8 recherche sur le mot-clé 'neuroticism'

Neuroticism and extraversion as predictors of first-lifetime onsets of depression, anxiety, and suicidality in high-risk adolescents / McKinley PAWLAK ; Hayley SCHMIDTLER ; Daniel C. KOPALA-SIBLEY in Development and Psychopathology, 37-1 (February 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-1 (February 2025) . - p.529-540 Titre : Neuroticism and extraversion as predictors of first-lifetime onsets of depression, anxiety, and suicidality in high-risk adolescents : Development and Psychopathology Type de document : texte imprimé Auteurs : McKinley PAWLAK, Auteur ; Hayley SCHMIDTLER, Auteur ; Daniel C. KOPALA-SIBLEY, Auteur Article en page(s) : p.529-540 Langues : Anglais (eng) Mots-clés : Anxiety  depression  extraversion  neuroticism  suicide Index. décimale : PER Périodiques Résumé : There is substantial evidence that personality traits, in particular neuroticism and extraversions predict depressive and anxiety episodes as well as suicidal ideation. However, little research has examined whether these traits predict the first onset of depressive and anxiety disorders and suicidal ideation. Moreover, the few studies to date have not adjusted for pre-existing subthreshold symptoms, assessed dimensionally. In this study, 144 adolescents were assessed at baseline, 9-, and 18-month follow-ups. Neuroticism and extraversion were assessed via self-report, and depressive and anxiety disorders and suicidal ideation were assessed with diagnostic interviews. Adjusting for age, sex, and baseline symptoms, logistic regression analyses showed that neuroticism predicted the first onset of depressive disorders. However, neither neuroticism nor extraversion predicted first onsets of anxiety disorders, extraversion did not predict depressive disorders, and neither trait predicted suicidal ideation onset or severity after adjusting for baseline symptoms. Neuroticism and extraversion may respectively predispose youth to depressive or anxiety disorders but not to suicidal ideation over and above pre-existing symptoms. Results have implications for the early identification of at-risk youth and prevention of depressive and anxiety disorders and suicidal ideation. En ligne : https://dx.doi.org/10.1017/S0954579424000130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Neuroticism and extraversion as predictors of first-lifetime onsets of depression, anxiety, and suicidality in high-risk adolescents : Development and Psychopathology [texte imprimé] / McKinley PAWLAK, Auteur ; Hayley SCHMIDTLER, Auteur ; Daniel C. KOPALA-SIBLEY, Auteur . - p.529-540. Langues : Anglais (eng) in Development and Psychopathology > 37-1 (February 2025) . - p.529-540 Mots-clés : Anxiety  depression  extraversion  neuroticism  suicide Index. décimale : PER Périodiques Résumé : There is substantial evidence that personality traits, in particular neuroticism and extraversions predict depressive and anxiety episodes as well as suicidal ideation. However, little research has examined whether these traits predict the first onset of depressive and anxiety disorders and suicidal ideation. Moreover, the few studies to date have not adjusted for pre-existing subthreshold symptoms, assessed dimensionally. In this study, 144 adolescents were assessed at baseline, 9-, and 18-month follow-ups. Neuroticism and extraversion were assessed via self-report, and depressive and anxiety disorders and suicidal ideation were assessed with diagnostic interviews. Adjusting for age, sex, and baseline symptoms, logistic regression analyses showed that neuroticism predicted the first onset of depressive disorders. However, neither neuroticism nor extraversion predicted first onsets of anxiety disorders, extraversion did not predict depressive disorders, and neither trait predicted suicidal ideation onset or severity after adjusting for baseline symptoms. Neuroticism and extraversion may respectively predispose youth to depressive or anxiety disorders but not to suicidal ideation over and above pre-existing symptoms. Results have implications for the early identification of at-risk youth and prevention of depressive and anxiety disorders and suicidal ideation. En ligne : https://dx.doi.org/10.1017/S0954579424000130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Exploring the autism spectrum: Moderating effects of neuroticism on stress reactivity and on the association between social context and negative affect / Jeroen VAN OOSTERHOUT in Development and Psychopathology, 34-4 (October 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-4 (October 2022) . - p.1366-1375 Titre : Exploring the autism spectrum: Moderating effects of neuroticism on stress reactivity and on the association between social context and negative affect Type de document : texte imprimé Auteurs : Jeroen VAN OOSTERHOUT, Auteur ; Kim VAN DER LINDEN, Auteur ; Claudia J.P. SIMONS, Auteur ; Thérèse VAN AMELSVOORT, Auteur ; Machteld MARCELIS, Auteur Article en page(s) : p.1366-1375 Langues : Anglais (eng) Mots-clés : Adult  Affect  Autism Spectrum Disorder/psychology  Autistic Disorder  Cross-Sectional Studies  Humans  Neuroticism  Social Environment  Stress, Psychological/psychology  