15 recherche sur le mot-clé 'major depressive disorder'

Association between adolescent oral contraceptive use and future major depressive disorder: a prospective cohort study / Christine ANDERL in Journal of Child Psychology and Psychiatry, 63-3 (March 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.333-341 Titre : Association between adolescent oral contraceptive use and future major depressive disorder: a prospective cohort study Type de document : texte imprimé Auteurs : Christine ANDERL, Auteur ; Anouk E. DE WIT, Auteur ; Erik J. GILTAY, Auteur ; Albertine J. OLDEHINKEL, Auteur ; Frances S. CHEN, Auteur Article en page(s) : p.333-341 Langues : Anglais (eng) Mots-clés : Oral contraceptive use  adolescence  major depressive disorder  risk factors Index. décimale : PER Périodiques Résumé : BACKGROUND: Because of the widespread use of oral contraceptives (OCs) and the devastating effects of depression both on an individual and a societal level, it is crucial to understand the nature of the previously reported relationship between OC use and depression risk. Insight into the impact of analytical choices on the association is important when interpreting available evidence. Hence, we examined the association between adolescent OC use and subsequent depression risk in early adulthood analyzing all theoretically justifiable models. METHODS: Data from the prospective cohort study TRacking Adolescents' Individual Lives Survey, among women aged 13-25 years were used. Adolescent OC use (ages 16-19 years) was used as a predictor and major depressive disorder (MDD) in early adulthood (ages 20-25 years), as assessed by the Diagnostic and Statistical Manual of Mental Disorders-IV oriented Lifetime Depression Assessment Self-Report and the Composite International Diagnostic Interview, was used as an outcome. A total of 818 analytical models were analyzed using Specification Curve Analysis in 534 adolescent OC users and 191 nonusers. RESULTS: Overall, there was an association of adolescent OC use and an episode of MDD in early adulthood [median odds ratio (OR)(median)  = 1.41; OR(min)  = 1.08; OR(max)  = 2.18, p < .001], which was driven by the group of young women with no history of MDD (OR(median)  = 1.72; OR(min)  = 1.21; OR(max)  = 2.18, p < .001). CONCLUSIONS: In summary, adolescent OC use was associated with a small but robust increased risk for experiencing an episode of MDD, especially among women with no history of MDD in adolescence. Understanding the potential side effects of OCs will help women and their doctors to make informed choices when deciding among possible methods of birth control. En ligne : http://dx.doi.org/10.1111/jcpp.13476 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Association between adolescent oral contraceptive use and future major depressive disorder: a prospective cohort study [texte imprimé] / Christine ANDERL, Auteur ; Anouk E. DE WIT, Auteur ; Erik J. GILTAY, Auteur ; Albertine J. OLDEHINKEL, Auteur ; Frances S. CHEN, Auteur . - p.333-341. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.333-341 Mots-clés : Oral contraceptive use  adolescence  major depressive disorder  risk factors Index. décimale : PER Périodiques Résumé : BACKGROUND: Because of the widespread use of oral contraceptives (OCs) and the devastating effects of depression both on an individual and a societal level, it is crucial to understand the nature of the previously reported relationship between OC use and depression risk. Insight into the impact of analytical choices on the association is important when interpreting available evidence. Hence, we examined the association between adolescent OC use and subsequent depression risk in early adulthood analyzing all theoretically justifiable models. METHODS: Data from the prospective cohort study TRacking Adolescents' Individual Lives Survey, among women aged 13-25 years were used. Adolescent OC use (ages 16-19 years) was used as a predictor and major depressive disorder (MDD) in early adulthood (ages 