34 recherche sur le mot-clé 'epigenetics'

Epigenetics of cognition and behavior: insights from Mendelian disorders of epigenetic machinery / Rowena NG in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : Epigenetics of cognition and behavior: insights from Mendelian disorders of epigenetic machinery Type de document : texte imprimé Auteurs : Rowena NG, Auteur ; Allison KALINOUSKY, Auteur ; Jacqueline HARRIS, Auteur Langues : Anglais (eng) Mots-clés : Epigenesis, Genetic  Cognition  Behavior  Epigenetics  Neurodevelopment Index. décimale : PER Périodiques Résumé : Epigenetics, one mechanism by which gene expression can change without any changes to the DNA sequence, was described nearly a century ago. However, the importance of epigenetic processes to neurodevelopment and higher order neurological functions like cognition and behavior is only now being realized. A group of disorders known as the Mendelian disorders of the epigenetic machinery are caused by the altered function of epigenetic machinery proteins, which consequently affects downstream expression of many genes. These disorders almost universally have cognitive dysfunction and behavioral issues as core features. Here, we review what is known about the neurodevelopmental phenotypes of some key examples of these disorders divided into categories based on the underlying function of the affected protein. Understanding these Mendelian disorders of the epigenetic machinery can illuminate the role of epigenetic regulation in typical brain function and can lead to future therapies and better management for a host of neurodevelopmental and neuropsychological disorders. En ligne : https://dx.doi.org/10.1186/s11689-023-09482-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Epigenetics of cognition and behavior: insights from Mendelian disorders of epigenetic machinery [texte imprimé] / Rowena NG, Auteur ; Allison KALINOUSKY, Auteur ; Jacqueline HARRIS, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Epigenesis, Genetic  Cognition  Behavior  Epigenetics  Neurodevelopment Index. décimale : PER Périodiques Résumé : Epigenetics, one mechanism by which gene expression can change without any changes to the DNA sequence, was described nearly a century ago. However, the importance of epigenetic processes to neurodevelopment and higher order neurological functions like cognition and behavior is only now being realized. A group of disorders known as the Mendelian disorders of the epigenetic machinery are caused by the altered function of epigenetic machinery proteins, which consequently affects downstream expression of many genes. These disorders almost universally have cognitive dysfunction and behavioral issues as core features. Here, we review what is known about the neurodevelopmental phenotypes of some key examples of these disorders divided into categories based on the underlying function of the affected protein. Understanding these Mendelian disorders of the epigenetic machinery can illuminate the role of epigenetic regulation in typical brain function and can lead to future therapies and better management for a host of neurodevelopmental and neuropsychological disorders. En ligne : https://dx.doi.org/10.1186/s11689-023-09482-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Epigenetics modifiers: potential hub for understanding and treating neurodevelopmental disorders from hypoxic injury / Ana G. CRISTANCHO in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Epigenetics modifiers: potential hub for understanding and treating neurodevelopmental disorders from hypoxic injury Type de document : texte imprimé Auteurs : Ana G. CRISTANCHO, Auteur ; Eric D. MARSH, Auteur Langues : Anglais (eng) Mots-clés : Brain  Child  DNA Methylation  Epigenesis, Genetic  Humans  Hypoxia  Infant, Newborn  Neurodevelopmental Disorders  Brain development  Epigenetics  Histone modification  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: The fetal brain is adapted to the hypoxic conditions present during normal in utero development. Relatively more hypoxic states, either chronic or acute, are pathologic and can lead to significant long-term neurodevelopmental sequelae. In utero hypoxic injury is associated with neonatal mortality and millions of lives lived with varying degrees of disability. MAIN BODY: Genetic studies of children with neurodevelopmental disease indicate that epigenetic modifiers regulating DNA methylation and histone remodeling are critical for normal brain development. Epigenetic modifiers are also regulated by environmental stimuli, such as hypoxia. Indeed, epigenetic modifiers that are mutated in children with genetic neurodevelopmental diseases are regulated by hypoxia in a number of preclinical models and may be part of the mechanism for the long-term neurodevelopmental sequelae seem in children with hypoxic brain injury. Thus, a comprehensive understanding the role of DNA methylation and histone modifications in hypoxic injury is critical for developing novel strategies to treat children with hypoxic injury. CONCLUSIONS: This review focuses on our current understanding of the intersection between epigenetics, brain development, and hypoxia. Opportunities for the use of epigenetics as biomarkers of neurodevelopmental disease after hypoxic injury