7 recherche sur le mot-clé 'for publication: Not applicable. Competing interests: The authors declare no'

Autistic traits are associated with lower perceived executive function but not poorer executive function task performance in the general population: complementary meta-analytic evidence / Michael K. YEUNG in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 48 Titre : Autistic traits are associated with lower perceived executive function but not poorer executive function task performance in the general population: complementary meta-analytic evidence Type de document : texte imprimé Auteurs : Michael K. YEUNG, Auteur ; Cassie T.Y. LI, Auteur ; Harris C.W. CHUNG, Auteur ; Tsz-Hei AU, Auteur ; Sin-Yue LEE, Auteur ; Jieru BAI, Auteur ; Michael K. YEUNG, Auteur ; Cassie T.Y. LI, Auteur ; Harris C.W. CHUNG, Auteur ; Tsz-Hei AU, Auteur ; Sin-Yue LEE, Auteur ; Jieru BAI, Auteur Article en page(s) : 48 Langues : Anglais (eng) Mots-clés : Humans  Executive Function/physiology  Autistic Disorder/psychology/physiopathology  Male  Adult  Bayes Theorem  Aq  Autism spectrum quotient  Autistic traits  Executive function  Meta-analysis  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals generally exhibit real-world executive function (EF) difficulties and perform poorly on EF tasks. However, while autistic traits are distributed continuously throughout the general population, the relationships between autistic traits and EF among nonclinical individuals remain unclear. Here, we conducted complementary meta-analyses to clarify the relationships between autistic traits and various aspects of EF in the general population. METHODS: A literature search was conducted using PubMed, PsycINFO, and Web of Science on July 11, 2025. After screening by two independent reviewers, 39 articles that reported 40 studies were included. These studies either compared EF between groups with high and low autistic traits, based on a cutoff, or investigated the relationships between continuous measures of autistic traits and EF. RESULTS: We found significant negative associations between autistic traits and EF among nonclinical individuals across EF processes. Notably, these relationships were observed only when EFs were measured using questionnaires rather than behavioral tasks. Specifically, random-effects and robust Bayesian meta-analyses revealed significant, strong correlations between higher autistic traits and poorer ratings on EF questionnaires, with primarily substantial evidence supporting the presence than absence of relationships. In contrast, the meta-analyses indicated nonsignificant, very weak correlations between higher autistic traits and poorer performances on EF tasks, with primarily substantial evidence supporting the absence than presence of relationships. LIMITATIONS: These findings were mainly based on self-reported measures of autistic traits in adults and derived from single studies without follow up or replication. CONCLUSIONS: Autistic traits are associated with lower perceived real-world EF behavior rather than poorer EF task performance in the general population. These findings underscore the importance of paying closer attention to addressing the concerns of individuals with high autistic traits and their parents regarding their own and their children's EF behavior. Based on the available evidence, we construct a picture of the relationships between autistic traits and EF across the trait's continuum. REGISTRATION: This study was preregistered at https://osf.io/zncv3 . En ligne : https://dx.doi.org/10.1186/s13229-025-00680-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Autistic traits are associated with lower perceived executive function but not poorer executive function task performance in the general population: complementary meta-analytic evidence [texte imprimé] / Michael K. YEUNG, Auteur ; Cassie T.Y. LI, Auteur ; Harris C.W. CHUNG, Auteur ; Tsz-Hei AU, Auteur ; Sin-Yue LEE, Auteur ; Jieru BAI, Auteur ; Michael K. YEUNG, Auteur ; Cassie T.Y. LI, Auteur ; Harris C.W. CHUNG, Auteur ; Tsz-Hei AU, Auteur ; Sin-Yue LEE, Auteur ; Jieru BAI, Auteur . - 48. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 48 Mots-clés : Humans  Executive Function/physiology  Autistic Disorder/psychology/physiopathology  Male  Adult  Bayes Theorem  Aq  Autism spectrum quotient  Autistic traits  Executive function  Meta-analysis  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals generally exhibit real-world executive function (EF) difficulties and perform poorly on EF tasks. However, while autistic traits are distributed continuously throughout the general population, the relationships between autistic traits and EF among nonclinical individuals remain unclear. Here, we conducted complementary meta-analyses to clarify the relationships between autistic traits and various aspects of EF in the general population. METHODS: A literature search was conducted using PubMed, PsycINFO, and Web of Science on July 11, 2025. After screening by two independent reviewers, 39 articles that reported 40 studies were included. These studies either compared EF between groups with high and low autistic traits, based on a cutoff, or investigated the relationships between continuous measures of autistic traits and EF. RESULTS: We found significant negative associations between autistic traits and EF among nonclinical individuals across EF processes. Notably, these relationships were observed only when EFs were measured using questionnaires rather than behavioral tasks. Specifically, random-effects and robust Bayesian meta-analyses revealed significant, strong correlations between higher autistic traits and poorer ratings on EF questionnaires, with primarily substantial evidence supporting the presence than absence of relationships. In contrast, the meta-analyses indicated nonsignificant, very weak correlations between higher autistic traits and poorer performances on EF tasks, with primarily substantial evidence supporting the absence than presence of relationships. LIMITATIONS: These findings were mainly based on self-reported measures of autistic traits in adults and derived from single studies without follow up or replication. CONCLUSIONS: Autistic traits are associated with lower perceived real-world EF behavior rather than poorer EF task performance in the general population. These findings underscore the importance of paying closer attention to addressing the concerns of individuals with high autistic traits and their parents regarding their own and their children's EF behavior. Based on the available evidence, we construct a picture of the relationships between autistic traits and EF across the trait's continuum. REGISTRATION: This study was preregistered at https://osf.io/zncv3 . En ligne : https://dx.doi.org/10.1186/s13229-025-00680-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Patient reported outcomes used in clinical trials and core outcome sets for individuals with genetic intellectual disability: a scoping review / Nadia Y. VAN SILFHOUT in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Patient reported outcomes used in clinical trials and core outcome sets for individuals with genetic intellectual disability: a scoping review Type de document : texte imprimé Auteurs : Nadia Y. VAN SILFHOUT, Auteur ; Maud M. VAN MUILEKOM, Auteur ; Clara D. VAN KARNEBEEK, Auteur ; Joost G. DAAMS, Auteur ; Lotte HAVERMAN, Auteur ; Agnies M. VAN EEGHEN, Auteur Langues : Anglais (eng) Mots-clés : Humans  Clinical Trials as Topic  Intellectual Disability/therapy/psychology/genetics  Patient Reported Outcome Measures  Quality of Life  Genetic intellectual disability  Patient reported outcome measures  Patient reported outcomes  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The impact of genetic intellectual disability (GID) on daily life is significant. To better understand the impact of GID, it is essential to measure relevant patient reported outcomes (PROs). The aim of this study is to provide an overview of PROs used for individuals with GID, laying the groundwork for a future generic core PRO set for GID. METHODS: To identify PROs used for individuals with GID, results of two literature reviews were integrated; (1) PROs extracted from a scoping review on outcomes in clinical trials, and (2) PROs identified from a scoping review on core outcome sets (COSs) for specific GIDs through a search in MEDLINE (Ovid), PsycINFO, Embase, and the COMET database. Descriptive analyses were performed. RESULTS: In the first scoping review, 66 different PROs were identified. In the second scoping review, 22 different PROs were identified. After integrating PROs, 18 unique PROs remained, which were classified into a conceptual framework. Most frequently reported