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Mood Disorders in High-Functioning Autism: The Importance of Alexithymia and Emotional Regulation / K. P. MORIE in Journal of Autism and Developmental Disorders, 49-7 (July 2019)
[article]
Titre : Mood Disorders in High-Functioning Autism: The Importance of Alexithymia and Emotional Regulation Type de document : Texte imprimé et/ou numérique Auteurs : K. P. MORIE, Auteur ; S. JACKSON, Auteur ; Z. W. ZHAI, Auteur ; M. N. POTENZA, Auteur ; B. DRITSCHEL, Auteur Article en page(s) : p.2935-2945 Langues : Anglais (eng) Mots-clés : Asd Alexithymia Autism Emotional regulation Mood disorders Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) often have co-morbid anxiety and depression. Alexithymia and emotion regulation difficulties are commonly seen in individuals with ASD and in mood disorders. We hypothesized that alexithymia and emotional regulation would mediate the relationship between autistic features and anxiety/depression symptom severity. We collected data about emotional regulation, alexithymia, autistic symptoms and depression/anxiety in a sample of 64 young adults with ASD. We constructed two serial multiple mediator models, using autistic features as the independent variable and anxiety/depression symptoms as outcome variables. The serial relationship between alexithymia and emotional regulation mediated associations between autistic features and depression and anxiety, separately. The findings suggest that targeting alexithymia may benefit therapies designed to alleviate mood disorders in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04020-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2935-2945[article] Mood Disorders in High-Functioning Autism: The Importance of Alexithymia and Emotional Regulation [Texte imprimé et/ou numérique] / K. P. MORIE, Auteur ; S. JACKSON, Auteur ; Z. W. ZHAI, Auteur ; M. N. POTENZA, Auteur ; B. DRITSCHEL, Auteur . - p.2935-2945.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2935-2945
Mots-clés : Asd Alexithymia Autism Emotional regulation Mood disorders Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) often have co-morbid anxiety and depression. Alexithymia and emotion regulation difficulties are commonly seen in individuals with ASD and in mood disorders. We hypothesized that alexithymia and emotional regulation would mediate the relationship between autistic features and anxiety/depression symptom severity. We collected data about emotional regulation, alexithymia, autistic symptoms and depression/anxiety in a sample of 64 young adults with ASD. We constructed two serial multiple mediator models, using autistic features as the independent variable and anxiety/depression symptoms as outcome variables. The serial relationship between alexithymia and emotional regulation mediated associations between autistic features and depression and anxiety, separately. The findings suggest that targeting alexithymia may benefit therapies designed to alleviate mood disorders in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04020-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study / Dominique RUDAZ in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)
[article]
Titre : Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study Type de document : Texte imprimé et/ou numérique Auteurs : Dominique RUDAZ, Auteur ; Caroline L. VANDELEUR, Auteur ; Mehdi GHOLAM, Auteur ; Enrique CASTELAO, Auteur ; Marie-Pierre F. STRIPPOLI, Auteur ; Pierre MARQUET, Auteur ; Jean-Michel AUBRY, Auteur ; Kathleen R. MERIKANGAS, Auteur ; Martin PREISIG, Auteur Article en page(s) : p.404-413 Langues : Anglais (eng) Mots-clés : Mood disorders anxiety disorders drug misuse offspring of bipolar parents offspring of depressed parents precursors Index. décimale : PER Périodiques Résumé : BACKGROUND: There is still limited evidence from prospective high-risk research on the evolution of specific disorders that may emerge early in the development of mood disorders. Moreover, few studies have examined the specificity of mood disorder subtypes among offspring of parents with both major subtypes of mood disorders and controls based on prospective tracking across the transition from childhood to adulthood. Our specific objectives were to (a) identify differences in patterns of psychopathological precursors among youth with (hypo)mania compared to MDD and (b) examine whether these patterns differ by subtypes of parental mood disorders. METHODS: Our data stem from a prospective cohort study of 449 directly interviewed offspring (51% female, mean age 10.1 years at study intake) of 88 patients with BPD, 71 with MDD, 30 with substance use disorders and 60 medical controls. The mean duration of follow-up was 13.2 years with evaluations conducted every three years. RESULTS: Within the whole cohort of offspring, MDE (Hazard Ratio = 4.44; 95%CI: 2.19-9.02), CD (HR = 3.31;1.55-7.07) and DUD (HR = 2.54; 1.15-5.59) predicted the onset of (hypo)manic episodes, whereas MDD in offspring was predicted by SAD (HR = 1.53; 1.09-2.15), generalized anxiety (HR = 2.56; 1.05-6.24), and panic disorder (HR = 3.13; 1.06-9.23). The early predictors of (hypo)mania in the whole cohort were also significantly associated with the onset of (hypo)mania among the offspring of parents with BPD. CONCLUSIONS: The onset of mood disorders is frequently preceded by identifiable depressive episodes and nonmood disorders. These precursors differed by mood subtype in offspring. High-risk offspring with these precursors should be closely monitored to prevent the further development of MDD or conversion to BPD. En ligne : http://dx.doi.org/10.1111/jcpp.13307 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.404-413[article] Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13-year prospective cohort high-risk study [Texte imprimé et/ou numérique] / Dominique RUDAZ, Auteur ; Caroline L. VANDELEUR, Auteur ; Mehdi GHOLAM, Auteur ; Enrique CASTELAO, Auteur ; Marie-Pierre F. STRIPPOLI, Auteur ; Pierre MARQUET, Auteur ; Jean-Michel AUBRY, Auteur ; Kathleen R. MERIKANGAS, Auteur ; Martin PREISIG, Auteur . - p.404-413.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.404-413
