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Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits / M. ARENELLA in Autism, 26-2 (February 2022)
[article]
Titre : Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : M. ARENELLA, Auteur ; G. CADBY, Auteur ; W. DE WITTE, Auteur ; R. M. JONES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; E. K. MOSES, Auteur ; A. FORNITO, Auteur ; Mark A. BELLGROVE, Auteur ; Z. HAWI, Auteur ; B. JOHNSON, Auteur ; J. TIEGO, Auteur ; Jan K. BUITELAAR, Auteur ; L. A. KIEMENEY, Auteur ; G. POELMANS, Auteur ; Janita B. BRALTEN, Auteur Article en page(s) : p.361-372 Langues : Anglais (eng) Mots-clés : autism spectrum disorders genetics immune system molecular and cellular biology conflicts of interest with respect to the research, authorship and/or publication of this article: In the past 3?years, J.K.B. has been a consultant to, member of advisory board of and speaker for Takeda/Shire, Roche, Medice, Novartis, Angelini and Servier. He is not an employee of any of these companies, and a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patients and royalties. G.P. is the director of Drug Target ID, Ltd. The other authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are complex, with a strong genetic basis. Genetic research in autism spectrum disorders is limited by the fact that these disorders are largely heterogeneous so that patients are variable in their clinical presentations. To address this limitation, we investigated the genetics of individual dimensions of the autism spectrum disorder phenotypes, or autistic-like traits. These autistic-like traits are continuous variations in autistic behaviours that occur in the general population. Therefore, we meta-analysed data from four different population cohorts in which autistic-like traits were measured. We performed a set of genetic analyses to identify common variants for autistic-like traits, understand how these variants related to autism spectrum disorders, and how they contribute to neurobiological processes. Our results showed genetic associations with specific autistic-like traits and a link to the immune system. We offer an example of the potential to use a dimensional approach when dealing with heterogeneous, complex disorder like autism spectrum disorder. Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. En ligne : http://dx.doi.org/10.1177/13623613211019547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Autism > 26-2 (February 2022) . - p.361-372[article] Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits [Texte imprimé et/ou numérique] / M. ARENELLA, Auteur ; G. CADBY, Auteur ; W. DE WITTE, Auteur ; R. M. JONES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; E. K. MOSES, Auteur ; A. FORNITO, Auteur ; Mark A. BELLGROVE, Auteur ; Z. HAWI, Auteur ; B. JOHNSON, Auteur ; J. TIEGO, Auteur ; Jan K. BUITELAAR, Auteur ; L. A. KIEMENEY, Auteur ; G. POELMANS, Auteur ; Janita B. BRALTEN, Auteur . - p.361-372.
Langues : Anglais (eng)
in Autism > 26-2 (February 2022) . - p.361-372
Mots-clés : autism spectrum disorders genetics immune system molecular and cellular biology conflicts of interest with respect to the research, authorship and/or publication of this article: In the past 3?years, J.K.B. has been a consultant to, member of advisory board of and speaker for Takeda/Shire, Roche, Medice, Novartis, Angelini and Servier. He is not an employee of any of these companies, and a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patients and royalties. G.P. is the director of Drug Target ID, Ltd. The other authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are complex, with a strong genetic basis. Genetic research in autism spectrum disorders is limited by the fact that these disorders are largely heterogeneous so that patients are variable in their clinical presentations. To address this limitation, we investigated the genetics of individual dimensions of the autism spectrum disorder phenotypes, or autistic-like traits. These autistic-like traits are continuous variations in autistic behaviours that occur in the general population. Therefore, we meta-analysed data from four different population cohorts in which autistic-like traits were measured. We performed a set of genetic analyses to identify common variants for autistic-like traits, understand how these variants related to autism spectrum disorders, and how they contribute to neurobiological processes. Our results showed genetic associations with specific autistic-like traits and a link to the immune system. We offer an example of the potential to use a dimensional approach when dealing with heterogeneous, complex disorder like autism spectrum disorder. Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. En ligne : http://dx.doi.org/10.1177/13623613211019547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 Bidirectional relationship between eating disorders and autoimmune diseases / A. HEDMAN in Journal of Child Psychology and Psychiatry, 60-7 (July 2019)
