4 recherche sur le mot-clé 'gut microbiome'

Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis / Xuejun KONG in Journal of Autism and Developmental Disorders, 51-1 (January 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.144-157 Titre : Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis Type de document : texte imprimé Auteurs : Xuejun KONG, Auteur ; Jun LIU, Auteur ; Kevin LIU, Auteur ; Madelyn KOH, Auteur ; Ruiyi TIAN, Auteur ; Clara HOBBIE, Auteur ; Michelle FONG, Auteur ; Qiuyi CHEN, Auteur ; Minxuan ZHAO, Auteur ; Christoph BUDJAN, Auteur ; Jian KONG, Auteur Article en page(s) : p.144-157 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASD)  Autonomic dysfunction  Biomarker  Gut microbiome  Gut-brain-axis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurological and developmental disorder, and a growing body of literature suggests the presence of autonomic nervous system (ANS) dysfunction in individuals with ASD. ANS is part of the "gut brain axis", which consists of an intricate interplay between the gut microbiome, mucosal immune system, enteric nervous system, ANS, and central processes receiving input from the vagus nerve. Measurements of the gut microbiome and the autonomic indices can serve as non-invasive markers of the status of the gut-brain axis in ASD. To our knowledge, no previous studies have explored the relationship between ANS and gut microbiome in individuals with ASD. Furthermore, while previous studies investigated the use of autonomic indices and gut microbiome independently as markers of ASD-related comorbidities, such as anxiety, cardiovascular issues, and gastrointestinal dysfunction, the use of combined autonomic indices and gut microbiome factors to classify ASD and control subjects has not been explored. In this study, we characterized autonomic function of a group of individuals with ASD in comparison to their paired, first-degree relative controls. Second, we explored the ASD gut-brain-axis through the relationship between gut microbiome markers and autonomic indices, as well as the correlation between the gut-brain-axis and clinical presentation of ASD. Lastly, this study explores the predictive capability of gut-brain-axis biomarkers (including autonomic and microbiome indices) in subtyping ASD cases, serving as a starting point to investigate the possibility of assisting in ASD screening and diagnosis that still heavily relies on psychological testing, which may be based on highly subjective standards. En ligne : http://dx.doi.org/10.1007/s10803-020-04524-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis [texte imprimé] / Xuejun KONG, Auteur ; Jun LIU, Auteur ; Kevin LIU, Auteur ; Madelyn KOH, Auteur ; Ruiyi TIAN, Auteur ; Clara HOBBIE, Auteur ; Michelle FONG, Auteur ; Qiuyi CHEN, Auteur ; Minxuan ZHAO, Auteur ; Christoph BUDJAN, Auteur ; Jian KONG, Auteur . - p.144-157. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.144-157 Mots-clés : Autism spectrum disorders (ASD)  Autonomic dysfunction  Biomarker  Gut microbiome  Gut-brain-axis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurological and developmental disorder, and a growing body of literature suggests the presence of autonomic nervous system (ANS) dysfunction in individuals with ASD. ANS is part of the "gut brain axis", which consists of an intricate interplay between the gut microbiome, mucosal immune system, enteric nervous system, ANS, and central processes receiving input from the vagus nerve. Measurements of the gut microbiome and the autonomic indices can serve as non-invasive markers of the status of the gut-brain axis in ASD. To our knowledge, no previous studies have explored the relationship between ANS and gut microbiome in individuals with ASD. Furthermore, while previous studies investigated the use of autonomic indices and gut microbiome independently as markers of ASD-related comorbidities, such as