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The estimation of environmental and genetic parental influences / Jared V. BALBONA in Development and Psychopathology, 34-5 (December 2022)
[article]
Titre : The estimation of environmental and genetic parental influences Type de document : Texte imprimé et/ou numérique Auteurs : Jared V. BALBONA, Auteur ; Yongkang KIM, Auteur ; Matthew C. KELLER, Auteur Article en page(s) : p.1876-1886 Langues : Anglais (eng) Mots-clés : genetic nurture heritability nature and nurture parental effects vertical transmission Index. décimale : PER Périodiques Résumé : Parents share half of their genes with their children, but they also share background social factors and actively help shape their child’s environment “ making it difficult to disentangle genetic and environmental causes of parent “offspring similarity. While adoption and extended twin family designs have been extremely useful for distinguishing genetic and nongenetic parental influences, these designs entail stringent assumptions about phenotypic similarity between relatives and require samples that are difficult to collect and therefore are typically small and not publicly shared. Here, we describe these traditional designs, as well as modern approaches that use large, publicly available genome-wide data sets to estimate parental effects. We focus in particular on an approach we recently developed, structural equation modeling (SEM)-polygenic score (PGS), that instantiates the logic of modern PGS-based methods within the flexible SEM framework used in traditional designs. Genetically informative designs such as SEM-PGS rely on different and, in some cases, less rigid assumptions than traditional approaches; thus, they allow researchers to capitalize on new data sources and answer questions that could not previously be investigated. We believe that SEM-PGS and similar approaches can lead to improved insight into how nature and nurture combine to create the incredible diversity underlying human behavior. En ligne : http://dx.doi.org/10.1017/S0954579422000761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492
in Development and Psychopathology > 34-5 (December 2022) . - p.1876-1886[article] The estimation of environmental and genetic parental influences [Texte imprimé et/ou numérique] / Jared V. BALBONA, Auteur ; Yongkang KIM, Auteur ; Matthew C. KELLER, Auteur . - p.1876-1886.
Langues : Anglais (eng)
in Development and Psychopathology > 34-5 (December 2022) . - p.1876-1886
Mots-clés : genetic nurture heritability nature and nurture parental effects vertical transmission Index. décimale : PER Périodiques Résumé : Parents share half of their genes with their children, but they also share background social factors and actively help shape their child’s environment “ making it difficult to disentangle genetic and environmental causes of parent “offspring similarity. While adoption and extended twin family designs have been extremely useful for distinguishing genetic and nongenetic parental influences, these designs entail stringent assumptions about phenotypic similarity between relatives and require samples that are difficult to collect and therefore are typically small and not publicly shared. Here, we describe these traditional designs, as well as modern approaches that use large, publicly available genome-wide data sets to estimate parental effects. We focus in particular on an approach we recently developed, structural equation modeling (SEM)-polygenic score (PGS), that instantiates the logic of modern PGS-based methods within the flexible SEM framework used in traditional designs. Genetically informative designs such as SEM-PGS rely on different and, in some cases, less rigid assumptions than traditional approaches; thus, they allow researchers to capitalize on new data sources and answer questions that could not previously be investigated. We believe that SEM-PGS and similar approaches can lead to improved insight into how nature and nurture combine to create the incredible diversity underlying human behavior. En ligne : http://dx.doi.org/10.1017/S0954579422000761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance / Sally I. Chun KUO in Development and Psychopathology, 34-5 (December 2022)
[article]
Titre : The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance Type de document : Texte imprimé et/ou numérique Auteurs : Sally I. Chun KUO, Auteur ; Holly E. POORE, Auteur ; Peter B. BARR, Auteur ; Isabella S. CHIRICO, Auteur ; Fazil ALIEV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Chella KAMARAJAN, Auteur ; John R. KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Martin H. PLAWECKI, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1865-1875 Langues : Anglais (eng) Mots-clés : adolescent externalizing gene-environment correlation genetic nurture parenting polygenic score Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents’ own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children’s externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent “child communication, less parent “child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children’s environmental experiences, and the role of children’s genotypes in shaping parent “child relationships. En ligne : http://dx.doi.org/10.1017/S0954579422000700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492
in Development and Psychopathology > 34-5 (December 2022) . - p.1865-1875[article] The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance [Texte imprimé et/ou numérique] / Sally I. Chun KUO, Auteur ; Holly E. POORE, Auteur ; Peter B. BARR, Auteur ; Isabella S. CHIRICO, Auteur ; Fazil ALIEV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Chella KAMARAJAN, Auteur ; John R. KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Martin H. PLAWECKI, Auteur ; Danielle M. DICK, Auteur . - p.1865-1875.
Langues : Anglais (eng)
in Development and Psychopathology > 34-5 (December 2022) . - p.1865-1875
Mots-clés : adolescent externalizing gene-environment correlation genetic nurture parenting polygenic score Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents’ own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children’s externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent “child communication, less parent “child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children’s environmental experiences, and the role of children’s genotypes in shaping parent “child relationships. En ligne : http://dx.doi.org/10.1017/S0954579422000700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs / Cen CHEN in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
[article]
Titre : Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs Type de document : Texte imprimé et/ou numérique Auteurs : Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.1513-1522 Langues : Anglais (eng) Mots-clés : Adolescent Humans Twins, Dizygotic Longitudinal Studies Psychopathology Mental Disorders/epidemiology/genetics Risk Factors Attention Deficit Disorder with Hyperactivity/epidemiology General factor of psychopathology genetic nurture multi-polygenic score polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (Î2) and then within DZ twin pairs (Î2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (Î2=0.09, 95% CI: [0.06, 0.12]; Î2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (Î2=0.04 [0.00, 0.08]; Î2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (Î2=0.07 [0.04, 0.11]; Î2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (Î2=0.08 [0.03, 0.13]; Î2(w) =0.19 [0.08, 0.30]) and specific inattention problems (Î2=0.05 [0.01, 0.09]; Î2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (Î2=0.06 [0.02, 0.10]; Î2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522[article] Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs [Texte imprimé et/ou numérique] / Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur . - p.1513-1522.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522
Mots-clés : Adolescent Humans Twins, Dizygotic Longitudinal Studies Psychopathology Mental Disorders/epidemiology/genetics Risk Factors Attention Deficit Disorder with Hyperactivity/epidemiology General factor of psychopathology genetic nurture multi-polygenic score polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (Î2) and then within DZ twin pairs (Î2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (Î2=0.09, 95% CI: [0.06, 0.12]; Î2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (Î2=0.04 [0.00, 0.08]; Î2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (Î2=0.07 [0.04, 0.11]; Î2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (Î2=0.08 [0.03, 0.13]; Î2(w) =0.19 [0.08, 0.30]) and specific inattention problems (Î2=0.05 [0.01, 0.09]; Î2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (Î2=0.06 [0.02, 0.10]; Î2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490