and potential clinical epigenetics targets to improve outcomes after injury are also discussed. While there have been many published studies on the epigenetics of hypoxia, more are needed in the developing brain in order to determine which epigenetic pathways may be most important for mitigating the long-term consequences of hypoxic brain injury. En ligne : https://dx.doi.org/10.1186/s11689-020-09344-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Epigenetics modifiers: potential hub for understanding and treating neurodevelopmental disorders from hypoxic injury [texte imprimé] / Ana G. CRISTANCHO, Auteur ; Eric D. MARSH, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Brain  Child  DNA Methylation  Epigenesis, Genetic  Humans  Hypoxia  Infant, Newborn  Neurodevelopmental Disorders  Brain development  Epigenetics  Histone modification  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: The fetal brain is adapted to the hypoxic conditions present during normal in utero development. Relatively more hypoxic states, either chronic or acute, are pathologic and can lead to significant long-term neurodevelopmental sequelae. In utero hypoxic injury is associated with neonatal mortality and millions of lives lived with varying degrees of disability. MAIN BODY: Genetic studies of children with neurodevelopmental disease indicate that epigenetic modifiers regulating DNA methylation and histone remodeling are critical for normal brain development. Epigenetic modifiers are also regulated by environmental stimuli, such as hypoxia. Indeed, epigenetic modifiers that are mutated in children with genetic neurodevelopmental diseases are regulated by hypoxia in a number of preclinical models and may be part of the mechanism for the long-term neurodevelopmental sequelae seem in children with hypoxic brain injury. Thus, a comprehensive understanding the role of DNA methylation and histone modifications in hypoxic injury is critical for developing novel strategies to treat children with hypoxic injury. CONCLUSIONS: This review focuses on our current understanding of the intersection between epigenetics, brain development, and hypoxia. Opportunities for the use of epigenetics as biomarkers of neurodevelopmental disease after hypoxic injury and potential clinical epigenetics targets to improve outcomes after injury are also discussed. While there have been many published studies on the epigenetics of hypoxia, more are needed in the developing brain in order to determine which epigenetic pathways may be most important for mitigating the long-term consequences of hypoxic brain injury. En ligne : https://dx.doi.org/10.1186/s11689-020-09344-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Commentary: Whither the epigenetics of child psychopathology? Some reflections provoked by Barker et al. (2018) / Edmund J.S. SONUGA-BARKE in Journal of Child Psychology and Psychiatry, 59-4 (April 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.323-326 Titre : Commentary: Whither the epigenetics of child psychopathology? Some reflections provoked by Barker et al. (2018) Type de document : texte imprimé Auteurs : Edmund J.S. SONUGA-BARKE, Auteur ; Pasco FEARON, Auteur Article en page(s) : p.323-326 Langues : Anglais (eng) Mots-clés : Epigenetics Index. décimale : PER Périodiques Résumé : Barker et al.'s. () review addresses one of the most fundamental questions in the fields of child psychology and psychiatry - How can adverse experiences shape development to a sufficient degree and in profound and enduring ways to create long term risk for later mental disorder and disability? In particular they discuss the plausibility of differential methylation as an epigenetic mechanism by which such exposures can become neuro-biologically embedded. Our commentary rises six question relating to key issues that need to be addressed as we search for definitive evidence from human studies that such mechanisms actually do make an important causal contribution to abnormal trajectories of development to disorder. En ligne : http://dx.doi.org/10.1111/jcpp.12906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353 [article] Commentary: Whither the epigenetics of child psychopathology? Some reflections provoked by Barker et al. (2018) [texte imprimé] / Edmund J.S. SONUGA-BARKE, Auteur ; Pasco FEARON, Auteur . - p.323-326. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.323-326 Mots-clés : Epigenetics Index. décimale : PER Périodiques Résumé : Barker et al.'s. () review addresses one of the most fundamental questions in the fields of child psychology and psychiatry - How can adverse experiences shape development to a sufficient degree and in profound and enduring ways to create long term risk for later mental disorder and disability? In particular they discuss the plausibility of differential methylation as an epigenetic mechanism by which such exposures can become neuro-biologically embedded. Our commentary rises six question relating to key issues that need to be addressed as we search for definitive evidence from human studies that such mechanisms actually do make an important causal contribution to abnormal trajectories of development to disorder. En ligne : http://dx.doi.org/10.1111/jcpp.12906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353

Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure / Pamela SCORZA in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.119-132 Titre : Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure Type de document : texte imprimé Auteurs : Pamela SCORZA, Auteur ; Cristiane S. DUARTE, Auteur ; Alison E. HIPWELL, Auteur ; Jonathan POSNER, Auteur ; Ana ORTIN, Auteur ; Glorisa CANINO, Auteur ; Catherine MONK, Auteur Article en page(s) : p.119-132 Langues : Anglais (eng) Mots-clés : Development  adversity  early life experience  endocrinology  epigenetics  gene-environment interaction  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: For decades, economists and sociologists have documented intergenerational transmission of socioeconomic disadvantage, demonstrating that economic, political, and social factors contribute to 'inherited hardship'. Drawing on biological factors, the developmental origins of adult health and disease model posits that fetal exposure to maternal prenatal distress associated with socioeconomic disadvantage compromises offspring's neurodevelopment, affecting short- and long-term physical and mental health, and thereby psychosocial standing and resources. Increasing evidence suggests that mother-to-child influence occurs prenatally, in part via maternal and offspring atypical HPA axis regulation, with negative effects on the maturation of prefrontal and subcortical neural circuits in the offspring. However, even this in utero timeframe may be insufficient to understand biological aspects of the transmission of factors contributing to disadvantage across generations. METHODS: We review animal studies and emerging human research indicating that parents' childhood experiences may transfer epigenetic marks that could impact the development of their offspring independently of and in interaction with their offspring's perinatal and early childhood direct exposures to stress stemming from socioeconomic disadvantage and adversity. RESULTS: Animal models point to epigenetic mechanisms by which traits that could contribute to disadvantage may be transmitted across generations. However, epigenetic pathways of parental childhood experiences influencing child outcomes in the next generation are only beginning to be studied in humans. With a focus on translational research, we point to design features and methodological considerations for human cohort studies to be able to test the intergenerational transmission hypothesis, and we illustrate this with existing longitudinal studies. CONCLUSIONS: Epigenetic intergenerational transmission, if at play in human populations, could have policy implications in terms of reducing the continuation of disadvantage across generations. Further research is needed to address this gap in the understanding of the perpetuation of compromised lives across generations. En ligne : http://dx.doi.org/10.1111/jcpp.12877 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure [texte imprimé] / Pamela SCORZA, Auteur ; Cristiane S. DUARTE, Auteur ; Alison E. HIPWELL, Auteur ; Jonathan POSNER, Auteur ; Ana ORTIN, Auteur ; Glorisa CANINO, Auteur ; Catherine MONK, Auteur . - p.119-132. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.119-132 Mots-clés : Development  adversity  early life experience  endocrinology  epigenetics  gene-environment interaction  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: For decades, economists and sociologists have documented intergenerational transmission of socioeconomic disadvantage, demonstrating that economic, political, and social factors contribute to 'inherited hardship'. Drawing on biological factors, the developmental origins of adult health and disease model posits that fetal exposure to maternal prenatal distress associated with socioeconomic disadvantage compromises offspring's neurodevelopment, affecting short- and long-term physical and mental health, and thereby psychosocial standing and resources. Increasing evidence suggests that mother-to-child influence occurs prenatally, in part via maternal and offspring atypical HPA axis regulation, with negative effects on the maturation of prefrontal and subcortical neural circuits in the offspring. However, even this in utero timeframe may be insufficient to understand biological aspects of the transmission of factors contributing to disadvantage across generations. METHODS: We review animal studies and emerging human research indicating that parents' childhood experiences may transfer epigenetic marks that could impact the development of their offspring independently of and in interaction with their offspring's perinatal and early childhood direct exposures to stress stemming from socioeconomic disadvantage and adversity. RESULTS: Animal models point to epigenetic mechanisms by which traits that could contribute to disadvantage may be transmitted across generations. However, epigenetic pathways of parental childhood experiences influencing child outcomes in the next generation are only beginning to be studied in humans. With a focus on translational research, we point to design features and methodological considerations for human cohort studies to be able to test the intergenerational transmission hypothesis, and we illustrate this with existing longitudinal studies. CONCLUSIONS: Epigenetic intergenerational transmission, if at play in human populations, could have policy implications in terms of reducing the continuation of disadvantage across generations. Further research is needed to address this gap in the understanding of the perpetuation of compromised lives across generations. En ligne : http://dx.doi.org/10.1111/jcpp.12877 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

