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Prenatal and perinatal risk factors and the clinical implications on autism spectrum disorder / Yi-Ling CHIEN in Autism, 23-3 (April 2019)
[article]
Titre : Prenatal and perinatal risk factors and the clinical implications on autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yi-Ling CHIEN, Auteur ; Miao-Churn CHOU, Auteur ; W. J. CHOU, Auteur ; Y. Y. WU, Auteur ; W. C. TSAI, Auteur ; Yen-Nan CHIU, Auteur ; S. S. GAU, Auteur Article en page(s) : p.783-791 Langues : Anglais (eng) Mots-clés : autism spectrum disorder perinatal prenatal sibling symptom Index. décimale : PER Périodiques Résumé : Prenatal and perinatal factors may increase the risk of autism spectrum disorder. However, little is known about whether unaffected siblings of probands with autism spectrum disorder also share the phenomenon and whether the prenatal/perinatal factors are related to the clinical severity of autistic symptoms. We compared the frequency of prenatal and perinatal factors among 323 probands with autism spectrum disorder (mean age +/- standard deviation, 10.7 +/- 3.5 years; males, 91.0%), 257 unaffected siblings (11.7 +/- 4.5; 42.8%), and 1504 typically developing controls (8.9 +/- 1.6 years; 53.1%); and investigated their effects on the severity of autistic symptoms. We found that probands with autism spectrum disorder and their unaffected siblings had more prenatal/perinatal events than typically developing controls with higher numbers of prenatal/perinatal factors in probands than in unaffected siblings. The prenatal/perinatal events were associated with greater stereotyped behaviors, social-emotional problems, socio-communication deficits, and overall severity. We also found that six prenatal/perinatal factors (i.e. preeclampsia, polyhydramnios, oligoamnios, placenta previa, umbilical cord knot, and gestational diabetes) were associated with the severity of autistic symptoms, particularly stereotyped behaviors and socio-communication deficits. Our findings suggest that prenatal and perinatal factors may potentially moderate the clinical expression of autism spectrum disorder. The underlying mechanism warrants further research. En ligne : http://dx.doi.org/10.1177/1362361318772813 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392
in Autism > 23-3 (April 2019) . - p.783-791[article] Prenatal and perinatal risk factors and the clinical implications on autism spectrum disorder [Texte imprimé et/ou numérique] / Yi-Ling CHIEN, Auteur ; Miao-Churn CHOU, Auteur ; W. J. CHOU, Auteur ; Y. Y. WU, Auteur ; W. C. TSAI, Auteur ; Yen-Nan CHIU, Auteur ; S. S. GAU, Auteur . - p.783-791.
Langues : Anglais (eng)
in Autism > 23-3 (April 2019) . - p.783-791
Mots-clés : autism spectrum disorder perinatal prenatal sibling symptom Index. décimale : PER Périodiques Résumé : Prenatal and perinatal factors may increase the risk of autism spectrum disorder. However, little is known about whether unaffected siblings of probands with autism spectrum disorder also share the phenomenon and whether the prenatal/perinatal factors are related to the clinical severity of autistic symptoms. We compared the frequency of prenatal and perinatal factors among 323 probands with autism spectrum disorder (mean age +/- standard deviation, 10.7 +/- 3.5 years; males, 91.0%), 257 unaffected siblings (11.7 +/- 4.5; 42.8%), and 1504 typically developing controls (8.9 +/- 1.6 years; 53.1%); and investigated their effects on the severity of autistic symptoms. We found that probands with autism spectrum disorder and their unaffected siblings had more prenatal/perinatal events than typically developing controls with higher numbers of prenatal/perinatal factors in probands than in unaffected siblings. The prenatal/perinatal events were associated with greater stereotyped behaviors, social-emotional problems, socio-communication deficits, and overall severity. We also found that six prenatal/perinatal