autism  momentary assessment  social context  stress reactivity Index. décimale : PER Périodiques Résumé : Neuroticism is associated with increased stress reactivity. In autism spectrum disorders (ASD), emotional stress reactivity is increased and there is some evidence for an increased negative affect (NA) when with less familiar people. The aim of this study was to compare adults with ASD and controls on levels of neuroticism and on interactions between neuroticism and appraised stress or social context in models of NA. This is a cross-sectional observational study comprising a group of 50 adults with ASD and 51 controls. Experience sampling method (ESM) reports were collected for 10 days to measure daily life stress, mood, and social context. Multilevel regression analyses revealed significantly higher neuroticism levels in ASD than in controls. Adults with ASD who scored high on neuroticism showed a significantly stronger association between activity/social stress and NA (i.e., higher stress reactivity) than those with low scores. Furthermore, the association between neuroticism and NA was stronger when adults with ASD were with less familiar people compared with being alone or with familiar people. No consistent corresponding significant interactions were found in the control group. In conclusion, in ASD, neuroticism moderates the association between appraised stress and NA as well as the association between social context and NA. En ligne : http://dx.doi.org/10.1017/s0954579420002278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Exploring the autism spectrum: Moderating effects of neuroticism on stress reactivity and on the association between social context and negative affect [texte imprimé] / Jeroen VAN OOSTERHOUT, Auteur ; Kim VAN DER LINDEN, Auteur ; Claudia J.P. SIMONS, Auteur ; Thérèse VAN AMELSVOORT, Auteur ; Machteld MARCELIS, Auteur . - p.1366-1375. Langues : Anglais (eng) in Development and Psychopathology > 34-4 (October 2022) . - p.1366-1375 Mots-clés : Adult  Affect  Autism Spectrum Disorder/psychology  Autistic Disorder  Cross-Sectional Studies  Humans  Neuroticism  Social Environment  Stress, Psychological/psychology  autism  momentary assessment  social context  stress reactivity Index. décimale : PER Périodiques Résumé : Neuroticism is associated with increased stress reactivity. In autism spectrum disorders (ASD), emotional stress reactivity is increased and there is some evidence for an increased negative affect (NA) when with less familiar people. The aim of this study was to compare adults with ASD and controls on levels of neuroticism and on interactions between neuroticism and appraised stress or social context in models of NA. This is a cross-sectional observational study comprising a group of 50 adults with ASD and 51 controls. Experience sampling method (ESM) reports were collected for 10 days to measure daily life stress, mood, and social context. Multilevel regression analyses revealed significantly higher neuroticism levels in ASD than in controls. Adults with ASD who scored high on neuroticism showed a significantly stronger association between activity/social stress and NA (i.e., higher stress reactivity) than those with low scores. Furthermore, the association between neuroticism and NA was stronger when adults with ASD were with less familiar people compared with being alone or with familiar people. No consistent corresponding significant interactions were found in the control group. In conclusion, in ASD, neuroticism moderates the association between appraised stress and NA as well as the association between social context and NA. En ligne : http://dx.doi.org/10.1017/s0954579420002278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene / Colin G. DEYOUNG in Journal of Child Psychology and Psychiatry, 52-8 (August 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-8 (August 2011) . - p.898-906 Titre : Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene Type de document : texte imprimé Auteurs : Colin G. DEYOUNG, Auteur ; Dante CICCHETTI, Auteur ; Fred A. ROGOSCH, Auteur Année de publication : 2011 Article en page(s) : p.898-906 Langues : Anglais (eng) Mots-clés : Neuroticism  CRHR1  maltreatment  genetics  personality  HPA axis Index. décimale : PER Périodiques Résumé : Background:  Neuroticism is a personality trait reflecting the tendency to experience negative affect. It is a major risk for psychopathology, especially depression and anxiety disorders. Childhood maltreatment is another major risk factor for psychopathology and may influence personality. Maltreatment may interact with genotype to predict developmental outcomes. Variation in three polymorphisms of the CRHR1 gene has been found to moderate the association of childhood maltreatment with depression, and we hypothesized that it would also be linked to neuroticism. Methods:  Variation in three CRHR1 SNPs (rs110402, rs242924, rs7209436) was assessed in 339 maltreated and 275 demographically similar nonmaltreated children, who participated in a day camp research program. Maltreated children were further categorized based on the number of types of maltreatment they had experienced and the most severe