Mots-clés : Mood disorders anxiety disorders drug misuse offspring of bipolar parents offspring of depressed parents precursors Index. décimale : PER Périodiques Résumé : BACKGROUND: There is still limited evidence from prospective high-risk research on the evolution of specific disorders that may emerge early in the development of mood disorders. Moreover, few studies have examined the specificity of mood disorder subtypes among offspring of parents with both major subtypes of mood disorders and controls based on prospective tracking across the transition from childhood to adulthood. Our specific objectives were to (a) identify differences in patterns of psychopathological precursors among youth with (hypo)mania compared to MDD and (b) examine whether these patterns differ by subtypes of parental mood disorders. METHODS: Our data stem from a prospective cohort study of 449 directly interviewed offspring (51% female, mean age 10.1 years at study intake) of 88 patients with BPD, 71 with MDD, 30 with substance use disorders and 60 medical controls. The mean duration of follow-up was 13.2 years with evaluations conducted every three years. RESULTS: Within the whole cohort of offspring, MDE (Hazard Ratio = 4.44; 95%CI: 2.19-9.02), CD (HR = 3.31;1.55-7.07) and DUD (HR = 2.54; 1.15-5.59) predicted the onset of (hypo)manic episodes, whereas MDD in offspring was predicted by SAD (HR = 1.53; 1.09-2.15), generalized anxiety (HR = 2.56; 1.05-6.24), and panic disorder (HR = 3.13; 1.06-9.23). The early predictors of (hypo)mania in the whole cohort were also significantly associated with the onset of (hypo)mania among the offspring of parents with BPD. CONCLUSIONS: The onset of mood disorders is frequently preceded by identifiable depressive episodes and nonmood disorders. These precursors differed by mood subtype in offspring. High-risk offspring with these precursors should be closely monitored to prevent the further development of MDD or conversion to BPD. En ligne : http://dx.doi.org/10.1111/jcpp.13307 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders / Holly R. ROBERTSON in Journal of Child Psychology and Psychiatry, 52-4 (April 2011)
[article]
Titre : Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders Type de document : Texte imprimé et/ou numérique Auteurs : Holly R. ROBERTSON, Auteur ; Guoping FENG, Auteur Année de publication : 2011 Article en page(s) : p.442-475 Langues : Anglais (eng) Mots-clés : Animal disorders Attention Deficit Hyperactivity Disorder autism Obsessive Compulsive Disorder mood disorders Index. décimale : PER Périodiques Résumé : Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect many school-age children, leading to a lower quality of life, including difficulties in school and personal relationships that persist into adulthood. Currently, the causes of these psychiatric disorders are poorly understood, resulting in difficulty diagnosing affected children, and insufficient treatment options. Family and twin studies implicate a genetic contribution for ADHD, ASD, mood disorders, OCSD, and SZ. Identification of candidate genes and chromosomal regions associated with a particular disorder provide targets for directed research, and understanding how these genes influence the disease state will provide valuable insights for improving the diagnosis and treatment of children with psychiatric disorders. Transgenic mouse models are one important approach in the study of human diseases, allowing for the use of a variety of experimental approaches to dissect the contribution of a specific chromosomal or genetic abnormality in human disorders. While it is impossible to model an entire psychiatric disorder in a single mouse model, these models can be extremely valuable in dissecting out the specific role of a gene, pathway, neuron subtype, or brain region in a particular abnormal behavior. In this review we discuss existing transgenic mouse models for childhood-onset psychiatric disorders. We compare the strength and weakness of various transgenic mouse models proposed for each of the common childhood-onset psychiatric disorders, and discuss future directions for the study of these disorders using cutting-edge genetic tools. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02380.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119
in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.442-475[article] Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders [Texte imprimé et/ou numérique] / Holly R. ROBERTSON, Auteur ; Guoping FENG, Auteur . - 2011 . - p.442-475.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.442-475
