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Fractures in Individuals With and Without a History of Infantile Autism. A Danish Register Study Based on Hospital Discharge Diagnoses / Svend Erik MOURIDSEN in Journal of Autism and Developmental Disorders, 42-4 (April 2012)
[article]
Titre : Fractures in Individuals With and Without a History of Infantile Autism. A Danish Register Study Based on Hospital Discharge Diagnoses Type de document : Texte imprimé et/ou numérique Auteurs : Svend Erik MOURIDSEN, Auteur ; Bente RICH, Auteur ; Torben ISAGER, Auteur Année de publication : 2012 Article en page(s) : p.619-624 Langues : Anglais (eng) Mots-clés : Infantile autism Fractures Bone health Epilepsy Index. décimale : PER Périodiques Résumé : We compared the prevalence and types of fractures in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with 336 matched controls from the general population. All participants were screened through the nationwide Danish National Hospital Register. The average observation time was 30.3 years (range 27.3–30.4 years), and mean age at follow-up was 42.7 years (range 27.3–57.3 years). Of the 118 individuals with IA, 14 (11.9%) were registered with at least one fracture diagnosis against 83 (24.7%) in the comparison group ( p = 0.004; OR = 0.41; 95%CI 0.22–0.76), but the nature of their fractures seems somewhat different. Epilepsy was a risk factor, but only in the comparison group. Our results lend no support to the notion that fracture is a common comorbid condition in a population of people diagnosed with IA as children. En ligne : http://dx.doi.org/10.1007/s10803-011-1286-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154
in Journal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.619-624[article] Fractures in Individuals With and Without a History of Infantile Autism. A Danish Register Study Based on Hospital Discharge Diagnoses [Texte imprimé et/ou numérique] / Svend Erik MOURIDSEN, Auteur ; Bente RICH, Auteur ; Torben ISAGER, Auteur . - 2012 . - p.619-624.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.619-624
Mots-clés : Infantile autism Fractures Bone health Epilepsy Index. décimale : PER Périodiques Résumé : We compared the prevalence and types of fractures in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with 336 matched controls from the general population. All participants were screened through the nationwide Danish National Hospital Register. The average observation time was 30.3 years (range 27.3–30.4 years), and mean age at follow-up was 42.7 years (range 27.3–57.3 years). Of the 118 individuals with IA, 14 (11.9%) were registered with at least one fracture diagnosis against 83 (24.7%) in the comparison group ( p = 0.004; OR = 0.41; 95%CI 0.22–0.76), but the nature of their fractures seems somewhat different. Epilepsy was a risk factor, but only in the comparison group. Our results lend no support to the notion that fracture is a common comorbid condition in a population of people diagnosed with IA as children. En ligne : http://dx.doi.org/10.1007/s10803-011-1286-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 Brief Report: Bone Fractures in Children and Adults with Autism Spectrum Disorders / Ann M. NEUMEYER in Journal of Autism and Developmental Disorders, 45-3 (March 2015)
[article]
Titre : Brief Report: Bone Fractures in Children and Adults with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ann M. NEUMEYER, Auteur ; Julia A. O’ROURKE, Auteur ; Alexandra MASSA, Auteur ; Hang LEE, Auteur ; Elizabeth A. LAWSON, Auteur ; Christopher J. MCDOUGLE, Auteur ; Madhusmita MISRA, Auteur Article en page(s) : p.881-887 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Autism Fractures Low bone density Osteoporosis Index. décimale : PER Périodiques Résumé : Peripubertal boys with autism spectrum disorder (ASD) have lower bone mineral density (BMD) than typically developing controls. However, it is not clear whether lower BMD in ASD results in an increased fracture rate. This study examined the rate of fractures in children and adults with and without ASD using a national database of emergency room visits (Nationwide Emergency Department Sample). A higher odds ratio for hip fractures in children and young adults (3–22 years) as well as older adults (23–50 years) with ASD than those without ASD, and a higher odds ratio for forearm and spine fractures in women ages 23–50 with ASD were found. Further studies are necessary to better understand the decreased bone density in ASD and its implications for fracture development. En ligne : http://dx.doi.org/10.1007/s10803-014-2228-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258
in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.881-887[article] Brief Report: Bone Fractures in Children and Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Ann M. NEUMEYER, Auteur ; Julia A. O’ROURKE, Auteur ; Alexandra MASSA, Auteur ; Hang LEE, Auteur ; Elizabeth A. LAWSON, Auteur ; Christopher J. MCDOUGLE, Auteur ; Madhusmita MISRA, Auteur . - p.881-887.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.881-887
Mots-clés : Autism spectrum disorders Autism Fractures Low bone density Osteoporosis Index. décimale : PER Périodiques Résumé : Peripubertal boys with autism spectrum disorder (ASD) have lower bone mineral density (BMD) than typically developing controls. However, it is not clear whether lower BMD in ASD results in an increased fracture rate. This study examined the rate of fractures in children and adults with and without ASD using a national database of emergency room visits (Nationwide Emergency Department Sample). A higher odds ratio for hip fractures in children and young adults (3–22 years) as well as older adults (23–50 years) with ASD than those without ASD, and a higher odds ratio for forearm and spine fractures in women ages 23–50 with ASD were found. Further studies are necessary to better understand the decreased bone density in ASD and its implications for fracture development. En ligne : http://dx.doi.org/10.1007/s10803-014-2228-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 Risperidone versus aripiprazole fracture risk in children and adolescents with autism spectrum disorders / R. HOUGHTON in Autism Research, 14-8 (August 2021)
[article]