20-25 years), as assessed by the Diagnostic and Statistical Manual of Mental Disorders-IV oriented Lifetime Depression Assessment Self-Report and the Composite International Diagnostic Interview, was used as an outcome. A total of 818 analytical models were analyzed using Specification Curve Analysis in 534 adolescent OC users and 191 nonusers. RESULTS: Overall, there was an association of adolescent OC use and an episode of MDD in early adulthood [median odds ratio (OR)(median)  = 1.41; OR(min)  = 1.08; OR(max)  = 2.18, p < .001], which was driven by the group of young women with no history of MDD (OR(median)  = 1.72; OR(min)  = 1.21; OR(max)  = 2.18, p < .001). CONCLUSIONS: In summary, adolescent OC use was associated with a small but robust increased risk for experiencing an episode of MDD, especially among women with no history of MDD in adolescence. Understanding the potential side effects of OCs will help women and their doctors to make informed choices when deciding among possible methods of birth control. En ligne : http://dx.doi.org/10.1111/jcpp.13476 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Brief Report: Major Depressive Disorder with Psychotic Features in Williams Syndrome: A Case Series / Francisca VALDES in Journal of Autism and Developmental Disorders, 48-3 (March 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.947-952 Titre : Brief Report: Major Depressive Disorder with Psychotic Features in Williams Syndrome: A Case Series Type de document : texte imprimé Auteurs : Francisca VALDES, Auteur ; Christopher J. KEARY, Auteur ; Jennifer E. MULLETT, Auteur ; Michelle L. PALUMBO, Auteur ; Jessica L. WAXLER, Auteur ; Barbara R. POBER, Auteur ; Christopher J. MCDOUGLE, Auteur Année de publication : 2018 Article en page(s) : p.947-952 Langues : Anglais (eng) Mots-clés : Co-morbidity  Major depressive disorder  Psychopharmacology  Psychosis  Williams syndrome Index. décimale : PER Périodiques Résumé : Descriptions of individuals with Williams syndrome (WS) and co-morbid major depressive disorder (MDD) with psychotic features have not appeared in the literature. In addition to reviewing previous reports of psychotic symptoms in persons with WS, this paper introduces clinical histories and therapeutic management strategies for three previously unreported adults with WS diagnosed with co-morbid MDD with psychotic features. Co-morbid medical disorders common in WS are highlighted with regard to safe and appropriate pharmacological treatment. The importance of assessment for co-morbid MDD with psychotic features in individuals with WS is emphasized. En ligne : https://doi.org/10.1007/s10803-017-3384-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Brief Report: Major Depressive Disorder with Psychotic Features in Williams Syndrome: A Case Series [texte imprimé] / Francisca VALDES, Auteur ; Christopher J. KEARY, Auteur ; Jennifer E. MULLETT, Auteur ; Michelle L. PALUMBO, Auteur ; Jessica L. WAXLER, Auteur ; Barbara R. POBER, Auteur ; Christopher J. MCDOUGLE, Auteur . - 2018 . - p.947-952. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.947-952 Mots-clés : Co-morbidity  Major depressive disorder  Psychopharmacology  Psychosis  Williams syndrome Index. décimale : PER Périodiques Résumé : Descriptions of individuals with Williams syndrome (WS) and co-morbid major depressive disorder (MDD) with psychotic features have not appeared in the literature. In addition to reviewing previous reports of psychotic symptoms in persons with WS, this paper introduces clinical histories and therapeutic management strategies for three previously unreported adults with WS diagnosed with co-morbid MDD with psychotic features. Co-morbid medical disorders common in WS are highlighted with regard to safe and appropriate pharmacological treatment. The importance of assessment for co-morbid MDD with psychotic features in individuals with WS is emphasized. En ligne : https://doi.org/10.1007/s10803-017-3384-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