PROs were quality of life, perceived health, cognitive functioning, anxiety/stress, and depressive symptoms. CONCLUSION: This study provides an overview of PROs used for individuals with GID. These results will assist in developing a generic core PRO set for GID, to harmonize PROs used in care and research. En ligne : https://dx.doi.org/10.1186/s11689-025-09633-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Patient reported outcomes used in clinical trials and core outcome sets for individuals with genetic intellectual disability: a scoping review [texte imprimé] / Nadia Y. VAN SILFHOUT, Auteur ; Maud M. VAN MUILEKOM, Auteur ; Clara D. VAN KARNEBEEK, Auteur ; Joost G. DAAMS, Auteur ; Lotte HAVERMAN, Auteur ; Agnies M. VAN EEGHEN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Clinical Trials as Topic  Intellectual Disability/therapy/psychology/genetics  Patient Reported Outcome Measures  Quality of Life  Genetic intellectual disability  Patient reported outcome measures  Patient reported outcomes  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: The impact of genetic intellectual disability (GID) on daily life is significant. To better understand the impact of GID, it is essential to measure relevant patient reported outcomes (PROs). The aim of this study is to provide an overview of PROs used for individuals with GID, laying the groundwork for a future generic core PRO set for GID. METHODS: To identify PROs used for individuals with GID, results of two literature reviews were integrated; (1) PROs extracted from a scoping review on outcomes in clinical trials, and (2) PROs identified from a scoping review on core outcome sets (COSs) for specific GIDs through a search in MEDLINE (Ovid), PsycINFO, Embase, and the COMET database. Descriptive analyses were performed. RESULTS: In the first scoping review, 66 different PROs were identified. In the second scoping review, 22 different PROs were identified. After integrating PROs, 18 unique PROs remained, which were classified into a conceptual framework. Most frequently reported PROs were quality of life, perceived health, cognitive functioning, anxiety/stress, and depressive symptoms. CONCLUSION: This study provides an overview of PROs used for individuals with GID. These results will assist in developing a generic core PRO set for GID, to harmonize PROs used in care and research. En ligne : https://dx.doi.org/10.1186/s11689-025-09633-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Effects of elastic therapeutic taping on reducing drooling in children with neurological disorders: a systematic review of randomized controlled trials / Krystal Tsz Ting LAM in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Effects of elastic therapeutic taping on reducing drooling in children with neurological disorders: a systematic review of randomized controlled trials Type de document : texte imprimé Auteurs : Krystal Tsz Ting LAM, Auteur ; Alex Tsz Wai HUNG, Auteur ; Kendy LAU, Auteur ; Eric Kam Pui LEE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Sialorrhea/therapy/etiology  Child  Randomized Controlled Trials as Topic  Nervous System Diseases/complications  Child, Preschool  Adolescent  Drooling  Elastic therapeutic taping  Kinesio-taping  Neurological disorders  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND & AIMS: Effective treatment for anterior drooling in children with neurological disorders can lead to improved social interactions, reduced physical complications such as perioral infections, and enhanced quality of life for both patients and their parents. Elastic therapeutic taping (ETT) has emerged a novel intervention for drooling, but its evidence was limited. This study systematically reviewed the effectiveness of ETT on reducing anterior drooling in children with neurological disorders. METHODS: Multiple electronic databases, such as Ovid MEDLINE, Embase, and Cochrane Library were searched from inception till 30th October 2024. Randomized controlled trials (RCTs) were included if they: (a) used ETT as a treatment for drooling or swallowing difficulties; (b) included participants aged < 18 years old; (c) included participants with anterior drooling and neurological disorders; (d) compared effects of ETT alone or combined with other treatments (e.g. oral motor therapy (OMT)) with no taping, sham taping or other treatments, and (e) published