Mots-clés : Animal disorders Attention Deficit Hyperactivity Disorder autism Obsessive Compulsive Disorder mood disorders Index. décimale : PER Périodiques Résumé : Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect many school-age children, leading to a lower quality of life, including difficulties in school and personal relationships that persist into adulthood. Currently, the causes of these psychiatric disorders are poorly understood, resulting in difficulty diagnosing affected children, and insufficient treatment options. Family and twin studies implicate a genetic contribution for ADHD, ASD, mood disorders, OCSD, and SZ. Identification of candidate genes and chromosomal regions associated with a particular disorder provide targets for directed research, and understanding how these genes influence the disease state will provide valuable insights for improving the diagnosis and treatment of children with psychiatric disorders. Transgenic mouse models are one important approach in the study of human diseases, allowing for the use of a variety of experimental approaches to dissect the contribution of a specific chromosomal or genetic abnormality in human disorders. While it is impossible to model an entire psychiatric disorder in a single mouse model, these models can be extremely valuable in dissecting out the specific role of a gene, pathway, neuron subtype, or brain region in a particular abnormal behavior. In this review we discuss existing transgenic mouse models for childhood-onset psychiatric disorders. We compare the strength and weakness of various transgenic mouse models proposed for each of the common childhood-onset psychiatric disorders, and discuss future directions for the study of these disorders using cutting-edge genetic tools. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02380.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 Severe mood problems in adolescents with autism spectrum disorder / Emily SIMONOFF in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)
[article]
Titre : Severe mood problems in adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Emily SIMONOFF, Auteur ; Catherine R. G. JONES, Auteur ; Andrew PICKLES, Auteur ; Francesca HAPPE, Auteur ; Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur Année de publication : 2012 Article en page(s) : p.1157-1166 Langues : Anglais (eng) Mots-clés : Severe mood dysregulation mood disorders childhood autism autism spectrum disorder SNAP Trouble de l'humeur Index. décimale : PER Périodiques Résumé : Introduction: Severe mood dysregulation and problems (SMP) in otherwise typically developing youth are recognized as an important mental health problem with a distinct set of clinical features, family history and neurocognitive characteristics. SMP in people with autism spectrum disorders (ASDs) have not previously been explored. Method: We studied a longitudinal, population-based cohort of adolescents with ASD in which we collected parent-reported symptoms of SMP that included rage, low and labile mood and depressive thoughts. Ninety-one adolescents with ASD provided data at age 16 years, of whom 79 had additional data from age 12. We studied whether SMP have similar correlates to those seen in typically developing youth. Results: Severe mood problems were associated with current (parent-rated) and earlier (parent- and teacher-rated) emotional problems. The number of prior psychiatric diagnoses increased the risk of subsequent SMP. Intellectual ability and adaptive functioning did not predict to SMP. Maternal mental health problems rated at 12 and 16 years were associated with SMP. Autism severity as rated by parents was associated with SMP, but the relationship did not hold for clinician ratings of autistic symptoms or diagnosis. SMP were associated with difficulty in identifying the facial expression of surprise, but not with performance recognizing other emotions. Relationships between SMP and tests of executive function (card sort and trail making) were not significant after controlling for IQ. Conclusions: This is the first study of the behavioural and cognitive correlates of severe mood problems in ASD. As in typically developing youth, SMP in adolescents with ASD are related to other affective symptoms and maternal mental health problems. Previously reported links to deficits in emotion recognition and cognitive flexibility were not found in the current sample. Further research is warranted using categorical and validated measures of SMP. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02600.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1157-1166[article] Severe mood problems in adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Emily SIMONOFF, Auteur ; Catherine R. G. JONES, Auteur ; Andrew PICKLES, Auteur ; Francesca HAPPE, Auteur ; Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur . - 2012 . - p.1157-1166.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1157-1166
Mots-clés : Severe mood dysregulation mood disorders childhood autism autism spectrum disorder SNAP Trouble de l'humeur Index. décimale : PER Périodiques Résumé : Introduction: Severe mood dysregulation and problems (SMP) in otherwise typically developing youth are recognized as an important mental health problem with a distinct set of clinical features, family history and neurocognitive characteristics. SMP in people with autism spectrum disorders (ASDs) have not previously been explored. Method: We studied a longitudinal, population-based cohort of adolescents with ASD in which we collected parent-reported symptoms of SMP that included rage, low and labile mood and depressive thoughts. Ninety-one adolescents with ASD provided data at age 16 years, of whom 79 had additional data from age 12. We studied whether SMP have similar correlates to those