form of maltreatment experienced. Genotype and maltreatment status were used to predict the Big Five personality traits, as assessed by camp counselors following a week of interaction with children. Results: CRHR1 genotype significantly moderated the association of maltreatment with neuroticism but none of the other traits. Having two copies of the TAT haplotype of CRHR1 was associated with higher levels of neuroticism among maltreated children relative to nonmaltreated children, with the exception of sexually abused children and children who had experienced 3 or 4 types of abuse. Effects sizes of these interactions ranged from η2 = .01 (p = .02) to η2 = .03 (p = .006). Conclusions:  Variation in CRHR1 moderates the association of maltreatment with neuroticism. The effects of specific types of maltreatment on neuroticism are differentially moderated by CRHR1 genotype, as are the effects of experiencing more or fewer types of maltreatment. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02404.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene [texte imprimé] / Colin G. DEYOUNG, Auteur ; Dante CICCHETTI, Auteur ; Fred A. ROGOSCH, Auteur . - 2011 . - p.898-906. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-8 (August 2011) . - p.898-906 Mots-clés : Neuroticism  CRHR1  maltreatment  genetics  personality  HPA axis Index. décimale : PER Périodiques Résumé : Background:  Neuroticism is a personality trait reflecting the tendency to experience negative affect. It is a major risk for psychopathology, especially depression and anxiety disorders. Childhood maltreatment is another major risk factor for psychopathology and may influence personality. Maltreatment may interact with genotype to predict developmental outcomes. Variation in three polymorphisms of the CRHR1 gene has been found to moderate the association of childhood maltreatment with depression, and we hypothesized that it would also be linked to neuroticism. Methods:  Variation in three CRHR1 SNPs (rs110402, rs242924, rs7209436) was assessed in 339 maltreated and 275 demographically similar nonmaltreated children, who participated in a day camp research program. Maltreated children were further categorized based on the number of types of maltreatment they had experienced and the most severe form of maltreatment experienced. Genotype and maltreatment status were used to predict the Big Five personality traits, as assessed by camp counselors following a week of interaction with children. Results: CRHR1 genotype significantly moderated the association of maltreatment with neuroticism but none of the other traits. Having two copies of the TAT haplotype of CRHR1 was associated with higher levels of neuroticism among maltreated children relative to nonmaltreated children, with the exception of sexually abused children and children who had experienced 3 or 4 types of abuse. Effects sizes of these interactions ranged from η2 = .01 (p = .02) to η2 = .03 (p = .006). Conclusions:  Variation in CRHR1 moderates the association of maltreatment with neuroticism. The effects of specific types of maltreatment on neuroticism are differentially moderated by CRHR1 genotype, as are the effects of experiencing more or fewer types of maltreatment. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02404.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence / Alex S.F. KWONG in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1462-1474 Titre : Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence Type de document : texte imprimé Auteurs : Alex S.F. KWONG, Auteur ; Tim T. MORRIS, Auteur ; Rebecca M. PEARSON, Auteur ; Nicholas J. TIMPSON, Auteur ; Frances RICE, Auteur ; Evangelia STERGIAKOULI, Auteur ; Kate TILLING, Auteur Article en page(s) : p.1462-1474 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Anxiety  Child  Cross-Sectional Studies  Depression/genetics  Depressive Disorder, Major/epidemiology/genetics  Genetic Predisposition to Disease/genetics  Genome-Wide Association Study  Humans  Longitudinal Studies  Multifactorial Inheritance/genetics  Neuroticism  Young Adult  Alspac  Polygenic risk scores  adolescence  depressive symptoms  development  longitudinal  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence marks a period where depression will commonly onset. Twin studies show that genetic influences play a role in how depression develops and changes across adolescence. Recent genome-wide association studies highlight that common genetic variants - which can be combined into polygenic risk scores (PRS) - are also implicated in depression. However, the role of PRS in adolescent depression and changes in adolescent depression is not yet understood. We aimed to examine associations between PRS for five psychiatric traits and depressive symptoms measured across adolescence using cross-sectional and growth-curve models. The five PRS were as follows: depression (DEP), major depressive disorder (MDD), anxiety (ANX), neuroticism (NEU) and schizophrenia (SCZ). METHODS: We used data from over 6,000 participants of the Avon Longitudinal Study of Parents and Children (ALSPAC) to examine associations between the five PRS and self-reported depressive symptoms (Short Mood and Feelings Questionnaire) over 9 occasions from 10 to 24 years. The PRS were created from well-powered genome-wide association studies conducted in adult populations. We examined cross-sectional associations between the PRS at each age and then again with longitudinal trajectories of depressive symptoms in a repeated measures framework using multilevel growth-curve analysis to examine the severity and the rate of change. RESULTS: There was strong evidence that higher PRS for DEP, MDD and NEU were associated with worse depressive symptoms throughout adolescence and into young adulthood in our cross-sectional analysis, with consistent associations observed across all nine occasions. Growth-curve analyses provided stronger associations (as measured by effect sizes) and additional insights, demonstrating that individuals with higher PRS for DEP, MDD and NEU had steeper trajectories of depressive symptoms across development, all with a greater increasing rate of change during adolescence. Evidence was less consistent for the ANX and SCZ PRS in the cross-sectional analysis, yet there was some evidence for an increasing rate of change in adolescence in the growth-curve analyses with the ANX PRS. CONCLUSIONS: These results show that common genetic variants as indexed by varying psychiatric PRS show patterns of specificity that influence both the severity and rate of change in depressive symptoms throughout adolescence and then into young adulthood. Longitudinal data that make use of repeated measures designs have the potential to provide greater insights how genetic factors influence the onset and persistence of adolescent depression. En ligne : http://dx.doi.org/10.1111/jcpp.13422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence [texte imprimé] / Alex S.F. KWONG, Auteur ; Tim T. MORRIS, Auteur ; Rebecca M. PEARSON, Auteur ; Nicholas J. TIMPSON, Auteur ; Frances RICE, Auteur ; Evangelia STERGIAKOULI, Auteur ; Kate TILLING, Auteur . - p.1462-1474. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1462-1474 Mots-clés : Adolescent  Adult  Anxiety  Child  Cross-Sectional Studies  Depression/genetics  Depressive Disorder, Major/epidemiology/genetics  Genetic Predisposition to Disease/genetics  Genome-Wide Association Study  Humans  Longitudinal Studies  Multifactorial Inheritance/genetics  Neuroticism  Young Adult  Alspac  Polygenic risk scores  adolescence  depressive symptoms  development  longitudinal  trajectories Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence marks a period where depression will commonly onset. Twin studies show that genetic influences play a role in how depression develops and changes across adolescence. Recent genome-wide association studies highlight that common genetic variants - which can be combined into polygenic risk scores (PRS) - are also implicated in depression. However, the role of PRS in adolescent depression and changes in adolescent depression is not yet understood. We aimed to examine associations between PRS for five psychiatric traits and depressive symptoms measured across adolescence using cross-sectional and growth-curve models. The five PRS were as follows: depression (DEP), major depressive disorder (MDD), anxiety (ANX), neuroticism (NEU) and schizophrenia (SCZ). METHODS: We used data from over 6,000 participants of the Avon Longitudinal Study of Parents and Children (ALSPAC) to examine associations between the five PRS and self-reported depressive symptoms (Short Mood and Feelings Questionnaire) over 9 occasions from 10 to 24 years. The PRS were created from well-powered genome-wide association studies conducted in adult populations. We examined cross-sectional associations between the PRS at each age and then again with longitudinal trajectories of depressive symptoms in a repeated measures framework using multilevel growth-curve analysis to examine the severity and the rate of change. RESULTS: There was strong evidence that higher PRS for DEP, MDD and NEU were associated with worse depressive symptoms throughout adolescence and into young adulthood in our cross-sectional analysis, with consistent associations observed across all nine occasions. Growth-curve analyses provided stronger associations (as measured by effect sizes) and additional insights, demonstrating that individuals with higher PRS for DEP, MDD and NEU had steeper trajectories of depressive symptoms across development, all with a greater increasing rate of change during adolescence. Evidence was less consistent for the ANX and SCZ PRS in the cross-sectional analysis, yet there was some evidence for an increasing rate of change in adolescence in the growth-curve analyses with the ANX PRS. CONCLUSIONS: These results show that common genetic variants as indexed by varying psychiatric PRS show patterns of specificity that influence both the severity and rate of change in depressive symptoms throughout adolescence and then into young adulthood. Longitudinal data that make use of repeated measures designs have the potential to provide greater insights how genetic factors influence the onset and persistence of adolescent depression. En ligne : http://dx.doi.org/10.1111/jcpp.13422 