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Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis / Anneli ANDERSSON in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)
[article]
Titre : Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Anneli ANDERSSON, Auteur ; Catherine TUVBLAD, Auteur ; Qi CHEN, Auteur ; Ebba DU RIETZ, Auteur ; Samuele CORTESE, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.1173-1183 Langues : Anglais (eng) Mots-clés : Adhd externalizing genetic internalizing neurodevelopmental overlap twins Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with other psychiatric disorders. Twin studies have established that these co-occurrences are in part due to shared genetic risks. However, the strength of these genetic overlaps and the potential heterogeneity accounted for by type of psychiatric symptoms, age, and methods of assessment remain unclear. We conducted a systematic review to fill this gap. METHODS: We searched PubMed, PsycINFO, Embase, and Web of Science until March 07, 2019. Genetic correlations (r(g) ) were used as effect size measures. RESULTS: A total of 31 independent studies fulfilled the inclusion criteria. The pooled estimates showed that the associations between ADHD and other psychiatric symptoms were partly explained by shared genetic factors, with a pooled genetic correlation of 0.50, 95% confidence interval: 0.46-0.60. The genetic correlations (r(g) ) between ADHD and externalizing (r(g) = .49 [0.37-0.61]), internalizing (r(g) = .50 [0.39-0.69]), and neurodevelopmental (r(g) = .56 [0.47-0.66]) symptoms were similar in magnitude. The genetic correlations in childhood and adulthood were r(g) = .53 (0.43-0.63) and r(g) = .51 (0.44-0.56), respectively. For methods of assessment, the genetic correlations were also similar in strength, self-reports r(g) = .52 (0.47-0.58), other informants r(g) = .55 (0.41-0.69), and combined raters r(g) = .50 (0.33-0.65). CONCLUSIONS: These findings indicate that the co-occurrence of externalizing, internalizing, and neurodevelopmental disorder symptoms in individuals with ADHD symptoms in part is due to a shared genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.13233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1173-1183[article] Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis [Texte imprimé et/ou numérique] / Anneli ANDERSSON, Auteur ; Catherine TUVBLAD, Auteur ; Qi CHEN, Auteur ; Ebba DU RIETZ, Auteur ; Samuele CORTESE, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Henrik LARSSON, Auteur . - p.1173-1183.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1173-1183
Mots-clés : Adhd externalizing genetic internalizing neurodevelopmental overlap twins Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with other psychiatric disorders. Twin studies have established that these co-occurrences are in part due to shared genetic risks. However, the strength of these genetic overlaps and the potential heterogeneity accounted for by type of psychiatric symptoms, age, and methods of assessment remain unclear. We conducted a systematic review to fill this gap. METHODS: We searched PubMed, PsycINFO, Embase, and Web of Science until March 07, 2019. Genetic correlations (r(g) ) were used as effect size measures. RESULTS: A total of 31 independent studies fulfilled the inclusion criteria. The pooled estimates showed that the associations between ADHD and other psychiatric symptoms were partly explained by shared genetic factors, with a pooled genetic correlation of 0.50, 95% confidence interval: 0.46-0.60. The genetic correlations (r(g) ) between ADHD and externalizing (r(g) = .49 [0.37-0.61]), internalizing (r(g) = .50 [0.39-0.69]), and neurodevelopmental (r(g) = .56 [0.47-0.66]) symptoms were similar in magnitude. The genetic correlations in childhood and adulthood were r(g) = .53 (0.43-0.63) and r(g) = .51 (0.44-0.56), respectively. For methods of assessment, the genetic correlations were also similar in strength, self-reports r(g) = .52 (0.47-0.58), other informants r(g) = .55 (0.41-0.69), and combined raters r(g) = .50 (0.33-0.65). CONCLUSIONS: These findings indicate that the co-occurrence of externalizing, internalizing, and neurodevelopmental disorder symptoms in individuals with ADHD symptoms in part is due to a shared genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.13233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 Characteristics of autism spectrum disorder in anorexia nervosa: A naturalistic study in an inpatient treatment programme / K. TCHANTURIA in Autism, 23-1 (January 2019)
[article]