factors (i.e. preeclampsia, polyhydramnios, oligoamnios, placenta previa, umbilical cord knot, and gestational diabetes) were associated with the severity of autistic symptoms, particularly stereotyped behaviors and socio-communication deficits. Our findings suggest that prenatal and perinatal factors may potentially moderate the clinical expression of autism spectrum disorder. The underlying mechanism warrants further research. En ligne : http://dx.doi.org/10.1177/1362361318772813 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392 Prenatal maternal infection and risk for autism in offspring: A meta-analysis / N. TIOLECO in Autism Research, 14-6 (June 2021)
[article]
Titre : Prenatal maternal infection and risk for autism in offspring: A meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : N. TIOLECO, Auteur ; A. E. SILBERMAN, Auteur ; K. STRATIGOS, Auteur ; Sharmila BANERJEE-BASU, Auteur ; M. N. SPANN, Auteur ; A. H. WHITAKER, Auteur ; J. Blake TURNER, Auteur Article en page(s) : p.1296-1316 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder/epidemiology Causality Female Humans Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects/epidemiology Risk Factors autism infections pregnancy prenatal risk factors Index. décimale : PER Périodiques Résumé : While prenatal maternal infection has received attention as a preventable and treatable risk factor for autism, findings have been inconsistent. This paper presents the results of a meta-analysis to determine whether the weight of the evidence supports such an association. Studies with a categorical diagnosis of autism as the outcome and an assessment of its association with prenatal maternal infection or fever (or the data necessary to compute this association) were included. A total of 36 studies met these criteria. Two independent reviewers extracted data on study design, methods of assessment, type of infectious agent, site of infection, trimester of exposure, definition of autism, and effect size. Analyses demonstrated a statistically significant association of maternal infection/fever with autism in offspring (OR = 1.32; 95% CI = 1.20-1.46). Adjustment for evident publication bias slightly weakened this association. There was little variation in effect sizes across agent or site of infection. Small differences across trimester of exposure were not statistically significant. There was some evidence that recall bias associated with status on the outcome variable leads to differential misclassification of exposure status. Nonetheless, the overall association is only modestly reduced when studies potentially contaminated by such bias are removed. Although causality has not been firmly established, these findings suggest maternal infection during pregnancy confers an increase in risk for autism in offspring. Given the prevalence of this risk factor, it is possible that the incidence of autism would be reduced by 12%-17% if maternal infections could be prevented or safely treated in a timely manner. LAY SUMMARY: This study is a meta-analysis of the association of maternal infection during pregnancy and subsequent autism in offspring. In combining the results from 36 studies of this association we find that a significant relationship is present. The association does not vary much across the types of infections or when they occur during pregnancy. We conclude that the incidence of autism could be substantially reduced if maternal infections could be prevented or safely treated in a timely manner. En ligne : http://dx.doi.org/10.1002/aur.2499 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-6 (June 2021) . - p.1296-1316[article] Prenatal maternal infection and risk for autism in offspring: A meta-analysis [Texte imprimé et/ou numérique] / N. TIOLECO, Auteur ; A. E. SILBERMAN, Auteur ; K. STRATIGOS, Auteur ; Sharmila BANERJEE-BASU, Auteur ; M. N. SPANN, Auteur ; A. H. WHITAKER, Auteur ; J. Blake TURNER, Auteur . - p.1296-1316.
