12 recherche sur le mot-clé 'randomised controlled trial'

Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA) / Stavros STIVAROS in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 12 p. Titre : Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA) Type de document : texte imprimé Auteurs : Stavros STIVAROS, Auteur ; Shruti GARG, Auteur ; Maria TZIRAKI, Auteur ; Ying CAI, Auteur ; Owen THOMAS, Auteur ; Joseph MELLOR, Auteur ; Andrew A. MORRIS, Auteur ; Carly JIM, Auteur ; Karolina SZUMANSKA-RYT, Auteur ; Laura M. PARKES, Auteur ; Hamied A. HAROON, Auteur ; Daniela MONTALDI, Auteur ; Nicholas WEBB, Auteur ; John KEANE, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Alcino J. SILVA, Auteur ; Sue HUSON, Auteur ; Simon WILLIAMS, Auteur ; D. GARETH EVANS, Auteur ; Richard EMSLEY, Auteur ; Jonathan GREEN, Auteur Article en page(s) : 12 p. Langues : Anglais (eng) Mots-clés : Autism  Neurofibromatosis type 1  Neuroimaging  Randomised controlled trial  Simvastatin  Statin Index. décimale : PER Périodiques Résumé : Background: Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects for the first time in younger children with NF1 and co-morbid autism and by using multiparametric imaging outcomes. Methods: A single-site triple-blind RCT of simvastatin vs. placebo was done. Assessment (baseline and 12-week endpoint) included peripheral MAPK assay, awake magnetic resonance imaging spectroscopy (MRS; GABA and glutamate+glutamine (Glx)), arterial spin labelling (ASL), apparent diffusion coefficient (ADC), resting state functional MRI, and autism behavioural outcomes (Aberrant Behaviour Checklist and Clinical Global Impression). Results: Thirty subjects had a mean age of 8.1 years (SD 1.8). Simvastatin was well tolerated. The amount of imaging data varied by test. Simvastatin treatment was associated with (i) increased frontal white matter MRS GABA (t(12) = - 2.12, p = .055), GABA/Glx ratio (t(12) = - 2.78, p = .016), and reduced grey nuclei Glx (ANCOVA p < 0.05, Mann-Whitney p < 0.01); (ii) increased ASL perfusion in ventral diencephalon (Mann-Whitney p < 0.01); and (iii) decreased ADC in cingulate gyrus (Mann-Whitney p < 0.01). Machine-learning classification of imaging outcomes achieved 79% (p < .05) accuracy differentiating groups at endpoint against chance level (64%, p = 0.25) at baseline. Three of 12 (25%) simvastatin cases compared to none in placebo met 'clinical responder' criteria for behavioural outcome. Conclusions: We show feasibility of peripheral MAPK assay and autism symptom measurement, but the study was not powered to test effectiveness. Multiparametric imaging suggests possible simvastatin effects in brain areas previously associated with NF1 pathophysiology and the social brain network. Trial registration: EU Clinical Trial Register (EudraCT) 2012-005742-38 (www.clinicaltrialsregister.eu). En ligne : http://dx.doi.org/10.1186/s13229-018-0190-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA) [texte imprimé] / Stavros STIVAROS, Auteur ; Shruti GARG, Auteur ; Maria TZIRAKI, Auteur ; Ying CAI, Auteur ; Owen THOMAS, Auteur ; Joseph MELLOR, Auteur ; Andrew A. MORRIS, Auteur ; Carly JIM, Auteur ; Karolina SZUMANSKA-RYT, Auteur ; Laura M. PARKES, Auteur ; Hamied A. HAROON, Auteur ; Daniela MONTALDI, Auteur ; Nicholas WEBB, Auteur ; John KEANE, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Alcino J. SILVA, Auteur ; Sue HUSON, Auteur ; Simon WILLIAMS, Auteur ; D. GARETH EVANS, Auteur ; Richard EMSLEY, Auteur ; Jonathan GREEN, Auteur . - 12 p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 12 p. Mots-clés : Autism  Neurofibromatosis type 1  Neuroimaging  Randomised controlled trial  Simvastatin  Statin Index. décimale : PER Périodiques Résumé : Background: Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects for the first time in younger children with NF1 and co-morbid autism and by using multiparametric imaging outcomes. Methods: A single-site triple-blind RCT of simvastatin vs. placebo was done. Assessment (baseline and 12-week endpoint) included peripheral MAPK assay, awake magnetic resonance imaging spectroscopy (MRS; GABA and glutamate+glutamine (Glx)), arterial spin labelling (ASL), apparent diffusion coefficient (ADC), resting state functional MRI, and autism behavioural outcomes (Aberrant Behaviour Checklist and Clinical Global Impression). Results: Thirty subjects had a mean age of 8.1 years (SD 1.8). Simvastatin was well tolerated. The amount of imaging