anxiety, cardiovascular issues, and gastrointestinal dysfunction, the use of combined autonomic indices and gut microbiome factors to classify ASD and control subjects has not been explored. In this study, we characterized autonomic function of a group of individuals with ASD in comparison to their paired, first-degree relative controls. Second, we explored the ASD gut-brain-axis through the relationship between gut microbiome markers and autonomic indices, as well as the correlation between the gut-brain-axis and clinical presentation of ASD. Lastly, this study explores the predictive capability of gut-brain-axis biomarkers (including autonomic and microbiome indices) in subtyping ASD cases, serving as a starting point to investigate the possibility of assisting in ASD screening and diagnosis that still heavily relies on psychological testing, which may be based on highly subjective standards. En ligne : http://dx.doi.org/10.1007/s10803-020-04524-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder / Christopher NEWELL in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 37p. Titre : Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder Type de document : texte imprimé Auteurs : Christopher NEWELL, Auteur ; Marc R. BOMHOF, Auteur ; Raylene A. REIMER, Auteur ; Dustin S. HITTEL, Auteur ; Jong M. RHO, Auteur ; Jane SHEARER, Auteur Article en page(s) : 37p. Langues : Anglais (eng) Mots-clés : Animals  Autism Spectrum Disorder/microbiology  Bacteria/isolation & purification  Behavior, Animal  Cecum/microbiology  Diet, Ketogenic  Disease Models, Animal  Feces/microbiology  Gastrointestinal Microbiome  Male  Mice  Mice, Inbred C57BL  Social Behavior  Autism spectrum disorder  BTBR mouse  Gut microbiome  Ketogenic diet Index. décimale : PER Périodiques Résumé : BACKGROUND: Gastrointestinal dysfunction and gut microbial composition disturbances have been widely reported in autism spectrum disorder (ASD). This study examines whether gut microbiome disturbances are present in the BTBR(T + tf/j) (BTBR) mouse model of ASD and if the ketogenic diet, a diet previously shown to elicit therapeutic benefit in this mouse model, is capable of altering the profile. FINDINGS: Juvenile male C57BL/6 (B6) and BTBR mice were fed a standard chow (CH, 13 % kcal fat) or ketogenic diet (KD, 75 % kcal fat) for 10-14 days. Following diets, fecal and cecal samples were collected for analysis. Main findings are as follows: (1) gut microbiota compositions of cecal and fecal samples were altered in BTBR compared to control mice, indicating that this model may be of utility in understanding gut-brain interactions in ASD; (2) KD consumption caused an anti-microbial-like effect by significantly decreasing total host bacterial abundance in cecal and fecal matter; (3) specific to BTBR animals, the KD counteracted the common ASD phenotype of a low Firmicutes to Bacteroidetes ratio in both sample types; and (4) the KD reversed elevated Akkermansia muciniphila content in the cecal and fecal matter of BTBR animals. CONCLUSIONS: Results indicate that consumption of a KD likely triggers reductions in total gut microbial counts and compositional remodeling in the BTBR mouse. These findings may explain, in part, the ability of a KD to mitigate some of the neurological symptoms associated with ASD in an animal model. En ligne : http://dx.doi.org/10.1186/s13229-016-0099-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder [texte imprimé] / Christopher NEWELL, Auteur ; Marc R. BOMHOF, Auteur ; Raylene A. REIMER, Auteur ; Dustin S. HITTEL, Auteur ; Jong M. RHO, Auteur ; Jane SHEARER, Auteur . - 37p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 37p. Mots-clés : Animals  Autism Spectrum Disorder/microbiology  Bacteria/isolation & purification  Behavior, Animal  Cecum/microbiology  Diet, Ketogenic  Disease Models, Animal  Feces/microbiology  Gastrointestinal Microbiome  Male  Mice  