Parent Perspectives Towards Genetic and Epigenetic Testing for Autism Spectrum Disorder / Kayla E. WAGNER in Journal of Autism and Developmental Disorders, 50-9 (September 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3114-3125 Titre : Parent Perspectives Towards Genetic and Epigenetic Testing for Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Kayla E. WAGNER, Auteur ; Jennifer B. MCCORMICK, Auteur ; Sarah BARNS, Auteur ; Molly CARNEY, Auteur ; Frank A. MIDDLETON, Auteur ; Steven D. HICKS, Auteur Article en page(s) : p.3114-3125 Langues : Anglais (eng) Mots-clés : Autism  Bioethics  Diagnosis  Epigenetics  Parent perspectives  biomarkers in autism spectrum disorder that is assigned to The Research Foundation  for the State University of New York, The Penn State Research Foundation and  Quadrant Biosciences Inc., and licensed to Quadrant Biosciences Inc. SDH is a paid  consultant for Quadrant Biosciences Inc. These conflicts of interest are actively  managed by the Penn State College of Medicine. KW and SB are employees of Quadrant  Biosciences Inc. Index. décimale : PER Périodiques Résumé : Examining community views on genetic/epigenetic research allows collaborative technology development. Parent perspectives toward genetic/epigenetic testing for autism spectrum disorder (ASD) are not well-studied. Parents of children with ASD (n = 131), non-ASD developmental delay (n = 39), and typical development (n = 74) completed surveys assessing genetic/epigenetic knowledge, genetic/epigenetic concerns, motives for research participation, and attitudes/preferences toward ASD testing. Most parents (96%) were interested in saliva-based molecular testing for ASD. Some had concerns about privacy (14%) and insurance-status (10%). None (0%) doubted scientific evidence behind genetic/epigenetic testing. Most reported familiarity with genetics (88%), but few understood differences from epigenetics (19%). Child developmental status impacted insurance concerns (p = 0.01). There is broad parent interest in a genetic/epigenetic test for ASD. It will be crucial to carefully consider and address bioethical issues surrounding this sensitive topic while developing such technology. En ligne : http://dx.doi.org/10.1007/s10803-019-03990-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Parent Perspectives Towards Genetic and Epigenetic Testing for Autism Spectrum Disorder [texte imprimé] / Kayla E. WAGNER, Auteur ; Jennifer B. MCCORMICK, Auteur ; Sarah BARNS, Auteur ; Molly CARNEY, Auteur ; Frank A. MIDDLETON, Auteur ; Steven D. HICKS, Auteur . - p.3114-3125. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3114-3125 Mots-clés : Autism  Bioethics  Diagnosis  Epigenetics  Parent perspectives  biomarkers in autism spectrum disorder that is assigned to The Research Foundation  for the State University of New York, The Penn State Research Foundation and  Quadrant Biosciences Inc., and licensed to Quadrant Biosciences Inc. SDH is a paid  consultant for Quadrant Biosciences Inc. These conflicts of interest are actively  managed by the Penn State College of Medicine. KW and SB are employees of Quadrant  Biosciences Inc. Index. décimale : PER Périodiques Résumé : Examining community views on genetic/epigenetic research allows collaborative technology development. Parent perspectives toward genetic/epigenetic testing for autism spectrum disorder (ASD) are not well-studied. Parents of children with ASD (n = 131), non-ASD developmental delay (n = 39), and typical development (n = 74) completed surveys assessing genetic/epigenetic knowledge, genetic/epigenetic concerns, motives for research participation, and attitudes/preferences toward ASD testing. Most parents (96%) were interested in saliva-based molecular testing for ASD. Some had concerns about privacy (14%) and insurance-status (10%). None (0%) doubted scientific evidence behind genetic/epigenetic testing. Most reported familiarity with genetics (88%), but few understood differences from epigenetics (19%). Child developmental status impacted insurance concerns (p = 0.01). There is broad parent interest in a genetic/epigenetic test for ASD. It will be crucial to carefully consider and address bioethical issues surrounding this sensitive topic while developing such technology. En ligne : http://dx.doi.org/10.1007/s10803-019-03990-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Understanding environmental contributions to autism: Causal concepts and the state of science / Irva HERTZ-PICCIOTTO in Autism Research, 11-4 (April 2018)  

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Accelerated epigenetic aging at birth interacts with parenting hostility to predict child temperament and subsequent psychological symptoms / Erika M. MANCZAK in Development and Psychopathology, 35-1 (February 2023)  

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Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology / Edward D. BARKER in Journal of Child Psychology and Psychiatry, 59-4 (April 2018)  

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Annual Research Review: Threats to the validity of child psychiatry and psychology / Michael RUTTER in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

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Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders / Jill ESCHER in Journal of Autism and Developmental Disorders, 52-10 (October 2022)  

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