 (August 2021) . - p.1724-1735[article] The association of adverse life events and parental mental health with emotional and behavioral outcomes in young adults with autism spectrum disorder [Texte imprimé et/ou numérique] / M. J. HOLLOCKS, Auteur ; R. MEISER-STEDMAN, Auteur ; R. KENT, Auteur ; S. LUKITO, Auteur ; Jackie BRISKMAN, Auteur ; D. STRINGER, Auteur ; C. LORD, Auteur ; A. PICKLES, Auteur ; Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur ; E. SIMONOFF, Auteur . - p.1724-1735.
Langues : Anglais (eng)
in Autism Research > 14-8 (August 2021) . - p.1724-1735
Mots-clés : Adolescent Adult Autism Spectrum Disorder/complications Child Emotions Humans Longitudinal Studies Mental Health Parents Young Adult anxiety co-morbid conditions depression environmental risk factors stress Index. décimale : PER Périodiques Résumé : People with autism spectrum disorder (ASD) are at increased risk of developing co-occurring mental health difficulties across the lifespan. Exposure to adverse life events and parental mental health difficulties are known risk factors for developing a range of mental health difficulties. This study investigates the association of adverse life events, parental stress and mental health with emotional and behavioral problems in young adults with ASD. One hundred and fifteen young adults with ASD derived from a population-based longitudinal study were assessed at three time-points (12-, 16-, and 23-year) on questionnaire measures of emotional and behavioral problems. Parent-reported exposure to adverse life events and parental stress/mental health were measured at age 23. We used structural equation modeling to investigate the stability of emotional and behavioral problems over time, and the association between adverse life events and parental stress and mental health and emotional and behavioral outcomes at 23-year. Our results indicate that exposure to adverse life events was significantly associated with increased emotional and behavioral problems in young adults with ASD, while controlling for symptoms in childhood and adolescence. Higher reported parental stress and mental health difficulties were associated with a higher frequency of behavioral, but not emotional problems, and did not mediate the impact of adverse life events. These results suggest that child and adolescent emotional and behavioral problems, exposure to life events and parent stress and mental health are independently associated, to differing degrees, with emotional or behavioral outcomes in early adulthood. LAY SUMMARY: People with autism experience high rates of mental health difficulties throughout childhood and into adult life. Adverse life events and parental stress and mental health may contribute to poor mental health in adulthood. We used data at three time points (12-, 16-, and 23-year) to understand how these factors relate to symptoms at 23-year. We found that emotional and behavioral problems in childhood, adverse life events and parent mental health were all associated with increased emotional and behavioral problems in adulthood. En ligne : http://dx.doi.org/10.1002/aur.2548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Maternal hirsutism and autism spectrum disorders in offspring / Brian K. LEE in Autism Research, 10-9 (September 2017)
[article]
Titre : Maternal hirsutism and autism spectrum disorders in offspring Type de document : Texte imprimé et/ou numérique Auteurs : Brian K. LEE, Auteur ; Stefan ARVER, Auteur ; Linnea WIDMAN, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Christina DALMAN, Auteur ; Kyriaki KOSIDOU, Auteur Article en page(s) : p.1544-1546 Langues : Anglais (eng) Mots-clés : epidemiology - analytic (risk factors) pre- and perinatal risk factors environmental risk factors Index. décimale : PER Périodiques Résumé : Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD. In the same sample, we have now examined whether maternal diagnoses of hirsutism were associated with ASD. In both unadjusted logistic regression models and models adjusted for a variety of covariates, hirsutism was associated with higher odds of ASD. The most adjusted odds ratios for associations with ASD for hirsutism diagnosis before birth and lifetime diagnosis of hirsutism were 1.64 (95% CI: 0.94, 2.83) and 1.26 (95% CI: 1.01, 1.57), respectively. The presence of an association of maternal hirsutism with child ASD is consistent with the hypothesis that androgens may be involved in the etiology of ASD. En ligne : http://dx.doi.org/10.1002/aur.1797 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320
in Autism Research > 10-9 (September 2017) . - p.1544-1546[article] Maternal hirsutism and autism spectrum disorders in offspring [Texte imprimé et/ou numérique] / Brian K. LEE, Auteur ; Stefan ARVER, Auteur ; Linnea WIDMAN, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Christina DALMAN, Auteur ; Kyriaki KOSIDOU, Auteur . - p.1544-1546.
Langues : Anglais (eng)
in Autism Research > 10-9 (September 2017) . - p.1544-1546
Mots-clés : epidemiology - analytic (risk factors) pre- and perinatal risk factors environmental risk factors Index. décimale : PER Périodiques Résumé : Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD. In the same sample, we have now examined whether maternal diagnoses of hirsutism were associated with ASD. In both unadjusted logistic regression models and models adjusted for a variety of covariates, hirsutism was associated with higher odds of ASD. The most adjusted odds ratios for associations with ASD for hirsutism diagnosis before birth and lifetime diagnosis of hirsutism were 1.64 (95% CI: 0.94, 2.83) and 1.26 (95% CI: 1.01, 1.57), respectively. The presence of an association of maternal hirsutism with child ASD is consistent with the hypothesis that androgens may be involved in the etiology of ASD. En ligne : http://dx.doi.org/10.1002/aur.1797 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320 Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder / Kumari ANSHU in Autism Research, 10-12 (December 2017)
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