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Autism prevalence in China is comparable to Western prevalence / X. SUN in Molecular Autism, 10 (2019)
[article]
Titre : Autism prevalence in China is comparable to Western prevalence Type de document : Texte imprimé et/ou numérique Auteurs : X. SUN, Auteur ; Carrie ALLISON, Auteur ; L. WEI, Auteur ; F. E. MATTHEWS, Auteur ; Bonnie AUYEUNG, Auteur ; Y. Y. WU, Auteur ; S. GRIFFITHS, Auteur ; J. ZHANG, Auteur ; Simon BARON-COHEN, Auteur ; Carol BRAYNE, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : *Autism *Children *China *Diagnosis *Prevalence *Screening University of Hong Kong and the Peking University Institutional Review Board. Consent was provided to participants via the screening package before participating. Participants were asked to indicate whether they continued to consent at the end of the study.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Autism prevalence in the West is approximately 1% of school age children. Autism prevalence in China has been reported to be lower than in the West. This is likely due to at least two reasons: (1) most studies in China only included the special school population, overlooking the mainstream school population; and (2) most studies in China have not used contemporary screening and diagnostic methods. To address this, we tested total autism prevalence (mainstream and special schools) in Jilin City, and mainstream school autism prevalence in Jiamusi and Shenzhen cities. Methods: The study included a three-step process: (1) screening; (2) clinical assessment of 'screen positives' plus controls; and (3) research diagnostic assessment of those meeting clinical threshold for concerns at step 2. Prevalence estimates per 10,000 children aged 6-10 years old were weighted for study design using diagnostic criteria applied at the research assessment stage. Results: In Jilin City, 77 cases of autism were identified from a total population of 7258, equating to a prevalence of 108 per 10,000 (95% confidence interval (CI) 89, 130). In Shenzhen City: 21,420 children were screened and 35 cases of autism were identified, resulting in a mainstream prevalence of 42 per 10,000 (95% CI 20-89). In Jiamusi City, 16,358 children were screened, with 10 autism cases being identified, with a mainstream prevalence of 19 per 10,000 (95% CI 10-38). Conclusions: Results from Jilin City, where both mainstream and special school data were available, revealed a similar prevalence of autism in China to the West, at around 1%. Results from Shenzhen and Jiamusi cities, where only mainstream data were available, prevalence is also in line with Western estimates. In all three cities, new cases of autism were identified by the study in mainstream schools, reflecting current under-diagnosis. Non-significant variation across different cities is seen indicating the need to explore potential variation of autism across diverse Chinese regions with large sample sizes to achieve a fully robust national picture. En ligne : https://dx.doi.org/10.1186/s13229-018-0246-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 10 (2019) . - 7 p.[article] Autism prevalence in China is comparable to Western prevalence [Texte imprimé et/ou numérique] / X. SUN, Auteur ; Carrie ALLISON, Auteur ; L. WEI, Auteur ; F. E. MATTHEWS, Auteur ; Bonnie AUYEUNG, Auteur ; Y. Y. WU, Auteur ; S. GRIFFITHS, Auteur ; J. ZHANG, Auteur ; Simon BARON-COHEN, Auteur ; Carol BRAYNE, Auteur . - 7 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 7 p.
