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Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood / I. POTE in Autism Research, 12-4 (April 2019)
[article]
Titre : Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : I. POTE, Auteur ; S. WANG, Auteur ; V. SETHNA, Auteur ; A. BLASI, Auteur ; Eileen DALY, Auteur ; M. KUKLISOVA-MURGASOVA, Auteur ; S. LLOYD-FOX, Auteur ; E. MERCURE, Auteur ; P. BUSUULWA, Auteur ; V. STOENCHEVA, Auteur ; Tony CHARMAN, Auteur ; S. C. R. WILLIAMS, Auteur ; M. H. JOHNSON, Auteur ; D. G. M. MURPHY, Auteur ; G. M. MCALONAN, Auteur Article en page(s) : p.614-627 Langues : Anglais (eng) Mots-clés : autism spectrum disorder cerebellum familial risk infants magnetic resonance imaging-structural mother-infant interaction subcortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at a higher risk of developing autistic traits or an ASD diagnosis, when compared to those with typically developing siblings. Reports of differences in brain anatomy and function in high-risk infants which predict later autistic behaviors are emerging, but although cerebellar and subcortical brain regions have been frequently implicated in ASD, no high-risk study has examined these regions. Therefore, in this study, we compared regional MRI volumes across the whole brain in 4-6-month-old infants with (high-risk, n = 24) and without (low-risk, n = 26) a sibling with ASD. Within the high-risk group, we also examined whether any regional differences observed were associated with autistic behaviors at 36 months. We found that high-risk infants had significantly larger cerebellar and subcortical volumes at 4-6-months of age, relative to low-risk infants; and that larger volumes in high-risk infants were linked to more repetitive behaviors at 36 months. Our preliminary observations require replication in longitudinal studies of larger samples. If correct, they suggest that the early subcortex and cerebellum volumes may be predictive biomarkers for childhood repetitive behaviors. Autism Res 2019, 12: 614-627. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published byWiley Periodicals, Inc. LAY SUMMARY: Individuals with a family history of autism spectrum disorder (ASD) are at risk of ASD and related developmental difficulties. This study revealed that 4-6-month-old infants at high-risk of ASD have larger cerebellum and subcortical volumes than low-risk infants, and that larger volumes in high-risk infants are associated with more repetitive behaviors in childhood. En ligne : https://dx.doi.org/10.1002/aur.2083 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Autism Research > 12-4 (April 2019) . - p.614-627[article] Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood [Texte imprimé et/ou numérique] / I. POTE, Auteur ; S. WANG, Auteur ; V. SETHNA, Auteur ; A. BLASI, Auteur ; Eileen DALY, Auteur ; M. KUKLISOVA-MURGASOVA, Auteur ; S. LLOYD-FOX, Auteur ; E. MERCURE, Auteur ; P. BUSUULWA, Auteur ; V. STOENCHEVA, Auteur ; Tony CHARMAN, Auteur ; S. C. R. WILLIAMS, Auteur ; M. H. JOHNSON, Auteur ; D. G. M. MURPHY, Auteur ; G. M. MCALONAN, Auteur . - p.614-627.
Langues : Anglais (eng)
in Autism Research > 12-4 (April 2019) . - p.614-627
Mots-clés : autism spectrum disorder cerebellum familial risk infants magnetic resonance imaging-structural mother-infant interaction subcortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at a higher risk of developing autistic traits or an ASD diagnosis, when compared to those with typically developing siblings. Reports of differences in brain anatomy and function in high-risk infants which predict later autistic behaviors are emerging, but although cerebellar and subcortical brain regions have been frequently implicated in ASD, no high-risk study has examined these regions. Therefore, in this study, we compared regional MRI volumes across the whole brain in 4-6-month-old infants with (high-risk, n = 24) and without (low-risk, n = 26) a sibling with ASD. Within the high-risk group, we also examined whether any regional differences observed were associated with autistic behaviors at 36 months. We found that high-risk infants had significantly larger cerebellar and subcortical volumes at 4-6-months of age, relative to low-risk infants; and that larger volumes in high-risk infants were linked to more repetitive behaviors at 36 months. Our preliminary observations require replication in longitudinal studies of larger samples. If correct, they suggest that the early subcortex and cerebellum volumes may be predictive biomarkers for childhood repetitive behaviors. Autism Res 2019, 12: 614-627. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published byWiley Periodicals, Inc. LAY SUMMARY: Individuals with a family history of autism spectrum disorder (ASD) are at risk of ASD and related developmental difficulties. This study revealed that 4-6-month-old infants at high-risk of ASD have larger cerebellum and subcortical volumes than low-risk infants, and that larger volumes in high-risk infants are associated with more repetitive behaviors in childhood. En ligne : https://dx.doi.org/10.1002/aur.2083 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders / Hannah M. BROWN in Journal of Child Psychology and Psychiatry, 54-6 (June 2013)
[article]