Langues : Anglais (eng)
in Autism Research > 14-6 (June 2021) . - p.1296-1316
Mots-clés : Autism Spectrum Disorder Autistic Disorder/epidemiology Causality Female Humans Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects/epidemiology Risk Factors autism infections pregnancy prenatal risk factors Index. décimale : PER Périodiques Résumé : While prenatal maternal infection has received attention as a preventable and treatable risk factor for autism, findings have been inconsistent. This paper presents the results of a meta-analysis to determine whether the weight of the evidence supports such an association. Studies with a categorical diagnosis of autism as the outcome and an assessment of its association with prenatal maternal infection or fever (or the data necessary to compute this association) were included. A total of 36 studies met these criteria. Two independent reviewers extracted data on study design, methods of assessment, type of infectious agent, site of infection, trimester of exposure, definition of autism, and effect size. Analyses demonstrated a statistically significant association of maternal infection/fever with autism in offspring (OR = 1.32; 95% CI = 1.20-1.46). Adjustment for evident publication bias slightly weakened this association. There was little variation in effect sizes across agent or site of infection. Small differences across trimester of exposure were not statistically significant. There was some evidence that recall bias associated with status on the outcome variable leads to differential misclassification of exposure status. Nonetheless, the overall association is only modestly reduced when studies potentially contaminated by such bias are removed. Although causality has not been firmly established, these findings suggest maternal infection during pregnancy confers an increase in risk for autism in offspring. Given the prevalence of this risk factor, it is possible that the incidence of autism would be reduced by 12%-17% if maternal infections could be prevented or safely treated in a timely manner. LAY SUMMARY: This study is a meta-analysis of the association of maternal infection during pregnancy and subsequent autism in offspring. In combining the results from 36 studies of this association we find that a significant relationship is present. The association does not vary much across the types of infections or when they occur during pregnancy. We conclude that the incidence of autism could be substantially reduced if maternal infections could be prevented or safely treated in a timely manner. En ligne : http://dx.doi.org/10.1002/aur.2499 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Prenatal and Perinatal Risk Factors for Autism in China / Xin ZHANG in Journal of Autism and Developmental Disorders, 40-11 (November 2010)
[article]
Titre : Prenatal and Perinatal Risk Factors for Autism in China Type de document : Texte imprimé et/ou numérique Auteurs : Xin ZHANG, Auteur ; Cong-Chao LV, Auteur ; Jiang TIAN, Auteur ; Ru-Juan MIAO, Auteur ; Wei XI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lihong QI, Auteur Année de publication : 2010 Article en page(s) : p.1311-1321 Langues : Anglais (eng) Mots-clés : Autism China Prenatal Perinatal Risk factors Index. décimale : PER Périodiques Résumé : We conducted a case–control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (<35 or >42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old). En ligne : http://dx.doi.org/10.1007/s10803-010-0992-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113
in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1311-1321[article] Prenatal and Perinatal Risk Factors for Autism in China [Texte imprimé et/ou numérique] / Xin ZHANG, Auteur ; Cong-Chao LV, Auteur ; Jiang TIAN, Auteur ; Ru-Juan MIAO, Auteur ; Wei XI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lihong QI, Auteur . - 2010 . - p.1311-1321.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1311-1321
Mots-clés : Autism China Prenatal Perinatal Risk factors Index. décimale : PER Périodiques Résumé : We conducted a case–control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (<35 or >42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old). En ligne : http://dx.doi.org/10.1007/s10803-010-0992-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113 Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model / Vanessa BABINEAU in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)
[article]
