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Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms / Meghan MILLER in Autism Research, 6-2 (April 2013)
[article]
Titre : Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Meghan MILLER, Auteur ; Karen L. BALES, Auteur ; Sandra L. TAYLOR, Auteur ; Jong YOON, Auteur ; Caroline M. HOSTETLER, Auteur ; Cameron S. CARTER, Auteur ; Marjorie SOLOMON, Auteur Année de publication : 2013 Article en page(s) : p.91-102 Langues : Anglais (eng) Mots-clés : neuropeptides oxytocin vasopressin autism sex differences repetitive behaviors anxiety Index. décimale : PER Périodiques Résumé : There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVP–OT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 8–18: 40 with high-functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. En ligne : http://dx.doi.org/10.1002/aur.1270 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199
in Autism Research > 6-2 (April 2013) . - p.91-102[article] Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms [Texte imprimé et/ou numérique] / Meghan MILLER, Auteur ; Karen L. BALES, Auteur ; Sandra L. TAYLOR, Auteur ; Jong YOON, Auteur ; Caroline M. HOSTETLER, Auteur ; Cameron S. CARTER, Auteur ; Marjorie SOLOMON, Auteur . - 2013 . - p.91-102.
Langues : Anglais (eng)
in Autism Research > 6-2 (April 2013) . - p.91-102
Mots-clés : neuropeptides oxytocin vasopressin autism sex differences repetitive behaviors anxiety Index. décimale : PER Périodiques Résumé : There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVP–OT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 8–18: 40 with high-functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. En ligne : http://dx.doi.org/10.1002/aur.1270 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199 Biologie des émotions / Catherine BELZUNG
Titre : Biologie des émotions Type de document : Texte imprimé et/ou numérique Auteurs : Catherine BELZUNG, Auteur Editeur : Louvain [Belgique] : De Boeck Université Année de publication : 2007 Collection : Neurosciences & cognition, ISSN 1374-0903 Importance : 470 p. Présentation : ill. Format : 17,5 cm × 24,0 cm × 2,5 cm ISBN/ISSN/EAN : 978-2-8041-5375-5 Note générale : Glossaire, Webogr., index auteurs, index notions Langues : Français (fre) Mots-clés : Biologie système neuromodulateur monoaminergique acide animé neuropeptides agression dépendance abstinence dégoût rire humour Index. décimale : PAR-D PAR-D - Emotions Résumé : Que se passe-t-il dans notre cerveau quand nous avons peur ou que nous sommes en colère ? Pourquoi ressentons-nous des modifications corporelles (accélération du rythme cardiaque, sudation, etc.) lorsque nous sommes émus ? Pourquoi certains sont-ils plus émotifs que d'autres ? Seul manuel de ce type aujourd'hui disponible en langue française, cet ouvrage très didactique nous fait découvrir les travaux les plus récents dans ce domaine de recherche en plein essor qu'est la psychobiologie. On y trouve une description générale des corrélats biologiques (cérébraux, génétiques, endocriniens) des émotions telles que la peur, la colère ou encore le rire. Conçu dans une perspective résolument intégrative et non réductionniste, il s'ouvre sur une partie plus générale dans laquelle l'auteur pose les bases de cette discipline (définition des émotions, différentes théories psychologiques, variations culturelles dans l'expression des émotions, grands débats) et passe en revue les différents systèmes biologiques impliqués. On trouvera ensuite exposé le substrat biologique de chaque émotion abordée (peur, dégoût, agression, douleur, plaisir, rire, émotion esthétique). Destiné aux étudiants en psychologie et biologie (fin de ter cycle et master), cet ouvrage est doté d'un appareil pédagogique spécialement conçu pour l'apprentissage. [Résumé d'Auteur/Editeur] Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231 Biologie des émotions [Texte imprimé et/ou numérique] / Catherine BELZUNG, Auteur . - Louvain [Belgique] : De Boeck Université, 2007 . - 470 p. : ill. ; 17,5 cm × 24,0 cm × 2,5 cm. - (Neurosciences & cognition, ISSN 1374-0903) .
