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The genetic and environmental etiology of child maltreatment in a parent-based extended family design / Katharina PITTNER in Development and Psychopathology, 31-1 (February 2019)
[article]
Titre : The genetic and environmental etiology of child maltreatment in a parent-based extended family design Type de document : Texte imprimé et/ou numérique Auteurs : Katharina PITTNER, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Lenneke R. A. ALINK, Auteur ; Renate S. M. BUISMAN, Auteur ; Laura H. C. G. COMPIER-DE BLOCK, Auteur ; Lisa J. M. VAN DEN BERG, Auteur ; Bernet M. ELZINGA, Auteur ; Jolanda LINDENBERG, Auteur ; Marieke S. TOLLENAAR, Auteur ; Vincent P. DIEGO, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur Article en page(s) : p.157-172 Langues : Anglais (eng) Mots-clés : child maltreatment common environmental factors extended family design genetic factors passive gene–environment correlation Index. décimale : PER Périodiques Résumé : Child maltreatment has been associated with various cumulative risk factors. However, little is known about the extent to which genetic and environmental factors contribute to individual differences between parents in perpetrating child maltreatment. To estimate the relative contribution of genetic and environmental factors to perpetrating maltreatment we used a parent-based extended family design. Child-reported perpetrated maltreatment was available for 556 parents (283 women) from 63 families. To explore reporter effects (i.e., child perspective on maltreatment), child reports were compared to multi-informant reports. Based on polygenic model analyses, most of the variance related to the perpetration of physical abuse and emotional neglect was explained by common environmental factors (physical abuse: c2 = 59%, SE = 12%, p = .006; emotional neglect: c2 = 47%, SE = 8%, p < .001) whereas genetic factors did not significantly contribute to the model. For perpetrated emotional abuse, in contrast, genetic factors did significantly contribute to perpetrated emotional abuse (h2 = 33%, SE = 8%, p < .001), whereas common environment factors did not. Multi-informant reports led to similar estimates of genetic and common environmental effects on all measures except for emotional abuse, where a multi-informant approach yielded higher estimates of the common environmental effects. Overall, estimates of unique environment, including measurement error, were lower using multi-informant reports. In conclusion, our findings suggest that genetic pathways play a significant role in perpetrating emotional abuse, while physical abuse and emotional neglect are transmitted primarily through common environmental factors. These findings imply that interventions may need to target different mechanisms dependings on maltreatment type. En ligne : http://dx.doi.org/10.1017/S0954579418001608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383
in Development and Psychopathology > 31-1 (February 2019) . - p.157-172[article] The genetic and environmental etiology of child maltreatment in a parent-based extended family design [Texte imprimé et/ou numérique] / Katharina PITTNER, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Lenneke R. A. ALINK, Auteur ; Renate S. M. BUISMAN, Auteur ; Laura H. C. G. COMPIER-DE BLOCK, Auteur ; Lisa J. M. VAN DEN BERG, Auteur ; Bernet M. ELZINGA, Auteur ; Jolanda LINDENBERG, Auteur ; Marieke S. TOLLENAAR, Auteur ; Vincent P. DIEGO, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur . - p.157-172.
Langues : Anglais (eng)
in Development and Psychopathology > 31-1 (February 2019) . - p.157-172
Mots-clés : child maltreatment common environmental factors extended family design genetic factors passive gene–environment correlation Index. décimale : PER Périodiques Résumé : Child maltreatment has been associated with various cumulative risk factors. However, little is known about the extent to which genetic and environmental factors contribute to individual differences between parents in perpetrating child maltreatment. To estimate the relative contribution of genetic and environmental factors to perpetrating maltreatment we used a parent-based extended family design. Child-reported perpetrated maltreatment was available for 556 parents (283 women) from 63 families. To explore reporter effects (i.e., child perspective on maltreatment), child reports were compared to multi-informant reports. Based on polygenic model analyses, most of the variance related to the perpetration of physical abuse and emotional neglect was explained by common environmental factors (physical abuse: c2 = 59%, SE = 12%, p = .006; emotional neglect: c2 = 47%, SE = 8%, p < .001) whereas genetic factors did not significantly contribute to the model. For perpetrated emotional abuse, in contrast, genetic factors did significantly contribute to perpetrated emotional abuse (h2 = 33%, SE = 8%, p < .001), whereas common environment factors did not. Multi-informant reports led to similar estimates of genetic and common environmental effects on all measures except for emotional abuse, where a multi-informant approach yielded higher estimates of the common environmental effects. Overall, estimates of unique environment, including measurement error, were lower using multi-informant reports. In conclusion, our findings suggest that genetic pathways play a significant role in perpetrating emotional abuse, while physical abuse and emotional neglect are transmitted primarily through common environmental factors. These findings imply that interventions may need to target different mechanisms dependings on maltreatment type. En ligne : http://dx.doi.org/10.1017/S0954579418001608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study / Linyan FU in Autism Research, 15-4 (April 2022)