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation / Merav H. SILVERMAN in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1085-1099 Titre : Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation Type de document : texte imprimé Auteurs : Merav H. SILVERMAN, Auteur ; Sylia WILSON, Auteur ; Ian S. RAMSAY, Auteur ; Ruskin H. HUNT, Auteur ; Kathleen M. THOMAS, Auteur ; Robert F. KRUEGER, Auteur ; William G. IACONO, Auteur Article en page(s) : p.1085-1099 Langues : Anglais (eng) Mots-clés : amygdala  emotion dysregulation  functional magnetic resonance imaging  negative emotion processing  neuroticism Index. décimale : PER Périodiques Résumé : Though theory suggests that individual differences in neuroticism (a tendency to experience negative emotions) would be associated with altered functioning of the amygdala (which has been linked with emotionality and emotion dysregulation in childhood, adolescence, and adulthood), results of functional neuroimaging studies have been contradictory and inconclusive. We aimed to clarify the relationship between neuroticism and three hypothesized neural markers derived from functional magnetic resonance imaging during negative emotion face processing: amygdala activation, amygdala habituation, and amygdala-prefrontal connectivity, each of which plays an important role in the experience and regulation of emotions. We used general linear models to examine the relationship between trait neuroticism and the hypothesized neural markers in a large sample of over 500 young adults. Although neuroticism was not significantly associated with magnitude of amygdala activation or amygdala habituation, it was associated with amygdala–ventromedial prefrontal cortex connectivity, which has been implicated in emotion regulation. Results suggest that trait neuroticism may represent a failure in top-down control and regulation of emotional reactions, rather than overactive emotion generation processes, per se. These findings suggest that neuroticism, which has been associated with increased rates of transdiagnostic psychopathology, may represent a failure in the inhibitory neurocircuitry associated with emotion regulation. En ligne : http://dx.doi.org/10.1017/S0954579419000610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Trait neuroticism and emotion neurocircuitry: Functional magnetic resonance imaging evidence for a failure in emotion regulation [texte imprimé] / Merav H. SILVERMAN, Auteur ; Sylia WILSON, Auteur ; Ian S. RAMSAY, Auteur ; Ruskin H. HUNT, Auteur ; Kathleen M. THOMAS, Auteur ; Robert F. KRUEGER, Auteur ; William G. IACONO, Auteur . - p.1085-1099. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1085-1099 Mots-clés : amygdala  emotion dysregulation  functional magnetic resonance imaging  negative emotion processing  neuroticism Index. décimale : PER Périodiques Résumé : Though theory suggests that individual differences in neuroticism (a tendency to experience negative emotions) would be associated with altered functioning of the amygdala (which has been linked with emotionality and emotion dysregulation in childhood, adolescence, and adulthood), results of functional neuroimaging studies have been contradictory and inconclusive. We aimed to clarify the relationship between neuroticism and three hypothesized neural markers derived from functional magnetic resonance imaging during negative emotion face processing: amygdala activation, amygdala habituation, and amygdala-prefrontal connectivity, each of which plays an important role in the experience and regulation of emotions. We used general linear models to examine the relationship between trait neuroticism and the hypothesized neural markers in a large sample of over 500 young adults. Although neuroticism was not significantly associated with magnitude of amygdala activation or amygdala habituation, it was associated with amygdala–ventromedial prefrontal cortex connectivity, which has been implicated in emotion regulation. Results suggest that trait neuroticism may represent a failure in top-down control and regulation of emotional reactions, rather than overactive emotion generation processes, per se. These findings suggest that neuroticism, which has been associated with increased rates of transdiagnostic psychopathology, may represent a failure in the inhibitory neurocircuitry associated with emotion regulation. En ligne : http://dx.doi.org/10.1017/S0954579419000610 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

An affective dimension within oppositional defiant disorder symptoms among boys: personality and psychopathology outcomes into early adulthood / Jeffrey D. BURKE in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)  

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A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality / Rachael G. GRAZIOPLENE in Journal of Child Psychology and Psychiatry, 54-8 (August 2013)  

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Psychophysiological influences on personality trajectories in adolescent females exposed to child maltreatment / Raha HASSAN in Development and Psychopathology, 32-4 (October 2020)  

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