in English. The Cochrane Risk-of-Bias tool was used to assess risk of bias for the included studies. RESULTS: Seven parallel-arm RCTs, which were conducted in South/southwest Asia, Africa, South America and Middle East, were included. In total, 220 children aged 1 to 11 were included, of which 97 received solely ETT in 4 studies, while 24 received ETT plus OMT in 2 studies. ETT combined with OMT was more effective in reducing drooling in the included 2 RCTs, though the results of ETT alone were inconsistent, likely due to heterogeneity observed in control conditions, application methods, and outcome measures. No side effects were reported in all studies. CONCLUSIONS: This review suggests that ETT combined with OMT is effective in reducing drooling in children with neurological disorders, with no evidence of side effects. TRIAL REGISTRATION: (PROSPERO no.: CRD42023488664). En ligne : https://dx.doi.org/10.1186/s11689-024-09584-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Effects of elastic therapeutic taping on reducing drooling in children with neurological disorders: a systematic review of randomized controlled trials [texte imprimé] / Krystal Tsz Ting LAM, Auteur ; Alex Tsz Wai HUNG, Auteur ; Kendy LAU, Auteur ; Eric Kam Pui LEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Sialorrhea/therapy/etiology  Child  Randomized Controlled Trials as Topic  Nervous System Diseases/complications  Child, Preschool  Adolescent  Drooling  Elastic therapeutic taping  Kinesio-taping  Neurological disorders  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND & AIMS: Effective treatment for anterior drooling in children with neurological disorders can lead to improved social interactions, reduced physical complications such as perioral infections, and enhanced quality of life for both patients and their parents. Elastic therapeutic taping (ETT) has emerged a novel intervention for drooling, but its evidence was limited. This study systematically reviewed the effectiveness of ETT on reducing anterior drooling in children with neurological disorders. METHODS: Multiple electronic databases, such as Ovid MEDLINE, Embase, and Cochrane Library were searched from inception till 30th October 2024. Randomized controlled trials (RCTs) were included if they: (a) used ETT as a treatment for drooling or swallowing difficulties; (b) included participants aged < 18 years old; (c) included participants with anterior drooling and neurological disorders; (d) compared effects of ETT alone or combined with other treatments (e.g. oral motor therapy (OMT)) with no taping, sham taping or other treatments, and (e) published in English. The Cochrane Risk-of-Bias tool was used to assess risk of bias for the included studies. RESULTS: Seven parallel-arm RCTs, which were conducted in South/southwest Asia, Africa, South America and Middle East, were included. In total, 220 children aged 1 to 11 were included, of which 97 received solely ETT in 4 studies, while 24 received ETT plus OMT in 2 studies. ETT combined with OMT was more effective in reducing drooling in the included 2 RCTs, though the results of ETT alone were inconsistent, likely due to heterogeneity observed in control conditions, application methods, and outcome measures. No side effects were reported in all studies. CONCLUSIONS: This review suggests that ETT combined with OMT is effective in reducing drooling in children with neurological disorders, with no evidence of side effects. TRIAL REGISTRATION: (PROSPERO no.: CRD42023488664). En ligne : https://dx.doi.org/10.1186/s11689-024-09584-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Impact of imitation abilities on social communication in autistic children: evidence from an Early Start Denver Model intervention study / Jing LI in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 23 Titre : Impact of imitation abilities on social communication in autistic children: evidence from an Early Start Denver Model intervention study Type de document : texte imprimé Auteurs : Jing LI, Auteur Article en page(s) : 23 Langues : Anglais (eng) Mots-clés : Humans  Male  Female  Imitative Behavior  Child, Preschool  Autistic Disorder/psychology/physiopathology  Communication  Social Skills  Social Behavior  Autism  Early Start Denver Model (ESDM)  Imitation  Social communication  by the Institute of Psychology, Chinese Academy of Sciences Child Subjects  Committee and was conducted in accordance with the Declaration of Helsinki.  