[article]
Titre : Bidirectional relationship between eating disorders and autoimmune diseases Type de document : Texte imprimé et/ou numérique Auteurs : A. HEDMAN, Auteur ; L. BREITHAUPT, Auteur ; C. HUBEL, Auteur ; L. M. THORNTON, Auteur ; A. TILLANDER, Auteur ; C. NORRING, Auteur ; A. BIRGEGARD, Auteur ; H. LARSSON, Auteur ; J. F. LUDVIGSSON, Auteur ; L. SAVENDAHL, Auteur ; Catarina ALMQVIST, Auteur ; Cynthia M. BULIK, Auteur Article en page(s) : p.803-812 Langues : Anglais (eng) Mots-clés : anorexia nervosa autoimmunity bulimia nervosa cox regression hazard immune system risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases. METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs. RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED. CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.12958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.803-812[article] Bidirectional relationship between eating disorders and autoimmune diseases [Texte imprimé et/ou numérique] / A. HEDMAN, Auteur ; L. BREITHAUPT, Auteur ; C. HUBEL, Auteur ; L. M. THORNTON, Auteur ; A. TILLANDER, Auteur ; C. NORRING, Auteur ; A. BIRGEGARD, Auteur ; H. LARSSON, Auteur ; J. F. LUDVIGSSON, Auteur ; L. SAVENDAHL, Auteur ; Catarina ALMQVIST, Auteur ; Cynthia M. BULIK, Auteur . - p.803-812.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.803-812
Mots-clés : anorexia nervosa autoimmunity bulimia nervosa cox regression hazard immune system risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases. METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs. RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED. CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.12958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 Research Review: The role of cytokines in depression in adolescents: a systematic review / Natalie T. MILLS in Journal of Child Psychology and Psychiatry, 54-8 (August 2013)
[article]
Titre : Research Review: The role of cytokines in depression in adolescents: a systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Natalie T. MILLS, Auteur ; James G. SCOTT, Auteur ; Naomi R. WRAY, Auteur ; Sarah COHEN-WOODS, Auteur ; BERNHARD T. BAUNE, Auteur Article en page(s) : p.816-835 Langues : Anglais (eng) Mots-clés : Cytokines inflammation immune system MDD cognition stress Index. décimale : PER Périodiques Résumé : Background While cytokines have been implicated in the pathophysiology of depression in adults, the potential role in younger age groups such as adolescents is less clear. This article therefore reviews the literature (a) to explore the relationship between cytokines and depression in adolescents, and (b) to examine how cytokines may be related to adolescent depression in the context of other neurobiological theories of depression. Method A systematic review of the scientific literature on the subject was conducted in February 2013, searching the Web of Knowledge, PubMed (Medline), PsycInfo and Cochrane electronic databases. Results Eighteen studies were identified measuring both depression or depressive symptoms and cytokines or immune markers in adolescents. Adolescents with depression show age-specific characteristics of the immune and inflammatory system, specifically in NK cell activity and in pro-inflammatory cytokines (such as IL-1? and TNF-?). In addition, the role of cytokines in adolescent depression is influenced by neurodevelopment, hormonal changes, stress and trauma. Conclusions There may be differences in the neurobiology of adolescent major depressive disorder (MDD) compared with adult MDD. Increased understanding of the role of cytokines in adolescent MDD may lead to improved outcomes in the treatment of adolescent depression. En ligne : http://dx.doi.org/10.1111/jcpp.12080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210
in Journal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.816-835[article] Research Review: The role of cytokines in depression in adolescents: a systematic review [Texte imprimé et/ou numérique] / Natalie T. MILLS, Auteur ; James G. SCOTT, Auteur ; Naomi R. WRAY, Auteur ; Sarah COHEN-WOODS, Auteur ; BERNHARD T. BAUNE, Auteur . - p.816-835.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.816-835