data varied by test. Simvastatin treatment was associated with (i) increased frontal white matter MRS GABA (t(12) = - 2.12, p = .055), GABA/Glx ratio (t(12) = - 2.78, p = .016), and reduced grey nuclei Glx (ANCOVA p < 0.05, Mann-Whitney p < 0.01); (ii) increased ASL perfusion in ventral diencephalon (Mann-Whitney p < 0.01); and (iii) decreased ADC in cingulate gyrus (Mann-Whitney p < 0.01). Machine-learning classification of imaging outcomes achieved 79% (p < .05) accuracy differentiating groups at endpoint against chance level (64%, p = 0.25) at baseline. Three of 12 (25%) simvastatin cases compared to none in placebo met 'clinical responder' criteria for behavioural outcome. Conclusions: We show feasibility of peripheral MAPK assay and autism symptom measurement, but the study was not powered to test effectiveness. Multiparametric imaging suggests possible simvastatin effects in brain areas previously associated with NF1 pathophysiology and the social brain network. Trial registration: EU Clinical Trial Register (EudraCT) 2012-005742-38 (www.clinicaltrialsregister.eu). En ligne : http://dx.doi.org/10.1186/s13229-018-0190-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

Cognitive Behaviour Therapy Versus a Counselling Intervention for Anxiety in Young People with High-Functioning Autism Spectrum Disorders: A Pilot Randomised Controlled Trial / Suzanne MURPHY in Journal of Autism and Developmental Disorders, 47-11 (November 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3446-3457 Titre : Cognitive Behaviour Therapy Versus a Counselling Intervention for Anxiety in Young People with High-Functioning Autism Spectrum Disorders: A Pilot Randomised Controlled Trial Type de document : texte imprimé Auteurs : Suzanne MURPHY, Auteur ; Uttom CHOWDHURY, Auteur ; Susan W. WHITE, Auteur ; Laura REYNOLDS, Auteur ; Louisa DONALD, Auteur ; Hilary GAHAN, Auteur ; Zeinab IQBAL, Auteur ; Mahesh KULKARNI, Auteur ; Louise SCRIVENER, Auteur ; Hadi SHAKER-NAEENI, Auteur ; Dee A. PRESS, Auteur Article en page(s) : p.3446-3457 Langues : Anglais (eng) Mots-clés : Adolescent  Anxiety  Autism spectrum disorder  Cognitive behavioural therapy  Counselling  Randomised controlled trial Index. décimale : PER Périodiques Résumé : The use of cognitive-behavioural therapy (CBT) as a treatment for children and adolescents with autism spectrum disorder (ASD) has been explored in a number of trials. Whilst CBT appears superior to no treatment or treatment as usual, few studies have assessed CBT against a control group receiving an alternative therapy. Our randomised controlled trial compared use of CBT against person-centred counselling for anxiety in 36 young people with ASD, ages 12-18. Outcome measures included parent- teacher- and self-reports of anxiety and social disability. Whilst each therapy produced improvements in participants, neither therapy was superior to the other to a significant degree on any measure. This is consistent with findings for adults. En ligne : http://dx.doi.org/10.1007/s10803-017-3252-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Cognitive Behaviour Therapy Versus a Counselling Intervention for Anxiety in Young People with High-Functioning Autism Spectrum Disorders: A Pilot Randomised Controlled Trial [texte imprimé] / Suzanne MURPHY, Auteur ; Uttom CHOWDHURY, Auteur ; Susan W. WHITE, Auteur ; Laura REYNOLDS, Auteur ; Louisa DONALD, Auteur ; Hilary GAHAN, Auteur ; Zeinab IQBAL, Auteur ; Mahesh KULKARNI, Auteur ; Louise SCRIVENER, Auteur ; Hadi SHAKER-NAEENI, Auteur ; Dee A. PRESS, Auteur . - p.3446-3457. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3446-3457 Mots-clés : Adolescent  Anxiety  Autism spectrum disorder  Cognitive behavioural therapy  Counselling  Randomised controlled trial Index. décimale : PER Périodiques Résumé : The use of cognitive-behavioural therapy (CBT) as a treatment for children and adolescents with autism spectrum disorder (ASD) has been explored in a number of trials. Whilst CBT appears superior to no treatment or treatment as usual, few studies have assessed CBT against a control group receiving an alternative therapy. Our randomised controlled trial compared use of CBT against person-centred counselling for anxiety in 36 young people with ASD, ages 12-18. Outcome measures included parent- teacher- and self-reports of anxiety and social disability. Whilst each therapy produced improvements in participants, neither therapy was superior to the