Informed consent was obtained from the parents or guardians of children. Consent  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : Imitation is foundational to early social learning, yet autistic children often exhibit significant impairments in imitation, potentially impacting their social communication skills. This study examined the relationship between imitation abilities and social communication in autistic children and evaluated the effectiveness of the Early Start Denver Model (ESDM) intervention. The study included 52 autistic children aged 2-5, divided into an experimental group receiving ESDM intervention and a control group undergoing standard rehabilitation. We assessed the children's imitation and social communication skills before and after the intervention. Results indicated a significant positive correlation between imitation and social communication skills both before and after the intervention. Specifically, various forms of imitation (e.g., vocal, gestural, object-related) were closely linked to different domains of social communication (e.g., expressive communication, joint attention, social skills). Baseline imitation levels and improvements in imitation were significant predictors of enhanced social communication, jointly accounting for over half of the observed improvements in social communication, with imitation improvement being the strongest predictor. Age positively moderated the relationship between imitation and social communication, with older children showing a stronger impact of imitation on social communication. Although these effects were evident across groups, the ESDM group showed greater gains in imitation skills compared to the control group. However, we did not find evidence of an intervention effect on social communication skills. This study underscores the critical role of imitation in the social communication development of autistic children. These findings support the enhancement of imitation skills in early interventions for autistic children, highlighting the effectiveness of ESDM in fostering imitation abilities. En ligne : https://dx.doi.org/10.1186/s13229-025-00656-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Impact of imitation abilities on social communication in autistic children: evidence from an Early Start Denver Model intervention study [texte imprimé] / Jing LI, Auteur . - 23. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 23 Mots-clés : Humans  Male  Female  Imitative Behavior  Child, Preschool  Autistic Disorder/psychology/physiopathology  Communication  Social Skills  Social Behavior  Autism  Early Start Denver Model (ESDM)  Imitation  Social communication  by the Institute of Psychology, Chinese Academy of Sciences Child Subjects  Committee and was conducted in accordance with the Declaration of Helsinki.  Informed consent was obtained from the parents or guardians of children. Consent  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : Imitation is foundational to early social learning, yet autistic children often exhibit significant impairments in imitation, potentially impacting their social communication skills. This study examined the relationship between imitation abilities and social communication in autistic children and evaluated the effectiveness of the Early Start Denver Model (ESDM) intervention. The study included 52 autistic children aged 2-5, divided into an experimental group receiving ESDM intervention and a control group undergoing standard rehabilitation. We assessed the children's imitation and social communication skills before and after the intervention. Results indicated a significant positive correlation between imitation and social communication skills both before and after the intervention. Specifically, various forms of imitation (e.g., vocal, gestural, object-related) were closely linked to different domains of social communication (e.g., expressive communication, joint attention, social skills). Baseline imitation levels and improvements in imitation were significant predictors of enhanced social communication, jointly accounting for over half of the observed improvements in social communication, with imitation improvement being the strongest predictor. Age positively moderated the relationship between imitation