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Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children / Stephane A. DE BRITO in Journal of Child Psychology and Psychiatry, 54-1 (January 2013)
[article]
Titre : Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children Type de document : Texte imprimé et/ou numérique Auteurs : Stephane A. DE BRITO, Auteur ; Essi VIDING, Auteur ; Catherine L. SEBASTIAN, Auteur ; Philip A. KELLY, Auteur ; Andrea MECHELLI, Auteur ; Helen MARIS, Auteur ; Eamon J. MCCRORY, Auteur Article en page(s) : 105-112 Langues : Anglais (eng) Mots-clés : maltreatment child abuse orbitofrontal cortex middle temporal gyrus voxel-based morphometry Index. décimale : PER Périodiques Résumé : Background: Childhood maltreatment is strongly associated with increased risk of psychiatric disorder. Previous neuroimaging studies have reported atypical neural structure in the orbitofrontal cortex, temporal lobe, amygdala, hippocampus and cerebellum in maltreated samples. It has been hypothesised that these structural differences may relate to increased psychiatric vulnerability. However, previous studies have typically recruited clinical samples with concurrent psychiatric disorders, or have poorly characterised the range of maltreatment experiences and levels of concurrent anxiety or depression, limiting the interpretation of the observed structural differences. Methods: We used voxel-based morphometry to compare grey matter volume in a group of 18 children (mean age 12.01 years, SD = 1.4), referred to community social services, with documented and well-characterised experiences of maltreatment at home and a group of 20 nonmaltreated children (mean age 12.6 years, SD = 1.3). Both groups were comparable on age, gender, cognitive ability, ethnicity and levels of anxiety, depression and posttraumatic stress symptoms. We examined five a priori regions of interest: the prefrontal cortex, temporal lobes, amygdala, hippocampus and cerebellum. Results: Maltreated children, compared to nonmaltreated peers, presented with reduced grey matter in the medial orbitofrontal cortex and the left middle temporal gyrus. Conclusions: The medial orbitofrontal cortex and the middle temporal gyrus have been implicated in reinforcement-based decision-making, emotion regulation and autobiographical memory, processes that are impaired in a number of psychiatric disorders associated with maltreatment. We speculate that grey matter disturbance in these regions in a community sample of maltreated children may represent a latent neurobiological risk factor for later psychopathology and heightened risk taking. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02597.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186
in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 105-112[article] Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children [Texte imprimé et/ou numérique] / Stephane A. DE BRITO, Auteur ; Essi VIDING, Auteur ; Catherine L. SEBASTIAN, Auteur ; Philip A. KELLY, Auteur ; Andrea MECHELLI, Auteur ; Helen MARIS, Auteur ; Eamon J. MCCRORY, Auteur . - 105-112.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 105-112
Mots-clés : maltreatment child abuse orbitofrontal cortex middle temporal gyrus voxel-based morphometry Index. décimale : PER Périodiques Résumé : Background: Childhood maltreatment is strongly associated with increased risk of psychiatric disorder. Previous neuroimaging studies have reported atypical neural structure in the orbitofrontal cortex, temporal lobe, amygdala, hippocampus and cerebellum in maltreated samples. It has been hypothesised that these structural differences may relate to increased psychiatric vulnerability. However, previous studies have typically recruited clinical samples with concurrent psychiatric disorders, or have poorly characterised the range of maltreatment experiences and levels of concurrent anxiety or depression, limiting the interpretation of the observed structural differences. Methods: We used voxel-based morphometry to compare grey matter volume in a group of 18 children (mean age 12.01 years, SD = 1.4), referred to community social services, with documented and well-characterised experiences of maltreatment at home and a group of 20 nonmaltreated children (mean age 12.6 years, SD = 1.3). Both groups were comparable on age, gender, cognitive ability, ethnicity and levels of anxiety, depression and posttraumatic stress symptoms. We examined five a priori regions of interest: the prefrontal cortex, temporal lobes, amygdala, hippocampus and cerebellum. Results: Maltreated children, compared to nonmaltreated peers, presented with reduced grey matter in the medial orbitofrontal cortex and the left middle temporal gyrus. Conclusions: The medial orbitofrontal cortex and the middle temporal gyrus have been implicated in reinforcement-based decision-making, emotion regulation and autobiographical memory, processes that are impaired in a number of psychiatric disorders associated with maltreatment. We speculate that grey matter disturbance in these regions in a community sample of maltreated children may represent a latent neurobiological risk factor for later psychopathology and heightened risk taking. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02597.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood / S. THIJSSEN in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)
[article]