Titre : Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders Type de document : Texte imprimé et/ou numérique Auteurs : Hannah M. BROWN, Auteur ; Tom A. MCADAMS, Auteur ; Kathryn J. LESTER, Auteur ; Robert GOODMAN, Auteur ; David M. CLARK, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.678-685 Langues : Anglais (eng) Mots-clés : Anxiety attention children familial risk Index. décimale : PER Périodiques Résumé : Background: Twin studies in children reveal that familial aggregation of anxiety disorders is due to both genetic and environmental factors. Cognitive biases for threat information are considered a robust characteristic of childhood anxiety. However, little is known regarding the underlying aetiology of such biases and their role in anxiety disorders. Method: A face version of the dot-probe task measuring attentional biases for negative (anger, fear, sad, disgust) and positive (happy) facial expressions was completed by 600, 8-year-old twins; the largest study of its kind. Twin correlations for attentional bias scores were compared to estimate genetic and environmental effects. Parent-report diagnostic interviews identified children with an anxiety disorder. Indices of inferred genetic and familial risk for anxiety disorders were created for each child. Data were analysed using a series of logistic regressions. Results: Anxious children showed greater attentional avoidance of negative faces than nonanxious children; t (548) = 2.55, p .05. Attentional avoidance was not under genetic or shared environmental influence. Risk for anxiety disorders was predicted by familial factors. Both attentional avoidance and inferred familial risk were significant but independent predictors of anxiety disorders (ORs = .65 and 3.64, respectively). Conclusions: Anxiety-related attentional biases and familial risk play important but independent roles in childhood anxiety disorders. If replicated, these findings indicate that links between genetic risk and anxiety disorders lie outside the domain of attentional processes. En ligne : http://dx.doi.org/10.1111/jcpp.12024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=200
in Journal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.678-685[article] Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders [Texte imprimé et/ou numérique] / Hannah M. BROWN, Auteur ; Tom A. MCADAMS, Auteur ; Kathryn J. LESTER, Auteur ; Robert GOODMAN, Auteur ; David M. CLARK, Auteur ; Thalia C. ELEY, Auteur . - p.678-685.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.678-685
Mots-clés : Anxiety attention children familial risk Index. décimale : PER Périodiques Résumé : Background: Twin studies in children reveal that familial aggregation of anxiety disorders is due to both genetic and environmental factors. Cognitive biases for threat information are considered a robust characteristic of childhood anxiety. However, little is known regarding the underlying aetiology of such biases and their role in anxiety disorders. Method: A face version of the dot-probe task measuring attentional biases for negative (anger, fear, sad, disgust) and positive (happy) facial expressions was completed by 600, 8-year-old twins; the largest study of its kind. Twin correlations for attentional bias scores were compared to estimate genetic and environmental effects. Parent-report diagnostic interviews identified children with an anxiety disorder. Indices of inferred genetic and familial risk for anxiety disorders were created for each child. Data were analysed using a series of logistic regressions. Results: Anxious children showed greater attentional avoidance of negative faces than nonanxious children; t (548) = 2.55, p .05. Attentional avoidance was not under genetic or shared environmental influence. Risk for anxiety disorders was predicted by familial factors. Both attentional avoidance and inferred familial risk were significant but independent predictors of anxiety disorders (ORs = .65 and 3.64, respectively). Conclusions: Anxiety-related attentional biases and familial risk play important but independent roles in childhood anxiety disorders. If replicated, these findings indicate that links between genetic risk and anxiety disorders lie outside the domain of attentional processes. En ligne : http://dx.doi.org/10.1111/jcpp.12024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=200 Brain function distinguishes female carriers and non-carriers of familial risk for autism / Adam T. EGGEBRECHT in Molecular Autism, 11 (2020)
[article]
Titre : Brain function distinguishes female carriers and non-carriers of familial risk for autism Type de document : Texte imprimé et/ou numérique Auteurs : Adam T. EGGEBRECHT, Auteur ; Ally DWORETSKY, Auteur ; Zoe HAWKS, Auteur ; Rebecca COALSON, Auteur ; Babatunde ADEYEMO, Auteur ; Savannah DAVIS, Auteur ; Daniel GRAY, Auteur ; Alana MCMICHAEL, Auteur ; Steven E. PETERSEN, Auteur ; John N. CONSTANTINO, Auteur ; John R. Jr PRUETT, Auteur Année de publication : 2020 Article en page(s) : 82 p. Langues : Anglais (eng) Mots-clés : Biological motion Endophenotype Familial risk Sex ratio Silent transmission Responsiveness Scale-2 (SRS-2), a quantitative measure of autistic traits used in this study—no royalties were generated from the implementation of the SRS-2 in this program of research. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by high population-level heritability and a three-to-one male-to-female ratio that occurs independent of sex linkage. Prior research in a mixed-sex pediatric sample identified neural signatures of familial risk elicited by passive viewing of point light motion displays, suggesting the possibility that both resilience and risk of autism might be associated with brain responses to biological motion. To confirm a relationship between these signatures and inherited risk of autism, we tested them in families enriched for genetic loading through undiagnosed ("carrier") females. METHODS: Using functional magnetic resonance imaging, we examined brain responses to passive viewing of point light displays-depicting biological versus non-biological motion-in a sample of undiagnosed adult females enriched for inherited susceptibility to ASD on the basis of affectation in their respective family pedigrees. Brain responses in carrier females were compared to responses in age-, SRS-, and IQ-matched non-carrier-females-i.e., females unrelated to individuals with ASD. We conducted a hypothesis-driven analysis focused on previously published regions of interest as well as exploratory, brain-wide analyses designed to characterize more fully the rich responses to this paradigm. RESULTS: We observed robust responses to biological motion. Notwithstanding, the 12 regions implicated by prior research did not exhibit the hypothesized interaction between group (carriers vs. controls) and point light displays (biological vs. non-biological motion). Exploratory, brain-wide analyses identified this interaction in three novel regions. Post hoc analyses additionally revealed significant variations in the time course of brain activation in 20 regions spanning occipital and temporal cortex, indicating group differences in response to point light displays (irrespective of the nature of motion) for exploration in future studies. LIMITATIONS: We were unable to successfully eye-track all participants, which prevented us from being able to control for potential differences in eye gaze position. CONCLUSIONS: These methods confirmed pronounced neural signatures that differentiate brain responses to biological and scrambled motion. Our sample of undiagnosed females enriched for family genetic loading enabled discovery of numerous contrasts between carriers and non-carriers of risk of ASD that may index variations in visual attention and motion processing related to genetic susceptibility and inform our understanding of mechanisms incurred by inherited liability for ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00381-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433
in Molecular Autism > 11 (2020) . - 82 p.[article] Brain function distinguishes female carriers and non-carriers of familial risk for autism [Texte imprimé et/ou numérique] / Adam T. EGGEBRECHT, Auteur ; Ally DWORETSKY, Auteur ; Zoe HAWKS, Auteur ; Rebecca COALSON, Auteur ; Babatunde ADEYEMO, Auteur ; Savannah DAVIS, Auteur ; Daniel GRAY, Auteur ; Alana MCMICHAEL, Auteur ; Steven E. PETERSEN, Auteur ; John N. CONSTANTINO, Auteur ; John R. Jr PRUETT, Auteur . - 2020 . - 82 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 82 p.
Mots-clés : Biological motion Endophenotype Familial risk Sex ratio Silent transmission Responsiveness Scale-2 (SRS-2), a quantitative measure of autistic traits used in this study—no royalties were generated from the implementation of the SRS-2 in this program of research. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by high population-level heritability and a three-to-one male-to-female ratio that occurs independent of sex linkage. Prior research in a mixed-sex pediatric sample identified neural signatures of familial risk elicited by passive viewing of point light motion displays, suggesting the possibility that both resilience and risk of autism might be associated with brain responses to biological motion. To confirm a relationship between these signatures and inherited risk of autism, we tested them in families enriched for genetic loading through undiagnosed ("carrier") females. METHODS: Using functional magnetic resonance imaging, we examined brain responses to passive viewing of point light displays-depicting biological versus non-biological motion-in a sample of undiagnosed adult females enriched for inherited susceptibility to ASD on the basis of affectation in their respective family pedigrees. Brain responses in carrier females were compared to responses in age-, SRS-, and IQ-matched non-carrier-females-i.e., females unrelated to individuals with ASD. We conducted a hypothesis-driven analysis focused on previously published regions of interest as well as exploratory, brain-wide analyses designed to characterize more fully the rich responses to this paradigm. RESULTS: We observed robust responses to biological motion. Notwithstanding, the 12 regions implicated by prior research did not exhibit the hypothesized interaction between group (carriers vs. controls) and point light displays (biological vs. non-biological motion). Exploratory, brain-wide analyses identified this interaction in three novel regions. Post hoc analyses additionally revealed significant variations in the time course of brain activation in 20 regions spanning occipital and temporal cortex, indicating group differences in response to point light displays (irrespective of the nature of motion) for