Psychoneuroendocrine stress response in female and male youth with major depressive disorder / Anka BERNHARD in Journal of Child Psychology and Psychiatry, 66-10 (October 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1563-1576 Titre : Psychoneuroendocrine stress response in female and male youth with major depressive disorder Type de document : texte imprimé Auteurs : Anka BERNHARD, Auteur ; Nikola FANN, Auteur ; Andreas G. CHIOCCHETTI, Auteur ; Katharina ACKERMANN, Auteur ; Anne MARTINELLI, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.1563-1576 Langues : Anglais (eng) Mots-clés : Major depressive disorder  adolescence  stress response  cortisol  testosterone  oxytocin Index. décimale : PER Périodiques Résumé : Background Exposure to psychosocial stress is one of the strongest risk factors for major depressive disorder (MDD) in youth, but underlying neurobiological mechanisms are poorly understood. Previous studies on the neuroendocrine stress response in youth with MDD are scarce, limited to cortisol, and rarely considered sex differences. Due to puberty-associated neuroendocrine transitions increasing the risk for MDD onset in adolescence, this study aimed to investigate sex-specific stress responses of stress and sex hormones as well as of neuropeptides. Methods In 103 pubertal youths with MDD and 72 healthy controls (HCs; 62% females, 12 18 years), psychological stress as well as salivary cortisol, testosterone, and oxytocin reactivity to a standardized psychosocial stress test (Trier Social Stress Test, TSST) were assessed. Effects of group and sex, and their interactions were analyzed using hierarchical linear models, while controlling for potentially confounding factors (such as age and pubertal status). Results Females and males with MDD showed a stronger psychological stress response than HCs. In contrast, both female and male youth with MDD showed blunted cortisol, testosterone, and oxytocin stress responses compared to HCs. In addition, baseline testosterone was elevated in MDD compared to HCs. Conclusions Results indicate a discrepant stress reactivity in youth with MDD, with increased psychological, but decreased neuroendocrine responses to psychosocial stress. Blunted neuroendocrine stress responses in youth with MDD were found across different neuroendocrine systems and in both females and males with MDD. These novel findings point to a fundamentally changed stress response in youth with MDD irrespective of sex, which may influence successful stress regulation in the affected adolescents. En ligne : https://doi.org/10.1111/jcpp.14168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Psychoneuroendocrine stress response in female and male youth with major depressive disorder [texte imprimé] / Anka BERNHARD, Auteur ; Nikola FANN, Auteur ; Andreas G. CHIOCCHETTI, Auteur ; Katharina ACKERMANN, Auteur ; Anne MARTINELLI, Auteur ; Christine M. FREITAG, Auteur . - p.1563-1576. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1563-1576 Mots-clés : Major depressive disorder  adolescence  stress response  cortisol  testosterone  oxytocin Index. décimale : PER Périodiques Résumé : Background Exposure to psychosocial stress is one of the strongest risk factors for major depressive disorder (MDD) in youth, but underlying neurobiological mechanisms are poorly understood. Previous studies on the neuroendocrine stress response in youth with MDD are scarce, limited to cortisol, and rarely considered sex differences. Due to puberty-associated neuroendocrine transitions increasing the risk for MDD onset in adolescence, this study aimed to investigate sex-specific stress responses of stress and sex hormones as well as of neuropeptides. Methods In 103 pubertal youths with MDD and 72 healthy controls (HCs; 62% females, 12 18 years), psychological stress as well as salivary cortisol, testosterone, and oxytocin reactivity to a standardized psychosocial stress test (Trier Social Stress Test, TSST) were assessed. Effects of group and sex, and their interactions were analyzed using hierarchical linear models, while controlling for potentially confounding factors (such as age and pubertal status). Results Females and males with MDD showed a stronger psychological stress response than HCs. In contrast, both female and male youth with MDD showed blunted cortisol, testosterone, and oxytocin stress responses compared to HCs. In addition, baseline testosterone was elevated in MDD compared to HCs. Conclusions Results indicate a discrepant stress reactivity in youth with MDD, with increased psychological, but decreased neuroendocrine responses to psychosocial stress. Blunted neuroendocrine stress responses in youth with MDD were found across different neuroendocrine systems and in both females and males with MDD. These novel findings point to a fundamentally changed stress response in youth with MDD irrespective of sex, which may influence successful stress regulation in the affected adolescents. En ligne : https://doi.org/10.1111/jcpp.14168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