ISBN : 978-2-8041-5375-5
Glossaire, Webogr., index auteurs, index notions
Langues : Français (fre)
Mots-clés : Biologie système neuromodulateur monoaminergique acide animé neuropeptides agression dépendance abstinence dégoût rire humour Index. décimale : PAR-D PAR-D - Emotions Résumé : Que se passe-t-il dans notre cerveau quand nous avons peur ou que nous sommes en colère ? Pourquoi ressentons-nous des modifications corporelles (accélération du rythme cardiaque, sudation, etc.) lorsque nous sommes émus ? Pourquoi certains sont-ils plus émotifs que d'autres ? Seul manuel de ce type aujourd'hui disponible en langue française, cet ouvrage très didactique nous fait découvrir les travaux les plus récents dans ce domaine de recherche en plein essor qu'est la psychobiologie. On y trouve une description générale des corrélats biologiques (cérébraux, génétiques, endocriniens) des émotions telles que la peur, la colère ou encore le rire. Conçu dans une perspective résolument intégrative et non réductionniste, il s'ouvre sur une partie plus générale dans laquelle l'auteur pose les bases de cette discipline (définition des émotions, différentes théories psychologiques, variations culturelles dans l'expression des émotions, grands débats) et passe en revue les différents systèmes biologiques impliqués. On trouvera ensuite exposé le substrat biologique de chaque émotion abordée (peur, dégoût, agression, douleur, plaisir, rire, émotion esthétique). Destiné aux étudiants en psychologie et biologie (fin de ter cycle et master), cet ouvrage est doté d'un appareil pédagogique spécialement conçu pour l'apprentissage. [Résumé d'Auteur/Editeur] Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DOC0002752 PAR-D BEL Livre Centre d'Information et de Documentation du CRA Rhône-Alpes PAR - Particularités et Fonctionnement Disponible Les abonnés qui ont emprunté ce document ont également emprunté :
Guider les enfants autistes dans les habiletés sociales RICHOZ, Mélanie Apprendre les habiletés sociales CASSE, Agnès High-Functioning Individuals with Autism SCHOPLER, Eric Troubles des apprentissages JUMEL, Bernard Au fil des émotions NÙÑEZ PEREIRA, Cristina Apprendre aux enfants autistes à comprendre la pensée des autres HOWLIN, Patricia The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial / Adam J. GUASTELLA in Journal of Child Psychology and Psychiatry, 56-4 (April 2015)
[article]
Titre : The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Adam J. GUASTELLA, Auteur ; Kylie M. GRAY, Auteur ; Nicole J. RINEHART, Auteur ; Gail A. ALVARES, Auteur ; Bruce J. TONGE, Auteur ; Ian B. HICKIE, Auteur ; Caroline M. KEATING, Auteur ; Cristina CACCIOTTI-SAIJA, Auteur ; Stewart L. EINFELD, Auteur Article en page(s) : p.444-452 Langues : Anglais (eng) Mots-clés : Social cognition neuropeptides developmental disorder emotion recognition placebo-controlled Index. décimale : PER Périodiques Résumé : Background There is increasing interest in oxytocin as a therapeutic to treat social deficits in autism spectrum disorders (ASD). The aim of this study was to investigate the efficacy of a course of oxytocin nasal spray to improve social behavior in youth with ASD. Methods In a double-blind, placebo-controlled trial across two Australian university sites between February 2009 and January 2012, 50 male participants aged between 12 and 18 years, with Autistic or Asperger's Disorder, were randomized to receive either oxytocin (n = 26) or placebo (n = 24) nasal sprays (either 18 or 24 International Units), administered twice-daily for 8 weeks. Participants were assessed at baseline, after 4- and 8-weeks of treatment, and at 3-month follow-up. Primary outcomes were change in total scores on the caregiver-completed Social Responsiveness Scale and clinician-ratings on the Clinical Global Impressions-Improvement scale. Secondary assessments included caregiver reports of repetitive and other developmental behaviors and social cognition. Clinical trial registration: Australian New Zealand Clinical Trials Registry www.anzctr.org.au ACTRN12609000513213. Results Participants who received oxytocin showed no benefit following treatment on primary or secondary outcomes. However, caregivers who believed their children received oxytocin reported greater improvements compared to caregivers who believed their child received placebo. Nasal sprays were well tolerated and there was no evidence of increased side effects resulting from oxytocin administration. Conclusions This is the first evaluation of the efficacy for a course of oxytocin treatment for youth with ASD. Although results did not suggest clinical efficacy, further research is needed to explore alternative delivery methods, earlier age of intervention, and the influence of caregiver expectation on treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.12305 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.444-452[article] The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial [Texte imprimé et/ou numérique] / Adam J. GUASTELLA, Auteur ; Kylie M. GRAY, Auteur ; Nicole J. RINEHART, Auteur ; Gail A. ALVARES, Auteur ; Bruce J. TONGE, Auteur ; Ian B. HICKIE, Auteur ; Caroline M. KEATING, Auteur ; Cristina CACCIOTTI-SAIJA, Auteur ; Stewart L. EINFELD, Auteur . - p.444-452.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.444-452
Mots-clés : Social cognition neuropeptides developmental disorder emotion recognition placebo-controlled Index. décimale : PER Périodiques Résumé : Background There is increasing interest in oxytocin as a therapeutic to treat social deficits in autism spectrum disorders (ASD). The aim of this study was to investigate the efficacy of a course of oxytocin nasal spray to improve social behavior in youth with ASD. Methods In a double-blind, placebo-controlled trial across two Australian university sites between February 2009 and January 2012, 50 male participants aged between 12 and 18 years, with Autistic or Asperger's Disorder, were randomized to receive either oxytocin (n = 26) or placebo (n = 24) nasal sprays (either 18 or 24 International Units), administered twice-daily for 8 weeks. Participants were assessed at baseline, after 4- and 8-weeks of treatment, and at 3-month follow-up. Primary outcomes were change in total scores on the caregiver-completed Social Responsiveness Scale and clinician-ratings on the Clinical Global Impressions-Improvement scale. Secondary assessments included caregiver reports of repetitive and other developmental behaviors and social cognition. Clinical trial registration: Australian New Zealand Clinical Trials Registry www.anzctr.org.au ACTRN12609000513213. Results Participants who received oxytocin showed no benefit following treatment on primary or secondary outcomes. However, caregivers who believed their children received oxytocin reported greater improvements compared to caregivers who believed their child received placebo. Nasal sprays were well tolerated and there was no evidence of increased side effects resulting from oxytocin administration. Conclusions This is the first evaluation of the efficacy for a course of oxytocin treatment for youth with ASD. Although results did not suggest clinical efficacy, further research is needed to explore alternative delivery methods, earlier age of intervention, and the influence of caregiver expectation on treatment response. En ligne : http://dx.doi.org/10.1111/jcpp.12305 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260