Mice, Inbred C57BL  Social Behavior  Autism spectrum disorder  BTBR mouse  Gut microbiome  Ketogenic diet Index. décimale : PER Périodiques Résumé : BACKGROUND: Gastrointestinal dysfunction and gut microbial composition disturbances have been widely reported in autism spectrum disorder (ASD). This study examines whether gut microbiome disturbances are present in the BTBR(T + tf/j) (BTBR) mouse model of ASD and if the ketogenic diet, a diet previously shown to elicit therapeutic benefit in this mouse model, is capable of altering the profile. FINDINGS: Juvenile male C57BL/6 (B6) and BTBR mice were fed a standard chow (CH, 13 % kcal fat) or ketogenic diet (KD, 75 % kcal fat) for 10-14 days. Following diets, fecal and cecal samples were collected for analysis. Main findings are as follows: (1) gut microbiota compositions of cecal and fecal samples were altered in BTBR compared to control mice, indicating that this model may be of utility in understanding gut-brain interactions in ASD; (2) KD consumption caused an anti-microbial-like effect by significantly decreasing total host bacterial abundance in cecal and fecal matter; (3) specific to BTBR animals, the KD counteracted the common ASD phenotype of a low Firmicutes to Bacteroidetes ratio in both sample types; and (4) the KD reversed elevated Akkermansia muciniphila content in the cecal and fecal matter of BTBR animals. CONCLUSIONS: Results indicate that consumption of a KD likely triggers reductions in total gut microbial counts and compositional remodeling in the BTBR mouse. These findings may explain, in part, the ability of a KD to mitigate some of the neurological symptoms associated with ASD in an animal model. En ligne : http://dx.doi.org/10.1186/s13229-016-0099-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study / Daniel FATORI in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2457-2467 Titre : Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study Type de document : texte imprimé Auteurs : Daniel FATORI, Auteur ; Elizabeth SHEPHARD, Auteur ; Danilo BENETTE, Auteur ; Nathalia Ferrazzo NASPOLINI, Auteur ; Grover Castro GUZMAN, Auteur ; Jaqueline Yu Ting WANG, Auteur ; Pedro TÓTOLO, Auteur ; Anthonieta Looman MAFRA, Auteur ; Caio ISAIAS, Auteur ; Davi Pereira DOS SANTOS, Auteur ; Fabiele Baldino RUSSO, Auteur ; Gerson KOBAYASHI, Auteur ; Adriana ARGEU, Auteur ; Monike TEIXEIRA, Auteur ; Ana Claudia MATTIELLO-SVERZUT, Auteur ; Maria Teresa Bechere FERNANDES, Auteur ; Danila Cristina PETIAN-ALONSO, Auteur ; Helena BRENTANI, Auteur ; Marilia SCLIAR, Auteur ; Paulo Alfonso SCHÃœROFF, Auteur ; Pedro ZUCCOLO, Auteur ; Rogério LERNER, Auteur ; Stephania GERALDINI, Auteur ; Veronica Luiza Vale EUCLYDES, Auteur ; Alicia MATIJASEVICH, Auteur ; Alline Cristina DE CAMPOS, Auteur ; André Carlos Ponce DE CARVALHO, Auteur ; André FUJITA, Auteur ; Carla R. TADDEI, Auteur ; Maria Rita PASSOS-BUENO, Auteur ; Patricia BELTRÃO-BRAGA, Auteur ; Guilherme Vanoni POLANCZYK, Auteur Article en page(s) : p.2457-2467 Langues : Anglais (eng) Mots-clés : child development  cohort study  electroencephalography  genetics  gut microbiome Index. décimale : PER Périodiques Résumé : This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments. En ligne : https://dx.doi.org/10.1017/S0954579425000069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study [texte imprimé] / Daniel FATORI, Auteur ; Elizabeth SHEPHARD, Auteur ; Danilo BENETTE, Auteur ; Nathalia Ferrazzo NASPOLINI, Auteur ; Grover Castro GUZMAN, Auteur ; Jaqueline Yu Ting WANG, Auteur ; Pedro TÓTOLO, Auteur ; Anthonieta Looman MAFRA, Auteur ; Caio ISAIAS, Auteur ; Davi Pereira DOS SANTOS, Auteur ; Fabiele Baldino RUSSO, Auteur ; Gerson KOBAYASHI, Auteur ; Adriana ARGEU, Auteur ; Monike TEIXEIRA, Auteur ; Ana Claudia MATTIELLO-SVERZUT, Auteur ; Maria Teresa Bechere FERNANDES, Auteur ; Danila Cristina PETIAN-ALONSO, Auteur ; Helena BRENTANI, Auteur ; Marilia SCLIAR, Auteur ; Paulo Alfonso SCHÃœROFF, Auteur ; Pedro ZUCCOLO, Auteur ; Rogério LERNER, Auteur ; Stephania GERALDINI, Auteur ; Veronica Luiza Vale EUCLYDES, Auteur ; Alicia MATIJASEVICH, Auteur ; Alline Cristina DE CAMPOS, Auteur ; André Carlos Ponce DE CARVALHO, Auteur ; André FUJITA, Auteur ; Carla R. TADDEI, Auteur ; Maria Rita PASSOS-BUENO, Auteur ; Patricia BELTRÃO-BRAGA, Auteur ; Guilherme Vanoni POLANCZYK, Auteur . - p.2457-2467. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2457-2467 Mots-clés : child development  cohort study  electroencephalography  genetics  gut microbiome Index. décimale : PER Périodiques Résumé : This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments. En ligne : https://dx.doi.org/10.1017/S0954579425000069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Gastrointestinal Symptoms and Oral Antibiotic Use in Children with Autism Spectrum Disorder: Retrospective Analysis of a Privately Insured U.S. Population / Troy VARGASON in Journal of Autism and Developmental Disorders, 49-2 (February 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.647-659 Titre : Gastrointestinal Symptoms and Oral Antibiotic Use in Children with Autism Spectrum Disorder: Retrospective Analysis of a Privately Insured U.S. Population Type de document : texte imprimé Auteurs : Troy VARGASON, Auteur ; Deborah L. MCGUINNESS, Auteur ; Juergen HAHN, Auteur Article en page(s) : p.647-659 Langues : Anglais (eng) Mots-clés : Administrative claims  Autism spectrum disorder  Gastrointestinal symptoms  Gut microbiome  Oral antibiotics  Retrospective analysis Index. décimale : PER Périodiques Résumé : A retrospective analysis of administrative claims data from a large U.S. health insurer was performed to study a potential association between oral antibiotic use during early childhood and occurrence of later gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Among 3253 children with ASD, 37.0% had a GI-related diagnosis during the last 2 years of their 5-year health coverage enrollment period, compared to 20.0% of 278,370 children from the general population without an ASD diagnosis. Greater numbers of oral antibiotic fills during the first 3 years of enrollment were found to significantly increase the hazard rate of having a later GI-related diagnosis (adjusted hazard ratio 1.48; 95% confidence interval 1.34, 1.63) in children both with and without ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3743-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 [article] Gastrointestinal Symptoms and Oral Antibiotic Use in Children with Autism Spectrum Disorder: Retrospective Analysis of a Privately Insured U.S. Population [texte imprimé] / Troy VARGASON, Auteur ; Deborah L. MCGUINNESS, Auteur ; Juergen HAHN, Auteur . - p.647-659. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.647-659 Mots-clés : Administrative claims  Autism spectrum disorder  Gastrointestinal symptoms  Gut microbiome  Oral antibiotics  Retrospective analysis Index. décimale : PER Périodiques Résumé : A retrospective analysis of administrative claims data from a large U.S. health insurer was performed to study a potential association between oral antibiotic use during early childhood and occurrence of later gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Among 3253 children with ASD, 37.0% had a GI-related diagnosis during the last 2 years of their 5-year health coverage enrollment period, compared to 20.0% of 278,370 children from the general population without an ASD diagnosis. Greater numbers of oral antibiotic fills during the first 3 years of enrollment were found to significantly increase the hazard rate of having a later GI-related diagnosis (adjusted hazard ratio 1.48; 95% confidence interval 1.34, 1.63) in children both with and without ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3743-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382