Mots-clés : *Autism *Children *China *Diagnosis *Prevalence *Screening University of Hong Kong and the Peking University Institutional Review Board. Consent was provided to participants via the screening package before participating. Participants were asked to indicate whether they continued to consent at the end of the study.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Autism prevalence in the West is approximately 1% of school age children. Autism prevalence in China has been reported to be lower than in the West. This is likely due to at least two reasons: (1) most studies in China only included the special school population, overlooking the mainstream school population; and (2) most studies in China have not used contemporary screening and diagnostic methods. To address this, we tested total autism prevalence (mainstream and special schools) in Jilin City, and mainstream school autism prevalence in Jiamusi and Shenzhen cities. Methods: The study included a three-step process: (1) screening; (2) clinical assessment of 'screen positives' plus controls; and (3) research diagnostic assessment of those meeting clinical threshold for concerns at step 2. Prevalence estimates per 10,000 children aged 6-10 years old were weighted for study design using diagnostic criteria applied at the research assessment stage. Results: In Jilin City, 77 cases of autism were identified from a total population of 7258, equating to a prevalence of 108 per 10,000 (95% confidence interval (CI) 89, 130). In Shenzhen City: 21,420 children were screened and 35 cases of autism were identified, resulting in a mainstream prevalence of 42 per 10,000 (95% CI 20-89). In Jiamusi City, 16,358 children were screened, with 10 autism cases being identified, with a mainstream prevalence of 19 per 10,000 (95% CI 10-38). Conclusions: Results from Jilin City, where both mainstream and special school data were available, revealed a similar prevalence of autism in China to the West, at around 1%. Results from Shenzhen and Jiamusi cities, where only mainstream data were available, prevalence is also in line with Western estimates. In all three cities, new cases of autism were identified by the study in mainstream schools, reflecting current under-diagnosis. Non-significant variation across different cities is seen indicating the need to explore potential variation of autism across diverse Chinese regions with large sample sizes to achieve a fully robust national picture. En ligne : https://dx.doi.org/10.1186/s13229-018-0246-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Assessing subtypes of restricted and repetitive behaviour using the Adult Repetitive Behaviour Questionnaire-2 in autistic adults / Sarah L. BARRETT in Molecular Autism, 9 (2018)
[article]
Titre : Assessing subtypes of restricted and repetitive behaviour using the Adult Repetitive Behaviour Questionnaire-2 in autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : Sarah L. BARRETT, Auteur ; M. ULJAREVIC, Auteur ; Catherine R. G. JONES, Auteur ; S. R. LEEKAM, Auteur Article en page(s) : 58 p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Aged Autistic Disorder/classification/*diagnosis Female Humans Male Middle Aged *Stereotyped Behavior Surveys and Questionnaires/*standards *Adults *Insistence on sameness *Principal components analysis *Questionnaire *Repetitive behaviours *Repetitive sensory and motor behaviours the Cardiff University School of Psychology Research Ethics Committee (EC.14.04.08.3784R2A3). All participants provided informed electronic consent before taking part in the study.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: The majority of previous research into restricted and repetitive behaviours (RRBs) has focussed on children, partly due to a lack of suitable measures for RRBs in adults. This study aimed to explore the psychometric properties of the Adult Repetitive Behaviour Questionnaire-2 (RBQ-2A) in a large sample of autistic adults using a self-report questionnaire method. Methods: The RBQ-2A and Autism-Spectrum Quotient (AQ) were administered online. Data from 275 autistic adults aged 18-66 (M = 36.56, SD = 12.24; 100 men and 171 women) were analysed using polychoric principal components analysis (PCA). Reliability and validity were assessed using Cronbach's alpha and correlation analyses. Results: PCA resulted in two components of the RBQ-2A, interpretable as repetitive sensory and motor behaviours (RSMB) and insistence on sameness (IS). Both components showed acceptable internal consistency (alpha = .70 and .81 respectively) and were significantly moderately correlated with scores on the AQ (r s = .25 and .42). Participants' scores on IS were higher than their scores on RSMB. RSMB, but not IS, was negatively associated with age, particularly in older adults (>/= 50 years). There were no gender differences. Conclusions: The RBQ-2A is a reliable and valid self-report measure of RRBs in the present sample of autistic adults. As one of the few measures of RRBs aimed at adults, it is suitable for adults with the ability to read and complete a self-report questionnaire. Results build on previous work with children using the Repetitive Behaviour Questionnaire-2 (RBQ-2). En ligne : https://dx.doi.org/10.1186/s13229-018-0242-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 9 (2018) . - 58 p.[article] Assessing subtypes of restricted and repetitive behaviour using the Adult Repetitive Behaviour Questionnaire-2 in autistic adults [Texte imprimé et/ou numérique] / Sarah L. BARRETT, Auteur ; M. ULJAREVIC, Auteur ; Catherine R. G. JONES, Auteur ; S. R. LEEKAM, Auteur . - 58 p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 58 p.