seen in typically developing youth. Results: Severe mood problems were associated with current (parent-rated) and earlier (parent- and teacher-rated) emotional problems. The number of prior psychiatric diagnoses increased the risk of subsequent SMP. Intellectual ability and adaptive functioning did not predict to SMP. Maternal mental health problems rated at 12 and 16 years were associated with SMP. Autism severity as rated by parents was associated with SMP, but the relationship did not hold for clinician ratings of autistic symptoms or diagnosis. SMP were associated with difficulty in identifying the facial expression of surprise, but not with performance recognizing other emotions. Relationships between SMP and tests of executive function (card sort and trail making) were not significant after controlling for IQ. Conclusions: This is the first study of the behavioural and cognitive correlates of severe mood problems in ASD. As in typically developing youth, SMP in adolescents with ASD are related to other affective symptoms and maternal mental health problems. Previously reported links to deficits in emotion recognition and cognitive flexibility were not found in the current sample. Further research is warranted using categorical and validated measures of SMP. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02600.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 Observational measures of early irritability predict children's psychopathology risk / Ola MOHAMED ALI in Development and Psychopathology, 34-4 (October 2022)
[article]
Titre : Observational measures of early irritability predict children's psychopathology risk Type de document : Texte imprimé et/ou numérique Auteurs : Ola MOHAMED ALI, Auteur ; Lindsay N. GABEL, Auteur ; Kasey STANTON, Auteur ; Erin A. KAUFMAN, Auteur ; Daniel N. KLEIN, Auteur ; Elizabeth P. HAYDEN, Auteur Article en page(s) : p.1531-1543 Langues : Anglais (eng) Mots-clés : Affective Symptoms Anger Child Child, Preschool Female Humans Irritable Mood Mood Disorders Psychopathology children development irritability measurement observational parent report Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic feature of diverse forms of psychopathology and a rapidly growing literature implicates the construct in child maladaptation. However, most irritability measures currently used are drawn from parent-report questionnaires not designed to measure irritability per se; furthermore, parent report methods have several important limitations. We therefore examined the utility of observational ratings of children's irritability in predicting later psychopathology symptoms. Four-hundred and nine 3-year-old children (208 girls) completed observational tasks tapping temperamental emotionality and parents completed questionnaires assessing child irritability and anger. Parent-reported child psychopathology symptoms were assessed concurrently to the irritability assessment and when children were 5 and 8 years old. Children's irritability observed during tasks that did not typically elicit anger predicted their later depressive and hyperactivity symptoms, above and beyond parent-reported irritability and context-appropriate observed anger. Our findings support the use of observational indices of irritability and have implications for the development of observational paradigms designed to assess this construct in childhood. En ligne : http://dx.doi.org/10.1017/s0954579421000183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Development and Psychopathology > 34-4 (October 2022) . - p.1531-1543[article] Observational measures of early irritability predict children's psychopathology risk [Texte imprimé et/ou numérique] / Ola MOHAMED ALI, Auteur ; Lindsay N. GABEL, Auteur ; Kasey STANTON, Auteur ; Erin A. KAUFMAN, Auteur ; Daniel N. KLEIN, Auteur ; Elizabeth P. HAYDEN, Auteur . - p.1531-1543.
Langues : Anglais (eng)
in Development and Psychopathology > 34-4 (October 2022) . - p.1531-1543
Mots-clés : Affective Symptoms Anger Child Child, Preschool Female Humans Irritable Mood Mood Disorders Psychopathology children development irritability measurement observational parent report Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic feature of diverse forms of psychopathology and a rapidly growing literature implicates the construct in child maladaptation. However, most irritability measures currently used are drawn from parent-report questionnaires not designed to measure irritability per se; furthermore, parent report methods have several important limitations. We therefore examined the utility of observational ratings of children's irritability in predicting later psychopathology symptoms. Four-hundred and nine 3-year-old children (208 girls) completed observational tasks tapping temperamental emotionality and parents completed questionnaires assessing child irritability and anger. Parent-reported child psychopathology symptoms were assessed concurrently to the irritability assessment and when children were 5 and 8 years old. Children's irritability observed during tasks that did not typically elicit anger predicted their later depressive and hyperactivity symptoms, above and beyond parent-reported irritability and context-appropriate observed anger. Our findings support the use of observational indices of irritability and have implications for the development of observational paradigms designed to assess this construct in childhood. En ligne : http://dx.doi.org/10.1017/s0954579421000183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489