exploration in future studies. LIMITATIONS: We were unable to successfully eye-track all participants, which prevented us from being able to control for potential differences in eye gaze position. CONCLUSIONS: These methods confirmed pronounced neural signatures that differentiate brain responses to biological and scrambled motion. Our sample of undiagnosed females enriched for family genetic loading enabled discovery of numerous contrasts between carriers and non-carriers of risk of ASD that may index variations in visual attention and motion processing related to genetic susceptibility and inform our understanding of mechanisms incurred by inherited liability for ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00381-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study / Stella W. Y. CHAN in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)
[article]
Titre : Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study Type de document : Texte imprimé et/ou numérique Auteurs : Stella W. Y. CHAN, Auteur ; Jessika E. SUSSMANN, Auteur ; Liana ROMANIUK, Auteur ; Tiffany STEWART, Auteur ; Stephen M. LAWRIE, Auteur ; Jeremy HALL, Auteur ; Andrew M. MCINTOSH, Auteur ; Heather C. WHALLEY, Auteur Article en page(s) : p.1277-1286 Langues : Anglais (eng) Mots-clés : Mood disorder major depressive disorder fMRI anterior cingulate facial recognition familial risk Index. décimale : PER Périodiques Résumé : Background Studies have identified perturbations in facial processing in bipolar disorder and major depressive disorder (MDD), but their relationship to genetic risk and early development of illness is unclear. Methods The Scottish Bipolar Family Study is a prospective longitudinal investigation examining young individuals (age 16–25) at familial risk of mood disorder. Participants underwent functional MRI using an implicit facial processing task employing angry and neutral faces. An explicit facial expression recognition task was completed outside the scanner. Clinical outcomes obtained 2 years after the scan were used to categorise participants into controls (n = 54), high-risk individuals who had developed MDD (HR MDD; n = 30) and high-risk individuals who remained well (HR Well, n = 43). Results All groups demonstrated activation patterns typically observed during facial processing, including activation of the amygdala, hippocampus, fusiform gyrus and middle frontal regions. Notably, the HR MDD group showed reduced activation of the anterior cingulate gyrus versus both the control and HR Well group for angry faces, and versus the HR Well group for neutral faces. Outside the scanner, the HR MDD group was less accurate in recognising fearful expressions than the HR Well group. Conclusions Here, we demonstrate functional abnormalities of the anterior cingulate cortex alongside facial emotional recognition deficits in high-risk individuals in the early stages of depression compared with both controls and at-risk individuals who remained well. These neural changes were associated with a current or future diagnosis of MDD and were not simply associated with increased familial risk. En ligne : http://dx.doi.org/10.1111/jcpp.12591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295
in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1277-1286[article] Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study [Texte imprimé et/ou numérique] / Stella W. Y. CHAN, Auteur ; Jessika E. SUSSMANN, Auteur ; Liana ROMANIUK, Auteur ; Tiffany STEWART, Auteur ; Stephen M. LAWRIE, Auteur ; Jeremy HALL, Auteur ; Andrew M. MCINTOSH, Auteur ; Heather C. WHALLEY, Auteur . - p.1277-1286.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1277-1286
Mots-clés : Mood disorder major depressive disorder fMRI anterior cingulate facial recognition familial risk Index. décimale : PER Périodiques Résumé : Background Studies have identified perturbations in facial processing in bipolar disorder and major depressive disorder (MDD), but their relationship to genetic risk and early development of illness is unclear. Methods The Scottish Bipolar Family Study is a prospective longitudinal investigation examining young individuals (age 16–25) at familial risk of mood disorder. Participants underwent functional MRI using an implicit facial processing task employing angry and neutral faces. An explicit facial expression recognition task was completed outside the scanner. Clinical outcomes obtained 2 years after the scan were used to categorise participants into controls (n = 54), high-risk individuals who had developed MDD (HR MDD; n = 30) and high-risk individuals who remained well (HR Well, n = 43). Results All groups demonstrated activation patterns typically observed during facial processing, including activation of the amygdala, hippocampus, fusiform gyrus and middle frontal regions. Notably, the HR MDD group showed reduced activation of the anterior cingulate gyrus versus both the control and HR Well group for angry faces, and versus the HR Well group for neutral faces. Outside the scanner, the HR MDD group was less accurate in recognising fearful expressions than the HR Well group. Conclusions Here, we demonstrate functional abnormalities of the anterior cingulate cortex alongside facial emotional recognition deficits in high-risk individuals in the early stages of depression compared with both controls and at-risk individuals who remained well. These neural changes were associated with a current or future diagnosis of MDD and were not simply associated with increased familial risk. En ligne : http://dx.doi.org/10.1111/jcpp.12591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 Empathic responding in preschool-aged children with familial risk for autism / Nicole M. MCDONALD in Autism Research, 10-10 (October 2017)