[article]
Titre : Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study Type de document : Texte imprimé et/ou numérique Auteurs : Linyan FU, Auteur ; Chunyan LI, Auteur ; Yun LI, Auteur ; Xin CHENG, Auteur ; Xiwen CUI, Auteur ; Jiying JIANG, Auteur ; Ning DING, Auteur ; Hui FANG, Auteur ; Tianyu TANG, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.628-640 Langues : Anglais (eng) Mots-clés : Anisotropy Autism Spectrum Disorder/diagnostic imaging/genetics Child Child, Preschool Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging/methods Humans White Matter autism spectrum disorder environmental effects genetic factors limbic tracts twins Index. décimale : PER Périodiques Résumé : Although the limbic system is closely related to emotion and social behaviors, little is known about the integrity of limbic pathways and how genetics influence the anatomical abnormalities of limbic networks in children with autism spectrum disorder (ASD). Therefore, we used an ASD twin study design to evaluate the microstructural integrity and autism-related differences in limbic pathways of young children with ASD and to estimate the heritability of limbic tracts microstructure variance. We obtained diffusion tensor imaging scans from 33 pairs of twins with ASD aged 2-9?years and 20 age-matched typically developing children. The ACE model was used to estimate the relative effects of additive genetic factors (A), shared environmental factors (C) and specific environmental factors (E) on the variability of diffusivity measurements. We found a significant decrease in fractional anisotropy (FA) in the bilateral fornix and uncinate fasciculus (UF), as well as increased mean diffusivity (MD) and radial diffusivity (RD) in the bilateral fornix and right UF of ASD children. Correlation analysis showed that FA, MD, and lateralization indices of UF were correlated with autism diagnostic observation schedule scores. The ACE model revealed that genetic effects may drive some of the variability of microstructure in the bilateral fornix, cingulum, and left UF. In conclusion, in children with ASD, there are abnormalities in the white matter microstructure of the limbic system, which is related to the core symptoms; these abnormalities may be related to the relative contribution of genetic and environmental effects on specific tracts. LAY SUMMARY: Autism spectrum disorder (ASD) children have abnormal white matter structure in limbic system related to ASD symptoms, and genetic factors play an important role in the development of limbic tracts. En ligne : https://dx.doi.org/10.1002/aur.2686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473
in Autism Research > 15-4 (April 2022) . - p.628-640[article] Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study [Texte imprimé et/ou numérique] / Linyan FU, Auteur ; Chunyan LI, Auteur ; Yun LI, Auteur ; Xin CHENG, Auteur ; Xiwen CUI, Auteur ; Jiying JIANG, Auteur ; Ning DING, Auteur ; Hui FANG, Auteur ; Tianyu TANG, Auteur ; Xiaoyan KE, Auteur . - p.628-640.
Langues : Anglais (eng)
in Autism Research > 15-4 (April 2022) . - p.628-640
Mots-clés : Anisotropy Autism Spectrum Disorder/diagnostic imaging/genetics Child Child, Preschool Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging/methods Humans White Matter autism spectrum disorder environmental effects genetic factors limbic tracts twins Index. décimale : PER Périodiques Résumé : Although the limbic system is closely related to emotion and social behaviors, little is known about the integrity of limbic pathways and how genetics influence the anatomical abnormalities of limbic networks in children with autism spectrum disorder (ASD). Therefore, we used an ASD twin study design to evaluate the microstructural integrity and autism-related differences in limbic pathways of young children with ASD and to estimate the heritability of limbic tracts microstructure variance. We obtained diffusion tensor imaging scans from 33 pairs of twins with ASD aged 2-9?years and 20 age-matched typically developing children. The ACE model was used to estimate the relative effects of additive genetic factors (A), shared environmental factors (C) and specific environmental factors (E) on the variability of diffusivity measurements. We found a significant decrease in fractional anisotropy (FA) in the bilateral fornix and uncinate fasciculus (UF), as well as increased mean diffusivity (MD) and radial diffusivity (RD) in the bilateral fornix and right UF of ASD children. Correlation analysis showed that FA, MD, and lateralization indices of UF were correlated with autism diagnostic observation schedule scores. The ACE model revealed that genetic effects may drive some of the variability of microstructure in the bilateral fornix, cingulum, and left UF. In conclusion, in children with ASD, there are abnormalities in the white matter microstructure of the limbic system, which is related to the core symptoms; these abnormalities may be related to the relative contribution of genetic and environmental effects on specific tracts. LAY SUMMARY: Autism spectrum disorder (ASD) children have abnormal white matter structure in limbic system related to ASD symptoms, and genetic factors play an important role in the development of limbic tracts. En ligne : https://dx.doi.org/10.1002/aur.2686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473