Titre : Characteristics of autism spectrum disorder in anorexia nervosa: A naturalistic study in an inpatient treatment programme Type de document : Texte imprimé et/ou numérique Auteurs : K. TCHANTURIA, Auteur ; J. ADAMSON, Auteur ; J. LEPPANEN, Auteur ; H. WESTWOOD, Auteur Article en page(s) : p.123-130 Langues : Anglais (eng) Mots-clés : anorexia nervosa autism spectrum disorder Autism Spectrum Quotient short version eating disorder eating-disorders cognitive remediation anxiety disorders social-adjustment traits quotient work comorbidity impairment overlap Psychology Index. décimale : PER Périodiques Résumé : Previous research has demonstrated links between anorexia nervosa and autism spectrum disorder however, few studies have examined the possible impact of symptoms of autism spectrum disorder on clinical outcomes in anorexia nervosa. The aim of this study was to examine the association between symptoms of autism spectrum disorder and eating disorders, and other psychopathology during the course of inpatient treatment in individuals with anorexia nervosa. Participants with anorexia nervosa (n = 171) completed questionnaires exploring eating disorder psychopathology, symptoms of depression and anxiety, and everyday functioning at both admission and discharge. Characteristics associated with autism spectrum disorder were assessed using the Autism Spectrum Quotient, short version. Autism spectrum disorder symptoms were significantly positively correlated with eating disorder psychopathology, work and social functioning, and symptoms of depression and anxiety, but not with body mass index. Autism Spectrum Quotient, short version scores remained relatively stable from admission to discharge but there was a small, significant reduction in scores. There was no interaction between time and Autism Spectrum Quotient, short version scores on clinical symptom change. In anorexia nervosa, autism spectrum disorder symptoms appear to be associated with a more severe clinical presentation on admission to inpatient care. Autism spectrum disorder symptoms as assessed by self-report measures may be exacerbated by other mental health psychopathology, which warrants further investigation. En ligne : http://dx.doi.org/10.1177/1362361317722431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379
in Autism > 23-1 (January 2019) . - p.123-130[article] Characteristics of autism spectrum disorder in anorexia nervosa: A naturalistic study in an inpatient treatment programme [Texte imprimé et/ou numérique] / K. TCHANTURIA, Auteur ; J. ADAMSON, Auteur ; J. LEPPANEN, Auteur ; H. WESTWOOD, Auteur . - p.123-130.
Langues : Anglais (eng)
in Autism > 23-1 (January 2019) . - p.123-130
Mots-clés : anorexia nervosa autism spectrum disorder Autism Spectrum Quotient short version eating disorder eating-disorders cognitive remediation anxiety disorders social-adjustment traits quotient work comorbidity impairment overlap Psychology Index. décimale : PER Périodiques Résumé : Previous research has demonstrated links between anorexia nervosa and autism spectrum disorder however, few studies have examined the possible impact of symptoms of autism spectrum disorder on clinical outcomes in anorexia nervosa. The aim of this study was to examine the association between symptoms of autism spectrum disorder and eating disorders, and other psychopathology during the course of inpatient treatment in individuals with anorexia nervosa. Participants with anorexia nervosa (n = 171) completed questionnaires exploring eating disorder psychopathology, symptoms of depression and anxiety, and everyday functioning at both admission and discharge. Characteristics associated with autism spectrum disorder were assessed using the Autism Spectrum Quotient, short version. Autism spectrum disorder symptoms were significantly positively correlated with eating disorder psychopathology, work and social functioning, and symptoms of depression and anxiety, but not with body mass index. Autism Spectrum Quotient, short version scores remained relatively stable from admission to discharge but there was a small, significant reduction in scores. There was no interaction between time and Autism Spectrum Quotient, short version scores on clinical symptom change. In anorexia nervosa, autism spectrum disorder symptoms appear to be associated with a more severe clinical presentation on admission to inpatient care. Autism spectrum disorder symptoms as assessed by self-report measures may be exacerbated by other mental health psychopathology, which warrants further investigation. En ligne : http://dx.doi.org/10.1177/1362361317722431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379