Titre : Risperidone versus aripiprazole fracture risk in children and adolescents with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : R. HOUGHTON, Auteur ; J. VAN DEN BERGH, Auteur ; K. LAW, Auteur ; Y. LIU, Auteur ; F. DE VRIES, Auteur Article en page(s) : p.1800-1814 Langues : Anglais (eng) Mots-clés : Adolescent Antipsychotic Agents/adverse effects Aripiprazole/adverse effects Autism Spectrum Disorder/complications/drug therapy/epidemiology Child Cohort Studies Female Fractures, Bone/drug therapy/epidemiology Humans Male Retrospective Studies Risperidone/adverse effects United States/epidemiology antipsychotics aripiprazole autism spectrum disorder fractures risperidone Index. décimale : PER Périodiques Résumé : Risperidone and aripiprazole, commonly used antipsychotics in children with autism spectrum disorder (ASD), have previously been associated with elevated fracture risk in other populations. The aim of this study was to evaluate and compare the risk of fracture among children with ASD using risperidone or aripiprazole. This was a retrospective, propensity-score matched cohort study, set between January 2013 and December 2018. We used the MarketScan Medicaid insurance data, which covers multiple states of the United States. We included ASD children aged 2-18?years, who were new users of aripiprazole or risperidone and with no prior history of antipsychotic use or fractures. The main exposure was the continued use of aripiprazole or risperidone. The incidence rates of any fracture during follow-up were evaluated, and the risk between aripiprazole and risperidone was compared via Cox-proportional hazard models. Results were stratified by age, sex, duration of exposure and fracture site. In total, 3312 patients (78% male; mean [SD] age 11.0 [3.7] years) were identified for each cohort. Over the full duration of follow-up, fracture incidence rates per 1000 patient-years were 23.2 for risperidone and 38.4 for aripiprazole (hazard ratio and 95% confidence interval: 0.60 [0.44-0.83]). Risks were similar between cohorts throughout the first 180?days on treatment, but significantly higher in the aripiprazole group thereafter. Extremity fractures drove most of the increased risk, with the biggest differences in lower leg and ankle fractures. Differences widened for children aged 10?years or younger (HR [95% CI]: 0.47 [0.30-0.74]). In conclusion, compared to aripiprazole, risperidone was associated with 40% lower risk of fracture. Further analysis on the mechanism and long-term bone health of antipsychotic-treated children with ASD is warranted. LAY SUMMARY: We compared the risk of bone fractures among 6624 children with autism spectrum disorder (ASD), half of whom used risperidone and half of whom used aripiprazole. Taking other factors into account, risks were similar between the two groups throughout the first 180?days on treatment, but significantly higher in the aripiprazole group thereafter. The biggest differences were in lower leg and ankle fractures. Overall, compared with aripiprazole, risperidone was associated with 40% lower risk of fracture. En ligne : http://dx.doi.org/10.1002/aur.2541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-8 (August 2021) . - p.1800-1814[article] Risperidone versus aripiprazole fracture risk in children and adolescents with autism spectrum disorders [Texte imprimé et/ou numérique] / R. HOUGHTON, Auteur ; J. VAN DEN BERGH, Auteur ; K. LAW, Auteur ; Y. LIU, Auteur ; F. DE VRIES, Auteur . - p.1800-1814.
Langues : Anglais (eng)
in Autism Research > 14-8 (August 2021) . - p.1800-1814
Mots-clés : Adolescent Antipsychotic Agents/adverse effects Aripiprazole/adverse effects Autism Spectrum Disorder/complications/drug therapy/epidemiology Child Cohort Studies Female Fractures, Bone/drug therapy/epidemiology Humans Male Retrospective Studies Risperidone/adverse effects United States/epidemiology antipsychotics aripiprazole autism spectrum disorder fractures risperidone Index. décimale : PER Périodiques Résumé : Risperidone and aripiprazole, commonly used antipsychotics in children with autism spectrum disorder (ASD), have previously been associated with elevated fracture risk in other populations. The aim of this study was to evaluate and compare the risk of fracture among children with ASD using risperidone or aripiprazole. This was a retrospective, propensity-score matched cohort study, set between January 2013 and December 2018. We used the MarketScan Medicaid insurance data, which covers multiple states of the United States. We included ASD children aged 2-18?years, who were new users of aripiprazole or risperidone and with no prior history of antipsychotic use or fractures. The main exposure was the continued use of aripiprazole or risperidone. The incidence rates of any fracture during follow-up were evaluated, and the risk between aripiprazole and risperidone was compared via Cox-proportional hazard models. Results were stratified by age, sex, duration of exposure and fracture site. In total, 3312 patients (78% male; mean [SD] age 11.0 [3.7] years) were identified for each cohort. Over the full duration of follow-up, fracture incidence rates per 1000 patient-years were 23.2 for risperidone and 38.4 for aripiprazole (hazard ratio and 95% confidence interval: 0.60 [0.44-0.83]). Risks were similar between cohorts throughout the first 180?days on treatment, but significantly higher in the aripiprazole group thereafter. Extremity fractures drove most of the increased risk, with the biggest differences in lower leg and ankle fractures. Differences widened for children aged 10?years or younger (HR [95% CI]: 0.47 [0.30-0.74]). In conclusion, compared to aripiprazole, risperidone was associated with 40% lower risk of fracture. Further analysis on the mechanism and long-term bone health of antipsychotic-treated children with ASD is warranted. LAY SUMMARY: We compared the risk of bone fractures among 6624 children with autism spectrum disorder (ASD), half of whom used risperidone and half of whom used aripiprazole. Taking other factors into account, risks were similar between the two groups throughout the first 180?days on treatment, but significantly higher in the aripiprazole group thereafter. The biggest differences were in lower leg and ankle fractures. Overall, compared with aripiprazole, risperidone was associated with 40% lower risk of fracture. En ligne : http://dx.doi.org/10.1002/aur.2541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449