and social communication, with older children showing a stronger impact of imitation on social communication. Although these effects were evident across groups, the ESDM group showed greater gains in imitation skills compared to the control group. However, we did not find evidence of an intervention effect on social communication skills. This study underscores the critical role of imitation in the social communication development of autistic children. These findings support the enhancement of imitation skills in early interventions for autistic children, highlighting the effectiveness of ESDM in fostering imitation abilities. En ligne : https://dx.doi.org/10.1186/s13229-025-00656-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome / Melissa R. JENKINS in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome Type de document : texte imprimé Auteurs : Melissa R. JENKINS, Auteur ; Jamie C. PEVEN, Auteur ; Lauren KUBIC, Auteur ; Benjamin L. HANDEN, Auteur ; Sharon J. KRINSKY-MCHALE, Auteur ; Christy L. HOM, Auteur ; Alice LEE, Auteur ; Dana L. TUDORASCU, Auteur ; Max MCLACHLAN, Auteur ; Matthew ZAMMIT, Auteur ; Davneet MINHAS, Auteur ; Weiquan LUO, Auteur ; Charles LAYMON, Auteur ; Joseph H. LEE, Auteur ; Ira LOTT, Auteur ; Annie COHEN, Auteur ; Beau M. ANCES, Auteur ; H. Diana ROSAS, Auteur ; Florence LAI, Auteur ; Shahid H. ZAMAN, Auteur ; Elizabeth HEAD, Auteur ; Mark MAPSTONE, Auteur ; Bradley T. CHRISTIAN, Auteur ; Sigan L. HARTLEY, Auteur ; ALZHEIMER BIOMARKER CONSORTIUM - DOWN SYNDROME, Auteur Langues : Anglais (eng) Mots-clés : Humans  Down Syndrome/complications/psychology/diagnostic imaging  Male  Female  Alzheimer Disease/psychology/diagnostic  imaging/complications/metabolism/physiopathology  Disease Progression  Middle Aged  Dementia/psychology/diagnostic imaging/complications/physiopathology  Adult  Positron-Emission Tomography  Cognitive Dysfunction/diagnostic imaging/psychology  Amyloid beta-Peptides/metabolism  Cohort Studies  Aged  Alzheimer’s disease  Amyloid  Down syndrome  Psychiatric symptoms  Tau  was approved by the Internal Review Boards of the University of Pittsburgh,  University of Wisconsin Madison, and University of California, Irvine. Consent  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Adults with Down syndrome (DS) have a 90% lifetime risk for Alzheimer's disease (AD), with neurobiological pathology present decades prior to dementia onset. The profile and timing of cognitive decline in DS is well-documented. However, there is a small body of research on whether Behavioral and Psychological Symptoms of Dementia (BPSD) occur early on in the progression of AD in DS and are associated with early AD pathology (i.e., amyloid-beta [Aβ] and neurofibrillary tau tangles [NFT]). METHODS: Data were analyzed from 337 adults with DS (M = 45.13 years, SD = 9.53 years) enrolled in a large cohort study. The Reiss Screen for Maladaptive Behavior (RSMB) measured common behaviors reported in BPSD across up to four study cycles (spaced approximately 16 months apart). Linear mixed models estimated change in BPSD as predicted by baseline (a) dementia status (i.e., cognitively stable, mild cognitive impairment [MCI], or dementia), (b) Aβ positron emission tomography (PET) tracer [(11)C] PiB, and (c) NFT PET tracer [(18)F]AV-1451. Models controlled for chronological age, sex, study site, premorbid intellectual disability level, APOE e4 allele carrier status, psychiatric diagnoses, and psychiatric medication use. RESULTS: Compared to cognitively stable participants, participants whose status was MCI or dementia, had significantly higher baseline RSMB subdomain scores. Increases in RSMB Depression-Behavioral, Depression-Physical, and Psychosis were observed for participants with MCI. Higher baseline Aβ and NFT were associated with higher RSMB Avoidant at baseline, and increases in RSMB Depression-Physical and Psychosis over time. CONCLUSIONS: BPSD are an important part of AD in DS, particularly during the prodromal stage. Elevated Aβ and NFT predict higher initial avoidance and change in physical depression behaviors and may indicate MCI in adults with DS. Broader increases in BPSD are observed as adults with DS progress from early to late-stage dementia. Clinicians should rule out other possible causes of BPSD when screening for AD, such as stressful life experiences or co-occurring medical