Research Review: Shared and distinct structural and functional brain alterations in adolescents with major depressive disorder ? a multimodal meta-analysis / Baolin WU in Journal of Child Psychology and Psychiatry, 66-7 (July 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.1084-1097 Titre : Research Review: Shared and distinct structural and functional brain alterations in adolescents with major depressive disorder ? a multimodal meta-analysis Type de document : texte imprimé Auteurs : Baolin WU, Auteur ; Xun ZHANG, Auteur ; Hongsheng XIE, Auteur ; Baoshuai ZHANG, Auteur ; Yanxin LING, Auteur ; Ruoqiu GAN, Auteur ; Lihua QIU, Auteur ; Neil ROBERTS, Auteur ; Zhiyun JIA, Auteur ; Qiyong GONG, Auteur Article en page(s) : p.1084-1097 Langues : Anglais (eng) Mots-clés : Major depressive disorder  adolescents  gray matter volume  resting state  brain activity  meta-analysis Index. décimale : PER Périodiques Résumé : Background Neuroimaging studies have identified brain structural and functional alterations in adolescents with major depressive disorder (MDD); however, the results are inconsistent, and whether patients exhibit spatially convergent structural and functional brain abnormalities remains unclear. Methods We conducted voxel-wise meta-analysis of voxel-based morphometry (VBM) and resting-state functional studies, respectively, to identify regional gray matter volume (GMV) and brain activity alterations in adolescent MDD patients. Multimodal analysis was performed to examine the overlap of regional GMV and brain activity alterations. Meta-regression analysis was conducted to evaluate the potential effects of clinical variables. Results Ten whole-brain VBM studies (403 patients and 319 controls) and 14 resting-state functional studies (510 patients and 474 controls) were included. Adolescent MDD patients showed conjoint structural and functional alterations in the left medial/dorsolateral prefrontal cortex, lateral temporal cortex and sensorimotor regions, and left insula. Adolescent MDD patients showed structural-specific abnormalities in the subcortical and prefrontal-limbic regions and functional-specific abnormalities in the right insula, right superior occipital gyrus, left inferior frontal gyrus and left precuneus. Meta-regression analyses revealed that the mean age of adolescents with MDD was positively associated with GMV in the right superior temporal gyrus and negatively associated with brain activity in the right insula, and the symptom severity of adolescents with MDD was positively associated with brain activity in the right superior occipital gyrus. Conclusions This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in adolescent MDD patients, which may advance our understanding of the neurobiology of adolescent MDD. En ligne : https://doi.org/10.1111/jcpp.14104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562 [article] Research Review: Shared and distinct structural and functional brain alterations in adolescents with major depressive disorder ? a multimodal meta-analysis [texte imprimé] / Baolin WU, Auteur ; Xun ZHANG, Auteur ; Hongsheng XIE, Auteur ; Baoshuai ZHANG, Auteur ; Yanxin LING, Auteur ; Ruoqiu GAN, Auteur ; Lihua QIU, Auteur ; Neil ROBERTS, Auteur ; Zhiyun JIA, Auteur ; Qiyong GONG, Auteur . - p.1084-1097. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.1084-1097 Mots-clés : Major depressive disorder  adolescents  gray matter volume  resting state  brain activity  meta-analysis Index. décimale : PER Périodiques Résumé : Background Neuroimaging studies have identified brain structural and functional alterations in adolescents with major depressive disorder (MDD); however, the results are inconsistent, and whether patients exhibit spatially convergent structural and functional brain abnormalities remains unclear. Methods We conducted voxel-wise meta-analysis of voxel-based morphometry (VBM) and resting-state functional studies, respectively, to identify regional gray matter volume (GMV) and brain activity alterations in adolescent MDD patients. Multimodal analysis was performed to examine the overlap of regional GMV and brain activity alterations. Meta-regression analysis was conducted to evaluate the potential effects of clinical variables. Results Ten whole-brain VBM studies (403 patients and 319 controls) and 14 resting-state functional studies (510 patients and 474 controls) were included. Adolescent MDD patients showed conjoint structural and functional alterations in the left medial/dorsolateral prefrontal cortex, lateral temporal cortex and sensorimotor regions, and left insula. Adolescent MDD patients showed structural-specific abnormalities in the subcortical and prefrontal-limbic regions and functional-specific abnormalities in the right insula, right superior occipital gyrus, left inferior frontal gyrus and left precuneus. Meta-regression analyses revealed that the mean age of adolescents with MDD was positively associated with GMV in the right superior temporal gyrus and negatively associated with brain activity in the right insula, and the symptom severity of adolescents with MDD was positively associated with brain activity in the right superior occipital gyrus. Conclusions This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in adolescent MDD patients, which may advance our understanding of the neurobiology of adolescent MDD. En ligne : https://doi.org/10.1111/jcpp.14104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562