Titre : Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa BABINEAU, Auteur ; Cathryn Gordon GREEN, Auteur ; Alexis JOLICOEUR-MARTINEAU, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Klaus MINDE, Auteur ; Roberto SASSI, Auteur ; Martin ST-ANDRÉ, Auteur ; Normand J. CARREY, Auteur ; Leslie ATKINSON, Auteur ; James L. KENNEDY, Auteur ; John LYDON, Auteur ; Meir STEINER, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Michael MEANEY, Auteur ; Ashley WAZANA, Auteur ; THE MAVAN PROJECT,, Auteur Article en page(s) : p.21-29 Langues : Anglais (eng) Mots-clés : Child development emotional dysregulation gene–environment interaction (GxE) longitudinal studies maternal depression Prenatal Index. décimale : PER Périodiques Résumé : Background Childhood dysregulation, which reflects deficits in the capacity to regulate or control one's thoughts, emotions and behaviours, is associated with psychopathology throughout childhood and into adulthood. Exposures to adversity during the prenatal period, including prenatal depression, can influence the development of dysregulation, and a number of candidate genes have been suggested as moderators of prenatal exposure, including polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). We examined whether prenatal depression and child 5-HTTLPR interact to predict childhood dysregulation. Method Sample of N = 213 mother–child pairs from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. Mothers reported the IBQ-R at 3 and 6 months, and the ECBQ at 18 and 36 months, from which measures of dysregulation were extracted. Mothers' self-reported symptoms of depression on the CES-D at 24–36 weeks of gestation, and at 6, 12, 24 and 36 months postnatal. 5-HTTLPR genotype was extracted from buccal swabs. Mixed-model and confirmatory analyses were conducted. Results Prenatal depression and 5-HTTLPR interacted to predict dysregulation from 3 to 36 months, within a model of strong differential susceptibility. Conclusion Children with S or LG alleles, when exposed to prenatal depression, have higher levels of dysregulation, and when exposed to lower or little prenatal depression, have higher capacity for regulation. Our findings support efforts to identify, support and treat prenatal depression. En ligne : http://dx.doi.org/10.1111/jcpp.12246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.21-29[article] Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model [Texte imprimé et/ou numérique] / Vanessa BABINEAU, Auteur ; Cathryn Gordon GREEN, Auteur ; Alexis JOLICOEUR-MARTINEAU, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Klaus MINDE, Auteur ; Roberto SASSI, Auteur ; Martin ST-ANDRÉ, Auteur ; Normand J. CARREY, Auteur ; Leslie ATKINSON, Auteur ; James L. KENNEDY, Auteur ; John LYDON, Auteur ; Meir STEINER, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Michael MEANEY, Auteur ; Ashley WAZANA, Auteur ; THE MAVAN PROJECT,, Auteur . - p.21-29.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.21-29
Mots-clés : Child development emotional dysregulation gene–environment interaction (GxE) longitudinal studies maternal depression Prenatal Index. décimale : PER Périodiques Résumé : Background Childhood dysregulation, which reflects deficits in the capacity to regulate or control one's thoughts, emotions and behaviours, is associated with psychopathology throughout childhood and into adulthood. Exposures to adversity during the prenatal period, including prenatal depression, can influence the development of dysregulation, and a number of candidate genes have been suggested as moderators of prenatal exposure, including polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). We examined whether prenatal depression and child 5-HTTLPR interact to predict childhood dysregulation. Method Sample of N = 213 mother–child pairs from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. Mothers reported the IBQ-R at 3 and 6 months, and the ECBQ at 18 and 36 months, from which measures of dysregulation were extracted. Mothers' self-reported symptoms of depression on the CES-D at 24–36 weeks of gestation, and at 6, 12, 24 and 36 months postnatal. 5-HTTLPR genotype was extracted from buccal swabs. Mixed-model and confirmatory analyses were conducted. Results Prenatal depression and 5-HTTLPR interacted to predict dysregulation from 3 to 36 months, within a model of strong differential susceptibility. Conclusion Children with S or LG alleles, when exposed to prenatal depression, have higher levels of dysregulation, and when exposed to lower or little prenatal depression, have higher capacity for regulation. Our findings support efforts to identify, support and treat prenatal depression. En ligne : http://dx.doi.org/10.1111/jcpp.12246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity / Ran LIU in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)
[article]