conditions. Caregivers of adults with DS should have resources on BPSD management and self-care strategies. En ligne : https://dx.doi.org/10.1186/s11689-025-09604-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome [texte imprimé] / Melissa R. JENKINS, Auteur ; Jamie C. PEVEN, Auteur ; Lauren KUBIC, Auteur ; Benjamin L. HANDEN, Auteur ; Sharon J. KRINSKY-MCHALE, Auteur ; Christy L. HOM, Auteur ; Alice LEE, Auteur ; Dana L. TUDORASCU, Auteur ; Max MCLACHLAN, Auteur ; Matthew ZAMMIT, Auteur ; Davneet MINHAS, Auteur ; Weiquan LUO, Auteur ; Charles LAYMON, Auteur ; Joseph H. LEE, Auteur ; Ira LOTT, Auteur ; Annie COHEN, Auteur ; Beau M. ANCES, Auteur ; H. Diana ROSAS, Auteur ; Florence LAI, Auteur ; Shahid H. ZAMAN, Auteur ; Elizabeth HEAD, Auteur ; Mark MAPSTONE, Auteur ; Bradley T. CHRISTIAN, Auteur ; Sigan L. HARTLEY, Auteur ; ALZHEIMER BIOMARKER CONSORTIUM - DOWN SYNDROME, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Down Syndrome/complications/psychology/diagnostic imaging  Male  Female  Alzheimer Disease/psychology/diagnostic  imaging/complications/metabolism/physiopathology  Disease Progression  Middle Aged  Dementia/psychology/diagnostic imaging/complications/physiopathology  Adult  Positron-Emission Tomography  Cognitive Dysfunction/diagnostic imaging/psychology  Amyloid beta-Peptides/metabolism  Cohort Studies  Aged  Alzheimer’s disease  Amyloid  Down syndrome  Psychiatric symptoms  Tau  was approved by the Internal Review Boards of the University of Pittsburgh,  University of Wisconsin Madison, and University of California, Irvine. Consent  for publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Adults with Down syndrome (DS) have a 90% lifetime risk for Alzheimer's disease (AD), with neurobiological pathology present decades prior to dementia onset. The profile and timing of cognitive decline in DS is well-documented. However, there is a small body of research on whether Behavioral and Psychological Symptoms of Dementia (BPSD) occur early on in the progression of AD in DS and are associated with early AD pathology (i.e., amyloid-beta [Aβ] and neurofibrillary tau tangles [NFT]). METHODS: Data were analyzed from 337 adults with DS (M = 45.13 years, SD = 9.53 years) enrolled in a large cohort study. The Reiss Screen for Maladaptive Behavior (RSMB) measured common behaviors reported in BPSD across up to four study cycles (spaced approximately 16 months apart). Linear mixed models estimated change in BPSD as predicted by baseline (a) dementia status (i.e., cognitively stable, mild cognitive impairment [MCI], or dementia), (b) Aβ positron emission tomography (PET) tracer [(11)C] PiB, and (c) NFT PET tracer [(18)F]AV-1451. Models controlled for chronological age, sex, study site, premorbid intellectual disability level, APOE e4 allele carrier status, psychiatric diagnoses, and psychiatric medication use. RESULTS: Compared to cognitively stable participants, participants whose status was MCI or dementia, had significantly higher baseline RSMB subdomain scores. Increases in RSMB Depression-Behavioral, Depression-Physical, and Psychosis were observed for participants with MCI. Higher baseline Aβ and NFT were associated with higher RSMB Avoidant at baseline, and increases in RSMB Depression-Physical and Psychosis over time. CONCLUSIONS: BPSD are an important part of AD in DS, particularly during the prodromal stage. Elevated Aβ and NFT predict higher initial avoidance and change in physical depression behaviors and may indicate MCI in adults with DS. Broader increases in BPSD are observed as adults with DS progress from early to late-stage dementia. Clinicians should rule out other possible causes of BPSD when screening for AD, such as stressful life experiences or co-occurring medical conditions. Caregivers of adults with DS should have resources on BPSD management and self-care strategies. En ligne : https://dx.doi.org/10.1186/s11689-025-09604-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Neural excitation/inhibition imbalance and neurodevelopmental pathology in human copy number variant syndromes: a systematic review / Amy L. SYLVESTER in Journal of Neurodevelopmental Disorders, 17 (2025)  

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Serotonin dysfunction in ADHD / Eleanor F. JACKSON in Journal of Neurodevelopmental Disorders, 17 (2025)  

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