other to a significant degree on any measure. This is consistent with findings for adults. En ligne : http://dx.doi.org/10.1007/s10803-017-3252-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Early-stage randomised controlled trial of therapist-supported online cognitive therapy for post-traumatic stress disorder in young people / Patrick SMITH in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1117-1128 Titre : Early-stage randomised controlled trial of therapist-supported online cognitive therapy for post-traumatic stress disorder in young people Type de document : texte imprimé Auteurs : Patrick SMITH, Auteur ; Anke EHLERS, Auteur ; Ewan CARR, Auteur ; David M. CLARK, Auteur ; Tim DALGLEISH, Auteur ; Gordon FORBES, Auteur ; Kimberley GOLDSMITH, Auteur ; Helena GRIFFITHS, Auteur ; Monica GUPTA, Auteur ; Dorothy KING, Auteur ; Sarah MILES, Auteur ; Dominic T. PLANT, Auteur ; Anne SMITH, Auteur ; Jess STEWARD, Auteur ; William YULE, Auteur ; Richard MEISER-STEDMAN, Auteur Article en page(s) : p.1117-1128 Langues : Anglais (eng) Mots-clés : Post-traumatic stress disorder  adolescence  cognitive therapy  E-health  Randomised Controlled Trial Index. décimale : PER Périodiques Résumé : Background Effective face-to-face treatments for Post-Traumatic Stress Disorder (PTSD) are available, but most young people with PTSD do not receive effective treatment. Therapist-supported online Cognitive Therapy has the potential to improve accessibility of effective treatment. This early-stage trial gathered data on the feasibility, acceptability, and initial signal of clinical efficacy of a novel online Cognitive Therapy program for young people with PTSD. Methods A two-arm, parallel-groups, single-blind, early-stage feasibility RCT compared online Cognitive Therapy to a waitlList condition. Participants were N 31 adolescents (12 17 years-old) with a diagnosis of PTSD, randomised in a 1:1 ratio using minimisation. Thresholds for progression to a larger trial were set a priori for recruitment rate, data completeness, and the initial signal of clinical efficacy. The primary clinical outcome was PTSD diagnosis at 16 weeks post-randomisation. Secondary clinical outcomes were continuous measures of PTSD, depression, and anxiety at 16 weeks; and at 38 weeks in the online Cognitive Therapy arm. Results All pre-determined feasibility thresholds for progression to a larger trial were met. We recruited to target at a rate of 1 2 participants/month. No patient dropped out of therapy; 94% of all participants were retained at 16 weeks. At 16-weeks, the intention-to-treat (ITT) effect adjusted odds ratio was 0.20 (95% CI, 0.02, 1.42), indicating that the odds of meeting PTSD caseness after online therapy were 80% lower than after the waitlist (10/16 participants met PTSD caseness after therapy compared to 11/13 after WL). Effect-size estimates for all secondary clinical outcomes were large-moderate; improvements were sustained 38 weeks after online Cognitive Therapy. Conclusions Therapist-supported online Cognitive Therapy for PTSD is acceptable to young people and has potential for meaningful and sustained clinical effects. A larger trial appears feasible to deliver. Further work is needed to refine the intervention and its delivery and to evaluate it in a larger confirmatory trial. En ligne : https://doi.org/10.1111/jcpp.14124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] Early-stage randomised controlled trial of therapist-supported online cognitive therapy for post-traumatic stress disorder in young people [texte imprimé] / Patrick SMITH, Auteur ; Anke EHLERS, Auteur ; Ewan CARR, Auteur ; David M. CLARK, Auteur ; Tim DALGLEISH, Auteur ; Gordon FORBES, Auteur ; Kimberley GOLDSMITH, Auteur ; Helena GRIFFITHS, Auteur ; Monica GUPTA, Auteur ; Dorothy KING, Auteur ; Sarah MILES, Auteur ; Dominic T. PLANT, Auteur ; Anne SMITH, Auteur ; Jess STEWARD, Auteur ; William YULE, Auteur ; Richard MEISER-STEDMAN, Auteur . - p.1117-1128. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1117-1128 Mots-clés : Post-traumatic stress disorder  adolescence  cognitive therapy  E-health  Randomised Controlled Trial Index. décimale : PER Périodiques Résumé : Background Effective face-to-face treatments for Post-Traumatic Stress Disorder (PTSD) are available, but most young people with PTSD do not receive effective treatment. Therapist-supported online Cognitive Therapy has the potential to improve accessibility of effective treatment. This early-stage trial gathered data on the feasibility, acceptability, and initial signal of clinical efficacy of a novel online Cognitive Therapy program for young people with PTSD. Methods A two-arm, parallel-groups, single-blind, early-stage feasibility RCT compared online Cognitive Therapy to a waitlList condition. Participants were N 31 adolescents (12 17 years-old) with a diagnosis of PTSD, randomised in a 1:1 ratio using minimisation. Thresholds for progression to a larger trial were set a priori for recruitment rate, data completeness, and the initial signal of clinical efficacy. The primary clinical outcome was PTSD diagnosis at 16 weeks post-randomisation. Secondary clinical outcomes were continuous measures of PTSD, depression, and anxiety at 16 weeks; and at 38 weeks in the online Cognitive Therapy arm. Results All pre-determined feasibility thresholds for progression to a larger trial were met. We recruited to target at a rate of 1 2 participants/month. No patient dropped out of therapy; 94% of all participants were retained at 16 weeks. At 16-weeks, the intention-to-treat (ITT) effect adjusted odds ratio was 0.20 (95% CI, 0.02, 1.42), indicating that the odds of meeting PTSD caseness after online therapy were 80% lower than after the waitlist (10/16 participants met PTSD caseness after therapy compared to 11/13 after WL). Effect-size estimates for all secondary clinical outcomes were large-moderate; improvements were sustained 38 weeks after online Cognitive Therapy. Conclusions Therapist-supported online Cognitive Therapy for PTSD is acceptable to young people and has potential for meaningful and sustained clinical effects. A larger trial appears feasible to deliver. Further work is needed to refine the intervention and its delivery and to evaluate it in a larger confirmatory trial. En ligne : https://doi.org/10.1111/jcpp.14124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

Evaluation of a parent-delivered early language enrichment programme: evidence from a randomised controlled trial / Kelly BURGOYNE in Journal of Child Psychology and Psychiatry, 59-5 (May 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-5 (May 2018) . - p.545-555 Titre : Evaluation of a parent-delivered early language enrichment programme: evidence from a randomised controlled trial Type de document : texte imprimé Auteurs : Kelly BURGOYNE, Auteur ; Rachel GARDNER, Auteur ; Helen WHITELEY, Auteur ; Margaret J. SNOWLING, Auteur ; Charles HULME, Auteur Article en page(s) : p.545-555 Langues : Anglais (eng) Mots-clés : Language  early literacy  education  motor skills  parents  randomised controlled trial Index. décimale : PER Périodiques Résumé : BACKGROUND: It is widely believed that increasing parental involvement can improve children's educational outcomes although we lack good evidence for such claims. This study evaluated the effectiveness of a parent-delivered early language enrichment programme. METHODS: We conducted a randomised controlled trial (RCT) with 208 preschool children and their parents living in socially diverse areas in the United Kingdom. Families were allocated to an oral language programme (N = 103) or an active control programme targeting motor skills (N = 105). Parents delivered the programmes to their child at home in daily 20-min sessions over 30 weeks of teaching. RESULTS: Children receiving the language programme made significantly larger gains in language (d = .21) and narrative skills (d = .36) than children receiving the motor skills programme at immediate posttest. Effects on language were maintained 6 months later (d = .34), and at this point, the language group also scored higher on tests of early literacy (d values=.35 and .42). There was no evidence that the movement programme improved motor skills. CONCLUSIONS: This study provides evidence for the effectiveness of a parent-delivered language enrichment programme. Further large-scale evaluations of the programme are needed to confirm and extend these findings. En ligne : http://dx.doi.org/10.1111/jcpp.12819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Evaluation of a parent-delivered early language enrichment programme: evidence from a randomised controlled trial [texte imprimé] / Kelly BURGOYNE, Auteur ; Rachel GARDNER, Auteur ; Helen WHITELEY, Auteur ; Margaret J. SNOWLING, Auteur ; Charles HULME, Auteur . - p.545-555. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-5 (May 2018) . - p.545-555 Mots-clés : Language  early literacy  education  motor skills  parents  randomised controlled trial Index. décimale : PER Périodiques Résumé : BACKGROUND: It is widely believed that increasing parental involvement can improve children's educational outcomes although we lack good evidence for such claims. This study evaluated the effectiveness of a parent-delivered early language enrichment programme. METHODS: We conducted a randomised controlled trial (RCT) with 208 preschool children and their parents living in socially diverse areas in the United Kingdom. Families were allocated to an oral language programme (N = 103) or an active control programme targeting motor skills (N = 105). Parents delivered the programmes to their child at home in daily 20-min sessions over 30 weeks of teaching. RESULTS: Children receiving the language programme made significantly larger gains in language (d = .21) and narrative skills (d = .36) than children receiving the motor skills programme at immediate posttest. Effects on language were maintained 6 months later (d = .34), and at this point, the language group also scored higher on tests of early literacy (d values=.35 and .42). There was no evidence that the movement programme improved motor skills. CONCLUSIONS: This study provides evidence for the effectiveness of a parent-delivered language enrichment programme. Further large-scale evaluations of the programme are needed to confirm and extend these findings. En ligne : http://dx.doi.org/10.1111/jcpp.12819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

Improving child and parenting outcomes following paediatric acquired brain injury: a randomised controlled trial of Stepping Stones Triple P plus Acceptance and Commitment Therapy / Felicity L. BROWN in Journal of Child Psychology and Psychiatry, 55-10 (October 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1172-1183 Titre : Improving child and parenting outcomes following paediatric acquired brain injury: a randomised controlled trial of Stepping Stones Triple P plus Acceptance and Commitment Therapy Type de document : texte imprimé Auteurs : Felicity L. BROWN, Auteur ; Koa WHITTINGHAM, Auteur ; Roslyn N. BOYD, Auteur ; Lynne MCKINLAY, Auteur ; Kate SOFRONOFF, Auteur Article en page(s) : p.1172-1183 Langues : Anglais (eng) Mots-clés : Acquired brain injury  acceptance and commitment therapy  Stepping Stones Triple P: Positive Parenting Program  behavioural and emotional functioning  parenting style  randomised controlled trial Index. décimale : PER Périodiques Résumé : Background Persistent behavioural difficulties are common following paediatric acquired brain injury (ABI). Parents and families also experience heightened stress, psychological symptoms and burden, and there is evidence of a reciprocal relationship between parent and child functioning, which may be mediated by the adoption of maladaptive parenting practices. Despite this, there is currently a paucity of research in family interventions in this population. The aim of this study was to determine the efficacy of Stepping Stones Triple P: Positive Parenting Program (SSTP), with an Acceptance and Commitment Therapy (ACT) workshop, in improving child outcomes and parenting practices following paediatric ABI. Methods Fifty-nine parents of children (mean age 7 years, SD 3 years, 1 month; 35 males, 24 females) with ABI (Traumatic injuries 58%, Tumour 17%, Encephalitis or meningitis 15%, Cardiovascular accident 7%, Hypoxia 3%) who were evidencing at least mild behaviour problems were randomly assigned to treatment or care-as-usual conditions over 10 weeks. Mixed-model repeated-measures linear regression analyses were conducted to compare conditions from pre- to postintervention on child behavioural and emotional functioning (Eyberg Child Behavior Inventory, Strengths and Difficulties Questionnaire) and dysfunctional parenting style (Parenting Scale). Assessment of maintenance of change was conducted at a 6-month follow-up. The trial was registered on Australian New Zealand Clinical Trials Registry (ID: ACTRN12610001051033, www.anzctr.org.au). Results Significant time-by-condition interactions were identified on number and intensity of child behaviour problems, child emotional symptoms and parenting laxness and overreactivity, indicating significant improvements in the treatment condition, with medium-to-large effect sizes. Most improvements were maintained at 6 months. Conclusions Group parenting interventions incorporating Triple P and ACT may be efficacious in improving child and parenting outcomes following paediatric ABI. En ligne : http://dx.doi.org/10.1111/jcpp.12227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239 [article] Improving child and parenting outcomes following paediatric acquired brain injury: a randomised controlled trial of Stepping Stones Triple P plus Acceptance and Commitment Therapy [texte imprimé] / Felicity L. BROWN, Auteur ; Koa WHITTINGHAM, Auteur ; Roslyn N. BOYD, Auteur ; Lynne MCKINLAY, Auteur ; Kate SOFRONOFF, Auteur . - p.1172-1183. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1172-1183 Mots-clés : Acquired brain injury  acceptance and commitment therapy  Stepping Stones Triple P: Positive Parenting Program  behavioural and emotional functioning  parenting style  randomised controlled trial Index. décimale : PER Périodiques Résumé : Background Persistent behavioural difficulties are common following paediatric acquired brain injury (ABI). Parents and families also experience heightened stress, psychological symptoms and burden, and there is evidence of a reciprocal relationship between parent and child functioning, which may be mediated by the adoption of maladaptive parenting practices. Despite this, there is currently a paucity of research in family interventions in this population. The aim of this study was to determine the efficacy of Stepping Stones Triple P: Positive Parenting Program (SSTP), with an Acceptance and Commitment Therapy (ACT) workshop, in improving child outcomes and parenting practices following paediatric ABI. Methods Fifty-nine parents of children (mean age 7 years, SD 3 years, 1 month; 35 males, 24 females) with ABI (Traumatic injuries 58%, Tumour 17%, Encephalitis or meningitis 15%, Cardiovascular accident 7%, Hypoxia 3%) who were evidencing at least mild behaviour problems were randomly assigned to treatment or care-as-usual conditions over 10 weeks. Mixed-model repeated-measures linear regression analyses were conducted to compare conditions from pre- to postintervention on child behavioural and emotional functioning (Eyberg Child Behavior Inventory, Strengths and Difficulties Questionnaire) and dysfunctional parenting style (Parenting Scale). Assessment of maintenance of change was conducted at a 6-month follow-up. The trial was registered on Australian New Zealand Clinical Trials Registry (ID: ACTRN12610001051033, www.anzctr.org.au). Results Significant time-by-condition interactions were identified on number and intensity of child behaviour problems, child emotional symptoms and parenting laxness and overreactivity, indicating significant improvements in the treatment condition, with medium-to-large effect sizes. Most improvements were maintained at 6 months. Conclusions Group parenting interventions incorporating Triple P and ACT may be efficacious in improving child and parenting outcomes following paediatric ABI. En ligne : http://dx.doi.org/10.1111/jcpp.12227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239

Managing Repetitive Behaviours in Young Children with Autism Spectrum Disorder (ASD): Pilot Randomised Controlled Trial of a New Parent Group Intervention / Victoria GRAHAME in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

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A pilot randomised controlled trial of a group based social skills intervention for adults with autism spectrum disorder / Ruth ASHMAN in Research in Autism Spectrum Disorders, 43-44 (November 2017)  

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A Pilot Randomised Controlled Trial of a School-Based Resilience Intervention to Prevent Depressive Symptoms for Young Adolescents with Autism Spectrum Disorder: A Mixed Methods Analysis / Bethany A. MACKAY in Journal of Autism and Developmental Disorders, 47-11 (November 2017)  

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A randomised controlled trial of an iPad-based application to complement early behavioural intervention in Autism Spectrum Disorder / Andrew J.O. WHITEHOUSE in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

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Web-based integrated bipolar parenting intervention for parents with bipolar disorder: a randomised controlled pilot trial / Steven H. JONES in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

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