Mots-clés : Cytokines inflammation immune system MDD cognition stress Index. décimale : PER Périodiques Résumé : Background While cytokines have been implicated in the pathophysiology of depression in adults, the potential role in younger age groups such as adolescents is less clear. This article therefore reviews the literature (a) to explore the relationship between cytokines and depression in adolescents, and (b) to examine how cytokines may be related to adolescent depression in the context of other neurobiological theories of depression. Method A systematic review of the scientific literature on the subject was conducted in February 2013, searching the Web of Knowledge, PubMed (Medline), PsycInfo and Cochrane electronic databases. Results Eighteen studies were identified measuring both depression or depressive symptoms and cytokines or immune markers in adolescents. Adolescents with depression show age-specific characteristics of the immune and inflammatory system, specifically in NK cell activity and in pro-inflammatory cytokines (such as IL-1? and TNF-?). In addition, the role of cytokines in adolescent depression is influenced by neurodevelopment, hormonal changes, stress and trauma. Conclusions There may be differences in the neurobiology of adolescent major depressive disorder (MDD) compared with adult MDD. Increased understanding of the role of cytokines in adolescent MDD may lead to improved outcomes in the treatment of adolescent depression. En ligne : http://dx.doi.org/10.1111/jcpp.12080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 Cluster Analysis of Autistic Patients Based on Principal Pathogenetic Components / Roberto SACCO in Autism Research, 5-2 (April 2012)
[article]
Titre : Cluster Analysis of Autistic Patients Based on Principal Pathogenetic Components Type de document : Texte imprimé et/ou numérique Auteurs : Roberto SACCO, Auteur ; Carlo LENTI, Auteur ; Monica SACCANI, Auteur ; Paolo CURATOLO, Auteur ; Barbara MANZI, Auteur ; Carmela BRAVACCIO, Auteur ; Antonio M. PERSICO, Auteur Année de publication : 2012 Article en page(s) : p.137-147 Langues : Anglais (eng) Mots-clés : pervasive developmental disorders cluster analysis immune system neurodevelopment principal component analysis Index. décimale : PER Périodiques Résumé : We have recently described four principal pathogenetic components in autism: (I) circadian and sensory dysfunction, (II) immune abnormalities, (III) neurodevelopmental delay, and (IV) stereotypic behaviors. Using hierarchical and k-means clustering, the same 245 patients assessed in our principal component analysis can be partitioned into four clusters: (a) 43 (17.6%) have prominent immune abnormalities accompanied by some circadian and sensory issues; (b) 44 (18.0%) display major circadian and sensory dysfunction, with little or no immune symptoms; (c) stereotypies predominate in 75 (31.0%); and (d) 83 (33.9%) show a mixture of all four components, with greater disruptive behaviors and mental retardation. The “immune” component provides the largest contributions to phenotypic variance (P = 2.7 x 10–45), followed by “stereotypic behaviors.” These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment. En ligne : http://dx.doi.org/10.1002/aur.1226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155
in Autism Research > 5-2 (April 2012) . - p.137-147[article] Cluster Analysis of Autistic Patients Based on Principal Pathogenetic Components [Texte imprimé et/ou numérique] / Roberto SACCO, Auteur ; Carlo LENTI, Auteur ; Monica SACCANI, Auteur ; Paolo CURATOLO, Auteur ; Barbara MANZI, Auteur ; Carmela BRAVACCIO, Auteur ; Antonio M. PERSICO, Auteur . - 2012 . - p.137-147.
Langues : Anglais (eng)
in Autism Research > 5-2 (April 2012) . - p.137-147
Mots-clés : pervasive developmental disorders cluster analysis immune system neurodevelopment principal component analysis Index. décimale : PER Périodiques Résumé : We have recently described four principal pathogenetic components in autism: (I) circadian and sensory dysfunction, (II) immune abnormalities, (III) neurodevelopmental delay, and (IV) stereotypic behaviors. Using hierarchical and k-means clustering, the same 245 patients assessed in our principal component analysis can be partitioned into four clusters: (a) 43 (17.6%) have prominent immune abnormalities accompanied by some circadian and sensory issues; (b) 44 (18.0%) display major circadian and sensory dysfunction, with little or no immune symptoms; (c) stereotypies predominate in 75 (31.0%); and (d) 83 (33.9%) show a mixture of all four components, with greater disruptive behaviors and mental retardation. The “immune” component provides the largest contributions to phenotypic variance (P = 2.7 x 10–45), followed by “stereotypic behaviors.” These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment. En ligne : http://dx.doi.org/10.1002/aur.1226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155