Titre : Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity Type de document : Texte imprimé et/ou numérique Auteurs : Ran LIU, Auteur ; David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Nathan A. FOX, Auteur ; Amy E. MARGOLIS, Auteur Article en page(s) : p.1037-1044 Langues : Anglais (eng) Mots-clés : Air pollution polycyclic aromatic hydrocarbons prenatal internalizing problems shyness anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Prenatal exposure to air pollution increases the risk for psychiatric disorders characterized by internalizing problems. In this study, we examined the roles of shyness and anterior cingulate cortex (ACC) activity in the association between prenatal exposure to polycyclic aromatic hydrocarbons (PAH) and children's internalizing problems at 79years old. Methods Participants include 53 children (31 girls, 22 boys). Personal air monitoring was conducted over 48 continuous hours during the third trimester of pregnancy to measure 8 PAHs. Mothers reported children's shyness (Emotionality Activity Sociability Temperament Survey) at age 5 and internalizing problems (Child Behavior Checklist) at ages 79. ACC activity was measured by fMRI during the Simon Spatial Incompatibility task at ages 79. Results Shyness mediated the association between prenatal PAH exposure and internalizing problems. Higher prenatal PAH exposure predicted increased shyness, which in turn predicted greater internalizing problems. Moreover, left ACC activity during the Simon task moderated the association between prenatal PAH exposure and internalizing problems. Prenatal PAH exposure predicted increased risk for internalizing problems only when children showed heightened left ACC activity during the resolution of cognitive conflict. Conclusions Our study innovatively synthesizes the fields of developmental psychology and environmental health science to offer new insights into the risk factors for anxiety disorders. Facilitating the development of healthy reactive and regulatory processes may improve the developmental outcomes for children highly exposed to air pollution. En ligne : https://doi.org/10.1111/jcpp.13768 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1037-1044[article] Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity [Texte imprimé et/ou numérique] / Ran LIU, Auteur ; David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Nathan A. FOX, Auteur ; Amy E. MARGOLIS, Auteur . - p.1037-1044.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.1037-1044
Mots-clés : Air pollution polycyclic aromatic hydrocarbons prenatal internalizing problems shyness anterior cingulate cortex Index. décimale : PER Périodiques Résumé : Background Prenatal exposure to air pollution increases the risk for psychiatric disorders characterized by internalizing problems. In this study, we examined the roles of shyness and anterior cingulate cortex (ACC) activity in the association between prenatal exposure to polycyclic aromatic hydrocarbons (PAH) and children's internalizing problems at 79years old. Methods Participants include 53 children (31 girls, 22 boys). Personal air monitoring was conducted over 48 continuous hours during the third trimester of pregnancy to measure 8 PAHs. Mothers reported children's shyness (Emotionality Activity Sociability Temperament Survey) at age 5 and internalizing problems (Child Behavior Checklist) at ages 79. ACC activity was measured by fMRI during the Simon Spatial Incompatibility task at ages 79. Results Shyness mediated the association between prenatal PAH exposure and internalizing problems. Higher prenatal PAH exposure predicted increased shyness, which in turn predicted greater internalizing problems. Moreover, left ACC activity during the Simon task moderated the association between prenatal PAH exposure and internalizing problems. Prenatal PAH exposure predicted increased risk for internalizing problems only when children showed heightened left ACC activity during the resolution of cognitive conflict. Conclusions Our study innovatively synthesizes the fields of developmental psychology and environmental health science to offer new insights into the risk factors for anxiety disorders. Facilitating the development of healthy reactive and regulatory processes may improve the developmental outcomes for children highly exposed to air pollution. En ligne : https://doi.org/10.1111/jcpp.13768 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 Prenatal family adversity and maternal mental health and vulnerability to peer victimisation at school / Suzet Tanya LEREYA in Journal of Child Psychology and Psychiatry, 54-6 (June 2013)
PermalinkPrenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression / X. LIU in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
PermalinkPrenatal maternal stress events and phenotypic outcomes in Autism Spectrum Disorder / Kandice J. VARCIN in Autism Research, 10-11 (November 2017)
PermalinkPrenatal maternal stress programs infant stress regulation / Elysia POGGI DAVIS in Journal of Child Psychology and Psychiatry, 52-2 (February 2011)
PermalinkPrenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex / Mengyu GAO in Development and Psychopathology, 33-5 (December 2021)
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