Titre : The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : S. THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; H. WEISS, Auteur ; M. LUCIANA, Auteur Article en page(s) : p.857-867 Langues : Anglais (eng) Mots-clés : Adolescent Adult Amygdala/diagnostic imaging Gyrus Cinguli Humans Magnetic Resonance Imaging Neural Pathways/diagnostic imaging Prefrontal Cortex/diagnostic imaging Young Adult Externalizing behavior amygdala anterior cingulate cortex functional connectivity orbitofrontal cortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Externalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala-anterior cingulate cortex (ACC) and amygdala-orbitofrontal cortex (OFC) resting-state functional connectivity in a sample of 111 typically developing participants aged 11-23 at baseline. METHODS: Participants completed two-to-four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self-Report questionnaire. Resting-state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala-ACC/OFC functional connectivity was examined using linear mixed effect models in R. RESULTS: Externalizing behavior was associated with increased amygdala-ACC and amygdala-OFC resting-state functional connectivity across adolescence and young adulthood. For amygdala-ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala-OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala-OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age-by-externalizing behavior interaction effect). CONCLUSIONS: Higher externalizing behavior is associated with increased resting-state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control. En ligne : http://dx.doi.org/10.1111/jcpp.13330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.857-867[article] The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood [Texte imprimé et/ou numérique] / S. THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; H. WEISS, Auteur ; M. LUCIANA, Auteur . - p.857-867.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.857-867
Mots-clés : Adolescent Adult Amygdala/diagnostic imaging Gyrus Cinguli Humans Magnetic Resonance Imaging Neural Pathways/diagnostic imaging Prefrontal Cortex/diagnostic imaging Young Adult Externalizing behavior amygdala anterior cingulate cortex functional connectivity orbitofrontal cortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Externalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala-anterior cingulate cortex (ACC) and amygdala-orbitofrontal cortex (OFC) resting-state functional connectivity in a sample of 111 typically developing participants aged 11-23 at baseline. METHODS: Participants completed two-to-four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self-Report questionnaire. Resting-state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala-ACC/OFC functional connectivity was examined using linear mixed effect models in R. RESULTS: Externalizing behavior was associated with increased amygdala-ACC and amygdala-OFC resting-state functional connectivity across adolescence and young adulthood. For amygdala-ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala-OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala-OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age-by-externalizing behavior interaction effect). CONCLUSIONS: Higher externalizing behavior is associated with increased resting-state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control. En ligne : http://dx.doi.org/10.1111/jcpp.13330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 Failure is Not an Option: Risk-Taking is Moderated by Anxiety and Also by Cognitive Ability in Children and Adolescents Diagnosed with an Autism Spectrum Disorder / Mikle SOUTH in Journal of Autism and Developmental Disorders, 41-1 (January 2011)
[article]
Titre : Failure is Not an Option: Risk-Taking is Moderated by Anxiety and Also by Cognitive Ability in Children and Adolescents Diagnosed with an Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mikle SOUTH, Auteur ; Julianne DANA, Auteur ; Sarah WHITE, Auteur ; Michael J. CROWLEY, Auteur Année de publication : 2011 Article en page(s) : p.55-65 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Anxiety Risk-taking Decision-making Amygdala Orbitofrontal cortex Index. décimale : PER Périodiques Résumé : Understanding hetereogeneity in symptom expression across the autism spectrum disorders (ASD) is a major challenge for identifying causes and effective treatments. In 40 children and adolescents diagnosed with ASD and 37 IQ—and age-matched comparison participants (the TYP group), we found no differences in summary measures on an experimental risk-taking task. However, anxiety and IQ predicted risk-taking only in the ASD group. Risk-taking was correlated with behavioral inhibition in the ASD group and behavioral activation in the TYP group. We suggest that performance on the task was motivated by fear of failure in the ASD group and by sensitivity to reward in the TYP group. Behavioral markers of anxiety and cognitive ability may improve conceptualization of heterogeneity in ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1021-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.55-65[article] Failure is Not an Option: Risk-Taking is Moderated by Anxiety and Also by Cognitive Ability in Children and Adolescents Diagnosed with an Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mikle SOUTH, Auteur ; Julianne DANA, Auteur ; Sarah WHITE, Auteur ; Michael J. CROWLEY, Auteur . - 2011 . - p.55-65.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.55-65
Mots-clés : Autism spectrum disorders Anxiety Risk-taking Decision-making Amygdala Orbitofrontal cortex Index. décimale : PER Périodiques Résumé : Understanding hetereogeneity in symptom expression across the autism spectrum disorders (ASD) is a major challenge for identifying causes and effective treatments. In 40 children and adolescents diagnosed with ASD and 37 IQ—and age-matched comparison participants (the TYP group), we found no differences in summary measures on an experimental risk-taking task. However, anxiety and IQ predicted risk-taking only in the ASD group. Risk-taking was correlated with behavioral inhibition in the ASD group and behavioral activation in the TYP group. We suggest that performance on the task was motivated by fear of failure in the ASD group and by sensitivity to reward in the TYP group. Behavioral markers of anxiety and cognitive ability may improve conceptualization of heterogeneity in ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1021-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114