Stress effects on cognitive function in patients with major depressive disorder: Does childhood trauma play a role? / Linn K. KUEHL in Development and Psychopathology, 32-3 (August 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-3 (August 2020) . - p.1007-1016 Titre : Stress effects on cognitive function in patients with major depressive disorder: Does childhood trauma play a role? Type de document : texte imprimé Auteurs : Linn K. KUEHL, Auteur ; Katharina SCHULTEBRAUCKS, Auteur ; Christian E. DEUTER, Auteur ; Anita MAY, Auteur ; Carsten SPITZER, Auteur ; Christian OTTE, Auteur ; Katja WINGENFELD, Auteur Article en page(s) : p.1007-1016 Langues : Anglais (eng) Mots-clés : adverse childhood experiences  attention  major depressive disorder  memory  trier social stress test Index. décimale : PER Périodiques Résumé : Impaired cognitive functioning constitutes an important symptom of major depressive disorder (MDD), potentially associated with elevated cortisol levels. Adverse childhood experiences (ACE) enhance the risk for MDD and can contribute to disturbances in the stress systems, including cortisol and cognitive functions. In healthy participants, cortisol administration as well as acute stress can affect cognitive performance. In the current study, we tested cognitive performance in MDD patients with (N = 32) and without (N = 52) ACE and healthy participants with (N = 22) and without (N = 37) ACE after psychosocial stress induction (Trier Social Stress Test, TSST) and a control condition (Placebo-TSST). MDD predicted lower performance in verbal learning and both selective and sustained attention, while ACE predicted lower performance in psychomotoric speed and working memory. There were no interaction effects of MDD and ACE. After stress, MDD patients were more likely to show lower performance in working memory as well as in selective and sustained attention compared with participants without MDD. Individuals with ACE were more likely to show lower performance in verbal memory after stress compared with individuals without ACE. Our results indicate negative effects of MDD and ACE on distinct cognitive domains. Furthermore, MDD and/or ACE seem to enhance susceptibility for stress-related cognitive impairments. En ligne : http://dx.doi.org/10.1017/s0954579419000932 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Stress effects on cognitive function in patients with major depressive disorder: Does childhood trauma play a role? [texte imprimé] / Linn K. KUEHL, Auteur ; Katharina SCHULTEBRAUCKS, Auteur ; Christian E. DEUTER, Auteur ; Anita MAY, Auteur ; Carsten SPITZER, Auteur ; Christian OTTE, Auteur ; Katja WINGENFELD, Auteur . - p.1007-1016. Langues : Anglais (eng) in Development and Psychopathology > 32-3 (August 2020) . - p.1007-1016 Mots-clés : adverse childhood experiences  attention  major depressive disorder  memory  trier social stress test Index. décimale : PER Périodiques Résumé : Impaired cognitive functioning constitutes an important symptom of major depressive disorder (MDD), potentially associated with elevated cortisol levels. Adverse childhood experiences (ACE) enhance the risk for MDD and can contribute to disturbances in the stress systems, including cortisol and cognitive functions. In healthy participants, cortisol administration as well as acute stress can affect cognitive performance. In the current study, we tested cognitive performance in MDD patients with (N = 32) and without (N = 52) ACE and healthy participants with (N = 22) and without (N = 37) ACE after psychosocial stress induction (Trier Social Stress Test, TSST) and a control condition (Placebo-TSST). MDD predicted lower performance in verbal learning and both selective and sustained attention, while ACE predicted lower performance in psychomotoric speed and working memory. There were no interaction effects of MDD and ACE. After stress, MDD patients were more likely to show lower performance in working memory as well as in selective and sustained attention compared with participants without MDD. Individuals with ACE were more likely to show lower performance in verbal memory after stress compared with individuals without ACE. Our results indicate negative effects of MDD and ACE on distinct cognitive domains. Furthermore, MDD and/or ACE seem to enhance susceptibility for stress-related cognitive impairments. En ligne : http://dx.doi.org/10.1017/s0954579419000932 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Treatment of Adults with Autism and Major Depressive Disorder Using Transcranial Magnetic Stimulation: An Open Label Pilot Study / McLeod Frampton GWYNETTE in Autism Research, 13-3 (March 2020)  

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Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder / Rossana GANZOLA in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

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EHMT1 mosaicism in apparently unaffected parents is associated with autism spectrum disorder and neurocognitive dysfunction / Anneke DE BOER in Molecular Autism, 9 (2018)  

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Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation / Sandra MACHLITT-NORTHEN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

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Annual Research Review: Defining and treating pediatric treatment-resistant depression / Jennifer B. DWYER in Journal of Child Psychology and Psychiatry, 61-3 (March 2020)  

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