Mots-clés : Adolescent Adult Aged Autistic Disorder/classification/*diagnosis Female Humans Male Middle Aged *Stereotyped Behavior Surveys and Questionnaires/*standards *Adults *Insistence on sameness *Principal components analysis *Questionnaire *Repetitive behaviours *Repetitive sensory and motor behaviours the Cardiff University School of Psychology Research Ethics Committee (EC.14.04.08.3784R2A3). All participants provided informed electronic consent before taking part in the study.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: The majority of previous research into restricted and repetitive behaviours (RRBs) has focussed on children, partly due to a lack of suitable measures for RRBs in adults. This study aimed to explore the psychometric properties of the Adult Repetitive Behaviour Questionnaire-2 (RBQ-2A) in a large sample of autistic adults using a self-report questionnaire method. Methods: The RBQ-2A and Autism-Spectrum Quotient (AQ) were administered online. Data from 275 autistic adults aged 18-66 (M = 36.56, SD = 12.24; 100 men and 171 women) were analysed using polychoric principal components analysis (PCA). Reliability and validity were assessed using Cronbach's alpha and correlation analyses. Results: PCA resulted in two components of the RBQ-2A, interpretable as repetitive sensory and motor behaviours (RSMB) and insistence on sameness (IS). Both components showed acceptable internal consistency (alpha = .70 and .81 respectively) and were significantly moderately correlated with scores on the AQ (r s = .25 and .42). Participants' scores on IS were higher than their scores on RSMB. RSMB, but not IS, was negatively associated with age, particularly in older adults (>/= 50 years). There were no gender differences. Conclusions: The RBQ-2A is a reliable and valid self-report measure of RRBs in the present sample of autistic adults. As one of the few measures of RRBs aimed at adults, it is suitable for adults with the ability to read and complete a self-report questionnaire. Results build on previous work with children using the Repetitive Behaviour Questionnaire-2 (RBQ-2). En ligne : https://dx.doi.org/10.1186/s13229-018-0242-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Sensory over-responsivity: parent report, direct assessment measures, and neural architecture / Teresa TAVASSOLI in Molecular Autism, 10 (2019)
[article]
Titre : Sensory over-responsivity: parent report, direct assessment measures, and neural architecture Type de document : Texte imprimé et/ou numérique Auteurs : Teresa TAVASSOLI, Auteur ; Annie BRANDES-AITKEN, Auteur ; R. CHU, Auteur ; L. PORTER, Auteur ; S. SCHOEN, Auteur ; L. J. MILLER, Auteur ; M. R. GERDES, Auteur ; J. OWEN, Auteur ; P. MUKHERJEE, Auteur ; E. J. MARCO, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : *Assessment *Diffusion Tensor Imaging *Neurodevelopmental disorder *Sensory over-responsivity *Sensory processing disorder *autism of California, San Francisco (10-01940). Written consent was collected from parents of the participants.All recruited participants/parents have given consent for publication during the recruitment process.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. Methods: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. Results: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. Conclusions: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. En ligne : https://dx.doi.org/10.1186/s13229-019-0255-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 10 (2019) . - 4 p.[article] Sensory over-responsivity: parent report, direct assessment measures, and neural architecture [Texte imprimé et/ou numérique] / Teresa TAVASSOLI, Auteur ; Annie BRANDES-AITKEN, Auteur ; R. CHU, Auteur ; L. PORTER, Auteur ; S. SCHOEN, Auteur ; L. J. MILLER, Auteur ; M. R. GERDES, Auteur ; J. OWEN, Auteur ; P. MUKHERJEE, Auteur ; E. J. MARCO, Auteur . - 4 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 4 p.
Mots-clés : *Assessment *Diffusion Tensor Imaging *Neurodevelopmental disorder *Sensory over-responsivity *Sensory processing disorder *autism of California, San Francisco (10-01940). Written consent was collected from parents of the participants.All recruited participants/parents have given consent for publication during the recruitment process.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. Methods: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. Results: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. Conclusions: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. En ligne : https://dx.doi.org/10.1186/s13229-019-0255-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389