[article]
Titre : Empathic responding in preschool-aged children with familial risk for autism Type de document : Texte imprimé et/ou numérique Auteurs : Nicole M. MCDONALD, Auteur ; Haley G. MURPHY, Auteur ; Daniel S. MESSINGER, Auteur Article en page(s) : p.1621-1628 Langues : Anglais (eng) Mots-clés : empathic responding high-risk siblings autism spectrum disorder preschool age familial risk Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) show deficits in social and emotional reciprocity, which often include empathic responding. The younger siblings of children with ASD (high-risk siblings) are at elevated risk for ASD and for subclinical deficits in social-emotional functioning. Higher levels of empathy in high-risk siblings during the second and third years of life predict fewer ASD symptoms and likelihood of diagnosis. We conducted a multi-method investigation of empathic responding to an examiner's accident in 30 low-risk and 48 high-risk siblings with (n?=?12) and without ASD outcomes (n?=?36) at 4–6 years of age. Empathic responding was measured through behavioral observation and parent report. Prosocial behavior did not differ by ASD outcome. Children with ASD exhibited lower levels of personal distress than high-risk and low-risk siblings without ASD. Per parent report, high-risk siblings without ASD demonstrated higher levels of empathic responding than low-risk children, while the ASD group did not differ from children without ASD on this measure. Higher levels of observed empathic concern, but not prosocial behavior, were associated with lower Social Affect scores on the Autism Diagnostic Observation Schedule in high-risk children. Results suggest that ASD diagnosis and symptoms are associated with reduced emotional responsiveness to an adult's distress, but not associated with deficits in prosocial behavior at preschool age. Results do not support the idea that empathic responding is negatively impacted in a broader autism phenotype. Findings extend previous research by suggesting that empathy may be a protective factor in the social-emotional development of children with familial risk for ASD. Autism Res 2017, 10: 1621–1628. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-10 (October 2017) . - p.1621-1628[article] Empathic responding in preschool-aged children with familial risk for autism [Texte imprimé et/ou numérique] / Nicole M. MCDONALD, Auteur ; Haley G. MURPHY, Auteur ; Daniel S. MESSINGER, Auteur . - p.1621-1628.
Langues : Anglais (eng)
in Autism Research > 10-10 (October 2017) . - p.1621-1628
Mots-clés : empathic responding high-risk siblings autism spectrum disorder preschool age familial risk Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) show deficits in social and emotional reciprocity, which often include empathic responding. The younger siblings of children with ASD (high-risk siblings) are at elevated risk for ASD and for subclinical deficits in social-emotional functioning. Higher levels of empathy in high-risk siblings during the second and third years of life predict fewer ASD symptoms and likelihood of diagnosis. We conducted a multi-method investigation of empathic responding to an examiner's accident in 30 low-risk and 48 high-risk siblings with (n?=?12) and without ASD outcomes (n?=?36) at 4–6 years of age. Empathic responding was measured through behavioral observation and parent report. Prosocial behavior did not differ by ASD outcome. Children with ASD exhibited lower levels of personal distress than high-risk and low-risk siblings without ASD. Per parent report, high-risk siblings without ASD demonstrated higher levels of empathic responding than low-risk children, while the ASD group did not differ from children without ASD on this measure. Higher levels of observed empathic concern, but not prosocial behavior, were associated with lower Social Affect scores on the Autism Diagnostic Observation Schedule in high-risk children. Results suggest that ASD diagnosis and symptoms are associated with reduced emotional responsiveness to an adult's distress, but not associated with deficits in prosocial behavior at preschool age. Results do not support the idea that empathic responding is negatively impacted in a broader autism phenotype. Findings extend previous research by suggesting that empathy may be a protective factor in the social-emotional development of children with familial risk for ASD. Autism Res 2017, 10: 1621–1628. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 The Familial Risk of Autism Spectrum Disorder with and without Intellectual Disability / Sherlly XIE in Autism Research, 13-12 (December 2020)
PermalinkInfant Neural Sensitivity to Dynamic Eye Gaze Relates to Quality of Parent–Infant Interaction at 7-Months in Infants at Risk for Autism / Mayada ELSABBAGH in Journal of Autism and Developmental Disorders, 45-2 (February 2015)
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